GO:2001237

From wiki-pain
Jump to: navigation, search
Name negative regulation of extrinsic apoptotic signaling pathway
Categary Process
Go Slim No
Go Link GO:2001237
Unique Molecular Interactions 117
Total Molecular Interactions 136
Total Single Events 720
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of extrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of extrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
2 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
3 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
4 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
5 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
6 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
7 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
8 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
9 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
10 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
11 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
12 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
13 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
14 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
15 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
16 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
17 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
18 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
19 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
20 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
21 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
22 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
23 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
24 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
25 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
26 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
27 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
28 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
29 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
30 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
31 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
32 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
33 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
34 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
35 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
36 INT291394 Gene_expression of HTT Negative_regulation of Gene_expression of Slc1a2 1 0.11 0.96 0.34
37 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
38 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
39 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
40 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
41 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
42 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
43 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
44 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
45 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
46 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
47 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
48 INT208264 Park7 Negative_regulation of Pten 1 0.16 1.16 0.15
49 INT317162 Binding of Bdnf and Htt 1 0.51 0.2 0.12
50 INT254227 Binding of Ripk1 and Ticam1 3 0.07 0.18 0.11
51 INT204996 Binding of Park7 and Pink1 2 0.34 1.09 0.11
52 INT171390 Src Positive_regulation of Phosphorylation of Egfr 1 0.13 0 0.11
53 INT171389 Src Positive_regulation of Positive_regulation of Mapk1 1 0.16 0 0.11
54 INT171388 Src Positive_regulation of Phosphorylation of Gpbar1 1 0.05 0 0.11
55 INT276064 Src Regulation of Positive_regulation of Rpa1 1 0.02 0.18 0.11
56 INT171387 Ppp1cc Positive_regulation of Phosphorylation of Src 1 0.07 0 0.11
57 INT292087 SRC Regulation of IL8 1 0.02 1.43 0.11
58 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
59 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
60 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
61 INT251566 Binding of Ripk1 and Gtf3a 1 0.00 0.67 0.08
62 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07
63 INT235006 IgG Positive_regulation of SRC 1 0.01 0.82 0.05
64 INT235010 Positive_regulation of Positive_regulation of SRC 1 0.01 0.84 0.05
65 INT317181 Binding of Htt and Uts2r 1 0.04 0 0.05
66 INT269249 Ptk2 Positive_regulation of Phosphorylation of Src 1 0.13 0.93 0.04
67 INT178435 Mapk1 Regulation of Phosphorylation of Src 1 0.03 0.49 0.04
68 INT269250 Ptk2 Positive_regulation of Src 1 0.13 0.86 0.04
69 INT231839 Pcdh8 Positive_regulation of Src 1 0.00 0 0.04
70 INT263377 Abl1 Regulation of Src 1 0.15 0 0.04
71 INT178439 Binding of Ar and Src 1 0.01 0.44 0.04
72 INT263381 Trib3 Regulation of Src 1 0.01 0 0.04
73 INT238113 SRC Regulation of Phosphorylation of STAT3 1 0.46 0 0.04
74 INT317161 Htt Regulation of Transcription of Bdnf 1 0.48 0.41 0.03
75 INT229006 MIA3 Positive_regulation of Phosphorylation of Src 1 0.02 0.44 0.03
76 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
77 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03
78 INT200820 Epo Positive_regulation of Src 1 0.25 1.41 0.03
79 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
80 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
81 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0
82 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0
83 INT285579 Binding of S100A8 and SRC 1 0.05 0.2 0
84 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0
85 INT243106 Binding of Crebbp and Src 1 0.05 0.52 0
86 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0
87 INT279289 TXK Regulation of SRC 1 0.04 0.68 0
88 INT317316 Park7 Positive_regulation of Protein_catabolism of Hmbs 1 0.11 0.68 0
89 INT299296 SRC Regulation of RPTOR 1 0.32 0 0
90 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
91 INT338189 SRC Positive_regulation of HGFAC 1 0.00 0.4 0
92 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0
93 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0
94 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0
95 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
96 INT299308 SRC Regulation of PI3 1 0.20 0 0
97 INT317324 Park7 Positive_regulation of Protein_catabolism of SNCAIP 1 0.38 0.69 0
98 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0
99 INT338195 Binding of SRC and FIBP 1 0.00 0.31 0
100 INT309906 Binding of EGF and SRC 1 0.11 0.64 0
101 INT261893 Binding of Htt and Hap1 1 0.13 0.49 0
102 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
103 INT308854 Bcl2a1a Positive_regulation of Gene_expression of HTT 1 0.14 0 0
104 INT340928 Negative_regulation of SRC Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
105 INT299294 SRC Regulation of VEGFA 1 0.20 0 0
106 INT238120 SRC Positive_regulation of Positive_regulation of STAT3 1 0.71 0 0
107 INT317163 Htt Regulation of Bdnf 1 0.29 0.19 0
108 INT238114 Binding of CSK and SRC 1 0.07 0 0
109 INT351158 CAV1 Regulation of SRC 1 0.01 0.68 0
110 INT317308 Binding of Park7 and Mul1 1 0.01 0.62 0
111 INT338196 Binding of SRC and CDCP1 1 0.00 0.31 0
112 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0
113 INT198019 NPY6R Negative_regulation of Gene_expression of SRC 1 0.06 1.75 0
114 INT292564 Binding of TNFRSF1A and RIPK1 1 0.06 0.09 0
115 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0
116 INT114711 SRC Positive_regulation of Gene_expression of INSRR 1 0.01 0.51 0
117 INT349296 Binding of CSF2 and PARK7 1 0.24 1.24 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of extrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of extrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
2 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
3 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
4 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
5 INT100222 Binding of Src 9 0.26 5.41 5.37
6 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
7 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
8 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
9 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69
10 INT122327 Regulation of Src 6 0.59 0.59 3.6
11 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
12 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
13 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
14 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
15 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
16 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
17 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
18 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
19 INT98455 Regulation of Src 4 0.20 1.76 1.48
20 INT114715 Binding of SRC 8 0.36 4.26 1.32
21 INT164706 Positive_regulation of Park7 2 0.50 2.28 1.28
22 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
23 INT249522 Positive_regulation of Binding of Src 1 0.22 0.68 1.12
24 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1
25 INT108997 Localization of Htt 28 0.77 3.76 1.07
26 INT317504 Protein_catabolism of Src 1 0.49 0.13 0.97
27 INT100221 Negative_regulation of Phosphorylation of Src 2 0.24 0.74 0.93
28 INT68692 Regulation of HTT 8 0.60 4.06 0.89
29 INT154886 Gene_expression of Htt 18 0.76 15.51 0.82
30 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8
31 INT121334 Binding of HTT 11 0.47 6.66 0.78
32 INT143912 Localization of Src 4 0.48 2.51 0.78
33 INT249506 Regulation of Phosphorylation of Src 1 0.13 0.48 0.77
34 INT33317 Negative_regulation of RIPK1 1 0.31 0.05 0.67
35 INT121336 Positive_regulation of HTT 10 0.45 10.88 0.59
36 INT235996 Negative_regulation of Gene_expression of Src 3 0.09 1.29 0.58
37 INT143910 Negative_regulation of Positive_regulation of Src 1 0.27 0.14 0.56
38 INT117998 Positive_regulation of Gene_expression of Src 4 0.36 1.45 0.51
39 INT119230 Negative_regulation of Htt 5 0.42 2.99 0.5
40 INT82608 Positive_regulation of Phosphorylation of SRC 3 0.49 1.28 0.48
41 INT161266 Positive_regulation of Ripk1 1 0.49 0.09 0.47
42 INT323314 Transcription of HTT 1 0.04 2.11 0.47
43 INT249504 Localization of Src 1 0.36 0.32 0.46
44 INT165597 Positive_regulation of Htt 8 0.60 4.27 0.44
45 INT98456 Negative_regulation of Src 17 0.42 8.3 0.42
46 INT132864 Binding of Htt 15 0.46 2.34 0.38
47 INT138051 Negative_regulation of Positive_regulation of SRC 3 0.57 0.84 0.33
48 INT249533 Regulation of Localization of Src 1 0.22 0.22 0.32
49 INT291388 Negative_regulation of Gene_expression of HTT 1 0.41 0.95 0.32
50 INT330091 Binding of Sh3rf1 1 0.15 1.2 0.31
51 INT68694 Positive_regulation of Gene_expression of HTT 7 0.49 4.29 0.29
52 INT349301 Negative_regulation of PARK7 1 0.41 3.44 0.26
53 INT171374 Binding of Src 2 0.13 0.44 0.24
54 INT302807 Gene_expression of Ripk1 1 0.04 0.93 0.23
55 INT164162 Negative_regulation of Phosphorylation of SRC 3 0.29 2.12 0.21
56 INT193603 Localization of HTT 13 0.16 2.74 0.19
57 INT235725 Regulation of SRC 7 0.44 4.71 0.19
58 INT240602 Gene_expression of RIPK1 2 0.58 0.69 0.16
59 INT249526 Positive_regulation of Localization of Src 1 0.24 0.1 0.16
60 INT281868 Negative_regulation of Park7 1 0.00 1.69 0.14
61 INT349300 Gene_expression of PARK7 1 0.75 8.65 0.12
62 INT204986 Gene_expression of Park7 5 0.38 5.48 0.1
63 INT173981 Gene_expression of Park7 2 0.56 0.73 0.1
64 INT299357 Localization of SRC 1 0.51 0 0.09
65 INT338740 Transcription of Src 1 0.43 1.24 0.07
66 INT68693 Regulation of Gene_expression of HTT 3 0.45 0.72 0.06
67 INT243711 Binding of Park7 3 0.25 1.5 0.06
68 INT261890 Positive_regulation of Gene_expression of Htt 1 0.43 0.85 0.06
69 INT101612 Protein_catabolism of HTT 3 0.86 1.44 0.05
70 INT238187 Regulation of Positive_regulation of SRC 2 0.26 1.37 0.05
71 INT204990 Positive_regulation of Gene_expression of Park7 2 0.24 1.79 0.05
72 INT317175 Positive_regulation of Localization of Htt 1 0.48 0 0.05
73 INT251555 Binding of Ripk1 1 0.17 1.16 0.04
74 INT261891 Negative_regulation of Gene_expression of Htt 1 0.37 1.12 0.04
75 INT204973 Positive_regulation of Park7 2 0.23 1.62 0.03
76 INT238193 Regulation of Gene_expression of SRC 1 0.44 0 0.03
77 INT193602 Negative_regulation of HTT 7 0.41 1.8 0
78 INT225256 Positive_regulation of Gene_expression of Src 3 0.20 0.75 0
79 INT154887 Transcription of Htt 3 0.66 0 0
80 INT204970 Localization of Park7 3 0.54 2.76 0
81 INT193599 Positive_regulation of Localization of HTT 2 0.10 0.46 0
82 INT261886 Regulation of Htt 2 0.43 2.06 0
83 INT349303 Positive_regulation of Positive_regulation of PARK7 1 0.49 1 0
84 INT338741 Negative_regulation of Binding of Src 1 0.30 0.75 0
85 INT225249 Negative_regulation of Phosphorylation of Src 1 0.16 1.51 0
86 INT193601 Regulation of Binding of HTT 1 0.05 1.28 0
87 INT292589 Positive_regulation of Localization of RIPK1 1 0.15 0 0
88 INT317177 Negative_regulation of Transcription of Htt 1 0.41 0 0
89 INT292578 Positive_regulation of RIPK1 1 0.07 0 0
90 INT349298 Phosphorylation of PARK7 1 0.79 0.9 0
91 INT349304 Positive_regulation of PARK7 1 0.67 9.44 0
92 INT299546 Negative_regulation of Gene_expression of RIPK1 1 0.02 0.06 0
93 INT200801 Positive_regulation of Localization of Src 1 0.28 1.92 0
94 INT252760 Binding of RIPK1 1 0.19 0.77 0
95 INT292592 Regulation of Localization of RIPK1 1 0.13 0 0
96 INT208272 Regulation of Gene_expression of Park7 1 0.19 0.27 0
97 INT349302 Localization of PARK7 1 0.78 3.09 0
98 INT349299 Binding of PARK7 1 0.41 1.86 0
99 INT238185 Regulation of Binding of SRC 1 0.44 0.06 0
100 INT292593 Localization of RIPK1 1 0.22 0 0
101 INT317170 Regulation of Binding of Htt 1 0.43 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox