GO:2000045

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Name regulation of G1/S transition of mitotic cell cycle
Categary Process
Go Slim No
Go Link GO:2000045
Unique Molecular Interactions 90
Total Molecular Interactions 118
Total Single Events 585
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of G1/S transition of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported for regulation of G1/S transition of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
2 INT112701 Bid Regulation of RFFL 1 0.00 0.52 0.62
3 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
4 INT164262 TGM7 Negative_regulation of E2F1 1 0.16 1.08 0.53
5 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
6 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
7 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
8 INT163040 E2f1 Positive_regulation of Transcription of Oprm1 1 0.00 0 0.46
9 INT306824 Binding of E2F1 and E2F2 1 0.15 0.15 0.46
10 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
11 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
12 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
13 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
14 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
15 INT165637 Ptpn6 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.57 0.23
16 INT165636 Ptpn6 Regulation of Nfkb1 1 0.01 0.36 0.2
17 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
18 INT172674 Ptpn6 Negative_regulation of Gene_expression of Plat 1 0.02 1.3 0.16
19 INT325056 Binding of E2f1 and Ang 1 0.06 1.3 0.12
20 INT226907 Binding of E2f1 and Nfkb1 1 0.14 0.6 0.12
21 INT338901 Binding of PECAM1 and PTPN6 1 0.03 0.18 0.1
22 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04
23 INT302975 Fadd Positive_regulation of Bid 1 0.13 1.14 0.04
24 INT204298 Bid Positive_regulation of Binding of Bak1 1 0.05 0.57 0.04
25 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04
26 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
27 INT185851 BID Positive_regulation of BAK1 1 0.43 0.73 0
28 INT314397 Binding of Ptpn6 and Slc17a7 1 0.05 0 0
29 INT196954 Binding of Atp8a1 and E2f1 1 0.40 0.49 0
30 INT322546 Negative_regulation of PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
31 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
32 INT201534 RASSF1 Negative_regulation of ID2 1 0.33 1.41 0
33 INT314393 Ptpn6 Regulation of 1190002H23Rik 1 0.01 0 0
34 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
35 INT185854 BID Positive_regulation of BAD 1 0.39 0.74 0
36 INT345505 E2f1 Positive_regulation of PMAIP1 1 0.18 0.62 0
37 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
38 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
39 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
40 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
41 INT314402 Positive_regulation of Ptpn6 Regulation of 1190002H23Rik 1 0.02 0 0
42 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
43 INT194924 CD22 Positive_regulation of PTPN6 1 0.05 0.08 0
44 INT196958 Phosphorylation of Rb1 Positive_regulation of Localization of E2f1 1 0.45 0.44 0
45 INT314403 Ptpn6 Positive_regulation of Gpsm2 1 0.12 0.07 0
46 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
47 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
48 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
49 INT314398 Ptpn6 Regulation of Gene_expression of Ctbs 1 0.03 0 0
50 INT196955 Binding of E2f1 and Rb1 1 0.36 1 0
51 INT217149 MIR20A Regulation of Gene_expression of E2F1 1 0.19 0.86 0
52 INT330052 Binding of Bax and Bid 1 0.15 0.62 0
53 INT201542 Positive_regulation of RASSF1 Negative_regulation of ID2 1 0.36 1.41 0
54 INT330057 Bid Positive_regulation of Bax 1 0.19 0.62 0
55 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
56 INT176284 Binding of E2f1 and p53-ps 1 0.02 0.28 0
57 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
58 INT337491 Binding of E2F1 and Tcf7 1 0.19 0 0
59 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
60 INT337261 Binding of E2F1 and PRB1 1 0.17 1.19 0
61 INT196943 E2f1 Negative_regulation of Rb1 1 0.42 0.44 0
62 INT231278 Ecd Positive_regulation of Positive_regulation of Gopc 1 0.03 0 0
63 INT322545 PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
64 INT237918 BID Positive_regulation of Gene_expression of BAX 1 0.04 1.31 0
65 INT201763 BID Positive_regulation of Positive_regulation of Bax 1 0.01 0.43 0
66 INT185850 BID Positive_regulation of BAX 1 0.41 0.73 0
67 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
68 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
69 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
70 INT201536 RASSF1 Regulation of ID2 1 0.41 1.42 0
71 INT314396 Binding of Ptpn6 and Slc17a6 1 0.05 0 0
72 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
73 INT286590 Binding of ID2 and Pkd2 1 0.13 0.13 0
74 INT196945 Rb1 Negative_regulation of Transcription of E2f1 1 0.42 0.35 0
75 INT201533 RASSF1 Positive_regulation of Gene_expression of ID2 1 0.38 1.41 0
76 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
77 INT330050 Binding of Bid and Hrk 1 0.02 0.62 0
78 INT217147 MIR17 Regulation of Gene_expression of E2F1 1 0.20 0.85 0
79 INT198005 Binding of BID and MCL1 1 0.24 2.04 0
80 INT314400 Binding of Ptpn6 and Gpsm2 1 0.07 0 0
81 INT198023 Binding of BAK1 and BID 1 0.12 0.82 0
82 INT147144 E2F1 Positive_regulation of Transcription of TYMS 1 0.26 0 0
83 INT237917 BID Positive_regulation of Positive_regulation of BAX 1 0.04 1.31 0
84 INT336034 CASP8 Positive_regulation of BID 1 0.03 0.5 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of G1/S transition of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported in regulation of G1/S transition of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
2 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
3 INT123787 Gene_expression of Bid 25 0.66 16 6.35
4 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
5 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
6 INT104928 Positive_regulation of BID 10 0.67 6.9 3.41
7 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
8 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15
9 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
10 INT163283 Gene_expression of E2F1 21 0.71 3.77 2.26
11 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
12 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
13 INT112698 Gene_expression of Bid 8 0.64 6.52 1.97
14 INT152629 Positive_regulation of Bid 6 0.46 6.74 1.78
15 INT162463 Localization of BID 6 0.73 7.47 1.5
16 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
17 INT121859 Negative_regulation of Protein_catabolism of BID 3 0.42 2.1 1.46
18 INT306868 Positive_regulation of Gene_expression of E2F1 6 0.46 1.01 1.28
19 INT104926 Positive_regulation of Protein_catabolism of BID 2 0.49 2.12 1.22
20 INT121861 Regulation of BID 4 0.31 2.73 1.15
21 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
22 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
23 INT118368 Positive_regulation of E2F1 10 0.69 0.8 1.13
24 INT126993 Binding of E2F1 5 0.44 1.39 1.12
25 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
26 INT55337 Negative_regulation of Ecd 1 0.17 0.14 1.11
27 INT142025 Localization of Bid 13 0.69 8.24 0.84
28 INT122811 Binding of Ecd 11 0.31 3.01 0.84
29 INT126990 Positive_regulation of Binding of E2F1 4 0.58 0 0.79
30 INT123784 Positive_regulation of Gene_expression of Bid 4 0.40 2.41 0.66
31 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
32 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
33 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
34 INT306839 Negative_regulation of Gene_expression of E2F1 2 0.39 0.24 0.61
35 INT133765 Regulation of Gene_expression of Bid 1 0.29 0.45 0.58
36 INT19716 Gene_expression of Ecd 9 0.41 2.18 0.57
37 INT118369 Regulation of E2F1 5 0.56 3.51 0.52
38 INT163038 Binding of E2f1 2 0.44 0.08 0.5
39 INT142972 Gene_expression of ID2 6 0.54 5.92 0.49
40 INT148985 Positive_regulation of Positive_regulation of BID 1 0.53 0.84 0.48
41 INT163035 Gene_expression of E2f1 8 0.71 2.68 0.47
42 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
43 INT204293 Protein_catabolism of Bid 9 0.65 6.07 0.45
44 INT163037 Positive_regulation of Gene_expression of E2f1 1 0.11 0 0.44
45 INT163036 Positive_regulation of E2f1 1 0.11 0 0.44
46 INT169952 Gene_expression of E2f1 12 0.64 4.35 0.43
47 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
48 INT321429 Positive_regulation of Gene_expression of PTPN6 1 0.03 1.78 0.41
49 INT172626 Localization of E2F1 3 0.78 1.97 0.4
50 INT147152 Negative_regulation of E2F1 6 0.56 0.89 0.38
51 INT121860 Negative_regulation of BID 2 0.29 1.92 0.38
52 INT121862 Negative_regulation of Negative_regulation of BID 1 0.29 0.54 0.38
53 INT123783 Transcription of Bid 2 0.08 0.68 0.34
54 INT116196 Protein_catabolism of Bid 7 0.66 6.24 0.32
55 INT126991 Regulation of Binding of E2F1 1 0.23 0 0.28
56 INT126992 Positive_regulation of Regulation of E2F1 1 0.58 0 0.28
57 INT19717 Positive_regulation of Ecd 2 0.08 0 0.27
58 INT252757 Negative_regulation of PTPN6 4 0.10 0.74 0.25
59 INT107593 Regulation of Ecd 2 0.21 1.16 0.23
60 INT152745 Positive_regulation of Bid 2 0.32 2.67 0.23
61 INT196920 Transcription of E2f1 4 0.68 2.65 0.21
62 INT322080 Regulation of Binding of Ecd 1 0.03 1.38 0.21
63 INT321425 Gene_expression of PTPN6 1 0.03 0.89 0.2
64 INT196929 Positive_regulation of E2f1 10 0.66 4.29 0.19
65 INT199844 Binding of Bid 3 0.24 3.92 0.19
66 INT204286 Positive_regulation of Localization of Bid 1 0.40 1.85 0.18
67 INT123785 Positive_regulation of Transcription of Bid 1 0.06 0.54 0.18
68 INT185911 Phosphorylation of BID 3 0.71 1.75 0.17
69 INT152630 Binding of Bid 2 0.32 0.54 0.17
70 INT325053 Regulation of E2f1 1 0.19 2.02 0.15
71 INT169928 Positive_regulation of Gene_expression of E2f1 3 0.48 1.29 0.13
72 INT231267 Localization of Ecd 3 0.18 0.84 0.12
73 INT142970 Positive_regulation of Gene_expression of ID2 2 0.40 2.39 0.11
74 INT142968 Negative_regulation of Gene_expression of ID2 1 0.19 0.98 0.11
75 INT89676 Gene_expression of BID 8 0.31 8.98 0.1
76 INT319782 Localization of Bid 2 0.30 1.06 0.1
77 INT341412 Negative_regulation of Positive_regulation of Bid 1 0.38 0.99 0.1
78 INT142971 Negative_regulation of Positive_regulation of ID2 1 0.20 0.69 0.09
79 INT142969 Positive_regulation of ID2 1 0.21 0.68 0.09
80 INT252729 Phosphorylation of PTPN6 2 0.03 0.67 0.08
81 INT194938 Regulation of PTPN6 2 0.29 0.48 0.08
82 INT276339 Localization of PTPN6 1 0.10 1.31 0.08
83 INT204287 Phosphorylation of Bid 1 0.70 1.08 0.07
84 INT163282 Negative_regulation of Phosphorylation of E2F1 1 0.35 0.33 0.07
85 INT163288 Phosphorylation of E2F1 1 0.66 0.33 0.07
86 INT123786 Negative_regulation of Gene_expression of Bid 1 0.05 0.37 0.06
87 INT341415 Positive_regulation of Positive_regulation of Bid 1 0.45 0.88 0.06
88 INT204294 Negative_regulation of Bid 1 0.37 1.09 0.05
89 INT169929 Negative_regulation of E2f1 12 0.41 3.03 0.04
90 INT196912 Binding of E2f1 6 0.46 2.3 0.03
91 INT336054 Binding of BID 3 0.19 1.32 0
92 INT237967 Positive_regulation of Localization of BID 2 0.21 2.83 0
93 INT282314 Negative_regulation of Gene_expression of Ptpn6 2 0.09 0.63 0
94 INT314379 Regulation of Localization of Ptpn6 1 0.10 0.08 0
95 INT217169 Positive_regulation of Transcription of E2F1 1 0.46 0.79 0
96 INT286577 Binding of ID2 1 0.19 0.12 0
97 INT231260 Positive_regulation of Binding of Ecd 1 0.09 0 0
98 INT258060 Positive_regulation of Protein_catabolism of E2F1 1 0.08 0.52 0
99 INT169927 Protein_catabolism of E2f1 1 0.44 0.12 0
100 INT196911 Phosphorylation of E2f1 1 0.77 0.39 0
101 INT196926 Localization of E2f1 1 0.76 1.17 0
102 INT336052 Negative_regulation of Binding of BID 1 0.22 0.56 0
103 INT196922 Positive_regulation of Positive_regulation of E2f1 1 0.44 0.75 0
104 INT336055 Regulation of Protein_catabolism of BID 1 0.14 0.5 0
105 INT196933 Positive_regulation of Binding of E2f1 1 0.44 0.31 0
106 INT196924 Negative_regulation of Gene_expression of E2f1 1 0.41 0.43 0
107 INT258047 Negative_regulation of Protein_catabolism of E2F1 1 0.07 0.52 0
108 INT218006 Regulation of Regulation of Ptpn6 1 0.05 0.25 0
109 INT194944 Positive_regulation of PTPN6 1 0.06 0.46 0
110 INT217233 Transcription of E2F1 1 0.48 0.78 0
111 INT196930 Regulation of E2f1 1 0.43 0.23 0
112 INT147150 Negative_regulation of Negative_regulation of E2F1 1 0.41 0 0
113 INT231262 Positive_regulation of Localization of Ecd 1 0.08 0 0
114 INT258062 Protein_catabolism of E2F1 1 0.11 1.05 0
115 INT337280 Regulation of Gene_expression of E2F1 1 0.41 0.16 0
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