GO:2000491

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Name positive regulation of hepatic stellate cell activation
Categary Process
Go Slim No
Go Link GO:2000491
Unique Molecular Interactions 139
Total Molecular Interactions 192
Total Single Events 1141
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of hepatic stellate cell activation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of hepatic stellate cell activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
3 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
4 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
5 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
6 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
7 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
8 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
9 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
10 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
11 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
12 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
13 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
14 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
15 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
16 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
17 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
18 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
19 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
20 INT28006 NPC1 Negative_regulation of Positive_regulation of Rps6ka1 1 0.01 0.37 0.33
21 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
22 INT28005 NPC1 Negative_regulation of Rps6ka1 1 0.01 0.45 0.32
23 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
24 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
25 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
26 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
27 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
28 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
29 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
30 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
31 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
32 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
33 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
34 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
35 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
36 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
37 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
38 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
39 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
40 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
41 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
42 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
43 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
44 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
45 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
46 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
47 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
48 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19
49 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
50 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
51 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
52 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
53 INT303980 Lep Positive_regulation of Transcription of IL2 1 0.10 0.24 0.16
54 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12
55 INT304500 Binding of Rps6ka1 and Mapk1 1 0.16 0.18 0.12
56 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
57 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
58 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11
59 INT303989 Lep Positive_regulation of IL12A 1 0.05 0.39 0.11
60 INT303966 Lep Regulation of Il1 2 0.09 0.41 0.1
61 INT303990 Binding of Lep and Positive_regulation of Gene_expression of LPL 1 0.03 0.35 0.1
62 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
63 INT123864 Lep Positive_regulation of Positive_regulation of Cck 1 0.45 0.1 0.09
64 INT242324 Lep Regulation of Gene_expression of Ucp1 1 0.58 1.47 0.09
65 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 0.48 1.66 0.09
66 INT213482 Lep Positive_regulation of Mapk1 1 0.06 0.08 0.09
67 INT222545 Lep Negative_regulation of Nmb 1 0.04 0.52 0.08
68 INT123866 Lep Negative_regulation of Olfr544 1 0.00 0.09 0.08
69 INT303999 Lep Positive_regulation of Gene_expression of ITGA2 1 0.06 0.29 0.08
70 INT268325 Lep Positive_regulation of Ptgs2 1 0.09 0.39 0.08
71 INT303970 Lep Positive_regulation of Gene_expression of Itga2 1 0.09 0.29 0.08
72 INT294743 Lep Positive_regulation of Transcription of Il6 1 0.18 0.42 0.07
73 INT294740 Lep Positive_regulation of Transcription of Ccl2 1 0.08 0.42 0.07
74 INT303997 IL1RL1 Positive_regulation of Lep 1 0.01 0.2 0.07
75 INT214153 Lep Regulation of Transcription of Nucb2 1 0.35 0.15 0.06
76 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
77 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05
78 INT314135 Negative_regulation of Nos2 Positive_regulation of Lep 1 0.52 0.44 0.05
79 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
80 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05
81 INT253376 Lep Regulation of Mtor 1 0.17 0.08 0.04
82 INT303986 Lep Positive_regulation of Gene_expression of TNF 1 0.49 0.29 0.04
83 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
84 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
85 INT222534 Gnrh1 Positive_regulation of Localization of Lep 1 0.07 0 0.04
86 INT303996 Lep Positive_regulation of Gene_expression of IL12A 1 0.08 0.29 0.04
87 INT303965 Lep Positive_regulation of Gene_expression of Il6 1 0.07 0.29 0.04
88 INT253374 Lep Positive_regulation of Phosphorylation of Eif4ebp1 1 0.04 0.16 0.03
89 INT253375 Lep Positive_regulation of Phosphorylation of Rps6kb1 1 0.41 0.16 0.03
90 INT253414 Lep Negative_regulation of BCL2A1 1 0.16 0 0.03
91 INT333885 Lep Positive_regulation of Il1 1 0.17 0.05 0.03
92 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
93 INT174290 Lep Positive_regulation of Pomc 2 0.50 0.47 0
94 INT138526 Lep Positive_regulation of Localization of Gnrh1 1 0.39 0 0
95 INT121772 Rps6ka1 Regulation of Phosphorylation of USHBP1 1 0.00 0 0
96 INT305279 Lep Regulation of Gene_expression of Akt1 1 0.18 0.83 0
97 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
98 INT305273 Binding of Lep and Leprot 1 0.06 0.92 0
99 INT214139 Lep Regulation of Localization of Pomc 1 0.20 0.4 0
100 INT214155 Lep Regulation of Gene_expression of Pomc 1 0.20 0.4 0
101 INT314133 Lep Positive_regulation of Gene_expression of Ppargc1a 1 0.51 0.79 0
102 INT305278 Lep Negative_regulation of Obsty1 1 0.07 0.94 0
103 INT303963 Lep Positive_regulation of Gene_expression of Il7 1 0.02 0.41 0
104 INT174287 Agrp Positive_regulation of Lep 1 0.19 0.49 0
105 INT163585 Lep Positive_regulation of Gene_expression of Epm2a 1 0.03 0.14 0
106 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
107 INT305272 Gene_expression of Lep Positive_regulation of Positive_regulation of Stat3 1 0.40 0.46 0
108 INT305264 Positive_regulation of Binding of Lep and Leprot 1 0.08 0.93 0
109 INT305280 Lep Positive_regulation of Gene_expression of Leprot 1 0.07 1.03 0
110 INT305258 Lep Regulation of Gene_expression of Stat3 1 0.24 0.92 0
111 INT289532 Lep Regulation of Arc 1 0.04 0.19 0
112 INT305277 Positive_regulation of Binding of Lep and Obsty1 1 0.08 0.93 0
113 INT288214 Lep Negative_regulation of Gene_expression of Ins1 1 0.35 0.05 0
114 INT305271 Binding of Lep and Obsty1 1 0.06 4.86 0
115 INT174288 Lep Positive_regulation of Npy 1 0.36 0.45 0
116 INT305267 Lep Regulation of Obsty1 1 0.04 0.97 0
117 INT174283 Lep Negative_regulation of Agrp 1 0.32 0.48 0
118 INT253364 Lep Positive_regulation of Rps6kb1 1 0.30 0.08 0
119 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
120 INT305261 Gene_expression of Lep Positive_regulation of Gene_expression of Stat3 1 0.40 0.46 0
121 INT253360 Lep Positive_regulation of Eif4ebp1 1 0.01 0.08 0
122 INT289520 Lep Regulation of Prkag1 1 0.00 0.08 0
123 INT218731 Lep Positive_regulation of Gene_expression of Trh 1 0.19 0.07 0
124 INT163584 Lep Positive_regulation of Epm2a 1 0.03 0.13 0
125 INT175548 Mdk Positive_regulation of Rps6ka1 1 0.08 0.71 0
126 INT253410 ATIC Regulation of Lep 1 0.03 0.7 0
127 INT174291 Lep Positive_regulation of Agrp 1 0.40 0.45 0
128 INT305269 Lep Positive_regulation of Phosphorylation of Stat3 1 0.40 1.03 0
129 INT174282 Negative_regulation of Lep Positive_regulation of Agrp 1 0.35 0.27 0
130 INT256574 Lep Regulation of Ins1 1 0.36 0.83 0
131 INT253367 Il6 Regulation of Gene_expression of Lep 1 0.31 1.66 0
132 INT307212 Ide Regulation of Lep 1 0.00 0.51 0
133 INT305270 Lep Negative_regulation of Localization of Car2 1 0.16 1.28 0
134 INT138525 Lep Positive_regulation of Localization of LH 1 0.18 0 0
135 INT289527 Lep Regulation of Rps6kb1 1 0.10 0.07 0
136 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of hepatic stellate cell activation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of hepatic stellate cell activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
2 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
3 INT73641 Regulation of Lep 45 0.62 26.2 12.59
4 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
5 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
6 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
7 INT82082 Localization of Lep 63 0.81 26.41 8.56
8 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
9 INT91338 Binding of Lep 31 0.48 26.86 5.39
10 INT102935 Regulation of Lep 31 0.60 18.47 5.24
11 INT97391 Binding of Lep 18 0.48 8.97 4.47
12 INT163581 Localization of Lep 27 0.79 18.99 4.08
13 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
14 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
15 INT102565 Positive_regulation of Phosphorylation of RPS6KA1 1 0.25 2.77 2.85
16 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
17 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
18 INT83392 Transcription of Lep 6 0.54 5.07 2.04
19 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
20 INT28003 Positive_regulation of Rps6ka1 4 0.16 2.25 1.46
21 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
22 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
23 INT213465 Transcription of Lep 4 0.68 2.11 1.15
24 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
25 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
26 INT102564 Phosphorylation of RPS6KA1 1 0.41 0.92 0.94
27 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
28 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
29 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
30 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
31 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
32 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
33 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
34 INT304786 Gene_expression of Rps6ka1 1 0.07 0.69 0.52
35 INT304788 Positive_regulation of Gene_expression of Rps6ka1 1 0.05 0.7 0.52
36 INT102566 Negative_regulation of Phosphorylation of RPS6KA1 1 0.22 0.47 0.47
37 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
38 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
39 INT28004 Negative_regulation of Rps6ka1 1 0.03 0.36 0.33
40 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
41 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
42 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
43 INT168614 Phosphorylation of Rps6ka1 1 0.22 0.64 0.21
44 INT168613 Positive_regulation of Phosphorylation of Rps6ka1 1 0.16 0.64 0.21
45 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
46 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
47 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
48 INT163815 Negative_regulation of Negative_regulation of Lep 1 0.43 0.32 0.12
49 INT304514 Binding of Rps6ka1 1 0.18 0.17 0.12
50 INT121768 Regulation of Rps6ka1 1 0.09 0 0.12
51 INT121764 Regulation of Phosphorylation of Rps6ka1 1 0.15 0 0.12
52 INT121767 Phosphorylation of Rps6ka1 2 0.31 0.75 0.11
53 INT226984 Regulation of Transcription of Lep 1 0.27 0.3 0.11
54 INT188250 Positive_regulation of RPS6KA1 1 0.45 0.42 0.09
55 INT213475 Negative_regulation of Positive_regulation of Lep 2 0.40 1.79 0.07
56 INT213466 Negative_regulation of Regulation of Lep 1 0.41 0 0.06
57 INT121766 Localization of Rps6ka1 1 0.24 0 0.03
58 INT121763 Gene_expression of Rps6ka1 4 0.30 2.39 0
59 INT121765 Positive_regulation of Rps6ka1 3 0.18 1.29 0
60 INT253406 Negative_regulation of Positive_regulation of Lep 2 0.41 0.74 0
61 INT121762 Positive_regulation of Gene_expression of Rps6ka1 2 0.27 1.51 0
62 INT150408 Regulation of Regulation of Lep 1 0.27 0 0
63 INT305226 Negative_regulation of Phosphorylation of Lep 1 0.42 1.89 0
64 INT188254 Gene_expression of RPS6KA1 1 0.70 1.35 0
65 INT305239 Positive_regulation of Phosphorylation of Lep 1 0.43 1.09 0
66 INT304182 Positive_regulation of Positive_regulation of Rps6ka1 1 0.12 0.59 0
67 INT332954 Regulation of Transcription of Lep 1 0.11 1.4 0
68 INT174279 Positive_regulation of Negative_regulation of Lep 1 0.46 0.16 0
69 INT309421 Positive_regulation of Regulation of Lep 1 0.41 0.61 0
70 INT188253 Localization of RPS6KA1 1 0.67 0.87 0
71 INT288213 Positive_regulation of Negative_regulation of Lep 1 0.47 0.06 0
72 INT175523 Negative_regulation of Gene_expression of Rps6ka1 1 0.16 1.51 0
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