GO:0090398

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Name cellular senescence
Categary Process
Go Slim No
Go Link GO:0090398
Unique Molecular Interactions 277
Total Molecular Interactions 364
Total Single Events 3192
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular senescence. They are ordered first by their pain relevance and then by number of times they were reported for cellular senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
3 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
4 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
5 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
6 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
7 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
8 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
9 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
10 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
11 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
12 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
13 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
14 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
15 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
16 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
17 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
18 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
19 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
20 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
21 INT134476 Cdk5 Regulation of Map2k1 1 0.69 0.88 0.71
22 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
23 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
24 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
25 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
26 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
27 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
28 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
29 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
30 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
31 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
32 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
33 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
34 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
35 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
36 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
37 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
38 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
39 INT95563 HRAS Positive_regulation of TNF 1 0.03 0.7 0.45
40 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
41 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
42 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
43 INT247287 Gene_expression of GLC1N Regulation of Gene_expression of HRAS 1 0.02 0.56 0.42
44 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
45 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
46 INT346222 Positive_regulation of Braf Positive_regulation of Map2k1 1 0.15 0.67 0.39
47 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
48 INT166792 Binding of CD44 and HRAS 3 0.12 1.49 0.37
49 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
50 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
51 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
52 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
53 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
54 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
55 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
56 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
57 INT303105 CAMK4 Positive_regulation of Hras1 1 0.04 0.16 0.31
58 INT166789 HRAS Regulation of Positive_regulation of NFKB1 1 0.05 0.31 0.3
59 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
60 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
61 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
62 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
63 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
64 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
65 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
66 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
67 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
68 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
69 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
70 INT346224 Braf Negative_regulation of Phosphorylation of Map2k1 1 0.14 0.62 0.22
71 INT60347 COL2A1 Positive_regulation of Gene_expression of Hras 1 0.05 0.92 0.2
72 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2
73 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
74 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18
75 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18
76 INT184194 Binding of HRAS and SPAM1 1 0.00 0.26 0.17
77 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
78 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
79 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
80 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16
81 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
82 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
83 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
84 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
85 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
86 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
87 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
88 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
89 INT247280 GLC1N Regulation of Gene_expression of HRAS 1 0.03 0.29 0.12
90 INT173122 PPA1 Positive_regulation of HRAS 1 0.08 0.5 0.12
91 INT283719 Id2 Regulation of Regulation of Hes7 1 0.00 0.31 0.12
92 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
93 INT283710 Binding of Id2 and Hes7 1 0.01 0.13 0.11
94 INT293417 HRAS Regulation of IL11 1 0.00 1.17 0.1
95 INT304499 Map2k1 Positive_regulation of Mapk1 1 0.12 0.8 0.1
96 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1
97 INT293408 HRAS Regulation of VEGFA 1 0.00 1.18 0.1
98 INT351426 SEPT5 Regulation of HRAS 1 0.00 0.7 0.09
99 INT351425 HRAS Regulation of SEPT5 1 0.00 0.7 0.09
100 INT224531 Positive_regulation of Map2k1 Positive_regulation of Positive_regulation of Ankh 1 0.07 0.54 0.09
101 INT293415 HRAS Positive_regulation of Localization of IL8 1 0.01 0.73 0.09
102 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
103 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
104 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
105 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
106 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
107 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
108 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
109 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
110 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
111 INT283721 Binding of Lpin1 and Id2 1 0.38 0.18 0.08
112 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
113 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
114 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
115 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
116 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
117 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
118 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
119 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
120 INT84752 Binding of HRAS and DCPS 1 0.18 2.61 0.07
121 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
122 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
123 INT286563 Binding of Id2 and P1Ehs1 1 0.00 0.17 0.06
124 INT286591 Binding of PKD1 and Id2 1 0.07 0.17 0.06
125 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
126 INT204992 Hmmr Positive_regulation of Hras1 1 0.00 0.58 0.06
127 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
128 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
129 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
130 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
131 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
132 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
133 INT194699 MAP2K1 Positive_regulation of MAPK8 1 0.05 0 0.04
134 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
135 INT194677 Binding of GADD45A and MAP2K1 1 0.27 0 0.04
136 INT194719 MAP2K1 Positive_regulation of MAPK1 1 0.27 0 0.04
137 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04
138 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04
139 INT235551 Gene_expression of Hras1 Negative_regulation of Positive_regulation of Apoe 1 0.03 0.57 0.04
140 INT194701 MAP2K1 Positive_regulation of MAP2K4 1 0.21 0 0.04
141 INT194732 MAP2K1 Positive_regulation of Gene_expression of MAPK1 1 0.27 0 0.04
142 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
143 INT194691 MAP2K1 Positive_regulation of MAP2K3 1 0.23 0 0.04
144 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
145 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
146 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
147 INT283720 Id2 Negative_regulation of Transcription of Cdkn2b 1 0.18 0.11 0.03
148 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
149 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
150 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
151 INT269502 Lta Negative_regulation of Map2k1 1 0.17 0.48 0.03
152 INT283712 Id2 Regulation of Gene_expression of Fos 1 0.43 0 0.03
153 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
154 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
155 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03
156 INT295474 IRF6 Positive_regulation of MAP2K1 1 0.18 0.41 0.03
157 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
158 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
159 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
160 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
161 INT182942 VDR Positive_regulation of CDKN1A 1 0.35 0.38 0
162 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
163 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
164 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
165 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
166 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
167 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0
168 INT172347 Eri1 Negative_regulation of Hras1 1 0.00 0.76 0
169 INT320959 Binding of HRAS and HMHA1 1 0.00 0.37 0
170 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
171 INT201534 RASSF1 Negative_regulation of ID2 1 0.33 1.41 0
172 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
173 INT225157 CDKN1A Regulation of CHKA 1 0.12 0.58 0
174 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0
175 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
176 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
177 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
178 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0
179 INT335705 Binding of ITGA4 and Calr 1 0.01 0.43 0
180 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
181 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
182 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
183 INT351732 SSD Regulation of CALR 1 0.01 2.95 0
184 INT176292 Fasl Regulation of Gene_expression of CDKN1A 1 0.34 0.84 0
185 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
186 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
187 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
188 INT214918 Gtf3a Positive_regulation of CDKN1A 1 0.01 0.66 0
189 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
190 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
191 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
192 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
193 INT182912 Binding of CDKN1A and FRA8E 1 0.02 0.37 0
194 INT272859 Binding of HRAS and M1 1 0.00 0.33 0
195 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
196 INT233274 Tpt1 Regulation of Cdkn1a 1 0.05 0.26 0
197 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
198 INT325152 CDKN1A Negative_regulation of CCNE2 1 0.07 0.1 0
199 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0
200 INT254693 Gene_expression of Map2k1 Regulation of Map2k2 1 0.29 0.78 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular senescence. They are ordered first by their pain relevance and then by number of times they were reported in cellular senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
2 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
3 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
4 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
5 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
6 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
7 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
8 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
9 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
10 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8
11 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
12 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
13 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
14 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
15 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
16 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
17 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
18 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
19 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
20 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
21 INT26546 Positive_regulation of Gene_expression of Hras1 35 0.70 16.59 4.54
22 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
23 INT20981 Binding of HRAS 42 0.48 24.49 4.23
24 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
25 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
26 INT169475 Localization of HRAS 14 0.73 9.02 3.9
27 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
28 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
29 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
30 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
31 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02
32 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
33 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
34 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
35 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
36 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
37 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
38 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
39 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
40 INT127756 Negative_regulation of Map2k1 10 0.41 6.69 2.04
41 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
42 INT70526 Binding of CALR 11 0.35 7.09 1.97
43 INT21941 Regulation of CALR 7 0.53 3.88 1.96
44 INT76993 Regulation of HRAS 8 0.60 7.81 1.95
45 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77
46 INT129610 Gene_expression of Id2 7 0.74 17.07 1.69
47 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
48 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59
49 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46
50 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
51 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
52 INT175525 Positive_regulation of Phosphorylation of Map2k1 8 0.33 7.02 1.37
53 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
54 INT54587 Positive_regulation of Hras1 12 0.27 5.54 1.3
55 INT66118 Binding of Calr 4 0.46 1.46 1.26
56 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
57 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
58 INT166171 Negative_regulation of Gene_expression of HRAS 5 0.07 3.98 1.11
59 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
60 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
61 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
62 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02
63 INT247294 Regulation of Gene_expression of HRAS 1 0.04 1.8 1.02
64 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
65 INT73459 Transcription of Hras1 3 0.69 2.01 0.95
66 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
67 INT26531 Regulation of Srf 3 0.18 0.62 0.9
68 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
69 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
70 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
71 INT71778 Positive_regulation of Gene_expression of MAP2K1 2 0.36 0.37 0.81
72 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
73 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
74 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
75 INT45293 Transcription of Srf 2 0.47 0.79 0.76
76 INT211909 Regulation of Positive_regulation of Map2k1 1 0.21 0.47 0.76
77 INT36887 Regulation of Hras 2 0.44 0.76 0.72
78 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
79 INT164957 Regulation of Gene_expression of Hras1 8 0.04 4.4 0.64
80 INT60343 Gene_expression of Hras 6 0.75 2.3 0.64
81 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
82 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
83 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
84 INT177557 Positive_regulation of Calr 12 0.48 5.47 0.61
85 INT162801 Localization of CALR 7 0.73 8.69 0.6
86 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
87 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
88 INT129615 Positive_regulation of Id2 2 0.66 2.22 0.57
89 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
90 INT104120 Positive_regulation of Positive_regulation of MAP2K1 1 0.49 0 0.54
91 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
92 INT82167 Transcription of HRAS 4 0.67 3.8 0.53
93 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
94 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
95 INT142972 Gene_expression of ID2 6 0.54 5.92 0.49
96 INT236915 Binding of Map2k1 2 0.15 1.51 0.49
97 INT120390 Phosphorylation of PRKCD 1 0.33 0.38 0.49
98 INT92384 Regulation of Positive_regulation of HRAS 2 0.60 2.05 0.48
99 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
100 INT169470 Positive_regulation of Localization of HRAS 1 0.49 0.89 0.43
101 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
102 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
103 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
104 INT120394 Positive_regulation of PRKCD 2 0.26 1.58 0.41
105 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
106 INT60346 Positive_regulation of Gene_expression of Hras 4 0.42 1.56 0.4
107 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
108 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
109 INT138282 Positive_regulation of Gene_expression of Map2k1 13 0.49 7.46 0.39
110 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37
111 INT283683 Binding of Id2 5 0.35 0.8 0.35
112 INT120391 Negative_regulation of Localization of PRKCD 1 0.22 0 0.34
113 INT120398 Positive_regulation of Positive_regulation of PRKCD 1 0.26 0 0.33
114 INT217379 Phosphorylation of Hras1 1 0.01 1.43 0.33
115 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
116 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
117 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
118 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
119 INT304526 Binding of Map2k1 1 0.11 0.6 0.32
120 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
121 INT80065 Binding of Hras1 4 0.03 1.14 0.31
122 INT60342 Negative_regulation of Gene_expression of Hras 2 0.56 0.6 0.31
123 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
124 INT247292 Positive_regulation of Positive_regulation of HRAS 1 0.03 0.62 0.31
125 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
126 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
127 INT240205 Regulation of MAP2K1 3 0.26 0.44 0.28
128 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
129 INT7610 Localization of Srf 3 0.67 0.98 0.27
130 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
131 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
132 INT82373 Positive_regulation of Regulation of HRAS 1 0.25 1.49 0.25
133 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
134 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
135 INT175506 Regulation of Positive_regulation of Map2k1 2 0.32 1.58 0.23
136 INT129612 Positive_regulation of Gene_expression of Id2 4 0.67 3.61 0.22
137 INT222087 Regulation of Calr 3 0.42 0.56 0.22
138 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22
139 INT188122 Negative_regulation of Hras1 12 0.02 8.38 0.21
140 INT174877 Localization of Hras1 4 0.04 0.97 0.2
141 INT335675 Localization of Calr 1 0.63 1.23 0.2
142 INT348917 Negative_regulation of Protein_catabolism of HRAS 1 0.02 0.57 0.2
143 INT54586 Negative_regulation of Positive_regulation of Hras1 2 0.04 0 0.19
144 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
145 INT177555 Regulation of Gene_expression of Calr 3 0.28 0.82 0.16
146 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
147 INT89766 Binding of SRF 1 0.17 0.89 0.15
148 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
149 INT60345 Regulation of Gene_expression of Hras 1 0.44 0.36 0.15
150 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
151 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
152 INT254671 Regulation of Map2k1 5 0.43 1.83 0.14
153 INT177554 Positive_regulation of Gene_expression of Calr 3 0.37 1.08 0.14
154 INT265533 Negative_regulation of Phosphorylation of Map2k1 1 0.41 0 0.14
155 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
156 INT183490 Regulation of Hras1 7 0.04 1.65 0.13
157 INT175527 Localization of Map2k1 4 0.31 2.41 0.13
158 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
159 INT184200 Positive_regulation of Protein_catabolism of HRAS 1 0.01 0.45 0.13
160 INT283702 Transcription of Id2 1 0.66 0.64 0.13
161 INT335686 Regulation of Localization of Calr 1 0.48 0.12 0.12
162 INT209698 Gene_expression of PRKCD 1 0.33 1.78 0.12
163 INT254673 Positive_regulation of Positive_regulation of Map2k1 3 0.35 1.65 0.11
164 INT283708 Localization of Id2 2 0.71 0.72 0.11
165 INT142970 Positive_regulation of Gene_expression of ID2 2 0.40 2.39 0.11
166 INT142968 Negative_regulation of Gene_expression of ID2 1 0.19 0.98 0.11
167 INT148991 Gene_expression of Cdkn1a 1 0.44 0.46 0.11
168 INT80063 Positive_regulation of Positive_regulation of Hras1 2 0.04 0.96 0.1
169 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
170 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09
171 INT142971 Negative_regulation of Positive_regulation of ID2 1 0.20 0.69 0.09
172 INT346497 Negative_regulation of Phosphorylation of Cdkn1a 1 0.41 0.83 0.09
173 INT142969 Positive_regulation of ID2 1 0.21 0.68 0.09
174 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
175 INT129614 Positive_regulation of Positive_regulation of Id2 1 0.48 0.31 0.08
176 INT192855 Transcription of Calr 1 0.11 0.99 0.08
177 INT215418 Positive_regulation of Phosphorylation of MAP2K1 1 0.03 0.51 0.08
178 INT209688 Negative_regulation of Positive_regulation of PRKCD 1 0.18 1.1 0.08
179 INT215420 Phosphorylation of MAP2K1 1 0.05 0.51 0.08
180 INT22789 Binding of Srf 1 0.37 0.07 0.07
181 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
182 INT328542 Regulation of Positive_regulation of Cdkn1a 1 0.03 0.79 0.07
183 INT354146 Regulation of Gene_expression of CALR 1 0.04 0.73 0.07
184 INT176262 Positive_regulation of Phosphorylation of CDKN1A 3 0.49 2.12 0.06
185 INT190544 Transcription of Srf 1 0.19 0.43 0.06
186 INT129613 Regulation of Gene_expression of Id2 1 0.43 0.24 0.06
187 INT190570 Localization of Srf 1 0.20 0.49 0.06
188 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
189 INT281764 Negative_regulation of Gene_expression of Map2k1 1 0.18 1.11 0.04
190 INT316430 Positive_regulation of Negative_regulation of Cdkn1a 1 0.19 1.24 0.04
191 INT316766 Negative_regulation of Calr 2 0.40 0.71 0.03
192 INT242969 Protein_catabolism of Calr 2 0.68 0.94 0.03
193 INT225411 Positive_regulation of Srf 1 0.05 0.27 0.03
194 INT224295 Protein_catabolism of CDKN1A 1 0.12 0.55 0.03
195 INT268102 Transcription of SRF 1 0.53 0.85 0.03
196 INT267192 Localization of Prkcd 1 0.78 0.96 0.03
197 INT225413 Binding of Srf 1 0.10 0.27 0.03
198 INT267186 Positive_regulation of Localization of Prkcd 1 0.49 0.97 0.03
199 INT353546 Positive_regulation of Localization of CALR 1 0.05 0.49 0.03
200 INT176092 Negative_regulation of Gene_expression of Hras1 5 0.03 3.31 0
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