GO:2000378

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Name negative regulation of reactive oxygen species metabolic process
Categary Process
Go Slim No
Go Link GO:2000378
Unique Molecular Interactions 51
Total Molecular Interactions 60
Total Single Events 174
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of reactive oxygen species metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of reactive oxygen species metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
2 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
3 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
4 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
5 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
6 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
7 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
8 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
9 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
10 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
11 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
12 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
13 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
14 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
15 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
16 INT309366 Pax2 Negative_regulation of Transcription of Slc6a5 1 0.03 0 0.31
17 INT309369 Ptf1a Positive_regulation of Pax2 1 0.10 0 0.3
18 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21
19 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 1 0.08 0.07 0.11
20 INT309372 Lhx5 Positive_regulation of Gene_expression of Pax2 1 0.09 0.07 0.11
21 INT191758 ROS1 Positive_regulation of TFAP2A 1 0.01 0.54 0.08
22 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
23 INT267214 Hspb8 Negative_regulation of Cryab 1 0.32 1.56 0.06
24 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
25 INT339979 Binding of PRDX2 and HDAC9 1 0.02 0.16 0.05
26 INT143993 Prdx2 Positive_regulation of Atp13a4 1 0.00 0 0.05
27 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
28 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
29 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03
30 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03
31 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
32 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03
33 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03
34 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0
35 INT244839 Lbx1 Positive_regulation of Pax2 1 0.39 0 0
36 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
37 INT296999 Binding of EPS15 and TFAP2A 1 0.06 0.2 0
38 INT267215 Binding of Cryab and Hspb1 1 0.25 7.19 0
39 INT245828 Binding of VEGFA and Tfap2a 1 0.01 0.64 0
40 INT283718 Binding of Id2 and Aatf 1 0.03 0.19 0
41 INT297691 Binding of Fut1 and Pax2 1 0.03 0 0
42 INT267216 Binding of Cryab and Hspb8 1 0.36 9.29 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of reactive oxygen species metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of reactive oxygen species metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108250 Regulation of Prdx2 5 0.25 2.02 2.08
2 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
3 INT108249 Negative_regulation of Prdx2 3 0.32 1.85 1.36
4 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
5 INT108243 Positive_regulation of Prdx2 3 0.34 0.85 0.95
6 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
7 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
8 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
9 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
10 INT193672 Gene_expression of Prdx2 3 0.50 2.75 0.64
11 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
12 INT80300 Gene_expression of TFAP2A 5 0.54 2.76 0.59
13 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
14 INT267196 Gene_expression of Cryab 17 0.64 22.5 0.38
15 INT80302 Binding of TFAP2A 7 0.39 1.67 0.38
16 INT106402 Positive_regulation of TFAP2A 2 0.13 0.35 0.35
17 INT213507 Gene_expression of Pax2 10 0.67 1.41 0.34
18 INT173635 Negative_regulation of TFAP2A 3 0.34 2.93 0.33
19 INT309354 Regulation of Pax2 1 0.10 0 0.29
20 INT309339 Negative_regulation of Localization of Pax2 1 0.15 0 0.28
21 INT292207 Negative_regulation of Gene_expression of TFAP2A 1 0.05 1.2 0.27
22 INT143991 Gene_expression of Prdx2 5 0.61 1.54 0.22
23 INT161959 Gene_expression of PRDX2 2 0.65 1.38 0.2
24 INT353278 Binding of Prdx2 1 0.21 0.05 0.18
25 INT353270 Regulation of Binding of Prdx2 1 0.25 0.05 0.18
26 INT267193 Positive_regulation of Gene_expression of Cryab 6 0.41 5.71 0.17
27 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
28 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
29 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
30 INT353274 Transcription of Prdx2 1 0.39 0.51 0.16
31 INT353264 Negative_regulation of Negative_regulation of Prdx2 1 0.24 0.45 0.15
32 INT309352 Localization of Pax2 1 0.27 0 0.14
33 INT267198 Positive_regulation of Cryab 1 0.46 6.69 0.13
34 INT193676 Positive_regulation of Gene_expression of Prdx2 2 0.06 1.31 0.09
35 INT97754 Regulation of Gene_expression of TFAP2A 1 0.36 0.13 0.06
36 INT244741 Positive_regulation of Gene_expression of Pax2 1 0.38 0 0.06
37 INT340756 Positive_regulation of PRDX2 1 0.02 1.23 0.04
38 INT143990 Regulation of Prdx2 1 0.22 0 0.03
39 INT206742 Negative_regulation of PRDX2 5 0.04 5.04 0
40 INT283691 Binding of Aatf 2 0.03 0.19 0
41 INT267203 Negative_regulation of Cryab 2 0.29 3.98 0
42 INT244782 Negative_regulation of Pax2 1 0.44 0 0
43 INT173648 Regulation of Binding of TFAP2A 1 0.03 0.32 0
44 INT283704 Phosphorylation of Aatf 1 0.05 0.19 0
45 INT340876 Positive_regulation of Negative_regulation of Cryab 1 0.20 0.62 0
46 INT256679 Gene_expression of Aatf 1 0.65 0.71 0
47 INT173631 Negative_regulation of Positive_regulation of TFAP2A 1 0.05 0.27 0
48 INT267200 Regulation of Gene_expression of Cryab 1 0.30 1.27 0
49 INT286557 Regulation of Binding of Aatf 1 0.02 0 0
50 INT173627 Negative_regulation of Binding of TFAP2A 1 0.08 0.28 0
51 INT173642 Transcription of TFAP2A 1 0.09 0.27 0
52 INT339996 Positive_regulation of Negative_regulation of PRDX2 1 0.05 1.27 0
53 INT283676 Regulation of Cryab 1 0.09 0.82 0
54 INT213529 Negative_regulation of Gene_expression of Pax2 1 0.37 0.23 0
55 INT173645 Regulation of TFAP2A 1 0.02 0.33 0
56 INT173630 Positive_regulation of Transcription of TFAP2A 1 0.06 0.54 0
57 INT311630 Negative_regulation of Tfap2a 1 0.34 0.23 0
58 INT267184 Negative_regulation of Gene_expression of Cryab 1 0.29 1.5 0
59 INT319128 Positive_regulation of Binding of Tfap2a 1 0.23 0.5 0
60 INT311626 Negative_regulation of Gene_expression of Tfap2a 1 0.34 0.29 0
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