GO:2000111

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Name positive regulation of macrophage apoptosis
Categary Process
Go Slim No
Go Link GO:2000111
Unique Molecular Interactions 61
Total Molecular Interactions 82
Total Single Events 893
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of macrophage apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of macrophage apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
3 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
4 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
5 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
6 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
7 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
8 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
9 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
10 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
11 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
12 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
13 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
14 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
15 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
16 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
17 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
18 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
19 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
20 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
21 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
22 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
23 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
24 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03
25 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
26 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
27 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
28 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
29 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
30 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
31 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
32 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
33 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
34 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
35 INT350706 Binding of Mef2c and Mir223 1 0.02 0.11 0
36 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0
37 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
38 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0
39 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
40 INT297213 Myoz1 Regulation of Mef2c 1 0.02 0.09 0
41 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
42 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0
43 INT184956 ID1 Negative_regulation of CDKN2A 1 0.42 0.21 0
44 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
45 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
46 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
47 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
48 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
49 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
50 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
51 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
52 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
53 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
54 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0
55 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
56 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
57 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
58 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0
59 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
60 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
61 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of macrophage apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of macrophage apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
2 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
3 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
4 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
5 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
6 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
7 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
8 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
9 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
10 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
11 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
12 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
13 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
14 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
15 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
16 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
17 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
18 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
19 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
20 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
21 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
22 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
23 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
24 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
25 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
26 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
27 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
28 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
29 INT238560 Regulation of Mef2c 9 0.45 2.12 0.33
30 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
31 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
32 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
33 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
34 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
35 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
36 INT202355 Transcription of Mef2c 3 0.69 0.6 0.21
37 INT248543 Positive_regulation of Mef2c 7 0.69 2.82 0.18
38 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
39 INT277602 Binding of Mef2c 10 0.39 4.35 0.16
40 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
41 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
42 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
43 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
44 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
45 INT290404 Positive_regulation of Negative_regulation of Mef2c 1 0.50 0.72 0.08
46 INT277578 Regulation of Negative_regulation of Mef2c 2 0.45 1.17 0.07
47 INT290417 Positive_regulation of Gene_expression of Mef2c 1 0.50 1.25 0.06
48 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
49 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
50 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
51 INT290407 Positive_regulation of Binding of Mef2c 1 0.44 0.93 0.04
52 INT290419 Regulation of Gene_expression of Mef2c 1 0.62 0.41 0.03
53 INT290399 Negative_regulation of Gene_expression of Mef2c 1 0.59 0.59 0.03
54 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
55 INT204349 Regulation of SIRT1 8 0.61 1.99 0
56 INT204353 Transcription of SIRT1 3 0.68 0.67 0
57 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
58 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
59 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
60 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
61 INT290400 Regulation of Regulation of Mef2c 1 0.45 0.24 0
62 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0
63 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
64 INT172979 Regulation of Negative_regulation of CDKN2A 1 0.44 0.57 0
65 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0
66 INT147147 Positive_regulation of Transcription of CDKN2A 1 0.49 0 0
67 INT290429 Negative_regulation of Negative_regulation of Mef2c 1 0.37 0.05 0
68 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
69 INT290425 Negative_regulation of Binding of Mef2c 1 0.37 0 0
70 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
71 INT185285 Negative_regulation of Transcription of CDKN2A 1 0.43 1.12 0
72 INT290409 Negative_regulation of Transcription of Mef2c 1 0.43 0.08 0
73 INT184623 Positive_regulation of Localization of CDKN2A 1 0.04 0.86 0
74 INT247424 Transcription of Cdkn2a 1 0.47 0.82 0
75 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
76 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
77 INT355162 Regulation of Localization of CDKN2A 1 0.40 1.13 0
78 INT204331 Binding of SIRT1 1 0.47 0.39 0
79 INT247425 Regulation of Transcription of Cdkn2a 1 0.18 0.82 0
80 INT277587 Localization of Mef2c 1 0.65 0.43 0
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