GO:2000060

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Name positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Categary Process
Go Slim No
Go Link GO:2000060
Unique Molecular Interactions 345
Total Molecular Interactions 510
Total Single Events 2713
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
2 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
3 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
4 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
5 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
6 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
7 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
8 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
9 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
10 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
11 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
12 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
13 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
14 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
15 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
16 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
17 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
18 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
19 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
20 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
21 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
22 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
23 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
24 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
25 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
26 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
27 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
28 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
29 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
30 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
31 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
32 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
33 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
34 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
35 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
36 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
37 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
38 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
39 INT251168 Clu Positive_regulation of Trpc7 1 0.15 0.2 0.59
40 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
41 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
42 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
43 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
44 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
45 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
46 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
47 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49
48 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
49 INT108329 EGF Positive_regulation of Phosphorylation of EPHB2 4 0.48 3.96 0.48
50 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
51 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
52 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
53 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
54 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
55 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
56 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
57 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
58 INT295406 Egf Regulation of Gene_expression of Oprk1 1 0.01 0.72 0.43
59 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43
60 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
61 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43
62 INT13281 Egf Regulation of Ngf 1 0.66 0.12 0.42
63 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
64 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
65 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
66 INT13279 Ngf Regulation of Egf 1 0.49 0.12 0.42
67 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
68 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
69 INT90807 EGF Positive_regulation of Oprd1 1 0.00 0.39 0.39
70 INT283840 Binding of Egf and hb 1 0.21 1.34 0.38
71 INT51341 Binding of Pomc and Clu 1 0.14 0 0.38
72 INT356274 Egf Positive_regulation of Localization of Stat3 1 0.13 0.22 0.36
73 INT295407 Egf Positive_regulation of Localization of Oprk1 1 0.02 0.67 0.36
74 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
75 INT94875 Binding of Calca and Egf 1 0.25 0 0.35
76 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
77 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
78 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
79 INT220740 EGF Positive_regulation of Regulation of NAV1 1 0.31 0.61 0.32
80 INT220749 EGF Positive_regulation of Positive_regulation of KRT20 1 0.01 0.61 0.32
81 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
82 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
83 INT75769 Egf Positive_regulation of Cpox 1 0.26 0.76 0.31
84 INT170496 Egf Positive_regulation of Mapk1 3 0.21 0.5 0.3
85 INT356288 Egf Positive_regulation of Trib3 1 0.00 0.17 0.3
86 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
87 INT303440 Egf Positive_regulation of Gene_expression of Col7a1 1 0.07 0.92 0.28
88 INT193027 EGF Positive_regulation of Positive_regulation of MRGPRX1 1 0.02 0 0.27
89 INT285243 EGF Positive_regulation of Egf 1 0.00 1.55 0.27
90 INT285238 EGF Positive_regulation of VEGFA 1 0.01 1.55 0.27
91 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27
92 INT195898 Negative_regulation of Egf Negative_regulation of Gene_expression of Cpox 1 0.03 0.3 0.26
93 INT171384 Egf Negative_regulation of Positive_regulation of Mapk1 1 0.16 0.24 0.26
94 INT332242 Binding of Egf and Pdgfa 1 0.07 0.97 0.25
95 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
96 INT220750 EGF Positive_regulation of PCa 1 0.05 0.45 0.23
97 INT173294 LPA Positive_regulation of EGF 1 0.01 0.07 0.23
98 INT173292 F2 Positive_regulation of EGF 1 0.00 0.07 0.23
99 INT9717 Binding of Egf and Fgfr1 1 0.15 0 0.22
100 INT9716 Binding of Egf and Pdgfc 1 0.20 0 0.22
101 INT193033 Binding of CHRM1 and EGF 1 0.01 1.96 0.22
102 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
103 INT9718 Binding of Egf and Ngf 1 0.30 0 0.21
104 INT193035 Positive_regulation of PDGFA Positive_regulation of EGF 1 0.05 0.53 0.21
105 INT188203 EGF Positive_regulation of Protein_catabolism of OSM 1 0.30 0.17 0.21
106 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
107 INT9715 Binding of Egf and Tgfa 1 0.18 0 0.21
108 INT112136 Egf Positive_regulation of Gene_expression of Ptgs2 1 0.21 0.19 0.21
109 INT193025 PDGFA Positive_regulation of EGF 1 0.05 0.53 0.21
110 INT193036 EGF Positive_regulation of PDGFA 1 0.05 0.53 0.21
111 INT193032 Positive_regulation of EGF Positive_regulation of PDGFA 1 0.05 0.53 0.21
112 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
113 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
114 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
115 INT14869 Binding of EGF and TGFB3 1 0.14 0.69 0.19
116 INT23655 Binding of POMC and Egf 1 0.04 0 0.19
117 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19
118 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
119 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
120 INT186098 EGF Positive_regulation of MAP2K5 1 0.01 0.19 0.18
121 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
122 INT251162 Clu Positive_regulation of Gene_expression of Trpv1 1 0.20 0.07 0.18
123 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
124 INT274168 Egf Positive_regulation of Gene_expression of Muc5ac 1 0.01 2.11 0.17
125 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
126 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
127 INT261477 Egf Positive_regulation of Positive_regulation of Ephb1 1 0.37 0.21 0.17
128 INT24668 Binding of COL7A1 and EGF 1 0.14 0.25 0.16
129 INT117137 Gene_expression of ROS1 Positive_regulation of Protein_catabolism of Egf 1 0.00 0 0.16
130 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
131 INT238329 EGF Regulation of Negative_regulation of ADAMTS5 1 0.03 0 0.14
132 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
133 INT238338 Binding of EGF and Regulation of Gene_expression of GOPC 1 0.05 0 0.14
134 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
135 INT238337 EGF Regulation of Gene_expression of GOPC 1 0.03 0 0.14
136 INT238342 Binding of EGF and Regulation of Gene_expression of ADAMTS1 1 0.05 0 0.14
137 INT356285 Binding of Stat3 and Egf 1 0.09 0.4 0.13
138 INT73924 EGF Positive_regulation of Localization of COL7A1 1 0.31 0.33 0.13
139 INT253015 Egf Regulation of PTTG1 1 0.02 0.44 0.13
140 INT108330 EGF Negative_regulation of EPHB2 1 0.41 1.15 0.13
141 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
142 INT195896 Egf Positive_regulation of Nos1 1 0.10 0.57 0.12
143 INT356276 Egf Positive_regulation of Positive_regulation of Mapk1 1 0.05 0.52 0.12
144 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
145 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
146 INT146937 Egf Regulation of Trpm6 1 0.03 0.27 0.11
147 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
148 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
149 INT156829 EGF Positive_regulation of MAPK3 2 0.08 0.87 0.1
150 INT356272 Egf Negative_regulation of Gene_expression of Egfr 1 0.15 0.2 0.1
151 INT222553 Binding of Sdc1 and Egf 1 0.02 0 0.1
152 INT286963 EGF Positive_regulation of Gene_expression of STAT3 1 0.03 0.57 0.1
153 INT51344 Binding of Clu and Vtn 1 0.06 0 0.1
154 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
155 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
156 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
157 INT27109 Egf Regulation of Gast 1 0.42 0 0.08
158 INT110856 TXK Negative_regulation of Egf 1 0.02 1.2 0.08
159 INT355582 VEGFA Regulation of Positive_regulation of PTK2 1 0.05 1.46 0.08
160 INT309903 Binding of EGF and TXK 1 0.03 0.23 0.08
161 INT110855 Pkia Negative_regulation of Egf 1 0.15 1.2 0.08
162 INT222139 Binding of Egf and Fgf2 1 0.12 0 0.07
163 INT188210 EGF Positive_regulation of OSM 1 0.28 0 0.07
164 INT188208 EGF Regulation of STAT3 1 0.46 0 0.07
165 INT329265 Binding of Ptk2 and Wnt2 1 0.05 1.04 0.07
166 INT299535 Binding of Egf and Lif 1 0.07 0 0.07
167 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 0.06 0.38 0.07
168 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 0.06 0.38 0.07
169 INT24666 Binding of EGF and FGF2 1 0.35 0 0.06
170 INT225262 Egf Regulation of Gene_expression of S100a7a 1 0.04 3.31 0.06
171 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
172 INT306510 INCENP Regulation of Gene_expression of Clu 1 0.00 1.92 0.05
173 INT338019 Egf Positive_regulation of AR 1 0.07 1.02 0.05
174 INT27738 CBS Positive_regulation of EGF 1 0.33 0.85 0.05
175 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05
176 INT225261 S100a7a Positive_regulation of Egf 1 0.07 1.13 0.05
177 INT27737 CBS Positive_regulation of Positive_regulation of EGF 1 0.36 0.85 0.05
178 INT295337 Egf Positive_regulation of Ptpn11 1 0.15 0.08 0.05
179 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
180 INT306505 Binding of Clu and Tnf 1 0.24 0.4 0.04
181 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
182 INT295358 Egf Positive_regulation of Ddr1 1 0.03 0.1 0.04
183 INT306501 Negative_regulation of Binding of Clu and Tnf 1 0.29 0.4 0.04
184 INT295352 Egf Positive_regulation of Grb7 1 0.42 0.06 0.03
185 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
186 INT295351 Egf Positive_regulation of Fig4 1 0.12 0.06 0.03
187 INT356277 Egf Positive_regulation of Phosphorylation of Mapk1 1 0.07 0.33 0.03
188 INT346331 Binding of Epo and Egf 1 0.19 0.1 0.03
189 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
190 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
191 INT295343 Negative_regulation of Egf Positive_regulation of Grb7 1 0.38 0.06 0.03
192 INT292464 Binding of PTK2 and MMRN1 1 0.03 0.26 0
193 INT295412 Egf Regulation of Transcription of Oprk1 1 0.01 0 0
194 INT292505 PTK2 Regulation of Birc5 1 0.29 0.76 0
195 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
196 INT285071 EGF Positive_regulation of CCL16 1 0.03 0.77 0
197 INT225258 Egf Positive_regulation of Gene_expression of S100a7a 1 0.07 1.7 0
198 INT306500 Clu Regulation of Esr1 1 0.22 0.13 0
199 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0
200 INT226732 Egf Negative_regulation of Egfr 1 0.01 0.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
2 INT11157 Binding of EGF 88 0.48 53.73 21.25
3 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
4 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
5 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
6 INT2036 Localization of EGF 42 0.77 21.5 9.74
7 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
8 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
9 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
10 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
11 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
12 INT13822 Localization of Egf 30 0.81 13.79 6.4
13 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
14 INT51337 Binding of Clu 3 0.12 0.05 5.45
15 INT37227 Regulation of EGF 19 0.45 11.16 5.17
16 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
17 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
18 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
19 INT23653 Binding of Egf 22 0.36 11.34 4.12
20 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
21 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
22 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
23 INT18920 Binding of Egf 24 0.48 9.43 3.57
24 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
25 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
26 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
27 INT192676 Binding of PTEN 14 0.46 10.58 3.06
28 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
29 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
30 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
31 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73
32 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
33 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
34 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
35 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
36 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
37 INT82226 Negative_regulation of Gene_expression of EGF 11 0.58 6.36 2.13
38 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09
39 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
40 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
41 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
42 INT172961 Localization of Egf 26 0.71 16.74 1.81
43 INT73721 Negative_regulation of Gene_expression of Egf 5 0.43 2.28 1.8
44 INT49347 Negative_regulation of Clu 4 0.58 1.63 1.79
45 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77
46 INT19747 Regulation of Egf 14 0.46 4.67 1.68
47 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
48 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
49 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
50 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
51 INT114525 Negative_regulation of Positive_regulation of Egf 4 0.35 2.93 1.5
52 INT228249 Binding of Pten 7 0.48 3.26 1.45
53 INT86382 Negative_regulation of Localization of EGF 5 0.43 1.75 1.44
54 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
55 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
56 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
57 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
58 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
59 INT35944 Regulation of Clu 4 0.20 0.15 1.3
60 INT251180 Phosphorylation of Clu 1 0.29 0.79 1.22
61 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
62 INT27108 Positive_regulation of Localization of Egf 5 0.50 2.91 1.21
63 INT190014 Regulation of Pten 8 0.62 6.03 1.2
64 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
65 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
66 INT87346 Binding of PTK2 6 0.37 4.03 1.18
67 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16
68 INT162124 Positive_regulation of Phosphorylation of Egf 3 0.45 0.77 1.14
69 INT22770 Regulation of Gene_expression of Egf 5 0.44 2.56 1.12
70 INT233561 Gene_expression of Clu 14 0.66 45.63 1.07
71 INT37207 Positive_regulation of Positive_regulation of Egf 4 0.50 0.76 1.07
72 INT13817 Protein_catabolism of EGF 3 1.00 1.44 1.06
73 INT105860 Positive_regulation of Positive_regulation of EGF 6 0.64 2.37 1.05
74 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
75 INT184240 Positive_regulation of Localization of Egf 2 0.27 3.58 0.99
76 INT100273 Localization of Clu 4 0.61 0.49 0.88
77 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
78 INT118290 Regulation of Phosphorylation of EGF 1 0.32 0.72 0.87
79 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
80 INT171372 Positive_regulation of Gene_expression of Egf 16 0.66 9.82 0.84
81 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
82 INT31759 Negative_regulation of Gene_expression of Egf 6 0.53 5.33 0.77
83 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
84 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
85 INT70666 Positive_regulation of CLU 16 0.45 12.95 0.74
86 INT94233 Positive_regulation of Gene_expression of Clu 3 0.69 2.64 0.71
87 INT22772 Positive_regulation of Negative_regulation of Egf 1 0.50 1.48 0.71
88 INT70652 Negative_regulation of Binding of EGF 7 0.43 4.23 0.7
89 INT110854 Phosphorylation of Egf 8 0.75 5.62 0.67
90 INT276199 Binding of Pten 2 0.30 0.4 0.67
91 INT228279 Regulation of Gene_expression of Egf 7 0.43 6.64 0.65
92 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
93 INT94232 Negative_regulation of Gene_expression of Clu 2 0.43 1.17 0.63
94 INT276179 Regulation of Pten 1 0.46 0.81 0.63
95 INT135294 Negative_regulation of Positive_regulation of Clu 1 0.37 0.35 0.59
96 INT161322 Localization of PTEN 9 0.73 5.65 0.57
97 INT260422 Positive_regulation of Localization of EGF 3 0.10 1.58 0.56
98 INT115532 Negative_regulation of Positive_regulation of Egf 3 0.28 1.38 0.52
99 INT251182 Regulation of Phosphorylation of Clu 1 0.16 0.13 0.52
100 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
101 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
102 INT117772 Binding of Ptk2 1 0.37 0.17 0.46
103 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
104 INT233552 Positive_regulation of Gene_expression of Clu 3 0.59 9.31 0.45
105 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
106 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
107 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
108 INT203816 Localization of Pten 4 0.75 1.37 0.4
109 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
110 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
111 INT82763 Regulation of Positive_regulation of Egf 1 0.26 0.68 0.35
112 INT102597 Regulation of Localization of Egf 2 0.62 0.1 0.34
113 INT225248 Positive_regulation of Phosphorylation of Egf 2 0.32 2.02 0.34
114 INT13824 Transcription of Egf 6 0.56 0.94 0.33
115 INT72107 Positive_regulation of Protein_catabolism of Egf 2 0.16 0.34 0.32
116 INT72106 Protein_catabolism of Egf 2 0.31 0.34 0.32
117 INT281469 Transcription of Pten 2 0.72 1.12 0.32
118 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
119 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
120 INT178301 Regulation of Egf 9 0.58 4.96 0.31
121 INT83594 Negative_regulation of Phosphorylation of Ptk2 5 0.42 1.62 0.29
122 INT122985 Negative_regulation of Gene_expression of CLU 4 0.57 4.58 0.27
123 INT145259 Binding of CLU 1 0.03 0.84 0.27
124 INT13818 Negative_regulation of Protein_catabolism of EGF 1 0.59 0.37 0.27
125 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
126 INT119080 Negative_regulation of PTK2 15 0.56 8.88 0.23
127 INT87338 Regulation of PTK2 10 0.62 4.75 0.21
128 INT122987 Negative_regulation of CLU 5 0.42 4.58 0.21
129 INT35945 Positive_regulation of Regulation of Clu 1 0.35 0 0.2
130 INT292483 Negative_regulation of Positive_regulation of PTK2 2 0.41 3.51 0.18
131 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
132 INT111291 Transcription of EGF 2 0.52 0.35 0.17
133 INT210123 Localization of Axin1 1 0.04 0.84 0.17
134 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
135 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
136 INT122984 Localization of CLU 2 0.78 2.46 0.16
137 INT122989 Positive_regulation of Localization of CLU 2 0.45 1.81 0.16
138 INT185256 Positive_regulation of Binding of Egf 3 0.32 2.17 0.15
139 INT147730 Regulation of Positive_regulation of PTK2 1 0.35 0.33 0.15
140 INT122986 Positive_regulation of Gene_expression of CLU 3 0.67 2.37 0.14
141 INT83595 Negative_regulation of Gene_expression of Ptk2 1 0.23 1.62 0.14
142 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
143 INT131114 Positive_regulation of Gene_expression of Ptk2 1 0.49 0.27 0.14
144 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
145 INT111294 Negative_regulation of Transcription of EGF 1 0.32 0.09 0.12
146 INT233567 Positive_regulation of Clu 3 0.59 2.91 0.09
147 INT70651 Positive_regulation of Binding of EGF 1 0.50 0.98 0.09
148 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
149 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
150 INT147735 Regulation of Binding of PTK2 1 0.35 0.23 0.08
151 INT144400 Positive_regulation of Gene_expression of PTK2 33 0.70 21.24 0.06
152 INT283831 Regulation of Regulation of Egf 2 0.29 1.5 0.06
153 INT233554 Negative_regulation of Gene_expression of Clu 2 0.39 1.96 0.05
154 INT233550 Localization of Clu 2 0.69 4.52 0.05
155 INT329775 Regulation of Regulation of PTK2 1 0.11 0.49 0.05
156 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
157 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04
158 INT295374 Positive_regulation of Ptk2 1 0.34 0.06 0.04
159 INT176144 Positive_regulation of Phosphorylation of PTEN 1 0.36 0.29 0.04
160 INT233844 Negative_regulation of Positive_regulation of Pten 1 0.17 0.73 0.04
161 INT161524 Regulation of Clu 4 0.38 3.18 0.03
162 INT292474 Negative_regulation of Gene_expression of PTK2 8 0.41 5.17 0
163 INT262779 Localization of PTK2 3 0.71 2.75 0
164 INT118289 Negative_regulation of Phosphorylation of EGF 3 0.40 0.47 0
165 INT233556 Regulation of Gene_expression of Clu 2 0.33 1.45 0
166 INT315882 Regulation of Negative_regulation of PTEN 2 0.44 1.39 0
167 INT305346 Positive_regulation of Negative_regulation of Pten 2 0.41 0.91 0
168 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
169 INT304183 Positive_regulation of Positive_regulation of Egf 1 0.27 1.52 0
170 INT321706 Negative_regulation of Phosphorylation of Pten 1 0.38 0.16 0
171 INT49344 Negative_regulation of Transcription of Clu 1 0.35 0.07 0
172 INT49345 Transcription of Clu 1 0.58 0.2 0
173 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
174 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0
175 INT292478 Negative_regulation of Negative_regulation of PTK2 1 0.41 0.97 0
176 INT351091 Negative_regulation of Binding of PTEN 1 0.09 0.23 0
177 INT233564 Regulation of Positive_regulation of Clu 1 0.38 0.98 0
178 INT329769 Positive_regulation of Localization of PTK2 1 0.17 1.42 0
179 INT295392 Positive_regulation of Localization of Ptk2 1 0.37 0 0
180 INT334324 Positive_regulation of Negative_regulation of PTEN 1 0.41 0.81 0
181 INT206738 Regulation of CLU 1 0.44 1.15 0
182 INT176158 Regulation of Positive_regulation of PTEN 1 0.32 0.23 0
183 INT354842 Protein_catabolism of CLU 1 0.28 1.6 0
184 INT306487 Binding of Clu 1 0.24 0.27 0
185 INT49348 Regulation of Transcription of Clu 1 0.50 0.13 0
186 INT318803 Regulation of Gene_expression of CLU 1 0.21 0.9 0
187 INT295387 Localization of Ptk2 1 0.55 0 0
188 INT233557 Transcription of Clu 1 0.45 0.77 0
189 INT172967 Negative_regulation of Phosphorylation of Egf 1 0.17 0.95 0
190 INT71715 Positive_regulation of Negative_regulation of Egf 1 0.06 0.07 0
191 INT318804 Negative_regulation of Localization of CLU 1 0.18 1.33 0
192 INT292481 Negative_regulation of Localization of PTK2 1 0.41 0.07 0
193 INT228244 Negative_regulation of Binding of Pten 1 0.16 0.72 0
194 INT329766 Positive_regulation of Positive_regulation of PTK2 1 0.11 0.51 0
195 INT295399 Negative_regulation of Transcription of Egf 1 0.35 0 0
196 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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