GO:0097108

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Name hedgehog family protein binding
Categary Function
Go Slim No
Go Link GO:0097108
Unique Molecular Interactions 54
Total Molecular Interactions 112
Total Single Events 413
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hedgehog family protein binding. They are ordered first by their pain relevance and then by number of times they were reported for hedgehog family protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
2 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
3 INT269454 Positive_regulation of Binding of GOPC and HHIP 1 0.01 0 0.73
4 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
5 INT269442 Binding of GOPC and HHIP 1 0.01 0 0.52
6 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42
7 INT269456 RAB5A Regulation of Binding of HHIP 1 0.04 0 0.38
8 INT269459 Binding of ISYNA1 and HHIP 1 0.00 0 0.27
9 INT269490 Binding of Racgap1 and HHIP 1 0.00 0 0.27
10 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
11 INT269446 Binding of EPHA3 and HHIP 1 0.01 0 0.2
12 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
13 INT269451 Negative_regulation of Binding of RAB5A and HHIP 1 0.03 0 0.15
14 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
15 INT269452 RAB5A Regulation of Localization of HHIP 1 0.04 0 0.15
16 INT269445 Localization of HHIP Regulation of Gene_expression of RAB5A 1 0.03 0 0.13
17 INT269457 RAB5A Regulation of Regulation of HHIP 1 0.02 0 0.13
18 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
19 INT269458 HHIP Regulation of Gene_expression of RAB5A 1 0.04 0 0.1
20 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
21 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
22 INT269453 HHIP Positive_regulation of RAB5A 1 0.04 0 0.03
23 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
24 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
25 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
26 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
27 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
28 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
29 INT342265 Binding of VDR and HHIP 1 0.00 0.93 0
30 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
31 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
32 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
33 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
34 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
35 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
36 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
37 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
38 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
39 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
40 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
41 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
42 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
43 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
44 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
45 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
46 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
47 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
48 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
49 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
50 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
51 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
52 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
53 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
54 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hedgehog family protein binding. They are ordered first by their pain relevance and then by number of times they were reported in hedgehog family protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57
2 INT178763 Binding of HHIP 37 0.08 6.3 5.29
3 INT125478 Localization of HHIP 32 0.80 3.43 4.68
4 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75
5 INT125480 Regulation of HHIP 17 0.38 6.16 2.16
6 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
7 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
8 INT125476 Regulation of Gene_expression of HHIP 2 0.39 1.1 1.1
9 INT269487 Positive_regulation of Binding of HHIP 1 0.06 0 1.08
10 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92
11 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
12 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
13 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
14 INT269461 Positive_regulation of Localization of HHIP 1 0.05 0 0.63
15 INT269465 Positive_regulation of Positive_regulation of HHIP 4 0.11 0.5 0.62
16 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
17 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43
18 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
19 INT269484 Negative_regulation of Localization of HHIP 1 0.04 0 0.22
20 INT269463 Phosphorylation of HHIP 1 0.05 0 0.22
21 INT269489 Positive_regulation of Phosphorylation of HHIP 1 0.04 0 0.22
22 INT269464 Negative_regulation of Gene_expression of HHIP 4 0.10 0.74 0.16
23 INT269486 Regulation of Localization of HHIP 1 0.04 0 0.15
24 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
25 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
26 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
27 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
28 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
29 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
30 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
31 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
32 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
33 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
34 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
35 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
36 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
37 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
38 INT342268 Positive_regulation of Negative_regulation of HHIP 1 0.04 0.91 0
39 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
40 INT349060 Regulation of Negative_regulation of HHIP 1 0.10 1.33 0
41 INT260089 Localization of PTCH1 1 0.70 0.37 0
42 INT233766 Negative_regulation of Regulation of HHIP 1 0.12 0.32 0
43 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
44 INT269469 Regulation of Positive_regulation of HHIP 1 0.04 0 0
45 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
46 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
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