GO:2000377

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Name regulation of reactive oxygen species metabolic process
Categary Process
Go Slim No
Go Link GO:2000377
Unique Molecular Interactions 92
Total Molecular Interactions 133
Total Single Events 612
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of reactive oxygen species metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for regulation of reactive oxygen species metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
2 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
3 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
4 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
5 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
6 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
7 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
8 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
9 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
10 INT141373 Ier3 Positive_regulation of CREM 1 0.00 0 0.95
11 INT149390 Foxm1 Positive_regulation of Trpa1 1 0.28 0.31 0.94
12 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85
13 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
14 INT289333 Binding of Ngfr and Rtn4r 1 0.03 2.35 0.72
15 INT289332 Binding of Ngfr and Lingo1 1 0.04 2.36 0.72
16 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 0.29 0.32 0.69
17 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
18 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
19 INT134528 Grin1 Regulation of Ngfr 1 0.03 0 0.57
20 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
21 INT76002 Ngf Positive_regulation of Ngfr 1 0.05 0.48 0.53
22 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53
23 INT138353 Foxm1 Positive_regulation of Phosphorylation of Trpv1 1 0.10 0.31 0.51
24 INT138352 Foxm1 Positive_regulation of Trpa1 1 0.05 0.33 0.51
25 INT206010 Foxm1 Positive_regulation of Gene_expression of Il18 1 0.03 0.72 0.5
26 INT86088 Foxm1 Positive_regulation of Binding of Crygs 1 0.04 0 0.49
27 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
28 INT86089 Foxm1 Regulation of Binding of Crygs 1 0.02 0 0.49
29 INT120295 Ngf Positive_regulation of Positive_regulation of Ngfr 1 0.47 0.22 0.43
30 INT127077 Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
31 INT127079 Gene_expression of Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
32 INT127078 Bdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
33 INT127076 Gene_expression of Bdnf Positive_regulation of Gene_expression of IER3 1 0.03 0.26 0.42
34 INT224894 Bdnf Positive_regulation of Positive_regulation of IER3 1 0.00 0.36 0.41
35 INT73537 Ntf3 Positive_regulation of Ngfr 1 0.21 0.1 0.38
36 INT73536 Ngf Regulation of Ngfr 1 0.22 0.08 0.37
37 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
38 INT112283 Bdnf Regulation of Gene_expression of Ngfr 1 0.14 0.28 0.34
39 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
40 INT139125 Adcyap1 Regulation of Ier3 1 0.54 0.8 0.29
41 INT225118 Foxm1 Positive_regulation of Gene_expression of MMP2 1 0.01 0.34 0.23
42 INT70182 PRCP Positive_regulation of IER3 1 0.15 0.1 0.22
43 INT225117 Foxm1 Regulation of Gene_expression of FN1 1 0.01 0.4 0.22
44 INT241451 Mag Positive_regulation of Ngfr 1 0.09 0.1 0.21
45 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21
46 INT280486 Binding of Ngfr and Ntrk2 2 0.18 1.21 0.17
47 INT241462 Binding of OMG and Ngfr 1 0.11 0.15 0.15
48 INT241457 Binding of Mag and Ngfr 1 0.09 0.15 0.15
49 INT241453 Binding of Ngfr and Rtn4r 1 0.03 0.15 0.15
50 INT286769 Tusc2 Regulation of Foxm1 1 0.02 1.55 0.15
51 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12
52 INT173119 PPA1 Regulation of IER3 1 0.00 0.36 0.12
53 INT349858 Binding of Ngfr and Ntrk2 1 0.09 0.32 0.11
54 INT280493 Ngfr Regulation of Protein_catabolism of BDNF 1 0.09 0.14 0.1
55 INT164675 Binding of NGF and Ngfr 1 0.00 0.5 0.08
56 INT164676 Negative_regulation of Binding of NGF and Ngfr 1 0.00 0.5 0.08
57 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
58 INT342726 Binding of Laptm5 and Park2 1 0.03 0.64 0.04
59 INT213803 Binding of Foxm1 and Tfe3 1 0.00 1.09 0.03
60 INT241449 Mag Positive_regulation of Protein_catabolism of Ngfr 1 0.09 0 0.03
61 INT213810 Binding of Foxm1 and Tfeb 1 0.00 1.09 0.03
62 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
63 INT201732 Ngfr Positive_regulation of Nfkb1 1 0.01 0.43 0.03
64 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
65 INT342725 Pink1 Positive_regulation of Phosphorylation of Park2 1 0.29 0.62 0
66 INT200063 Binding of MAGED1 and Ngfr 1 0.44 0.45 0
67 INT272132 IER3 Regulation of Transcription of Ie 1 0.00 0.71 0
68 INT317300 Binding of Park2 and Pink1 1 0.48 1.23 0
69 INT338013 Binding of Ngfrap1 and Ngfr 1 0.06 1.3 0
70 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0
71 INT206178 Foxm1 Positive_regulation of Protein_catabolism of Olr1 1 0.00 0.47 0
72 INT342727 Pink1 Positive_regulation of Park2 1 0.29 0.62 0
73 INT200053 Binding of Nuc and Ngfr 1 0.10 0.3 0
74 INT200057 Binding of Ndn and Ngfr 1 0.43 1.96 0
75 INT232045 Binding of FOXM1 and RNPC3 1 0.00 0.31 0
76 INT232051 Binding of FOXM1 and KRAS 1 0.00 0.63 0
77 INT206180 Foxm1 Positive_regulation of Transcription of Olr1 1 0.00 0.48 0
78 INT317302 Binding of Park2 and Mul1 1 0.01 0.62 0
79 INT320346 Binding of Ngfr and Np4 1 0.01 0 0
80 INT201742 Binding of Ngfr and Gtf3a 1 0.00 0.77 0
81 INT200061 Binding of Ngfr and Fez1 1 0.31 0.3 0
82 INT232044 Binding of FOXM1 and LMBRD1 1 0.00 0.32 0
83 INT249828 Foxm1 Positive_regulation of Transcription of BIRC5 1 0.56 0.12 0
84 INT290372 Binding of Ngfr and Scarb1 1 0.01 0.48 0
85 INT330384 IER3 Regulation of USH2A 1 0.00 0.87 0
86 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
87 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
88 INT249824 Ppp4c Positive_regulation of Foxm1 1 0.24 0 0
89 INT232046 Binding of DDR1 and FOXM1 1 0.00 0.63 0
90 INT200055 Binding of Ngfr and Mageh1 1 0.33 0.45 0
91 INT249827 Foxm1 Positive_regulation of Transcription of Cenpb 1 0.56 0.12 0
92 INT341632 Binding of EGFR and FOXM1 1 0.02 0.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of reactive oxygen species metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in regulation of reactive oxygen species metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
2 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
3 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
4 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
5 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
6 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
7 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
8 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48
9 INT55513 Binding of Foxm1 19 0.37 2.37 5.54
10 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07
11 INT64711 Regulation of Ngfr 10 0.45 3.12 4.33
12 INT121170 Positive_regulation of Gene_expression of Ngfr 10 0.64 9.32 3.94
13 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89
14 INT55907 Binding of Ngfr 13 0.47 5.79 3.75
15 INT66585 Gene_expression of IER3 13 0.63 7.39 3.48
16 INT61540 Negative_regulation of Gene_expression of Ngfr 11 0.59 6.36 3.43
17 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81
18 INT61541 Positive_regulation of Gene_expression of Ngfr 7 0.53 2.87 2.75
19 INT75225 Transcription of Ngfr 4 0.60 1.95 2.44
20 INT113203 Regulation of Foxm1 8 0.34 7.5 2.36
21 INT64712 Localization of Ngfr 4 0.78 1.19 1.91
22 INT68767 Positive_regulation of IER3 6 0.28 2.59 1.8
23 INT95253 Regulation of IER3 4 0.23 1.89 1.6
24 INT140247 Negative_regulation of Negative_regulation of Ngfr 3 0.33 3.15 1.59
25 INT232644 Transcription of IER3 1 0.01 0.97 1.58
26 INT163594 Regulation of Ngfr 5 0.43 2.55 1.53
27 INT64713 Regulation of Gene_expression of Ngfr 4 0.50 2.04 1.36
28 INT138939 Positive_regulation of Transcription of Ngfr 3 0.43 0.89 1.31
29 INT164372 Positive_regulation of Positive_regulation of Ngfr 6 0.62 4.1 1.22
30 INT110392 Transcription of Ngfr 3 0.52 2.48 1.19
31 INT138349 Phosphorylation of Foxm1 1 0.10 0.9 1.05
32 INT163595 Positive_regulation of Regulation of Ngfr 1 0.46 0.57 1.04
33 INT72710 Negative_regulation of Negative_regulation of Foxm1 3 0.10 0.55 0.84
34 INT95252 Regulation of Positive_regulation of IER3 1 0.03 0.73 0.78
35 INT317733 Positive_regulation of Binding of Ngfr 1 0.18 0.51 0.71
36 INT133018 Regulation of Gene_expression of Ngfr 2 0.43 1.47 0.7
37 INT82542 Negative_regulation of Gene_expression of IER3 3 0.13 0.16 0.65
38 INT203749 Binding of FOXM1 10 0.31 6.1 0.64
39 INT249764 Regulation of Binding of Foxm1 1 0.39 0.19 0.58
40 INT139929 Phosphorylation of Ngfr 3 0.58 1.67 0.57
41 INT118729 Regulation of Transcription of Ngfr 1 0.36 0.45 0.57
42 INT206006 Negative_regulation of Gene_expression of Foxm1 4 0.43 2.63 0.56
43 INT110393 Positive_regulation of Transcription of Ngfr 1 0.46 1 0.54
44 INT86087 Negative_regulation of Binding of Foxm1 1 0.28 0 0.52
45 INT206009 Transcription of Foxm1 2 0.68 1.49 0.51
46 INT141364 Positive_regulation of Positive_regulation of Ier3 1 0.00 0 0.48
47 INT141363 Positive_regulation of Ier3 1 0.00 0 0.47
48 INT50336 Negative_regulation of Positive_regulation of Foxm1 1 0.30 0 0.38
49 INT165518 Positive_regulation of Regulation of Ngfr 2 0.47 0.47 0.37
50 INT249785 Positive_regulation of Gene_expression of Foxm1 13 0.69 4.71 0.36
51 INT139124 Transcription of Ier3 1 0.61 0.81 0.29
52 INT145538 Localization of IER3 3 0.12 0.5 0.28
53 INT297460 Regulation of Regulation of Ngfr 1 0.33 0.32 0.21
54 INT201239 Gene_expression of FOXM1 9 0.51 4.07 0.19
55 INT203750 Positive_regulation of FOXM1 8 0.39 2.72 0.19
56 INT203751 Negative_regulation of FOXM1 2 0.20 0.94 0.11
57 INT297459 Protein_catabolism of Ngfr 1 0.21 0.5 0.1
58 INT342696 Gene_expression of Park2 1 0.65 1.19 0.08
59 INT329427 Binding of Ier3 1 0.31 0.7 0.05
60 INT317299 Binding of Park2 1 0.36 0.61 0.04
61 INT249792 Regulation of Gene_expression of Foxm1 1 0.45 0.45 0.04
62 INT241405 Localization of Ngfr 2 0.56 0.4 0.03
63 INT306285 Positive_regulation of Gene_expression of IER3 1 0.15 1.13 0.03
64 INT241402 Protein_catabolism of Ngfr 1 0.39 0 0.03
65 INT249769 Localization of Foxm1 6 0.74 1.13 0
66 INT342695 Phosphorylation of Park2 1 0.79 0.62 0
67 INT207724 Transcription of FOXM1 1 0.58 0.85 0
68 INT193880 Regulation of Phosphorylation of Ngfr 1 0.02 0.25 0
69 INT249793 Regulation of Transcription of Foxm1 1 0.45 0 0
70 INT201629 Negative_regulation of Positive_regulation of Ngfr 1 0.07 0.37 0
71 INT249780 Positive_regulation of Binding of Foxm1 1 0.50 0.5 0
72 INT249768 Regulation of Localization of Foxm1 1 0.39 0 0
73 INT296536 Gene_expression of Ier3 1 0.04 1.19 0
74 INT296568 Regulation of Gene_expression of Ier3 1 0.02 1.26 0
75 INT249776 Negative_regulation of Localization of Foxm1 1 0.37 0.46 0
76 INT203752 Regulation of FOXM1 1 0.02 0 0
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