GO:2001240

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Name negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Categary Process
Go Slim No
Go Link GO:2001240
Unique Molecular Interactions 143
Total Molecular Interactions 195
Total Single Events 1077
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
2 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
3 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
4 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
5 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
6 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
7 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
8 INT180812 Gdnf Positive_regulation of Gene_expression of Sorbs1 1 0.02 0.83 1.61
9 INT180811 Gdnf Positive_regulation of Regulation of Sorbs1 1 0.01 0.83 1.61
10 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
11 INT180790 Gdnf Regulation of Localization of Trpv1 1 0.15 1.21 1.43
12 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
13 INT180802 Gdnf Positive_regulation of Sorbs1 1 0.02 0.98 1.34
14 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
15 INT242605 Gdnf Positive_regulation of Trpv1 1 0.26 0.17 1.3
16 INT148435 Binding of Bdnf and Gdnf 2 0.35 1.9 1.17
17 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
18 INT242625 Gdnf Positive_regulation of Pax3 1 0.01 0.34 1.15
19 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
20 INT180770 Gdnf Positive_regulation of Zbtb38 1 0.00 0.27 0.99
21 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98
22 INT180780 Ngf Regulation of Gdnf 1 0.22 0.28 0.96
23 INT180803 Sorbs1 Regulation of Gdnf 1 0.01 0.28 0.95
24 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
25 INT147505 Binding of Ret and Gdnf 1 0.27 0.81 0.92
26 INT242621 Gdnf Positive_regulation of Gene_expression of Scn11a 1 0.05 0.12 0.88
27 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
28 INT103331 Ngf Positive_regulation of Gdnf 1 0.01 0.57 0.8
29 INT103334 Gdnf Regulation of Gene_expression of TRPV1 1 0.02 0.53 0.77
30 INT103333 Gdnf Regulation of TRPV1 1 0.02 0.53 0.77
31 INT180773 Calca Regulation of Binding of Gdnf 1 0.18 0.15 0.72
32 INT180783 Binding of Gdnf and Man2a2 1 0.00 0.52 0.71
33 INT180775 Binding of Gdnf and Gfra1 1 0.06 0.52 0.71
34 INT102121 Gdnf Regulation of Gene_expression of Cnr1 1 0.45 0.42 0.71
35 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
36 INT122777 Gdnf Negative_regulation of Gene_expression of Trpv1 1 0.36 0.8 0.62
37 INT122774 Gdnf Negative_regulation of Positive_regulation of Trpv1 1 0.32 0.78 0.61
38 INT242584 Gdnf Regulation of Gene_expression of Qrfp 1 0.00 0.09 0.58
39 INT91267 Gdnf Negative_regulation of Gdnf 1 0.05 0.81 0.58
40 INT242598 Binding of Gdnf and Gfra2 4 0.16 0.38 0.51
41 INT242614 Binding of Gdnf and Gfra1 1 0.03 0 0.51
42 INT356279 Gdnf Regulation of Positive_regulation of Mapk1 1 0.03 0.76 0.5
43 INT98117 Gdnf Regulation of SCN11A 1 0.05 0.39 0.5
44 INT242597 Gene_expression of Gdnf Negative_regulation of Trpv1 1 0.27 0.08 0.5
45 INT98116 Gdnf Regulation of SCN10A 1 0.03 0.39 0.5
46 INT242638 Binding of BDNF and Gdnf 1 0.29 0 0.49
47 INT242600 Binding of Gdnf and Gopc 1 0.06 0 0.49
48 INT165582 Binding of Bdnf and Gdnf 1 0.36 0.47 0.49
49 INT242604 Gdnf Regulation of Gene_expression of Trpv1 1 0.17 0.36 0.48
50 INT98119 Gdnf Regulation of SCN10A 1 0.01 0.34 0.45
51 INT98118 Gdnf Regulation of SCN11A 1 0.01 0.34 0.45
52 INT104459 Gdnf Regulation of Ngf 1 0.26 0.56 0.45
53 INT127074 Gdnf Regulation of Gene_expression of Jun 1 0.10 0.28 0.43
54 INT127072 Gdnf Regulation of Gene_expression of Fos 1 0.38 0.28 0.43
55 INT127077 Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
56 INT127079 Gene_expression of Gdnf Positive_regulation of Gene_expression of IER3 1 0.02 0.26 0.42
57 INT148436 Binding of Gdnf and Ngf 1 0.35 1.14 0.4
58 INT78627 Gdnf Negative_regulation of Negative_regulation of P2rx3 1 0.00 0.42 0.38
59 INT140869 Binding of Gdnf and Trib3 1 0.04 0.15 0.37
60 INT356278 Gdnf Positive_regulation of Mapk1 1 0.05 0.17 0.3
61 INT356282 Gdnf Positive_regulation of Trib3 1 0.00 0.17 0.3
62 INT180788 Gdnf Regulation of Trpv1 1 0.13 0.2 0.28
63 INT277434 Cd5 Regulation of Gdnf 1 0.01 0 0.21
64 INT333255 Cxcl12 Regulation of Mcl1 1 0.12 1.12 0.15
65 INT326385 Mtdh Regulation of Gdnf 1 0.00 0.41 0.14
66 INT193551 Mtpn Positive_regulation of Gene_expression of Gdnf 1 0.02 0.34 0.13
67 INT193552 Gdnf Positive_regulation of Gene_expression of Mtpn 1 0.02 0.34 0.13
68 INT277433 Wibg Positive_regulation of Gdnf 1 0.01 0.6 0.13
69 INT277430 Wibg Positive_regulation of Gene_expression of Gdnf 1 0.01 0.6 0.13
70 INT193548 Gdnf Positive_regulation of Ephb1 1 0.40 0.34 0.13
71 INT141281 ARTN Regulation of Gdnf 1 0.48 0.32 0.12
72 INT141279 Nrtn Regulation of Gdnf 1 0.14 0.32 0.12
73 INT141280 PSPN Regulation of Gdnf 1 0.48 0.32 0.12
74 INT96518 Regulation of Gdnf Positive_regulation of Ret 1 0.00 0.23 0.11
75 INT213554 Gdnf Regulation of Bdnf 1 0.13 0.14 0.1
76 INT213550 Bdnf Regulation of Gdnf 1 0.13 0.14 0.1
77 INT96519 Gdnf Positive_regulation of Ret 1 0.00 0.22 0.1
78 INT356275 Gdnf Positive_regulation of Phosphorylation of Mapk1 1 0.05 0.21 0.09
79 INT242594 Binding of Gdnf and Ret 1 0.21 0 0.08
80 INT326381 Binding of Gdnf and Pcdhb16 1 0.00 0.3 0.08
81 INT326382 Binding of Gdnf and Ncam1 1 0.01 0.3 0.08
82 INT277431 Positive_regulation of Grm3 Positive_regulation of Gene_expression of Gdnf 1 0.18 0 0.07
83 INT277432 Ptpn2 Positive_regulation of Gdnf 1 0.29 1.41 0.06
84 INT224696 TNF Positive_regulation of Gene_expression of Mcl1 1 0.01 1.07 0.05
85 INT333252 Positive_regulation of Binding of Bcl2 and Mcl1 1 0.03 0.88 0.04
86 INT268665 Ptger2 Positive_regulation of Gene_expression of Mcl1 1 0.03 0.9 0.04
87 INT333254 Binding of Mcl1 and Cxcl12 1 0.10 0.88 0.04
88 INT79985 Gdnf Negative_regulation of Negative_regulation of GAD1 1 0.04 0.46 0.04
89 INT79986 Gdnf Negative_regulation of Gene_expression of GAD1 1 0.03 0.46 0.04
90 INT333253 Binding of Bcl2 and Mcl1 1 0.02 2.14 0.04
91 INT333244 Positive_regulation of Binding of Mcl1 and Cxcl12 1 0.13 0.88 0.04
92 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
93 INT221624 Binding of Fyn and Plxna1 1 0.01 0.29 0.03
94 INT242601 Gdnf Positive_regulation of Chat 1 0.29 0.15 0.03
95 INT172892 Negative_regulation of Lox Negative_regulation of Gene_expression of Mcl1 1 0.06 1.13 0.03
96 INT224682 Mcl1 Regulation of Bak1 1 0.01 1.09 0.03
97 INT277429 Ptpn2 Regulation of Gdnf 1 0.34 0.47 0.03
98 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03
99 INT221640 Sema3a Positive_regulation of Phosphorylation of Fyn 1 0.16 0.29 0.03
100 INT221651 Binding of Fyn and Plxna2 1 0.01 0.29 0.03
101 INT221623 Fyn Regulation of Fes 1 0.14 0.2 0.03
102 INT172896 Lox Negative_regulation of Gene_expression of Mcl1 1 0.05 1.13 0.03
103 INT277427 Ptpn2 Positive_regulation of Gene_expression of Gdnf 1 0.32 0.47 0.03
104 INT329729 Binding of LCK and Fyn 1 0.00 0.21 0.03
105 INT224689 Binding of Bak1 and Mcl1 1 0.01 1.09 0.03
106 INT224676 Binding of Bax and Mcl1 1 0.01 1.09 0.03
107 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
108 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
109 INT224690 Mcl1 Regulation of Bax 1 0.00 1.09 0.03
110 INT277428 Positive_regulation of Ptpn2 Positive_regulation of Gdnf 1 0.29 0.47 0.03
111 INT198011 Binding of BAX and MCL1 2 0.20 3.04 0
112 INT346522 Binding of MCL1 and PTH 1 0.00 0 0
113 INT325284 Binding of COMP and MCL1 1 0.01 1.69 0
114 INT217145 Gene_expression of MIR26B Negative_regulation of Gene_expression of MCL1 1 0.10 1 0
115 INT198022 AKT1 Regulation of Gene_expression of MCL1 1 0.15 2.25 0
116 INT217143 MIR29A Regulation of Gene_expression of MCL1 1 0.24 1 0
117 INT198014 Binding of MCL1 and BCL2L11 1 0.11 0.82 0
118 INT115368 Binding of GDNF and RAPGEF5 1 0.32 0 0
119 INT333261 Binding of Bcl2l1 and Mcl1 1 0.02 1.25 0
120 INT345485 Binding of MCL1 and BBC3 1 0.01 0.79 0
121 INT322555 TNFSF10 Positive_regulation of MCL1 1 0.16 1.26 0
122 INT254695 Positive_regulation of Map2k2 Regulation of Mcl1 1 0.03 0.84 0
123 INT271280 Stat1 Regulation of Mcl1 1 0.28 0.67 0
124 INT345484 Binding of MCL1 and PMAIP1 1 0.04 0.8 0
125 INT342043 Binding of Gdnf and Unc5a 1 0.20 0.78 0
126 INT198021 Binding of BCL2 and MCL1 1 0.17 2.88 0
127 INT228118 Binding of Fyn and Vav1 1 0.11 0.21 0
128 INT198025 PIK3CA Positive_regulation of Gene_expression of MCL1 1 0.28 1.24 0
129 INT240271 Binding of GDNF and RET 1 0.09 1.04 0
130 INT198013 MTOR Regulation of Gene_expression of MCL1 1 0.29 1.3 0
131 INT198004 MCL1 Negative_regulation of C12orf65 1 0.01 1.12 0
132 INT302149 Binding of BCL2L1 and MCL1 1 0.03 1.1 0
133 INT303987 Binding of LEPR and Fyn 1 0.02 0.62 0
134 INT198001 Negative_regulation of PIK3CA Negative_regulation of Gene_expression of MCL1 1 0.26 0.89 0
135 INT342038 Binding of Gdnf and Ntn1 1 0.01 0.78 0
136 INT356271 Gdnf Positive_regulation of Positive_regulation of Mapk1 1 0.05 0.25 0
137 INT198005 Binding of BID and MCL1 1 0.24 2.04 0
138 INT198020 PIK3CA Regulation of Gene_expression of MCL1 1 0.16 2.25 0
139 INT198015 Binding of BAK1 and MCL1 1 0.26 5.16 0
140 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0
141 INT221645 Fyn Regulation of Phosphorylation of Fer 1 0.12 0.08 0
142 INT198006 ERI3 Negative_regulation of MCL1 1 0.01 1.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06
2 INT48890 Gene_expression of Gdnf 91 0.77 28.62 31.49
3 INT77793 Positive_regulation of Gdnf 54 0.70 23.76 25.08
4 INT102897 Positive_regulation of Gene_expression of Gdnf 34 0.69 11.13 13.28
5 INT79981 Positive_regulation of Gene_expression of Gdnf 27 0.70 12.49 10.77
6 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5
7 INT85844 Regulation of Gdnf 18 0.50 11.08 10.43
8 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62
9 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29
10 INT77795 Localization of Gdnf 26 0.81 6.29 8.55
11 INT77794 Binding of Gdnf 15 0.48 8.38 8.22
12 INT92003 Positive_regulation of Transcription of Gdnf 10 0.66 5.54 7.84
13 INT87546 Transcription of Gdnf 15 0.71 7.49 7.76
14 INT92001 Regulation of Gene_expression of Gdnf 12 0.62 6.62 6.65
15 INT87548 Negative_regulation of Gene_expression of Gdnf 9 0.54 5.67 5.94
16 INT115087 Negative_regulation of Gdnf 10 0.51 5.78 5.73
17 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39
18 INT78626 Regulation of Gdnf 7 0.45 3.3 4.64
19 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
20 INT88008 Positive_regulation of Gene_expression of GDNF 14 0.70 8.9 3.61
21 INT78625 Regulation of Gene_expression of Gdnf 7 0.37 2.5 3.47
22 INT209744 Transcription of Gdnf 5 0.67 1.36 2.84
23 INT164582 Negative_regulation of MCL1 56 0.56 67.11 2.82
24 INT164588 Regulation of MCL1 12 0.43 14.09 2.63
25 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
26 INT144366 Negative_regulation of Positive_regulation of Gdnf 4 0.41 1.43 2.41
27 INT98650 Positive_regulation of Localization of Gdnf 4 0.68 0.94 2.27
28 INT101641 Gene_expression of Mcl1 25 0.54 20.3 2.23
29 INT88006 Positive_regulation of GDNF 5 0.45 2.55 2.14
30 INT180801 Regulation of Binding of Gdnf 1 0.20 1.31 2.03
31 INT164583 Negative_regulation of Gene_expression of MCL1 19 0.56 22.45 1.94
32 INT209745 Positive_regulation of Transcription of Gdnf 4 0.58 0.97 1.91
33 INT93182 Binding of Gdnf 7 0.35 1.96 1.64
34 INT98651 Regulation of Positive_regulation of Gdnf 3 0.44 0.97 1.58
35 INT21951 Negative_regulation of Gene_expression of GDNF 5 0.43 2.82 1.57
36 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44
37 INT87547 Negative_regulation of Transcription of Gdnf 1 0.58 1.24 1.4
38 INT108130 Localization of GDNF 3 0.74 1.36 1.38
39 INT98653 Negative_regulation of Localization of Gdnf 1 0.57 0.31 1.35
40 INT166016 Protein_catabolism of MCL1 4 0.76 4.05 1.17
41 INT130477 Negative_regulation of Fyn 3 0.29 1.59 1.14
42 INT143867 Positive_regulation of Mcl1 7 0.58 9.24 1.13
43 INT166022 Positive_regulation of Protein_catabolism of MCL1 1 0.39 1.17 1.12
44 INT198042 Regulation of Gene_expression of MCL1 8 0.26 10.05 1.1
45 INT180795 Positive_regulation of Positive_regulation of Gdnf 2 0.29 0.1 1.07
46 INT108985 Negative_regulation of Regulation of Gdnf 1 0.43 1.11 1.04
47 INT146940 Gene_expression of Fyn 2 0.52 2.76 0.83
48 INT121947 Negative_regulation of Positive_regulation of Gdnf 1 0.20 0.07 0.76
49 INT166020 Positive_regulation of Regulation of MCL1 1 0.39 0.68 0.69
50 INT236094 Localization of Gdnf 4 0.70 2.51 0.68
51 INT209746 Regulation of Positive_regulation of Gdnf 2 0.37 0.11 0.68
52 INT241673 Phosphorylation of GDNF 2 0.79 1.06 0.61
53 INT166014 Negative_regulation of Negative_regulation of MCL1 1 0.33 0.63 0.61
54 INT85138 Binding of GDNF 6 0.37 2.01 0.58
55 INT101640 Regulation of Gene_expression of Mcl1 2 0.11 1.67 0.58
56 INT98112 Positive_regulation of Negative_regulation of Gdnf 1 0.05 0.44 0.57
57 INT249509 Gene_expression of Fyn 2 0.35 1.79 0.56
58 INT158327 Negative_regulation of Mcl1 5 0.42 4.08 0.55
59 INT158329 Positive_regulation of Gene_expression of Mcl1 9 0.32 7.53 0.54
60 INT198027 Localization of MCL1 5 0.72 7.46 0.51
61 INT198052 Positive_regulation of Gene_expression of MCL1 19 0.48 24.19 0.47
62 INT127069 Regulation of Localization of Gdnf 1 0.34 0.46 0.46
63 INT148433 Negative_regulation of Binding of Gdnf 1 0.41 1.14 0.4
64 INT158331 Regulation of Mcl1 3 0.15 4.4 0.39
65 INT249525 Positive_regulation of Gene_expression of Fyn 1 0.21 0.23 0.34
66 INT165917 Negative_regulation of Gene_expression of Mcl1 2 0.23 1.35 0.32
67 INT249523 Regulation of Localization of Fyn 1 0.19 0.22 0.32
68 INT249516 Negative_regulation of Gene_expression of Fyn 1 0.18 0.23 0.32
69 INT88012 Regulation of Gene_expression of GDNF 2 0.43 0.48 0.31
70 INT165912 Negative_regulation of Localization of Mcl1 1 0.23 0.77 0.31
71 INT165918 Localization of Mcl1 1 0.41 0.76 0.31
72 INT165913 Positive_regulation of Localization of Mcl1 1 0.28 0.76 0.31
73 INT249510 Localization of Fyn 1 0.32 0.22 0.29
74 INT242536 Negative_regulation of Gene_expression of Gdnf 1 0.30 0.06 0.28
75 INT158330 Binding of Mcl1 1 0.14 1.32 0.26
76 INT338874 Binding of Fyn 1 0.08 0.53 0.19
77 INT88007 Regulation of GDNF 2 0.34 0.82 0.16
78 INT277419 Positive_regulation of Positive_regulation of Gdnf 1 0.47 0 0.12
79 INT158328 Regulation of Positive_regulation of Mcl1 1 0.11 0.8 0.12
80 INT88013 Transcription of GDNF 2 0.40 0.22 0.11
81 INT88011 Positive_regulation of Transcription of GDNF 1 0.35 0.22 0.11
82 INT277418 Regulation of Binding of Gdnf 1 0.42 0 0.08
83 INT199074 Positive_regulation of Fyn 1 0.18 0.05 0.07
84 INT347981 Positive_regulation of Phosphorylation of Gdnf 1 0.11 0.79 0.07
85 INT347993 Regulation of Phosphorylation of Gdnf 1 0.10 0.87 0.07
86 INT347980 Phosphorylation of Gdnf 1 0.19 0.79 0.07
87 INT149789 Positive_regulation of Phosphorylation of Fyn 2 0.67 0.31 0.04
88 INT329716 Negative_regulation of Fyn 1 0.03 0.21 0.03
89 INT195266 Binding of MCL1 12 0.46 8.75 0
90 INT198051 Regulation of Negative_regulation of MCL1 1 0.43 4.05 0
91 INT333228 Protein_catabolism of Mcl1 1 0.24 1.08 0
92 INT198050 Regulation of Binding of MCL1 1 0.43 0.9 0
93 INT307413 Positive_regulation of Positive_regulation of MCL1 1 0.13 2.15 0
94 INT325288 Negative_regulation of Positive_regulation of MCL1 1 0.31 1.76 0
95 INT333211 Phosphorylation of Mcl1 1 0.20 0.69 0
96 INT198046 Positive_regulation of Negative_regulation of MCL1 1 0.48 3.05 0
97 INT325287 Negative_regulation of Localization of MCL1 1 0.31 1.76 0
98 INT198047 Regulation of Positive_regulation of MCL1 1 0.43 0.77 0
99 INT331205 Protein_catabolism of Gdnf 1 0.03 0.57 0
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