GO:2000134

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Name negative regulation of G1/S transition of mitotic cell cycle
Categary Process
Go Slim No
Go Link GO:2000134
Unique Molecular Interactions 46
Total Molecular Interactions 55
Total Single Events 537
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of G1/S transition of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of G1/S transition of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29
2 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
3 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
4 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
5 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
6 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
7 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
8 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
9 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
10 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
11 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
12 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
13 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21
14 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2
15 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
16 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
17 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
18 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
19 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
20 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
21 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
22 INT133481 TNF Positive_regulation of Phosphorylation of PTEN 1 0.13 0.61 0.09
23 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
24 INT221815 PPARA Negative_regulation of PTEN 1 0.15 0.5 0.05
25 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03
26 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03
27 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
28 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
29 INT201541 Binding of NPC1 and BRD7 1 0.35 1.59 0
30 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
31 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
32 INT285908 AKT1 Regulation of Pten 1 0.01 0.53 0
33 INT348723 ED Positive_regulation of PTEN 1 0.04 1.3 0
34 INT313885 XRCC1 Positive_regulation of Localization of PTEN 1 0.00 0.65 0
35 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
36 INT351682 Fut1 Positive_regulation of PTEN 1 0.01 1.81 0
37 INT223574 PTEN Negative_regulation of AKT1 1 0.06 0.56 0
38 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
39 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
40 INT285910 Pten Regulation of AKT1 1 0.00 0.53 0
41 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0
42 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0
43 INT338508 Binding of FHL1 and CFHR1 1 0.08 0.37 0
44 INT338514 Binding of FHL1 and CFH 1 0.08 0.37 0
45 INT293804 PTEN Regulation of AKT1 1 0.04 0.07 0
46 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of G1/S transition of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of G1/S transition of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16110 Positive_regulation of ZC3H12D 30 0.46 6.27 18.72
2 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
3 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
4 INT5156 Regulation of ZC3H12D 7 0.27 2.64 5.53
5 INT54577 Gene_expression of ZC3H12D 4 0.58 1.72 3.9
6 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
7 INT16787 Negative_regulation of ZC3H12D 8 0.42 2.22 3.82
8 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
9 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
10 INT192676 Binding of PTEN 14 0.46 10.58 3.06
11 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
12 INT49886 Positive_regulation of Positive_regulation of ZC3H12D 1 0.06 0.61 2.75
13 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
14 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
15 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
16 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
17 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
18 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
19 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
20 INT228249 Binding of Pten 7 0.48 3.26 1.45
21 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
22 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
23 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
24 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
25 INT190014 Regulation of Pten 8 0.62 6.03 1.2
26 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
27 INT172510 Positive_regulation of Gene_expression of ZC3H12D 1 0.04 0 1.08
28 INT276177 Regulation of Gene_expression of Pten 1 0.34 1.51 0.84
29 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75
30 INT27593 Positive_regulation of FHL1 3 0.37 2.29 0.75
31 INT276199 Binding of Pten 2 0.30 0.4 0.67
32 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63
33 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
34 INT276179 Regulation of Pten 1 0.46 0.81 0.63
35 INT172509 Binding of ZC3H12D 1 0.03 0.08 0.61
36 INT161322 Localization of PTEN 9 0.73 5.65 0.57
37 INT176146 Positive_regulation of Localization of PTEN 3 0.36 1.69 0.5
38 INT107207 Binding of FHL1 3 0.40 0.76 0.5
39 INT276174 Regulation of Negative_regulation of Pten 1 0.34 0.63 0.47
40 INT16111 Negative_regulation of Positive_regulation of ZC3H12D 1 0.37 0.08 0.45
41 INT276180 Positive_regulation of Negative_regulation of Pten 1 0.35 0.89 0.43
42 INT276202 Negative_regulation of Protein_catabolism of Pten 1 0.32 0.78 0.42
43 INT276204 Protein_catabolism of Pten 1 0.75 0.77 0.41
44 INT203816 Localization of Pten 4 0.75 1.37 0.4
45 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35
46 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35
47 INT281469 Transcription of Pten 2 0.72 1.12 0.32
48 INT281474 Regulation of Transcription of Pten 1 0.62 0.35 0.32
49 INT263819 Regulation of Gene_expression of PTEN 1 0.25 0.63 0.32
50 INT133488 Negative_regulation of Phosphorylation of PTEN 4 0.41 1.88 0.26
51 INT224616 Regulation of Negative_regulation of Pten 1 0.13 1.21 0.18
52 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16
53 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12
54 INT5532 Regulation of FHL1 2 0.07 0.24 0.09
55 INT319415 Transcription of FHL1 1 0.31 1.01 0.09
56 INT286583 Localization of PKD2 1 0.35 0.17 0.06
57 INT261879 Binding of PKD2 3 0.13 2.59 0.05
58 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04
59 INT176144 Positive_regulation of Phosphorylation of PTEN 1 0.36 0.29 0.04
60 INT233844 Negative_regulation of Positive_regulation of Pten 1 0.17 0.73 0.04
61 INT338603 Gene_expression of FHL1 3 0.22 0.74 0
62 INT241245 Negative_regulation of PKD2 2 0.42 2.35 0
63 INT315882 Regulation of Negative_regulation of PTEN 2 0.44 1.39 0
64 INT305346 Positive_regulation of Negative_regulation of Pten 2 0.41 0.91 0
65 INT321706 Negative_regulation of Phosphorylation of Pten 1 0.38 0.16 0
66 INT304062 Regulation of Localization of PTEN 1 0.43 1.29 0
67 INT351091 Negative_regulation of Binding of PTEN 1 0.09 0.23 0
68 INT351438 Regulation of Gene_expression of FHL1 1 0.07 0.24 0
69 INT338644 Protein_catabolism of FHL1 1 0.25 0.06 0
70 INT334324 Positive_regulation of Negative_regulation of PTEN 1 0.41 0.81 0
71 INT232493 Negative_regulation of Positive_regulation of PKD2 1 0.23 0.61 0
72 INT201574 Localization of BRD7 1 0.68 1.37 0
73 INT261878 Negative_regulation of Binding of PKD2 1 0.14 0.6 0
74 INT201562 Positive_regulation of Gene_expression of BRD7 1 0.59 1.51 0
75 INT176158 Regulation of Positive_regulation of PTEN 1 0.32 0.23 0
76 INT232491 Positive_regulation of PKD2 1 0.27 0.56 0
77 INT338653 Positive_regulation of Protein_catabolism of FHL1 1 0.14 0.06 0
78 INT201566 Gene_expression of BRD7 1 0.66 1.51 0
79 INT228244 Negative_regulation of Binding of Pten 1 0.16 0.72 0
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