GO:2000773

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Name negative regulation of cellular senescence
Categary Process
Go Slim No
Go Link GO:2000773
Unique Molecular Interactions 73
Total Molecular Interactions 92
Total Single Events 501
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cellular senescence. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cellular senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
3 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
4 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
5 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
6 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
7 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
8 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
9 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
10 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
11 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
12 INT185278 Binding of CCND1 and CDK6 3 0.13 1.62 0.08
13 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
14 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
15 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
16 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
17 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
18 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
19 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
20 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
21 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
22 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
23 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
24 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
25 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
26 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
27 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
28 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
29 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
30 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
31 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
32 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
33 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
34 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
35 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
36 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
37 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
38 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
39 INT215706 Binding of Cdk6 and Lamtor1 1 0.04 0 0
40 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
41 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
42 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
43 INT215700 Binding of Cdkn2b and Cdk6 1 0.02 0 0
44 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
45 INT215690 Binding of Cdk6 and Cdkn1c 1 0.03 0 0
46 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
47 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
48 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
49 INT185280 Binding of CDK4 and CDK6 1 0.20 0.87 0
50 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
51 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
52 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
53 INT215682 Binding of Cdkn1b and Cdk6 1 0.03 0 0
54 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
55 INT215701 Slc3a1 Regulation of Cdk6 1 0.01 0.05 0
56 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
57 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
58 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
59 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
60 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
61 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
62 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
63 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
64 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
65 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
66 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
67 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
68 INT215703 Binding of Kras and Cdk6 1 0.01 0 0
69 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
70 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
71 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cellular senescence. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cellular senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
2 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
3 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
4 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
5 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
6 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
7 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
8 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
9 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
10 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
11 INT250699 Binding of CDK6 3 0.33 2.54 0.97
12 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
13 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
14 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
15 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
16 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
17 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
18 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
19 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
20 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
21 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
22 INT226422 Negative_regulation of Cdk6 3 0.12 1.83 0.19
23 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
24 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
25 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14
26 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
27 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
28 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
29 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
30 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
31 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
32 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
33 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
34 INT271084 Negative_regulation of Gene_expression of Cdk6 1 0.11 1.1 0.06
35 INT271086 Gene_expression of Cdk6 1 0.14 1.09 0.06
36 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
37 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
38 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
39 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
40 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
41 INT273406 Positive_regulation of Gene_expression of TWIST1 4 0.57 8.42 0.04
42 INT141476 Regulation of Gene_expression of TWIST1 2 0.50 2.57 0.04
43 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
44 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
45 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
46 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
47 INT204349 Regulation of SIRT1 8 0.61 1.99 0
48 INT256134 Localization of Sirt1 5 0.50 2.99 0
49 INT149440 Negative_regulation of TWIST1 4 0.41 1.5 0
50 INT204353 Transcription of SIRT1 3 0.68 0.67 0
51 INT204060 Gene_expression of Cdk6 3 0.26 0.83 0
52 INT325167 Gene_expression of CDK6 2 0.43 0 0
53 INT304047 Positive_regulation of Transcription of TWIST1 1 0.10 0.57 0
54 INT338245 Positive_regulation of Positive_regulation of TWIST1 1 0.38 2.95 0
55 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
56 INT289569 Transcription of Sirt1 1 0.71 0.25 0
57 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
58 INT300287 Localization of Sirt1 1 0.66 1.46 0
59 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
60 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
61 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
62 INT333821 Regulation of Cdk6 1 0.23 0 0
63 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
64 INT204061 Negative_regulation of Gene_expression of Cdk6 1 0.12 0.47 0
65 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
66 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
67 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
68 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
69 INT273393 Phosphorylation of TWIST1 1 0.16 0.4 0
70 INT302260 Negative_regulation of CDK6 1 0.19 0.29 0
71 INT215749 Regulation of Gene_expression of Cdk6 1 0.17 0 0
72 INT325171 Regulation of Gene_expression of CDK6 1 0.25 0 0
73 INT204331 Binding of SIRT1 1 0.47 0.39 0
74 INT236709 Phosphorylation of Cdk6 1 0.34 0.82 0
75 INT304055 Transcription of TWIST1 1 0.14 0.57 0
76 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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