GO:0097191

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Name extrinsic apoptotic signaling pathway
Categary Process
Go Slim No
Go Link GO:0097191
Unique Molecular Interactions 976
Total Molecular Interactions 1328
Total Single Events 13591
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for extrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for extrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
2 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
3 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
4 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
5 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
6 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
7 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
8 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
9 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
10 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
11 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
12 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
13 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
14 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
15 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
16 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
17 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
18 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
19 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
20 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
21 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
22 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
23 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
24 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
25 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
26 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
27 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
28 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
29 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
30 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
31 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
32 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
33 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
34 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
35 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
36 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
37 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
38 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
39 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
40 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
41 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
42 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
43 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
44 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
45 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
46 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
47 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
48 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
49 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
50 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
51 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
52 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
53 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
54 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
55 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
56 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
57 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
58 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
59 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
60 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
61 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
62 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
63 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
64 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
65 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
66 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
67 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
68 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
69 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
70 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
71 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
72 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
73 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
74 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
75 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
76 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
77 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
78 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
79 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
80 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
81 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
82 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
83 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
84 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
85 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
86 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
87 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
88 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
89 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
90 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
91 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
92 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
93 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
94 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
95 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
96 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
97 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
98 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
99 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
100 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
101 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
102 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
103 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
104 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
105 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
106 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
107 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
108 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
109 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
110 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
111 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
112 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
113 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
114 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
115 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
116 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
117 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
118 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84
119 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
120 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
121 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
122 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
123 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
124 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
125 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
126 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79
127 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
128 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78
129 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
130 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
131 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
132 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
133 INT130138 TNF Negative_regulation of Gene_expression of S100A10 1 0.06 1.32 0.78
134 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
135 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
136 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77
137 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
138 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
139 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
140 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76
141 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75
142 INT113472 TNF Positive_regulation of Localization of MMP14 1 0.47 0.45 0.75
143 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
144 INT354455 Il11 Negative_regulation of Gene_expression of Tnf 1 0.31 1.21 0.74
145 INT301141 Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
146 INT301142 Negative_regulation of Nsa2 Positive_regulation of TNF 1 0.01 0.6 0.74
147 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
148 INT86657 TNF Regulation of H2-Ab1 1 0.02 0.84 0.74
149 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
150 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74
151 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74
152 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73
153 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72
154 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
155 INT51006 PDYN Positive_regulation of TNF 1 0.11 0.84 0.72
156 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 0.06 0.29 0.71
157 INT113499 TNF Positive_regulation of Gene_expression of BHLHE23 1 0.25 0.1 0.71
158 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
159 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7
160 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7
161 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 0.06 0.29 0.7
162 INT117533 TNF Positive_regulation of Positive_regulation of SETBP1 1 0.34 0.29 0.7
163 INT83628 TNF Positive_regulation of Gene_expression of Cd59 1 0.06 1.09 0.7
164 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69
165 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69
166 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69
167 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
168 INT113959 TNF Positive_regulation of Gene_expression of IK 1 0.02 0.66 0.69
169 INT190527 TNF Positive_regulation of Gene_expression of Ros1 1 0.01 1.02 0.68
170 INT119107 Negative_regulation of Binding of LTBR and TNF 1 0.17 1.16 0.68
171 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
172 INT231349 Il10 Negative_regulation of Gene_expression of TNF 2 0.23 1.82 0.67
173 INT119105 Binding of FCGR1A and TNF 1 0.03 1.16 0.67
174 INT119106 Negative_regulation of Binding of FCGR1A and TNF 1 0.03 1.16 0.67
175 INT264338 Binding of IL-17 and Positive_regulation of Localization of TNF 1 0.04 1.71 0.67
176 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
177 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
178 INT137142 Binding of ITIH4 and Positive_regulation of Localization of TNF 1 0.40 0.71 0.66
179 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
180 INT252293 Binding of TNF and Positive_regulation of Gene_expression of Ccl20 1 0.04 0.54 0.66
181 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
182 INT120146 seb Positive_regulation of Gene_expression of Tnf 1 0.40 0.86 0.66
183 INT120145 seb Positive_regulation of Tnf 1 0.40 0.85 0.65
184 INT254230 Ik Negative_regulation of Gene_expression of TNF 1 0.00 1.29 0.65
185 INT132689 Tnf Regulation of Dnajc13 1 0.01 1.27 0.65
186 INT295705 Binding of IK and TNF 1 0.00 0.27 0.64
187 INT292893 TNF Regulation of IL8 2 0.27 1.3 0.63
188 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
189 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63
190 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
191 INT165048 Trib3 Positive_regulation of Gene_expression of Tnf 1 0.08 0.8 0.63
192 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
193 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
194 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
195 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
196 INT9163 Tnf Regulation of Gene_expression of Glul 1 0.12 1.99 0.62
197 INT230595 Binding of TNF and Tecr 1 0.03 1 0.62
198 INT172048 Binding of TNF and MICA 1 0.29 1.63 0.62
199 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
200 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61

Single Events

The table below shows the top 100 pain related interactions that have been reported for extrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in extrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT6481 Binding of TNF 624 0.48 510.2 214.82
7 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
8 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
9 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
10 INT9660 Regulation of TNF 363 0.62 312.94 139.99
11 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
12 INT10166 Localization of Tnf 237 0.81 153.95 88.64
13 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
14 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
15 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
16 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
17 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
18 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
19 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
20 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
21 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
22 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
23 INT13354 Transcription of TNF 108 0.72 85.81 42.32
24 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
25 INT35406 Localization of Tnf 94 0.81 64.63 31.65
26 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
27 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
28 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
29 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
30 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
31 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
32 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
33 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
34 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
35 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
36 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
37 INT10173 Binding of Tnf 45 0.48 35.6 14.32
38 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
39 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
40 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
41 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
42 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
43 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
44 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
45 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
46 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
47 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
48 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
49 INT68299 Binding of Tnf 17 0.39 12.55 7.49
50 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
51 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
52 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
53 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
54 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
55 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
56 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
57 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
58 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
59 INT36575 Gene_expression of TNFRSF10A 10 0.65 10.1 4.17
60 INT133602 Positive_regulation of Fadd 2 0.54 0.38 4.02
61 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
62 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
63 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
64 INT133604 Negative_regulation of Fadd 4 0.57 0.81 3.5
65 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
66 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9
67 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
68 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
69 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
70 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
71 INT158827 Positive_regulation of FADD 7 0.43 2.6 2.54
72 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
73 INT109970 Negative_regulation of Casp8 5 0.52 9.34 2.19
74 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
75 INT116194 Gene_expression of Casp8 14 0.75 14.61 2.13
76 INT133607 Regulation of Fadd 1 0.60 0.41 2.04
77 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
78 INT133605 Positive_regulation of Negative_regulation of Fadd 1 0.46 0.28 1.96
79 INT139174 Positive_regulation of Fadd 1 0.59 0.83 1.94
80 INT119189 Positive_regulation of TNFRSF10A 10 0.67 10.58 1.93
81 INT139185 Phosphorylation of Fadd 1 0.69 0.59 1.92
82 INT133609 Negative_regulation of Positive_regulation of Fadd 2 0.46 0.24 1.9
83 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
84 INT139177 Regulation of Fadd 1 0.60 0.78 1.69
85 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
86 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
87 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56
88 INT134148 Gene_expression of FADD 4 0.66 3.35 1.54
89 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
90 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
91 INT38948 Binding of TNFRSF10A 3 0.36 3.47 1.32
92 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
93 INT134147 Positive_regulation of Gene_expression of FADD 2 0.59 1.59 1.31
94 INT187835 Gene_expression of Tradd 5 0.53 3.3 1.2
95 INT133610 Negative_regulation of Negative_regulation of Fadd 1 0.50 0.19 1.19
96 INT129587 Protein_catabolism of Tnf 2 0.86 1.41 1.08
97 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08
98 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05
99 INT153628 Phosphorylation of Fadd 2 0.74 0.45 1
100 INT139176 Gene_expression of Fadd 5 0.51 5.26 0.92
101 INT158825 Phosphorylation of FADD 1 0.81 1.63 0.89
102 INT134307 Negative_regulation of Protein_catabolism of Tnf 1 0.41 0.57 0.88
103 INT115822 Regulation of Transcription of Tnf 3 0.35 1.96 0.87
104 INT134310 Positive_regulation of Protein_catabolism of Tnf 1 0.49 0.57 0.87
105 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78
106 INT102199 Regulation of Transcription of Tnf 2 0.45 2.25 0.78
107 INT133612 Gene_expression of Fadd 1 0.76 0.27 0.76
108 INT139173 Positive_regulation of Phosphorylation of Fadd 1 0.42 0.28 0.76
109 INT133613 Regulation of Gene_expression of Fadd 1 0.44 0.27 0.76
110 INT237158 Negative_regulation of Negative_regulation of Tnf 2 0.13 1.37 0.74
111 INT139182 Binding of Fadd 3 0.36 2.74 0.71
112 INT155089 Negative_regulation of FADD 2 0.42 1.31 0.71
113 INT156875 Positive_regulation of Gene_expression of Casp8 2 0.49 2.49 0.7
114 INT162988 Positive_regulation of Positive_regulation of Fadd 1 0.36 0.07 0.7
115 INT203826 Negative_regulation of Tradd 1 0.29 1.46 0.65
116 INT139179 Negative_regulation of Fadd 1 0.36 0.35 0.64
117 INT51263 Regulation of Phosphorylation of TNF 2 0.26 1.06 0.63
118 INT139175 Regulation of Binding of Fadd 1 0.44 0.34 0.63
119 INT235079 Negative_regulation of Phosphorylation of TNF 2 0.41 1.16 0.6
120 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
121 INT203834 Regulation of Tradd 1 0.31 0.68 0.53
122 INT187834 Binding of Tradd 5 0.24 4.42 0.52
123 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52
124 INT127634 Localization of TNFRSF10A 1 0.66 0.39 0.51
125 INT235753 Gene_expression of Tradd 3 0.62 5.41 0.48
126 INT141194 Regulation of Negative_regulation of Tnf 3 0.42 1.57 0.47
127 INT158823 Positive_regulation of Binding of FADD 1 0.43 0.23 0.47
128 INT203835 Negative_regulation of Gene_expression of Tradd 1 0.40 0.17 0.47
129 INT158826 Binding of FADD 1 0.41 0.23 0.47
130 INT138003 Positive_regulation of Negative_regulation of Tnf 2 0.49 2.07 0.43
131 INT72086 Regulation of Regulation of Tnf 1 0.45 0.3 0.4
132 INT142872 Regulation of Casp8 6 0.29 3.11 0.39
133 INT159782 Phosphorylation of Tnf 2 0.79 1.51 0.36
134 INT162980 Binding of Fadd 1 0.33 0.1 0.36
135 INT143535 Protein_catabolism of Tnf 2 0.86 3.43 0.33
136 INT158821 Positive_regulation of Phosphorylation of FADD 1 0.49 0.58 0.33
137 INT119186 Positive_regulation of Gene_expression of TNFRSF10A 1 0.05 1.03 0.33
138 INT116034 Negative_regulation of Transcription of Tnf 2 0.41 0.17 0.29
139 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28
140 INT187832 Positive_regulation of Gene_expression of Tradd 1 0.32 0.68 0.28
141 INT176260 Binding of CASP8 5 0.36 2.73 0.27
142 INT159323 Negative_regulation of Protein_catabolism of CASP8 1 0.31 0.59 0.27
143 INT167206 Positive_regulation of Positive_regulation of Casp8 4 0.49 2.11 0.26
144 INT158822 Regulation of Phosphorylation of FADD 1 0.39 0.55 0.25
145 INT194643 Positive_regulation of Regulation of TNF 2 0.28 2.4 0.21
146 INT81351 Negative_regulation of Regulation of TNF 1 0.33 0.23 0.21
147 INT159783 Positive_regulation of Phosphorylation of Tnf 1 0.12 0.39 0.19
148 INT116193 Protein_catabolism of Casp8 5 0.17 4.37 0.17
149 INT235758 Positive_regulation of Gene_expression of Tradd 2 0.49 2.16 0.17
150 INT251578 Positive_regulation of Protein_catabolism of TNF 1 0.41 0.26 0.16
151 INT269998 Localization of TRADD 2 0.32 0.23 0.15
152 INT170142 Regulation of Protein_catabolism of Tnf 1 0.44 1.53 0.13
153 INT252622 Localization of Tradd 1 0.53 0.6 0.12
154 INT323740 Regulation of FADD 1 0.13 1.08 0.11
155 INT203815 Negative_regulation of Negative_regulation of Tradd 1 0.29 0.29 0.1
156 INT252621 Negative_regulation of Gene_expression of Tradd 1 0.30 0.57 0.1
157 INT185901 Localization of CASP8 7 0.55 5.38 0.09
158 INT199848 Binding of Casp8 3 0.15 3.29 0.09
159 INT295324 Regulation of Binding of Tnf 2 0.44 1.11 0.09
160 INT203823 Localization of Tradd 1 0.51 0.14 0.09
161 INT203833 Negative_regulation of Localization of Tradd 1 0.29 0.14 0.09
162 INT252620 Binding of Tradd 1 0.34 0.59 0.08
163 INT252617 Regulation of Gene_expression of Tradd 1 0.32 0.86 0.08
164 INT251553 Positive_regulation of Binding of Fadd 1 0.19 1.19 0.07
165 INT235743 Regulation of Tradd 1 0.49 2.14 0.06
166 INT336053 Regulation of Positive_regulation of CASP8 2 0.04 1.44 0.04
167 INT256923 Regulation of Gene_expression of Casp8 2 0.11 2.31 0.04
168 INT302962 Positive_regulation of Gene_expression of Fadd 2 0.27 1.45 0.04
169 INT203838 Regulation of Gene_expression of Tradd 1 0.31 0.07 0.04
170 INT199851 Positive_regulation of Protein_catabolism of Casp8 1 0.07 1.04 0.04
171 INT292858 Localization of Casp8 2 0.27 1.68 0.03
172 INT237978 Negative_regulation of Negative_regulation of CASP8 1 0.07 1.65 0.03
173 INT234430 Negative_regulation of Gene_expression of CASP8 4 0.06 3.79 0
174 INT265477 Positive_regulation of Gene_expression of CASP8 2 0.17 1.57 0
175 INT116855 Regulation of TNFRSF10A 2 0.04 1.78 0
176 INT234423 Regulation of Gene_expression of CASP8 2 0.07 3.03 0
177 INT203927 Positive_regulation of Localization of CASP8 2 0.08 1.98 0
178 INT234405 Regulation of Negative_regulation of CASP8 1 0.09 3.05 0
179 INT159591 Positive_regulation of Binding of Tnf 1 0.43 0.06 0
180 INT292588 Positive_regulation of Positive_regulation of FADD 1 0.11 0.2 0
181 INT292573 Binding of TRADD 1 0.20 0 0
182 INT322579 Positive_regulation of Binding of CASP8 1 0.09 0.25 0
183 INT144879 Negative_regulation of TNFRSF10A 1 0.06 0.06 0
184 INT235756 Positive_regulation of Tradd 1 0.40 1.04 0
185 INT292579 Regulation of Positive_regulation of TRADD 1 0.25 0 0
186 INT292574 Positive_regulation of TRADD 1 0.27 0 0
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