GO:2001238

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Name positive regulation of extrinsic apoptotic signaling pathway
Categary Process
Go Slim No
Go Link GO:2001238
Unique Molecular Interactions 197
Total Molecular Interactions 292
Total Single Events 1396
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of extrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of extrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
2 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
3 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
4 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
5 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
6 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
7 INT146462 TNFSF10 Positive_regulation of Gene_expression of TNFRSF10D 1 0.27 1.45 0.71
8 INT119107 Negative_regulation of Binding of LTBR and TNF 1 0.17 1.16 0.68
9 INT139189 Binding of Daxx and Fadd 1 0.03 0.27 0.57
10 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
11 INT306935 Tnfsf12 Positive_regulation of Gene_expression of Cxcl10 1 0.03 3.55 0.55
12 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53
13 INT162991 Binding of Fadd and Ppm1e 1 0.03 0.09 0.52
14 INT330451 Ltbr Regulation of Trpv1 1 0.01 0.05 0.5
15 INT171278 TNFSF12 Positive_regulation of CCL5 1 0.02 0.93 0.48
16 INT330522 Binding of CD8A and TNFSF10 1 0.17 1.24 0.48
17 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
18 INT162993 Binding of Trib3 and Fadd 1 0.05 0.1 0.46
19 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
20 INT306936 Binding of Tnfsf12 and Tnfrsf12a 1 0.05 4.84 0.45
21 INT354395 TNFSF12 Regulation of Gene_expression of IL18 1 0.47 0.79 0.45
22 INT126019 Binding of Ltbr and Tnf 1 0.18 1.61 0.43
23 INT315333 Binding of Cflar and Fadd 1 0.01 0.49 0.42
24 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4
25 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4
26 INT211115 Positive_regulation of Binding of LTBR and TNF 1 0.01 0.31 0.39
27 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38
28 INT171296 TNFSF12 Positive_regulation of IL8 1 0.01 0.87 0.37
29 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36
30 INT174657 IL8 Positive_regulation of Gene_expression of LTBR 1 0.01 1.53 0.3
31 INT174659 TNF Positive_regulation of Gene_expression of LTBR 1 0.22 1.54 0.3
32 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
33 INT171257 TNFSF12 Positive_regulation of CCL2 1 0.01 0.3 0.29
34 INT228500 Fadd Positive_regulation of FAS 1 0.14 1.12 0.28
35 INT349537 Smcp Positive_regulation of Tnfsf10 1 0.38 3.48 0.28
36 INT187170 Binding of Ltbr and Tnfrsf1b 1 0.06 0.88 0.28
37 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
38 INT306941 Tnfsf12 Positive_regulation of Gene_expression of CCL2 1 0.03 1.65 0.27
39 INT306937 Tnfsf12 Positive_regulation of Gene_expression of Vcam1 1 0.05 1.79 0.27
40 INT306942 Tnfsf12 Positive_regulation of Gene_expression of ICAM1 1 0.04 1.78 0.27
41 INT254224 Binding of Ltbr and Tnfrsf11a 1 0.01 0.59 0.25
42 INT354394 TNFSF12 Regulation of Localization of UNK 1 0.21 0 0.25
43 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
44 INT171271 TNFSF12 Positive_regulation of Transcription of IL8 1 0.01 0.44 0.25
45 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24
46 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
47 INT220528 Ugt1a6b Positive_regulation of Cav1 1 0.01 1.31 0.22
48 INT285639 Col3a1 Regulation of Tnfrsf12a 1 0.19 0.16 0.22
49 INT285640 Eln Regulation of Tnfrsf12a 1 0.14 0.16 0.22
50 INT302822 Tnfsf10 Positive_regulation of Protein_catabolism of Psmd9 1 0.03 0.78 0.21
51 INT171287 TNFSF12 Positive_regulation of CXCL10 1 0.01 0.8 0.21
52 INT171303 Binding of TNFSF12 and Positive_regulation of Localization of IL6 1 0.01 0.82 0.21
53 INT330520 Positive_regulation of Binding of CD8A and TNFSF10 1 0.19 0.62 0.21
54 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
55 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
56 INT220520 Ugt1a6b Positive_regulation of Gene_expression of Cav1 1 0.01 0.81 0.17
57 INT354400 IL18 Regulation of Gene_expression of TNFSF12 1 0.35 0.55 0.17
58 INT171870 Binding of Ltbr and Sumo1 1 0.00 1.44 0.16
59 INT349540 Tnfsf10 Positive_regulation of Positive_regulation of Casp8 1 0.05 0.65 0.15
60 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
61 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14
62 INT79229 Binding of Icam1 and Ltbr 1 0.09 0.37 0.14
63 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
64 INT354398 Binding of TNF and TNFSF12 1 0.16 0.64 0.13
65 INT354403 IL18 Regulation of TNFSF12 1 0.35 0.11 0.13
66 INT171298 TNFSF12 Positive_regulation of Gene_expression of CXCL10 1 0.01 0.06 0.12
67 INT321410 EGR1 Negative_regulation of Gene_expression of TNFSF10 1 0.10 2.07 0.12
68 INT171269 TNFSF12 Positive_regulation of Gene_expression of IL8 1 0.01 0.09 0.12
69 INT171262 TNFSF12 Positive_regulation of Gene_expression of TNF 1 0.03 0.06 0.12
70 INT182481 Binding of Cav1 and Ighg2b 1 0.10 0 0.12
71 INT182482 Binding of Cav1 and Cxcl16 1 0.07 0 0.12
72 INT171277 Binding of TNFSF12 and Positive_regulation of Transcription of IL8 1 0.01 0.21 0.12
73 INT254227 Binding of Ripk1 and Ticam1 3 0.07 0.18 0.11
74 INT60746 Ltbr Negative_regulation of TNF 1 0.16 1.23 0.11
75 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11
76 INT220517 Negative_regulation of Ugt1a6b Positive_regulation of Cav1 1 0.01 0.35 0.1
77 INT354401 TNFSF12 Regulation of IL18 1 0.47 0 0.1
78 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
79 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
80 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
81 INT123461 Binding of TNFSF10 and Tnfrsf11b 1 0.00 1.34 0.08
82 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
83 INT331576 IFN1@ Positive_regulation of TNFSF10 1 0.00 0.27 0.08
84 INT331575 Negative_regulation of IFN1@ Positive_regulation of TNFSF10 1 0.00 0.27 0.08
85 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
86 INT171272 TNFSF12 Positive_regulation of PTGER2 1 0.00 0.57 0.08
87 INT354402 IL18 Positive_regulation of Gene_expression of TNFSF12 1 0.39 0.55 0.08
88 INT171263 TNFSF12 Positive_regulation of MMP1 1 0.01 0.57 0.08
89 INT251566 Binding of Ripk1 and Gtf3a 1 0.00 0.67 0.08
90 INT171267 TNFSF12 Negative_regulation of IL8 1 0.00 0.06 0.07
91 INT322560 Binding of TNFSF10 and DICER1 1 0.07 1.76 0.07
92 INT171299 TNFSF12 Negative_regulation of MMP1 1 0.01 0.06 0.07
93 INT171286 TNFSF12 Positive_regulation of Gene_expression of PTGER2 1 0.00 0 0.06
94 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
95 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
96 INT354397 Positive_regulation of IL18 Regulation of Gene_expression of TNFSF12 1 0.18 0 0.05
97 INT354392 TNFSF12 Regulation of NCR1 1 0.10 0.09 0.05
98 INT183853 Gene_expression of CAV1 Negative_regulation of Positive_regulation of MAPK1 1 0.28 0.25 0.05
99 INT164128 TNFSF10 Positive_regulation of MAPK14 1 0.28 2.09 0.05
100 INT171285 TNFSF12 Negative_regulation of Gene_expression of MMP1 1 0.01 0 0.04
101 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04
102 INT171255 TNFSF12 Positive_regulation of IL6 1 0.00 0.38 0.04
103 INT302975 Fadd Positive_regulation of Bid 1 0.13 1.14 0.04
104 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04
105 INT171294 TNFSF12 Positive_regulation of Gene_expression of IL6 1 0.01 0.39 0.04
106 INT190095 Negative_regulation of Binding of Hivep3 and Traf2 1 0.15 0.08 0.04
107 INT171273 TNFSF12 Negative_regulation of Gene_expression of IL8 1 0.01 0 0.04
108 INT171259 TNF Positive_regulation of Gene_expression of TNFSF12 1 0.03 0.37 0.04
109 INT171270 TNFSF12 Negative_regulation of Gene_expression of PTGER2 1 0.00 0 0.04
110 INT190096 Binding of Hivep3 and Traf2 1 0.17 0.08 0.04
111 INT354390 TNFSF12 Regulation of Gene_expression of NCR1 1 0.13 0 0.04
112 INT171291 IL1B Positive_regulation of Gene_expression of TNFSF12 1 0.01 0.37 0.04
113 INT171283 TNFSF12 Positive_regulation of Localization of IL8 1 0.01 0.19 0.04
114 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04
115 INT251565 Binding of Casp8 and Fadd 1 0.04 1.18 0.04
116 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03
117 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03
118 INT171260 TNFSF12 Positive_regulation of Gene_expression of MMP1 1 0.01 0 0.03
119 INT220512 Cav1 Regulation of Positive_regulation of Cdkn1b 1 0.06 0.85 0.03
120 INT183896 Gene_expression of CAV1 Negative_regulation of Positive_regulation of Racgap1 1 0.01 0.64 0.03
121 INT292553 Binding of TRAF2 and TRADD 1 0.09 0.1 0
122 INT260807 Binding of Chkb and Tnfsf10 1 0.14 0.85 0
123 INT234622 IGFBP3 Positive_regulation of TNFSF10 1 0.56 1.08 0
124 INT261123 Tnfsf10 Positive_regulation of Casp8 1 0.04 1 0
125 INT351167 CAV1 Negative_regulation of Ppp2r1a 1 0.08 1.5 0
126 INT322559 TNFSF10 Positive_regulation of CASP9 1 0.03 1.79 0
127 INT292560 Binding of TNFRSF1A and TRAF2 1 0.08 0.09 0
128 INT322558 Binding of AKT1 and TNFSF10 1 0.05 1.59 0
129 INT323703 FADD Positive_regulation of FAS 1 0.26 0.75 0
130 INT288584 Cav1 Regulation of Gene_expression of Kcnma1 1 0.14 0 0
131 INT288594 Regulation of Binding of CAV1 and Kcnma1 1 0.01 0 0
132 INT288588 Binding of Cav1 and Neu3 1 0.01 0 0
133 INT183895 CAV1 Regulation of Positive_regulation of Racgap1 1 0.01 0.37 0
134 INT322561 Negative_regulation of TNFSF10 Positive_regulation of CASP9 1 0.03 1.15 0
135 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
136 INT351166 Gtf3a Positive_regulation of Gene_expression of CAV1 1 0.01 0.79 0
137 INT322555 TNFSF10 Positive_regulation of MCL1 1 0.16 1.26 0
138 INT351156 VEGFA Positive_regulation of Gene_expression of CAV1 1 0.07 0.79 0
139 INT349530 Tnfsf10 Negative_regulation of Smcp 1 0.28 0.88 0
140 INT349542 SCFV Positive_regulation of Tnfsf10 1 0.12 0.56 0
141 INT280961 Binding of Cav1 and Cpox 1 0.04 0 0
142 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
143 INT307225 CYLD Regulation of TNFRSF11A 1 0.14 0.81 0
144 INT288587 Cav1 Regulation of Binding of Kcnma1 1 0.14 0 0
145 INT288597 Binding of CAV1 and Kcnma1 1 0.01 0.17 0
146 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0
147 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0
148 INT235774 Binding of Tradd and Tnfrsf12a 1 0.10 1.21 0
149 INT261124 Binding of HLA-DRB4 and Tnfsf10 1 0.02 0.68 0
150 INT288596 Positive_regulation of Binding of CAV1 and Kcnma1 1 0.01 0.1 0
151 INT288590 Binding of Cav1 and Abhd14a 1 0.00 0 0
152 INT349535 Binding of Smcp and Tnfsf10 1 0.36 6.79 0
153 INT183857 CAV1 Positive_regulation of RHOC 1 0.46 0.21 0
154 INT171282 TNFSF12 Positive_regulation of Gene_expression of CCL5 1 0.01 0 0
155 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
156 INT183861 Binding of CAV1 and CDC42EP5 1 0.03 3.21 0
157 INT288593 Cav1 Positive_regulation of Binding of Kcnma1 1 0.15 0 0
158 INT183864 Gene_expression of CAV1 Negative_regulation of Positive_regulation of RHOC 1 0.39 0.95 0
159 INT351165 Binding of CAV1 and Nos3 1 0.09 1.46 0
160 INT322557 TNFSF10 Positive_regulation of BIRC3 1 0.12 1.27 0
161 INT351157 TSC1 Positive_regulation of Gene_expression of CAV1 1 0.01 1.43 0
162 INT349543 Tnfsf10 Positive_regulation of NGFR 1 0.01 0.43 0
163 INT183860 Binding of RHOC and CAV1 1 0.34 0.4 0
164 INT183856 Negative_regulation of RHOC Positive_regulation of Gene_expression of CAV1 1 0.42 0.09 0
165 INT183868 CAV1 Positive_regulation of PAF1 1 0.54 0.41 0
166 INT288591 Cav1 Positive_regulation of Kcnma1 1 0.15 0 0
167 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
168 INT292559 Binding of TNFRSF1A and FADD 1 0.05 0.09 0
169 INT267256 Binding of FAS and Fadd 1 0.11 1.14 0
170 INT202509 Positive_regulation of Binding of Ltbr and Traf3 1 0.07 0.51 0
171 INT298103 Binding of Cav1 and Ca2 1 0.03 0 0
172 INT351164 CAV1 Negative_regulation of Ppp1cc 1 0.11 1.5 0
173 INT220518 Cav1 Negative_regulation of Akt1 1 0.04 1.02 0
174 INT164129 TNFSF10 Positive_regulation of MAPK9 1 0.37 2.04 0
175 INT164130 TNFSF10 Positive_regulation of CDK20 1 0.50 1.06 0
176 INT351158 CAV1 Regulation of SRC 1 0.01 0.68 0
177 INT261122 Binding of Tnfrsf10b and Tnfsf10 1 0.08 0.74 0
178 INT349532 Positive_regulation of Binding of Smcp and Tnfsf10 1 0.35 2.16 0
179 INT222870 Traf2 Positive_regulation of Chuk 1 0.03 0.37 0
180 INT288592 Binding of Cav1 and Olfr1012 1 0.01 0 0
181 INT183866 CAV1 Regulation of RHOC 1 0.25 0.2 0
182 INT183867 Binding of CAV1 and Positive_regulation of Positive_regulation of RHOC 1 0.46 0.1 0
183 INT298104 Ca2 Negative_regulation of Cav1 1 0.04 0.09 0
184 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0
185 INT288586 Cav1 Positive_regulation of Regulation of Kcnma1 1 0.21 0 0
186 INT183852 CAV1 Regulation of Positive_regulation of RHOC 1 0.41 0.63 0
187 INT292564 Binding of TNFRSF1A and RIPK1 1 0.06 0.09 0
188 INT288558 Binding of CAV1 and KCNMA1 1 0.00 0 0
189 INT288583 Negative_regulation of Binding of Cav1 and Kcnma1 1 0.13 0 0
190 INT220526 Binding of Akt1 and Cav1 1 0.03 1.02 0
191 INT288589 Cav1 Regulation of Kcnma1 1 0.19 0.05 0
192 INT202504 Binding of Ltbr and Traf3 1 0.05 0.51 0
193 INT351159 CAV1 Positive_regulation of AKT1 1 0.11 0.87 0
194 INT183854 Regulation of CAV1 Positive_regulation of RHOC 1 0.41 0.26 0
195 INT329480 Binding of TNFRSF11B and TNFSF10 1 0.03 0.71 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of extrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of extrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48
2 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
3 INT178174 Gene_expression of Tnfsf10 78 0.76 56.83 8.64
4 INT150528 Positive_regulation of Gene_expression of TNFSF10 26 0.67 30.71 5.43
5 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56
6 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
7 INT133602 Positive_regulation of Fadd 2 0.54 0.38 4.02
8 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
9 INT133604 Negative_regulation of Fadd 4 0.57 0.81 3.5
10 INT60745 Gene_expression of Ltbr 10 0.61 7.86 3.21
11 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
12 INT171346 Gene_expression of TNFSF12 7 0.58 4.19 2.62
13 INT158827 Positive_regulation of FADD 7 0.43 2.6 2.54
14 INT2731 Negative_regulation of LTBR 7 0.58 5.35 2.44
15 INT27230 Gene_expression of LTBR 10 0.75 8.57 2.34
16 INT79228 Binding of Ltbr 8 0.10 7.2 2.33
17 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
18 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14
19 INT104931 Binding of TNFSF10 15 0.36 17.44 2.07
20 INT133607 Regulation of Fadd 1 0.60 0.41 2.04
21 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
22 INT133605 Positive_regulation of Negative_regulation of Fadd 1 0.46 0.28 1.96
23 INT139174 Positive_regulation of Fadd 1 0.59 0.83 1.94
24 INT139185 Phosphorylation of Fadd 1 0.69 0.59 1.92
25 INT125869 Regulation of Gene_expression of TNFSF10 5 0.38 8.77 1.9
26 INT133609 Negative_regulation of Positive_regulation of Fadd 2 0.46 0.24 1.9
27 INT226894 Negative_regulation of Tnfsf10 14 0.57 16.64 1.87
28 INT125865 Regulation of TNFSF10 12 0.44 15.75 1.81
29 INT130771 Transcription of TNFSF10 3 0.51 3.4 1.74
30 INT2729 Binding of LTBR 4 0.37 4.23 1.71
31 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
32 INT139177 Regulation of Fadd 1 0.60 0.78 1.69
33 INT224643 Positive_regulation of Gene_expression of Tnfsf10 13 0.46 11.1 1.67
34 INT306930 Gene_expression of Tnfsf12 1 0.31 21.25 1.65
35 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
36 INT134148 Gene_expression of FADD 4 0.66 3.35 1.54
37 INT171329 Binding of TNFSF12 1 0.04 3.87 1.51
38 INT140108 Negative_regulation of Ltbr 1 0.45 2.07 1.35
39 INT134147 Positive_regulation of Gene_expression of FADD 2 0.59 1.59 1.31
40 INT130926 Negative_regulation of TNFSF10 9 0.36 10.18 1.3
41 INT190067 Binding of Traf2 5 0.20 3.28 1.27
42 INT141862 Binding of Cav1 11 0.36 1.32 1.25
43 INT133610 Negative_regulation of Negative_regulation of Fadd 1 0.50 0.19 1.19
44 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
45 INT250322 Negative_regulation of Binding of Ltbr 2 0.06 0.89 1.11
46 INT260802 Transcription of Tnfsf10 5 0.67 6.75 1.1
47 INT2730 Positive_regulation of LTBR 4 0.48 2.37 1.06
48 INT153628 Phosphorylation of Fadd 2 0.74 0.45 1
49 INT136613 Negative_regulation of Cav1 2 0.57 2.28 0.96
50 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
51 INT139176 Gene_expression of Fadd 5 0.51 5.26 0.92
52 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
53 INT158825 Phosphorylation of FADD 1 0.81 1.63 0.89
54 INT141442 Negative_regulation of Phosphorylation of Cav1 1 0.59 0.94 0.87
55 INT130776 Positive_regulation of Transcription of TNFSF10 1 0.17 0.68 0.87
56 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
57 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78
58 INT354424 Transcription of TNFSF12 1 0.53 1.48 0.78
59 INT130057 Positive_regulation of CAV1 12 0.65 8.96 0.77
60 INT260803 Regulation of Tnfsf10 4 0.44 5.04 0.76
61 INT133612 Gene_expression of Fadd 1 0.76 0.27 0.76
62 INT139173 Positive_regulation of Phosphorylation of Fadd 1 0.42 0.28 0.76
63 INT133613 Regulation of Gene_expression of Fadd 1 0.44 0.27 0.76
64 INT228474 Regulation of Gene_expression of Tnfsf10 3 0.44 3.81 0.75
65 INT171326 Negative_regulation of TNFSF12 2 0.32 0.77 0.75
66 INT87827 Positive_regulation of Ltbr 1 0.44 0.99 0.74
67 INT112088 Regulation of Cav1 2 0.44 0.51 0.73
68 INT139182 Binding of Fadd 3 0.36 2.74 0.71
69 INT155089 Negative_regulation of FADD 2 0.42 1.31 0.71
70 INT162988 Positive_regulation of Positive_regulation of Fadd 1 0.36 0.07 0.7
71 INT153667 Localization of CAV1 15 0.76 11.92 0.68
72 INT33317 Negative_regulation of RIPK1 1 0.31 0.05 0.67
73 INT52900 Phosphorylation of LTBR 1 0.54 2.46 0.67
74 INT139179 Negative_regulation of Fadd 1 0.36 0.35 0.64
75 INT139175 Regulation of Binding of Fadd 1 0.44 0.34 0.63
76 INT178172 Localization of Tnfsf10 14 0.78 11.67 0.62
77 INT86700 Regulation of Cav1 7 0.54 0.92 0.61
78 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61
79 INT11907 Regulation of LTBR 2 0.41 1.7 0.61
80 INT131001 Regulation of CAV1 6 0.44 3.77 0.59
81 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
82 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
83 INT141863 Negative_regulation of Gene_expression of Cav1 4 0.49 1.77 0.58
84 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
85 INT260801 Negative_regulation of Gene_expression of Tnfsf10 7 0.42 6.49 0.54
86 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
87 INT260793 Binding of Tnfsf10 12 0.36 11.93 0.47
88 INT86702 Localization of Cav1 8 0.69 0.76 0.47
89 INT158823 Positive_regulation of Binding of FADD 1 0.43 0.23 0.47
90 INT161266 Positive_regulation of Ripk1 1 0.49 0.09 0.47
91 INT158826 Binding of FADD 1 0.41 0.23 0.47
92 INT153672 Negative_regulation of Negative_regulation of CAV1 1 0.25 0.2 0.46
93 INT132542 Transcription of LTBR 1 0.66 0.87 0.46
94 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43
95 INT171325 Positive_regulation of TNFSF12 4 0.35 0.88 0.43
96 INT166240 Regulation of Gene_expression of Cav1 3 0.51 1.03 0.43
97 INT151011 Positive_regulation of Gene_expression of Ltbr 1 0.45 1.59 0.43
98 INT126017 Negative_regulation of Gene_expression of Ltbr 1 0.18 1.8 0.42
99 INT306929 Regulation of Gene_expression of Tnfsf12 1 0.18 4.05 0.4
100 INT181179 Binding of CYLD 4 0.43 7.06 0.39
101 INT330523 Regulation of Binding of TNFSF10 1 0.36 1.21 0.39
102 INT220506 Binding of Cav1 13 0.45 5.46 0.38
103 INT260794 Positive_regulation of Transcription of Tnfsf10 2 0.43 2.56 0.38
104 INT135953 Negative_regulation of Positive_regulation of Cav1 2 0.37 1.09 0.37
105 INT285619 Gene_expression of Tnfrsf12a 1 0.47 0.87 0.36
106 INT162980 Binding of Fadd 1 0.33 0.1 0.36
107 INT163277 Negative_regulation of Gene_expression of CAV1 17 0.56 10.77 0.35
108 INT185432 Negative_regulation of CYLD 4 0.52 3.19 0.35
109 INT171337 Regulation of TNFSF12 2 0.20 0 0.35
110 INT306931 Binding of Tnfsf12 1 0.19 7.53 0.35
111 INT166108 Localization of TNFSF10 5 0.64 3.58 0.33
112 INT158821 Positive_regulation of Phosphorylation of FADD 1 0.49 0.58 0.33
113 INT141867 Positive_regulation of Transcription of Cav1 2 0.52 0.46 0.29
114 INT141868 Transcription of Cav1 2 0.54 1.48 0.29
115 INT354408 Positive_regulation of Transcription of TNFSF12 1 0.37 0 0.29
116 INT141861 Negative_regulation of Binding of Cav1 1 0.44 0.4 0.29
117 INT166107 Negative_regulation of Gene_expression of TNFSF10 5 0.39 6.04 0.26
118 INT171347 Regulation of Gene_expression of TNFSF12 2 0.34 0.45 0.26
119 INT158822 Regulation of Phosphorylation of FADD 1 0.39 0.55 0.25
120 INT224628 Negative_regulation of Tnfsf12 1 0.07 0.24 0.24
121 INT224631 Regulation of Tnfsf12 1 0.06 0.24 0.23
122 INT302807 Gene_expression of Ripk1 1 0.04 0.93 0.23
123 INT135956 Phosphorylation of Cav1 5 0.64 2.24 0.22
124 INT135954 Positive_regulation of Phosphorylation of Cav1 2 0.40 0.64 0.22
125 INT141860 Regulation of Localization of Cav1 1 0.20 0.2 0.22
126 INT185452 Regulation of CYLD 6 0.40 6.09 0.21
127 INT306932 Positive_regulation of Gene_expression of Tnfsf12 1 0.28 1.68 0.21
128 INT171328 Localization of TNFSF12 1 0.05 0.23 0.2
129 INT171339 Regulation of Positive_regulation of TNFSF12 2 0.29 0 0.19
130 INT302803 Positive_regulation of Negative_regulation of Tnfsf10 1 0.16 1.47 0.19
131 INT220497 Regulation of Gene_expression of Cav1 4 0.36 1.84 0.18
132 INT86697 Negative_regulation of Regulation of Cav1 1 0.41 0 0.18
133 INT131000 Positive_regulation of Positive_regulation of CAV1 1 0.49 0 0.17
134 INT226882 Regulation of Gene_expression of Ltbr 1 0.09 0.34 0.17
135 INT306934 Binding of Tnfrsf12a 1 0.11 1.58 0.17
136 INT252702 Binding of TRAF2 3 0.23 2.21 0.16
137 INT240602 Gene_expression of RIPK1 2 0.58 0.69 0.16
138 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
139 INT171331 Negative_regulation of Binding of TNFSF12 1 0.03 0.26 0.16
140 INT145253 Negative_regulation of Cav1 9 0.46 3.02 0.15
141 INT163278 Regulation of Gene_expression of CAV1 5 0.45 4.36 0.14
142 INT307231 Positive_regulation of Gene_expression of CYLD 1 0.45 2.37 0.14
143 INT214975 Localization of Cav1 7 0.75 2.7 0.13
144 INT185449 Regulation of Regulation of CYLD 1 0.21 2.03 0.13
145 INT260800 Protein_catabolism of Tnfsf10 1 0.64 0.54 0.13
146 INT251559 Binding of Traf2 1 0.23 1.68 0.13
147 INT306933 Positive_regulation of Tnfsf12 1 0.24 3.58 0.13
148 INT306928 Negative_regulation of Positive_regulation of Tnfsf12 1 0.15 2.26 0.13
149 INT177966 Negative_regulation of Gene_expression of LTBR 1 0.08 0.38 0.12
150 INT323740 Regulation of FADD 1 0.13 1.08 0.11
151 INT307240 Localization of CYLD 3 0.72 3.09 0.1
152 INT194601 Regulation of Localization of TNFSF10 1 0.38 0.25 0.1
153 INT251560 Positive_regulation of Traf2 1 0.13 0.47 0.09
154 INT185440 Negative_regulation of Negative_regulation of CYLD 1 0.20 1.02 0.08
155 INT237963 Positive_regulation of Localization of TNFSF10 1 0.10 0.95 0.08
156 INT220491 Transcription of Cav1 2 0.54 1.1 0.07
157 INT251553 Positive_regulation of Binding of Fadd 1 0.19 1.19 0.07
158 INT220500 Positive_regulation of Transcription of Cav1 1 0.16 0.9 0.07
159 INT354419 Positive_regulation of Gene_expression of TNFSF12 1 0.37 0.06 0.07
160 INT354420 Regulation of Transcription of TNFSF12 1 0.34 0 0.06
161 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05
162 INT220502 Positive_regulation of Positive_regulation of Cav1 1 0.24 0.21 0.05
163 INT315009 Regulation of Phosphorylation of Cav1 1 0.36 0.2 0.05
164 INT307229 Phosphorylation of CYLD 1 0.73 1.02 0.05
165 INT300713 Regulation of Localization of Cav1 2 0.42 1.37 0.04
166 INT302962 Positive_regulation of Gene_expression of Fadd 2 0.27 1.45 0.04
167 INT354415 Negative_regulation of Gene_expression of TNFSF12 1 0.32 0 0.04
168 INT322340 Transcription of Ltbr 1 0.06 1.04 0.04
169 INT251555 Binding of Ripk1 1 0.17 1.16 0.04
170 INT314252 Transcription of CAV1 1 0.50 0.07 0.04
171 INT322588 Regulation of Regulation of TNFSF10 1 0.13 0.79 0.04
172 INT182642 Localization of LTBR 2 0.03 0.64 0.03
173 INT183878 Negative_regulation of Positive_regulation of CAV1 1 0.41 0.16 0.03
174 INT237977 Positive_regulation of Positive_regulation of TNFSF10 1 0.10 2.47 0.03
175 INT183883 Binding of CAV1 8 0.46 3.89 0
176 INT283550 Negative_regulation of Binding of Cav1 2 0.33 0.11 0
177 INT109048 Positive_regulation of Negative_regulation of LTBR 1 0.50 0 0
178 INT298115 Regulation of Binding of Cav1 1 0.12 0 0
179 INT292588 Positive_regulation of Positive_regulation of FADD 1 0.11 0.2 0
180 INT349529 Phosphorylation of Tnfsf10 1 0.74 1.32 0
181 INT307235 Positive_regulation of Binding of CYLD 1 0.45 1.1 0
182 INT261119 Positive_regulation of Localization of Tnfsf10 1 0.36 1.25 0
183 INT350507 Positive_regulation of Binding of TNFSF10 1 0.05 0.59 0
184 INT183890 Regulation of Negative_regulation of CAV1 1 0.43 0.38 0
185 INT292589 Positive_regulation of Localization of RIPK1 1 0.15 0 0
186 INT288581 Negative_regulation of Binding of CAV1 1 0.03 0 0
187 INT292578 Positive_regulation of RIPK1 1 0.07 0 0
188 INT222849 Gene_expression of Traf2 1 0.12 0.38 0
189 INT315010 Negative_regulation of Transcription of Cav1 1 0.34 0.21 0
190 INT307244 Regulation of Gene_expression of CYLD 1 0.24 1.84 0
191 INT299546 Negative_regulation of Gene_expression of RIPK1 1 0.02 0.06 0
192 INT210198 Positive_regulation of Gene_expression of LTBR 1 0.02 0.09 0
193 INT260798 Negative_regulation of Transcription of Tnfsf10 1 0.41 1.51 0
194 INT252712 Phosphorylation of TRAF2 1 0.28 1.38 0
195 INT252760 Binding of RIPK1 1 0.19 0.77 0
196 INT285587 Positive_regulation of Localization of Cav1 1 0.11 0.08 0
197 INT327507 Negative_regulation of Localization of CYLD 1 0.05 0.58 0
198 INT292592 Regulation of Localization of RIPK1 1 0.13 0 0
199 INT348474 Regulation of Gene_expression of TRAF2 1 0.23 0.41 0
200 INT288580 Regulation of Binding of CAV1 1 0.03 0 0
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