GO:2000272

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Name negative regulation of receptor activity
Categary Process
Go Slim No
Go Link GO:2000272
Unique Molecular Interactions 37
Total Molecular Interactions 70
Total Single Events 455
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
3 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
4 INT187226 Vip Positive_regulation of Gene_expression of Il1rn 1 0.04 0.96 0.82
5 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
6 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67
7 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
8 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
9 INT279398 Binding of IL1RN and Il1rn 1 0.00 0.51 0.63
10 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
11 INT255997 Binding of Il1rn and H7 1 0.01 1.21 0.63
12 INT254637 Bdkrb2 Regulation of Gene_expression of Ccl5 1 0.17 1.22 0.56
13 INT85265 Binding of Il1rn and Insrr 1 0.01 0 0.54
14 INT171896 Binding of Ifnar1 and Il1rn 1 0.00 0.81 0.54
15 INT316735 Il1 Positive_regulation of Gene_expression of Il1rn 1 0.00 0.53 0.53
16 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45
17 INT171898 Il1rn Regulation of Gene_expression of Il1 1 0.02 0.92 0.4
18 INT186758 Il13 Regulation of Ccl5 2 0.17 0.17 0.39
19 INT237415 Il1rn Regulation of Il10 1 0.03 0.96 0.39
20 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39
21 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36
22 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36
23 INT181432 Csf2 Positive_regulation of Ccl5 1 0.03 0.81 0.29
24 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
25 INT255996 H7 Negative_regulation of Il1rn 1 0.01 0.25 0.27
26 INT237088 Binding of Cxcl9 and Ccl5 1 0.29 1.51 0.26
27 INT246438 Ccl5 Positive_regulation of Gene_expression of Cd79a 1 0.13 0.83 0.26
28 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17
29 INT173938 Il1rn Negative_regulation of Il1 1 0.00 0.18 0.17
30 INT246440 Ccl5 Positive_regulation of Positive_regulation of Xcl1 1 0.27 1.28 0.16
31 INT186767 Ccl11 Regulation of Ccl5 1 0.01 0 0.07
32 INT186766 Il5 Regulation of Ccl5 1 0.01 0 0.07
33 INT246441 Ccl5 Positive_regulation of Gene_expression of Aif1 1 0.03 0.71 0.06
34 INT246436 Ccl5 Regulation of Aif1 1 0.01 0.67 0.06
35 INT247774 Binding of Ccl5 and Ccrl2 1 0.14 0.29 0.04
36 INT247766 Binding of Ccl2 and Ccl5 1 0.14 0.28 0.04
37 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
2 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08
3 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
4 INT181348 Localization of Ccl5 24 0.65 19.55 6.8
5 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25
6 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44
7 INT181363 Regulation of Ccl5 16 0.46 13.65 5.09
8 INT181362 Negative_regulation of Ccl5 21 0.40 15.63 4.96
9 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83
10 INT176614 Positive_regulation of Gene_expression of Ccl5 20 0.59 16.2 4.81
11 INT181042 Binding of Ccl5 18 0.41 9.34 4.51
12 INT181378 Negative_regulation of Gene_expression of Ccl5 12 0.46 9.64 3.59
13 INT181418 Regulation of Gene_expression of Ccl5 11 0.52 9.86 3.37
14 INT171888 Binding of Il1rn 13 0.38 5.53 3.13
15 INT173931 Regulation of Gene_expression of Il1rn 3 0.60 2.68 1.84
16 INT173929 Regulation of Il1rn 5 0.26 3.02 0.93
17 INT255990 Localization of Il1rn 6 0.73 1.74 0.9
18 INT181351 Transcription of Ccl5 5 0.64 2.19 0.9
19 INT171889 Negative_regulation of Gene_expression of Il1rn 3 0.08 2.31 0.9
20 INT116032 Transcription of Il1rn 4 0.70 2.19 0.84
21 INT181390 Negative_regulation of Positive_regulation of Ccl5 2 0.31 2.31 0.77
22 INT181349 Positive_regulation of Localization of Ccl5 2 0.37 0.89 0.62
23 INT194225 Positive_regulation of Positive_regulation of Ccl5 1 0.07 1.13 0.55
24 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
25 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
26 INT114182 Negative_regulation of Positive_regulation of Il1rn 1 0.15 0 0.49
27 INT255986 Negative_regulation of Negative_regulation of Il1rn 1 0.34 0.26 0.45
28 INT268760 Positive_regulation of Binding of Ccl5 1 0.13 0.91 0.39
29 INT344829 Positive_regulation of Positive_regulation of Il1rn 1 0.02 0.53 0.33
30 INT116035 Negative_regulation of Transcription of Il1rn 1 0.57 0.1 0.29
31 INT255991 Negative_regulation of Binding of Il1rn 1 0.34 0.26 0.27
32 INT323609 Positive_regulation of Binding of Il1rn 1 0.21 0.63 0.26
33 INT255985 Protein_catabolism of Il1rn 1 0.52 0.37 0.25
34 INT285224 Positive_regulation of Transcription of Il1rn 1 0.45 0.72 0.15
35 INT233838 Regulation of Binding of Ccl5 1 0.21 1 0.15
36 INT246434 Negative_regulation of Negative_regulation of Ccl5 1 0.40 1.72 0.09
37 INT267251 Gene_expression of Ptprj 1 0.12 2.02 0.05
38 INT267249 Positive_regulation of Gene_expression of Ptprj 1 0.08 0.39 0.03
39 INT285222 Negative_regulation of Regulation of Il1rn 1 0.42 1.02 0
40 INT267250 Positive_regulation of Ptprj 1 0.08 1.31 0
41 INT189478 Regulation of Transcription of Ccl5 1 0.38 0.63 0
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