GO:2000310

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Name regulation of N-methyl-D-aspartate selective glutamate receptor activity
Categary Process
Go Slim No
Go Link GO:2000310
Unique Molecular Interactions 370
Total Molecular Interactions 600
Total Single Events 4554
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of N-methyl-D-aspartate selective glutamate receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for regulation of N-methyl-D-aspartate selective glutamate receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
2 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
3 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
4 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
5 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
6 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
7 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
8 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
9 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
10 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
11 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
12 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
13 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
14 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
15 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
16 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
17 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
18 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 0.44 0 2.35
19 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
20 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
21 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
22 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
23 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
24 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
25 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
26 INT30954 Crh Negative_regulation of LH 5 0.46 1.4 2.06
27 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
28 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
29 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
30 INT29715 Crh Negative_regulation of Localization of LH 5 0.43 0 1.78
31 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
32 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
33 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
34 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
35 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
36 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
37 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 0.04 1.81 1.7
38 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
39 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
40 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
41 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
42 INT151020 Binding of Pdyn and Crh 1 0.14 0.42 1.59
43 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
44 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
45 INT209087 Crh Positive_regulation of Ceacam3 1 0.24 1.45 1.54
46 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
47 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
48 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
49 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
50 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
51 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
52 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
53 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
54 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
55 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4
56 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
57 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
58 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
59 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
60 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
61 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
62 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
63 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
64 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
65 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
66 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
67 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
68 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
69 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
70 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
71 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
72 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
73 INT29714 Crh Regulation of Localization of LH 2 0.26 0 1.19
74 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
75 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
76 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
77 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
78 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
79 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
80 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
81 INT29713 Crh Negative_regulation of Localization of Gnrhr 1 0.39 0 1.12
82 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
83 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
84 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
85 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
86 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
87 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
88 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
89 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04
90 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
91 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
92 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
93 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
94 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
95 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
96 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1
97 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
98 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
99 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98
100 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97
101 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
102 INT36002 Negative_regulation of Crh Negative_regulation of LH 2 0.29 0.66 0.96
103 INT40287 OPRM1 Positive_regulation of Negative_regulation of Prl 1 0.00 0.93 0.96
104 INT133076 STAT6 Positive_regulation of OPRM1 1 0.38 0 0.95
105 INT18247 Binding of CRH and GNRH1 1 0.51 1.57 0.95
106 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
107 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
108 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
109 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
110 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
111 INT62449 Gnrh1 Regulation of Crh 1 0.40 0.34 0.91
112 INT89314 Binding of CRYGS and OPRM1 1 0.07 0.08 0.91
113 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
114 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
115 INT66371 Pomc Regulation of Gene_expression of Crh 2 0.49 0 0.88
116 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85
117 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85
118 INT21006 Oprl1 Regulation of Localization of Crh 1 0.19 0 0.84
119 INT64629 Binding of Gal and Crh 1 0.18 0.1 0.83
120 INT64627 Binding of Oxt and Crh 1 0.07 0.1 0.83
121 INT97012 Binding of CALM1 and OPRM1 1 0.18 0 0.82
122 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
123 INT90382 Binding of CRH and GH1 1 0.34 0.05 0.81
124 INT89529 OPRM1 Regulation of CALM1 1 0.27 0 0.81
125 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 0.31 0.07 0.8
126 INT36003 Crh Positive_regulation of Localization of LH 2 0.45 0 0.79
127 INT151807 Binding of NFATC1 and OPRM1 1 0.19 0 0.79
128 INT133074 CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.77
129 INT79532 Crh Regulation of Ugt1a10 1 0.00 0 0.76
130 INT151808 NFATC1 Positive_regulation of Positive_regulation of OPRM1 1 0.20 0 0.76
131 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
132 INT28620 Penk Regulation of Crh 2 0.40 0.25 0.75
133 INT128861 LBR Positive_regulation of Positive_regulation of OPRM1 1 0.19 0.36 0.75
134 INT151810 JUND Positive_regulation of Positive_regulation of OPRM1 1 0.26 0 0.74
135 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
136 INT260895 CRH Regulation of MMP1 1 0.11 0.31 0.74
137 INT133070 Positive_regulation of CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.74
138 INT151806 TRAF3IP2 Positive_regulation of Positive_regulation of OPRM1 1 0.06 0 0.74
139 INT30838 Crh Negative_regulation of D230030E09Rik 1 0.17 0.1 0.73
140 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72
141 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72
142 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
143 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
144 INT162162 ARF6 Regulation of OPRM1 1 0.19 0 0.71
145 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71
146 INT82759 Binding of IGHG3 and OPRM1 2 0.06 0 0.7
147 INT12022 Crh Positive_regulation of Localization of Prl 1 0.02 0.14 0.7
148 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7
149 INT107741 Binding of OPRM1 and Pld2 1 0.01 0 0.69
150 INT55205 Prl Positive_regulation of Localization of Crh 1 0.47 0 0.69
151 INT55209 Prl Positive_regulation of Crh 1 0.51 0 0.69
152 INT253825 Cck Positive_regulation of Crh 1 0.74 0 0.69
153 INT130717 Binding of OPRM1 and Positive_regulation of Localization of CCL2 1 0.00 0.72 0.68
154 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68
155 INT30503 OPRM1 Regulation of Localization of Prl 1 0.00 0 0.67
156 INT169215 Binding of OPRM1 and CARTPT 1 0.00 0.22 0.67
157 INT169219 Binding of OPRM1 and Coc 1 0.01 0.22 0.67
158 INT135119 Binding of Pomc and Crh 1 0.35 0 0.67
159 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66
160 INT137140 HIVEP1 Regulation of Gene_expression of OPRM1 1 0.25 0.69 0.66
161 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
162 INT101716 JUND Regulation of Regulation of OPRM1 1 0.09 0.06 0.65
163 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
164 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64
165 INT322385 PPBP Negative_regulation of Positive_regulation of OPRM1 1 0.00 0 0.64
166 INT137145 HIVEP1 Regulation of OPRM1 1 0.10 0.7 0.64
167 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64
168 INT34212 PSG2 Regulation of Localization of Crh 1 0.02 0.09 0.63
169 INT34211 DNM2 Regulation of Localization of Crh 1 0.01 0.09 0.63
170 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
171 INT30502 Negative_regulation of OPRM1 Negative_regulation of Gh 1 0.00 0 0.63
172 INT23576 Binding of Penk and Crh 2 0.18 0 0.62
173 INT20162 Crh Regulation of GNRH1 2 0.02 0.07 0.62
174 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61
175 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61
176 INT101718 PLAT Positive_regulation of Transcription of OPRM1 1 0.22 0.06 0.61
177 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
178 INT126951 PNOC Positive_regulation of OPRM1 1 0.21 0.06 0.6
179 INT57246 Crh Positive_regulation of Positive_regulation of Caprin2 1 0.01 0.55 0.6
180 INT104050 Binding of Crh and Nts 1 0.40 0 0.6
181 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 0.42 0.55 0.59
182 INT34311 Regulation of CRH Positive_regulation of POMC 1 0.24 0 0.59
183 INT59540 Crh Regulation of Gnrh1 2 0.36 2.61 0.58
184 INT91393 Crh Positive_regulation of SST 1 0.01 0.73 0.58
185 INT121813 IL6 Positive_regulation of OPRM1 1 0.28 0.28 0.58
186 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
187 INT62445 Pomc Negative_regulation of Localization of Crh 1 0.12 0.07 0.58
188 INT61505 ABAT Negative_regulation of Localization of CRH 1 0.09 0 0.57
189 INT30268 Binding of Gnrh1 and Crh 1 0.45 0.65 0.57
190 INT159125 Binding of OPRM1 and SUGT1 1 0.03 0.31 0.57
191 INT77367 IFNA1 Positive_regulation of Positive_regulation of Crh 1 0.05 0.76 0.57
192 INT30267 Binding of Crh and Gnrhr 1 0.33 0.65 0.57
193 INT94499 Tnf Positive_regulation of Gene_expression of Crh 1 0.27 0.97 0.56
194 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
195 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
196 INT141020 Crh Positive_regulation of Gene_expression of Pomc 1 0.05 0.17 0.55
197 INT55872 Binding of ADRA1D and CRH 1 0.26 0 0.54
198 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
199 INT137143 HIVEP1 Positive_regulation of OPRM1 1 0.15 0.43 0.52
200 INT87557 Crh Positive_regulation of Prkaca 1 0.27 0 0.52

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of N-methyl-D-aspartate selective glutamate receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in regulation of N-methyl-D-aspartate selective glutamate receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
2 INT1562 Localization of Crh 499 0.81 126.74 236.68
3 INT438 Gene_expression of Crh 376 0.78 159.11 169.17
4 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
5 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
6 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14
7 INT1898 Regulation of Crh 220 0.62 61.33 102.64
8 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
9 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
10 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28
11 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92
12 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
13 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
14 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23
15 INT5454 Localization of CRH 124 0.79 79.18 41.53
16 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
17 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74
18 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26
19 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
20 INT5514 Negative_regulation of Localization of Crh 64 0.58 8.12 29.29
21 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
22 INT16879 Binding of Crh 72 0.48 21.65 28.43
23 INT21379 Transcription of Crh 65 0.72 15.64 27.92
24 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12
25 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34
26 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73
27 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
28 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
29 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
30 INT5452 Regulation of CRH 56 0.62 15.32 12.42
31 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37
32 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
33 INT5498 Positive_regulation of Positive_regulation of Crh 19 0.70 9.82 7.97
34 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
35 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
36 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
37 INT22336 Positive_regulation of Transcription of Crh 18 0.68 4.61 6.91
38 INT20922 Positive_regulation of Localization of CRH 18 0.67 11.12 6.79
39 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41
40 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
41 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
42 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
43 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7
44 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
45 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
46 INT22485 Negative_regulation of Positive_regulation of Crh 13 0.59 4.49 5.46
47 INT18244 Regulation of Positive_regulation of Crh 11 0.45 3.87 5.41
48 INT22338 Negative_regulation of Transcription of Crh 11 0.43 2.09 5.24
49 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
50 INT63441 Regulation of Transcription of Crh 9 0.60 4.51 3.9
51 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
52 INT7559 Transcription of CRH 37 0.69 4.84 3.61
53 INT25029 Positive_regulation of Positive_regulation of CRH 7 0.49 6.77 3.52
54 INT63534 Binding of CRH 23 0.47 6.84 3.43
55 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
56 INT28715 Negative_regulation of Regulation of Crh 7 0.43 0.97 3.06
57 INT23763 Regulation of Localization of CRH 6 0.48 0.22 3.04
58 INT5510 Negative_regulation of Negative_regulation of Crh 8 0.43 1.05 2.61
59 INT22339 Positive_regulation of Negative_regulation of Crh 5 0.67 1.36 2.59
60 INT64062 Negative_regulation of Regulation of OPRM1 2 0.41 0.3 2.48
61 INT32980 Positive_regulation of Regulation of OPRM1 2 0.45 0 1.98
62 INT30834 Regulation of Negative_regulation of Crh 3 0.45 0.62 1.81
63 INT142684 Protein_catabolism of OPRM1 2 0.66 0.48 1.81
64 INT12835 Negative_regulation of Positive_regulation of CRH 6 0.42 3.15 1.76
65 INT18710 Regulation of Regulation of Crh 6 0.60 0.79 1.6
66 INT115963 Negative_regulation of Gene_expression of CRH 9 0.59 4.53 1.48
67 INT34312 Regulation of Gene_expression of CRH 6 0.46 1.97 1.48
68 INT115804 Regulation of Localization of OPRM1 2 0.33 0.12 1.33
69 INT67450 Negative_regulation of Localization of OPRM1 2 0.06 0.24 1.26
70 INT35786 Negative_regulation of Negative_regulation of OPRM1 2 0.33 0.91 1.1
71 INT25043 Positive_regulation of Regulation of Crh 5 0.50 1 1.06
72 INT58050 Regulation of Binding of Crh 2 0.42 0.84 0.86
73 INT97763 Negative_regulation of Binding of CRH 2 0.42 0 0.76
74 INT194127 Negative_regulation of Transcription of CRH 2 0.41 0.16 0.51
75 INT12833 Regulation of Regulation of CRH 2 0.27 1.32 0.44
76 INT305077 Localization of CRHBP 1 0.76 0.28 0.44
77 INT83897 Protein_catabolism of Crh 2 0.86 1.75 0.39
78 INT7558 Regulation of Transcription of CRH 1 0.60 0.06 0.35
79 INT247097 Binding of CRHBP 3 0.34 0.4 0.28
80 INT67420 Negative_regulation of Negative_regulation of CRH 2 0.43 0.81 0.28
81 INT28717 Regulation of Positive_regulation of CRH 2 0.29 1.4 0.24
82 INT12834 Positive_regulation of Transcription of CRH 3 0.67 1 0.2
83 INT55986 Positive_regulation of Binding of Crh 1 0.48 0.76 0.19
84 INT92090 Negative_regulation of Protein_catabolism of Crh 1 0.04 0.99 0.12
85 INT264799 Regulation of Binding of CRH 1 0.04 0 0.11
86 INT243988 Binding of Nrxn1 1 0.01 0.21 0.07
87 INT243932 Gene_expression of Nrxn1 1 0.02 0.28 0.06
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