GO:0090399

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Name replicative senescence
Categary Process
Go Slim No
Go Link GO:0090399
Unique Molecular Interactions 336
Total Molecular Interactions 434
Total Single Events 3488
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for replicative senescence. They are ordered first by their pain relevance and then by number of times they were reported for replicative senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
4 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
5 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
6 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
7 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
8 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
9 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
10 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
11 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
12 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
13 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
14 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
15 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
16 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
17 INT189687 INSRR Negative_regulation of Transcription of TERT 1 0.00 0.24 0.35
18 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
19 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
20 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
21 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
22 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
23 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
24 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
25 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
26 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
27 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
28 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
29 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
30 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
31 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
32 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
33 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
34 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
35 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
36 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
37 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
38 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
39 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
40 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
41 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
42 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
43 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
44 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
45 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
46 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
47 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
48 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
49 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
50 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
51 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
52 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
53 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
54 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
55 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
56 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
57 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
58 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
59 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17
60 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
61 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
62 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
63 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
64 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
65 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
66 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
67 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
68 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
69 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
70 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14
71 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
72 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
73 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
74 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
75 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
76 INT285948 IL17A Regulation of Gene_expression of TERT 1 0.00 0.58 0.11
77 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
78 INT189702 CHKB Regulation of Gene_expression of TERT 1 0.06 0.55 0.1
79 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
80 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
81 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
82 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
83 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
84 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
85 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
86 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
87 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
88 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
89 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
90 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
91 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
92 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
93 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
94 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
95 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
96 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
97 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
98 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
99 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
100 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
101 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05
102 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
103 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05
104 INT189677 CHKB Regulation of Transcription of TERT 1 0.10 1 0.05
105 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
106 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
107 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
108 INT189679 INSRR Regulation of Transcription of TERT 1 0.00 1 0.05
109 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
110 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
111 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05
112 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
113 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
114 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
115 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
116 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05
117 INT220812 Tert Positive_regulation of Gene_expression of hl 1 0.01 0.14 0.04
118 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
119 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
120 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
121 INT220811 Tert Positive_regulation of Gene_expression of Krt36 1 0.41 0.14 0.04
122 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
123 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
124 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
125 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
126 INT220808 Tert Positive_regulation of Gene_expression of Krt31 1 0.43 0.14 0.04
127 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
128 INT285944 IL6 Positive_regulation of Gene_expression of TERT 1 0.01 0.36 0.04
129 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
130 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
131 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
132 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
133 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
134 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
135 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
136 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
137 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
138 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
139 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
140 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
141 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
142 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
143 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
144 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
145 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
146 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
147 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
148 INT296163 Mcph1 Regulation of Tert 1 0.03 0.19 0
149 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
150 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
151 INT304020 AR Regulation of TP53 1 0.24 1.11 0
152 INT315221 Tpt1 Regulation of Positive_regulation of Trp53 1 0.33 1.04 0
153 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
154 INT203901 HIVEP1 Positive_regulation of Gene_expression of TP53 1 0.04 0.86 0
155 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
156 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
157 INT232006 Binding of Trp53 and Tsp1 1 0.06 0.75 0
158 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
159 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
160 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
161 INT313307 TERT Positive_regulation of NFE2L2 1 0.01 0 0
162 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
163 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
164 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
165 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
166 INT333690 Hr Negative_regulation of Transcription of Trp53 1 0.23 0.51 0
167 INT217776 TP53 Regulation of MITF 1 0.00 1.28 0
168 INT334322 Binding of RB1 and TP53 1 0.34 2 0
169 INT342007 Mta1 Regulation of Trp53 1 0.15 0.15 0
170 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
171 INT179095 Myc Positive_regulation of Gene_expression of Trp53 1 0.43 0.83 0
172 INT315397 Binding of IFNA1 and Tp53 1 0.00 0.43 0
173 INT333689 Hr Positive_regulation of Protein_catabolism of Trp53 1 0.25 1.71 0
174 INT331091 Tert Positive_regulation of Positive_regulation of Cd4 1 0.24 0.76 0
175 INT189703 MZF1 Regulation of TERT 1 0.03 0.46 0
176 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0
177 INT286044 Wwox Positive_regulation of Tp53 1 0.05 0.63 0
178 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
179 INT285941 IL6 Regulation of Gene_expression of TERT 1 0.01 0.12 0
180 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
181 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
182 INT241256 TP53 Regulation of OPCML 1 0.12 1.31 0
183 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
184 INT305542 Binding of Rb1 and Trp53 1 0.00 0.9 0
185 INT352625 Trp53 Regulation of CEL 1 0.00 0.71 0
186 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
187 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
188 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
189 INT177793 EGR1 Positive_regulation of Negative_regulation of TP53 1 0.18 0.44 0
190 INT284232 Binding of TP53 and HNRNPUL1 1 0.26 0.88 0
191 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
192 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
193 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
194 INT278186 Binding of TP53 and GOPC 1 0.02 0.85 0
195 INT337708 Naf1 Regulation of Gene_expression of Tp53 1 0.09 0.22 0
196 INT220819 Myc Regulation of Transcription of Tert 1 0.44 0.1 0
197 INT345337 Binding of TP53 and BCC1 1 0.11 1.05 0
198 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
199 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
200 INT268513 MIR34A Regulation of Gene_expression of TP53 1 0.00 0.9 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for replicative senescence. They are ordered first by their pain relevance and then by number of times they were reported in replicative senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
4 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
5 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
6 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
7 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
8 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
9 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
10 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42
11 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
12 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
13 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
14 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
15 INT121494 Transcription of TERT 64 0.69 10.03 5.55
16 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
17 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
18 INT60585 Regulation of TP53 59 0.59 54.55 5.21
19 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
20 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
21 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
22 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
23 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
24 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
25 INT8103 Binding of TP53 46 0.44 40.2 2.96
26 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
27 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
28 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
29 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
30 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
31 INT133194 Negative_regulation of TERT 23 0.48 4.01 2.45
32 INT55952 Transcription of TP53 16 0.61 12.14 2.36
33 INT189770 Positive_regulation of Transcription of TERT 1 0.28 1.36 2.14
34 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
35 INT189766 Regulation of Transcription of TERT 1 0.25 3.48 1.99
36 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
37 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
38 INT65855 Localization of TP53 18 0.76 17.08 1.89
39 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
40 INT147403 Regulation of Gene_expression of TERT 11 0.27 3.45 1.54
41 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
42 INT220783 Gene_expression of Tert 39 0.77 12.55 1.49
43 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
44 INT129712 Positive_regulation of Gene_expression of TERT 12 0.70 7.3 1.44
45 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
46 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
47 INT172953 Binding of Trp53 33 0.37 20.76 1.41
48 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
49 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
50 INT133193 Positive_regulation of TERT 16 0.50 6.43 1.38
51 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
52 INT145221 Binding of Tp53 10 0.37 8.59 1.37
53 INT147607 Binding of TERT 16 0.48 12.36 1.31
54 INT189736 Regulation of TERT 22 0.40 3.58 1.29
55 INT38916 Positive_regulation of Tert 3 0.33 1.92 1.28
56 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
57 INT174156 Localization of Trp53 16 0.72 13.52 1.18
58 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
59 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
60 INT133195 Negative_regulation of Transcription of TERT 4 0.42 2.9 1.08
61 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
62 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
63 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
64 INT189734 Negative_regulation of Gene_expression of TERT 8 0.24 1.84 0.85
65 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
66 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
67 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
68 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
69 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
70 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
71 INT28118 Binding of Atm 13 0.38 12.24 0.68
72 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
73 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
74 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
75 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
76 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
77 INT48212 Binding of ATM 5 0.47 3.89 0.57
78 INT160777 Transcription of CHEK2 1 0.52 1.03 0.57
79 INT160778 Transcription of ATM 1 0.40 1.03 0.57
80 INT291268 Gene_expression of Atr 1 0.06 1.48 0.57
81 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
82 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
83 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
84 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
85 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
86 INT189756 Positive_regulation of Phosphorylation of TERT 1 0.28 0.2 0.5
87 INT189728 Phosphorylation of TERT 1 0.34 0.2 0.5
88 INT220787 Localization of Tert 5 0.69 0.87 0.49
89 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
90 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
91 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
92 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
93 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
94 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
95 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
96 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37
97 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
98 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
99 INT189760 Negative_regulation of Negative_regulation of TERT 1 0.24 0.11 0.34
100 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
101 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
102 INT189739 Negative_regulation of Regulation of TERT 1 0.18 0.17 0.32
103 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
104 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
105 INT96569 Negative_regulation of CHEK1 4 0.32 3.08 0.29
106 INT245337 Gene_expression of ATR 3 0.27 2.06 0.29
107 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
108 INT220770 Binding of Tert 7 0.37 1.09 0.27
109 INT167438 Localization of ATM 3 0.55 1.61 0.27
110 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
111 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
112 INT220785 Positive_regulation of Tert 15 0.68 6.9 0.25
113 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
114 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
115 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25
116 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
117 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
118 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
119 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
120 INT220777 Positive_regulation of Gene_expression of Tert 9 0.68 2.34 0.18
121 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
122 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
123 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
124 INT220767 Regulation of Tert 1 0.53 1 0.16
125 INT105012 Negative_regulation of Atr 1 0.34 0.35 0.16
126 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16
127 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
128 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
129 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
130 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
131 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
132 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
133 INT220774 Negative_regulation of Gene_expression of Tert 1 0.58 1.09 0.14
134 INT189761 Positive_regulation of Regulation of TERT 1 0.19 0.14 0.14
135 INT245341 Regulation of Gene_expression of ATR 1 0.18 0.94 0.14
136 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
137 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
138 INT167440 Regulation of ATM 2 0.20 0.68 0.12
139 INT245339 Regulation of ATR 1 0.18 0.92 0.11
140 INT186980 Transcription of Tert 1 0.34 0.34 0.11
141 INT186973 Regulation of Transcription of Tert 1 0.21 0.34 0.11
142 INT211717 Gene_expression of CHEK2 13 0.37 2.13 0.1
143 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
144 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
145 INT111139 Localization of Tp53 4 0.45 2.4 0.09
146 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
147 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
148 INT252551 Phosphorylation of CHEK2 4 0.48 4.73 0.08
149 INT252552 Positive_regulation of Phosphorylation of CHEK2 1 0.23 0.26 0.08
150 INT220780 Regulation of Gene_expression of Tert 1 0.44 0 0.08
151 INT352605 Regulation of Negative_regulation of Trp53 1 0.45 0.72 0.07
152 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
153 INT139362 Negative_regulation of CHEK2 2 0.35 1.66 0.06
154 INT139365 Negative_regulation of Negative_regulation of CHEK1 1 0.23 1.67 0.06
155 INT139364 Negative_regulation of Negative_regulation of CHEK2 1 0.26 1.67 0.06
156 INT171421 Regulation of Positive_regulation of TP53 1 0.48 0.45 0.05
157 INT186977 Gene_expression of Tert 1 0.36 1.49 0.05
158 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
159 INT315213 Negative_regulation of Binding of Trp53 1 0.32 0.11 0.05
160 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04
161 INT305536 Positive_regulation of Binding of Trp53 1 0.35 0.32 0.04
162 INT220784 Regulation of Regulation of Tert 1 0.39 0 0.04
163 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
164 INT220786 Negative_regulation of Tert 8 0.43 2.55 0.03
165 INT207803 Regulation of Atm 3 0.41 1.15 0.03
166 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03
167 INT259061 Negative_regulation of Regulation of TP53 2 0.10 2.23 0.03
168 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0
169 INT207807 Localization of Atm 4 0.74 0.21 0
170 INT333669 Positive_regulation of Transcription of Trp53 3 0.45 2.33 0
171 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
172 INT274377 Localization of TERT 3 0.70 0.78 0
173 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0
174 INT208213 Localization of ATR 2 0.50 0.19 0
175 INT113348 Negative_regulation of Binding of TP53 2 0.28 1.49 0
176 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
177 INT220792 Transcription of Tert 2 0.71 0.56 0
178 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
179 INT223278 Positive_regulation of Binding of TERT 2 0.44 1.35 0
180 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0
181 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
182 INT217820 Regulation of Negative_regulation of TP53 2 0.37 1.92 0
183 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
184 INT252642 Transcription of Atm 1 0.53 0.18 0
185 INT186978 Positive_regulation of Positive_regulation of Tert 1 0.22 0.44 0
186 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0
187 INT186985 Positive_regulation of Transcription of Tert 1 0.24 0 0
188 INT186976 Binding of Tert 1 0.17 0.55 0
189 INT333668 Regulation of Protein_catabolism of Trp53 1 0.24 1.58 0
190 INT347316 Negative_regulation of Binding of TERT 1 0.18 0.26 0
191 INT252553 Positive_regulation of Positive_regulation of CHEK2 1 0.17 0 0
192 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0
193 INT189751 Regulation of Regulation of TERT 1 0.11 0.08 0
194 INT172979 Regulation of Negative_regulation of CDKN2A 1 0.44 0.57 0
195 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0
196 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
197 INT147147 Positive_regulation of Transcription of CDKN2A 1 0.49 0 0
198 INT331373 Positive_regulation of Transcription of Tert 1 0.24 0.17 0
199 INT260376 Protein_catabolism of TERT 1 0.02 0.36 0
200 INT186974 Negative_regulation of Transcription of Tert 1 0.27 0 0
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