GO:2000059

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Name negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Categary Process
Go Slim No
Go Link GO:2000059
Unique Molecular Interactions 51
Total Molecular Interactions 73
Total Single Events 901
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
2 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42
3 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
4 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
5 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
6 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
7 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
8 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
9 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
10 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
11 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
12 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
13 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05
14 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05
15 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
16 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
17 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
18 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
19 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
20 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
21 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
22 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
23 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
24 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
25 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
26 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
27 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
28 INT268521 Binding of WNT1 and MIR221 1 0.02 1.36 0
29 INT297855 Binding of Ndp and Wnt1 1 0.38 1.18 0
30 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
31 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
32 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
33 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
34 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
35 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
36 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
37 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
38 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
39 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
40 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
41 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
42 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
43 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
44 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
45 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
3 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
4 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
5 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
6 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
7 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
8 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
9 INT163544 Binding of Psen1 40 0.36 15.28 2.42
10 INT141833 Gene_expression of WNT1 14 0.75 10.57 2.1
11 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
12 INT60723 Localization of Psen2 5 0.68 2.11 2.02
13 INT29035 Negative_regulation of Wnt1 3 0.41 1.47 2
14 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
15 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
16 INT97062 Binding of PML 10 0.41 11.63 1.65
17 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
18 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
19 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
20 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
21 INT141834 Negative_regulation of Gene_expression of WNT1 3 0.57 1.31 1.2
22 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
23 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
24 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
25 INT141835 Negative_regulation of WNT1 2 0.41 1.02 0.83
26 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
27 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82
28 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
29 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
30 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
31 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
32 INT78649 Binding of Psen2 7 0.36 5.9 0.73
33 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
34 INT262726 Localization of PML 6 0.57 7.13 0.72
35 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
36 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
37 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
38 INT228057 Positive_regulation of WNT1 1 0.49 1.8 0.44
39 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
40 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
41 INT193856 Localization of Psen1 19 0.73 9.79 0.41
42 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
43 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
44 INT216379 Positive_regulation of Gene_expression of WNT1 5 0.30 3.1 0.34
45 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
46 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
47 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
48 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
49 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
50 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
51 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
52 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
53 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
54 INT353965 Negative_regulation of Gene_expression of Wnt1 1 0.41 0 0.18
55 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
56 INT217569 Binding of Wnt1 2 0.36 1.07 0.15
57 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
58 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
59 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
60 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
61 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
62 INT349072 Positive_regulation of Gene_expression of PML 1 0.13 1.49 0.1
63 INT282824 Regulation of PML 3 0.44 2.66 0.09
64 INT266241 Regulation of Wnt1 1 0.26 0.59 0.09
65 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
66 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
67 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
68 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
69 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
70 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
71 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
72 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
73 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
74 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
75 INT304937 Transcription of Wnt1 1 0.22 0.65 0.05
76 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
77 INT287956 Regulation of WNT1 2 0.26 2.38 0.04
78 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04
79 INT311648 Regulation of Gene_expression of Wnt1 1 0.39 0.09 0.04
80 INT287936 Regulation of Gene_expression of WNT1 1 0.20 1.06 0.04
81 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
82 INT202633 Positive_regulation of Gene_expression of Wnt1 3 0.43 0.85 0
83 INT265229 Binding of PSEN2 2 0.16 1.37 0
84 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
85 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
86 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
87 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
88 INT224297 Regulation of Transcription of PSEN2 1 0.20 0.06 0
89 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
90 INT337424 Phosphorylation of Wnt1 1 0.79 0 0
91 INT177774 Transcription of PSEN1 1 0.33 0.09 0
92 INT330665 Negative_regulation of PML 1 0.13 1.15 0
93 INT311632 Positive_regulation of Wnt1 1 0.43 0.19 0
94 INT235058 Localization of Wnt1 1 0.64 0.56 0
95 INT354892 Negative_regulation of Psen2 1 0.37 0.95 0
96 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
97 INT331463 Regulation of Gene_expression of PSEN2 1 0.04 0 0
98 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
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