GO:2000481

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Name positive regulation of cAMP-dependent protein kinase activity
Categary Process
Go Slim No
Go Link GO:2000481
Unique Molecular Interactions 173
Total Molecular Interactions 226
Total Single Events 1936
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cAMP-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cAMP-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
3 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
4 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
5 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
6 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
7 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
8 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
9 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
10 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
11 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
12 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
13 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
14 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
15 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28
16 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
17 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23
18 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22
19 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
20 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21
21 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
22 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
23 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
24 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2
25 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
26 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
27 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
28 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
29 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
30 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
31 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
32 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
33 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15
34 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
35 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
36 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
37 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12
38 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
39 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
40 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
41 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12
42 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
43 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12
44 INT257467 Fat1 Regulation of Gene_expression of Adipoq 1 0.08 0.56 0.11
45 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1
46 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
47 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
48 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
49 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09
50 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
51 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
52 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
53 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08
54 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
55 INT257466 Psd Negative_regulation of Gene_expression of Adipoq 1 0.22 0.66 0.08
56 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
57 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
58 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
59 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
60 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
61 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
62 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
63 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
64 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
65 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
66 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07
67 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06
68 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
69 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
70 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
71 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05
72 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
73 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
74 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
75 INT236590 Binding of Adipoq and Ncoa2 1 0.15 0.2 0.03
76 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
77 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
78 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
79 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
80 INT236592 Positive_regulation of Binding of Adipoq and Ncoa2 1 0.19 0.2 0.03
81 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
82 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
83 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
84 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
85 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
86 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
87 INT227305 Zbp1 Regulation of Gene_expression of Adipoq 1 0.21 1.27 0
88 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
89 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 0.08 0.12 0
90 INT352516 Binding of POMT1 and Adipoq 1 0.01 0.4 0
91 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
92 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
93 INT204322 Binding of ADIPOQ and Positive_regulation of Gene_expression of PPARGC1A 1 0.30 0.07 0
94 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
95 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
96 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
97 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
98 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
99 INT140814 Adipoq Regulation of Retn 1 0.03 0.8 0
100 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
101 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
102 INT227302 Zbp1 Regulation of Transcription of Adipoq 1 0.09 1.27 0
103 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
104 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
105 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
106 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
107 INT350254 Slc12a6 Regulation of Gene_expression of Adipoq 1 0.02 0.63 0
108 INT197915 Des Positive_regulation of Adipoq 1 0.07 0 0
109 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0
110 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
111 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0
112 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
113 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
114 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
115 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
116 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
117 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
118 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
119 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
120 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
121 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0
122 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
123 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
124 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cAMP-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cAMP-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
2 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
3 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
4 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
5 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
6 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
7 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
8 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
9 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
10 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
11 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
12 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
13 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
14 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
15 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
16 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
17 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
18 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
19 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
20 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
21 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
22 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
23 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
24 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
25 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
26 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
27 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
28 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
29 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
30 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
31 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
32 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
33 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
34 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
35 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
36 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
37 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
38 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
39 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
40 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
41 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
42 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
43 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
44 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
45 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
46 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
47 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
48 INT179491 Transcription of Adipoq 4 0.51 0.98 0.32
49 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
50 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
51 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3
52 INT253941 Positive_regulation of Localization of Adipoq 5 0.24 2.59 0.21
53 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
54 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18
55 INT197872 Regulation of Regulation of Adipoq 3 0.35 1.11 0.17
56 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
57 INT28026 Positive_regulation of Binding of Adipoq 1 0.27 0 0.17
58 INT137455 Protein_catabolism of ADIPOQ 1 0.66 0.25 0.17
59 INT228162 Negative_regulation of Localization of Adipoq 1 0.38 1.29 0.17
60 INT308978 Negative_regulation of Regulation of Adipoq 1 0.28 0.92 0.17
61 INT263001 Regulation of Gene_expression of ADIPOQ 5 0.45 3.77 0.16
62 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14
63 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
64 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
65 INT262999 Negative_regulation of Gene_expression of ADIPOQ 7 0.43 9.52 0.12
66 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
67 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
68 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
69 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
70 INT157267 Negative_regulation of Localization of Adipoq 1 0.24 0.94 0.09
71 INT327816 Regulation of Positive_regulation of ADIPOQ 1 0.04 1.2 0.09
72 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
73 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
74 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
75 INT353069 Positive_regulation of Positive_regulation of ADIPOQ 1 0.13 1.75 0.05
76 INT245905 Negative_regulation of Transcription of ADIPOQ 1 0.42 1.26 0.05
77 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
78 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
79 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
80 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
81 INT228584 Phosphorylation of Adipoq 1 0.38 0.61 0.04
82 INT251940 Positive_regulation of Transcription of ADIPOQ 1 0.01 0 0.04
83 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
84 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
85 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
86 INT240621 Negative_regulation of Localization of ADIPOQ 1 0.39 0.64 0.03
87 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
88 INT204349 Regulation of SIRT1 8 0.61 1.99 0
89 INT256134 Localization of Sirt1 5 0.50 2.99 0
90 INT204353 Transcription of SIRT1 3 0.68 0.67 0
91 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
92 INT289569 Transcription of Sirt1 1 0.71 0.25 0
93 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
94 INT300287 Localization of Sirt1 1 0.66 1.46 0
95 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
96 INT257464 Negative_regulation of Transcription of Adipoq 1 0.41 0.45 0
97 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
98 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
99 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
100 INT263530 Negative_regulation of Positive_regulation of ADIPOQ 1 0.31 1.43 0
101 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
102 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
103 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
104 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
105 INT227262 Regulation of Transcription of Adipoq 1 0.35 0.47 0
106 INT204331 Binding of SIRT1 1 0.47 0.39 0
107 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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