GO:2001243

From wiki-pain
Jump to: navigation, search
Name negative regulation of intrinsic apoptotic signaling pathway
Categary Process
Go Slim No
Go Link GO:2001243
Unique Molecular Interactions 141
Total Molecular Interactions 167
Total Single Events 1013
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of intrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of intrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
2 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
3 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
4 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
5 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
6 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
7 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
8 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
9 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
10 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
11 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
12 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
13 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
14 INT97056 Cpz Regulation of Gene_expression of Bcl2l1 1 0.22 0.57 0.83
15 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
16 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
17 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
18 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
19 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
20 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
21 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
22 INT83800 Aap Regulation of Gene_expression of Bcl2l1 1 0.28 0.58 0.64
23 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
24 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
25 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
26 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
27 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
28 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
29 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
30 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
31 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
32 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
33 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
34 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
35 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
36 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
37 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
38 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
39 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
40 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
41 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
42 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
43 INT172901 Binding of Bad and Bcl2l1 3 0.13 6.51 0.27
44 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
45 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
46 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
47 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
48 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
49 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
50 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19
51 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13
52 INT172899 Binding of Bcl2 and Bcl2l1 3 0.02 5.54 0.12
53 INT171390 Src Positive_regulation of Phosphorylation of Egfr 1 0.13 0 0.11
54 INT171389 Src Positive_regulation of Positive_regulation of Mapk1 1 0.16 0 0.11
55 INT171388 Src Positive_regulation of Phosphorylation of Gpbar1 1 0.05 0 0.11
56 INT276064 Src Regulation of Positive_regulation of Rpa1 1 0.02 0.18 0.11
57 INT171387 Ppp1cc Positive_regulation of Phosphorylation of Src 1 0.07 0 0.11
58 INT292087 SRC Regulation of IL8 1 0.02 1.43 0.11
59 INT279962 Binding of A1BG and BCL2L1 1 0.13 1.11 0.1
60 INT275184 Bad Positive_regulation of Positive_regulation of Bcl2l1 1 0.12 0.62 0.09
61 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
62 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
63 INT242482 Ciapin1 Positive_regulation of Gene_expression of Bcl2l1 1 0.31 1.05 0.07
64 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07
65 INT235006 IgG Positive_regulation of SRC 1 0.01 0.82 0.05
66 INT235010 Positive_regulation of Positive_regulation of SRC 1 0.01 0.84 0.05
67 INT304172 Il5 Positive_regulation of Bcl2l1 1 0.02 0.91 0.05
68 INT348523 BCL2L1 Negative_regulation of NLRP1 1 0.01 0.63 0.05
69 INT269249 Ptk2 Positive_regulation of Phosphorylation of Src 1 0.13 0.93 0.04
70 INT178435 Mapk1 Regulation of Phosphorylation of Src 1 0.03 0.49 0.04
71 INT269250 Ptk2 Positive_regulation of Src 1 0.13 0.86 0.04
72 INT231839 Pcdh8 Positive_regulation of Src 1 0.00 0 0.04
73 INT263377 Abl1 Regulation of Src 1 0.15 0 0.04
74 INT178439 Binding of Ar and Src 1 0.01 0.44 0.04
75 INT263381 Trib3 Regulation of Src 1 0.01 0 0.04
76 INT238113 SRC Regulation of Phosphorylation of STAT3 1 0.46 0 0.04
77 INT106486 Gene_expression of CD177 Negative_regulation of Gene_expression of Bcl2l1 1 0.01 1.87 0.04
78 INT192165 Binding of BAK1 and BCL2L1 2 0.06 1.35 0.03
79 INT192166 Negative_regulation of Binding of BAK1 and BCL2L1 1 0.05 1.06 0.03
80 INT229006 MIA3 Positive_regulation of Phosphorylation of Src 1 0.02 0.44 0.03
81 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
82 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03
83 INT200820 Epo Positive_regulation of Src 1 0.25 1.41 0.03
84 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
85 INT308750 Binding of BCL2L1 and MIR184 1 0.13 0.11 0.03
86 INT185856 Binding of BAD and BCL2L1 4 0.39 2.73 0
87 INT172906 Binding of Bax and Bcl2l1 2 0.16 2.03 0
88 INT285031 Binding of Bcl2 and Bcl2l1 1 0.27 0.1 0
89 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0
90 INT295920 Mir761 Positive_regulation of Transcription of Bcl2l1 1 0.00 1.43 0
91 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0
92 INT292447 Negative_regulation of Binding of BAD and BCL2L1 1 0.02 0.81 0
93 INT285579 Binding of S100A8 and SRC 1 0.05 0.2 0
94 INT185849 Binding of BCL2L1 and BIK 1 0.29 0.59 0
95 INT285029 Binding of Bax and Bcl2l1 1 0.25 0.1 0
96 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0
97 INT333261 Binding of Bcl2l1 and Mcl1 1 0.02 1.25 0
98 INT243106 Binding of Crebbp and Src 1 0.05 0.52 0
99 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0
100 INT279289 TXK Regulation of SRC 1 0.04 0.68 0
101 INT299296 SRC Regulation of RPTOR 1 0.32 0 0
102 INT201757 Binding of BCL2L1 and Positive_regulation of Negative_regulation of Akt1 1 0.01 0.3 0
103 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
104 INT338189 SRC Positive_regulation of HGFAC 1 0.00 0.4 0
105 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0
106 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0
107 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0
108 INT201773 Binding of BCL2L1 and Positive_regulation of Negative_regulation of PIK3CG 1 0.01 0.3 0
109 INT265342 sb Negative_regulation of Bcl2l1 1 0.00 0.65 0
110 INT286043 Wwox Positive_regulation of Negative_regulation of Bcl2l1 1 0.04 0.7 0
111 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
112 INT299308 SRC Regulation of PI3 1 0.20 0 0
113 INT292459 Phosphorylation of BAD Negative_regulation of Binding of BCL2L1 1 0.02 0.82 0
114 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0
115 INT338195 Binding of SRC and FIBP 1 0.00 0.31 0
116 INT201774 Binding of BCL2 and BCL2L1 1 0.00 0.37 0
117 INT201765 Binding of BCL2L1 and Bax 1 0.00 0.28 0
118 INT227697 Stat3 Regulation of Bcl2l1 1 0.05 1.29 0
119 INT333695 Trp53 Positive_regulation of Localization of Bcl2l1 1 0.23 1.33 0
120 INT309906 Binding of EGF and SRC 1 0.11 0.64 0
121 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
122 INT144031 STAT3 Regulation of BCL2L1 1 0.11 0.06 0
123 INT340928 Negative_regulation of SRC Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
124 INT299294 SRC Regulation of VEGFA 1 0.20 0 0
125 INT333691 Trp53 Positive_regulation of Bcl2l1 1 0.23 1.33 0
126 INT238120 SRC Positive_regulation of Positive_regulation of STAT3 1 0.71 0 0
127 INT201760 Binding of BCL2L1 and Positive_regulation of Bad 1 0.01 0.3 0
128 INT302149 Binding of BCL2L1 and MCL1 1 0.03 1.1 0
129 INT238114 Binding of CSK and SRC 1 0.07 0 0
130 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
131 INT351158 CAV1 Regulation of SRC 1 0.01 0.68 0
132 INT254699 Positive_regulation of Map2k2 Regulation of Bcl2l1 1 0.04 0.89 0
133 INT193960 Binding of Bcl2l1 and Ps 1 0.01 0.6 0
134 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
135 INT338196 Binding of SRC and CDCP1 1 0.00 0.31 0
136 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0
137 INT198019 NPY6R Negative_regulation of Gene_expression of SRC 1 0.06 1.75 0
138 INT254091 EPO Positive_regulation of Gene_expression of Bcl2l1 1 0.11 0.66 0
139 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0
140 INT352149 Ift88 Negative_regulation of Bcl2l1 1 0.00 0.19 0
141 INT114711 SRC Positive_regulation of Gene_expression of INSRR 1 0.01 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of intrinsic apoptotic signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of intrinsic apoptotic signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39
2 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
3 INT99505 Gene_expression of Bcl2l1 42 0.77 33.12 10.15
4 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
5 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
6 INT99506 Negative_regulation of Bcl2l1 25 0.58 15.7 6.09
7 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
8 INT100222 Binding of Src 9 0.26 5.41 5.37
9 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32
10 INT99507 Positive_regulation of Bcl2l1 17 0.69 9.23 4.97
11 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
12 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
13 INT116614 Positive_regulation of Gene_expression of Bcl2l1 12 0.67 11.39 4.68
14 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
15 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28
16 INT83798 Negative_regulation of Gene_expression of Bcl2l1 28 0.58 20.26 4.21
17 INT83796 Regulation of Gene_expression of Bcl2l1 10 0.61 7.85 4.05
18 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95
19 INT95423 Negative_regulation of Bcl2l1 26 0.41 21.66 3.81
20 INT122327 Regulation of Src 6 0.59 0.59 3.6
21 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
22 INT86245 Positive_regulation of Bcl2l1 15 0.46 12.67 3.11
23 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
24 INT99508 Regulation of Bcl2l1 12 0.61 10.44 2.71
25 INT156016 Binding of BCL2L1 10 0.36 7.42 2.64
26 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
27 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
28 INT97748 Positive_regulation of BCL2L1 12 0.67 9.83 2.26
29 INT91836 Negative_regulation of Gene_expression of BCL2L1 9 0.49 8.59 2.25
30 INT83799 Phosphorylation of Bcl2l1 8 0.82 7.86 2.23
31 INT102752 Positive_regulation of Gene_expression of BCL2L1 14 0.67 13.8 2.19
32 INT101645 Regulation of Gene_expression of Bcl2l1 8 0.36 5.27 2.05
33 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
34 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
35 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
36 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
37 INT97749 Regulation of BCL2L1 10 0.41 9.72 1.65
38 INT106413 Transcription of Bcl2l1 8 0.53 3.35 1.52
39 INT98455 Regulation of Src 4 0.20 1.76 1.48
40 INT114715 Binding of SRC 8 0.36 4.26 1.32
41 INT105881 Phosphorylation of Bcl2l1 3 0.51 1.99 1.31
42 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
43 INT249522 Positive_regulation of Binding of Src 1 0.22 0.68 1.12
44 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1
45 INT135806 Regulation of Bcl2l1 10 0.44 7.21 1.05
46 INT164863 Positive_regulation of Phosphorylation of Bcl2l1 1 0.31 0.57 1.01
47 INT317504 Protein_catabolism of Src 1 0.49 0.13 0.97
48 INT100221 Negative_regulation of Phosphorylation of Src 2 0.24 0.74 0.93
49 INT156015 Negative_regulation of Protein_catabolism of BCL2L1 1 0.42 1.23 0.93
50 INT156014 Protein_catabolism of BCL2L1 1 0.64 1.23 0.93
51 INT156017 Positive_regulation of Binding of BCL2L1 1 0.49 1.21 0.91
52 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8
53 INT143912 Localization of Src 4 0.48 2.51 0.78
54 INT249506 Regulation of Phosphorylation of Src 1 0.13 0.48 0.77
55 INT131567 Negative_regulation of Positive_regulation of Bcl2l1 1 0.41 0.66 0.7
56 INT131568 Positive_regulation of Positive_regulation of Bcl2l1 1 0.48 0.64 0.68
57 INT235996 Negative_regulation of Gene_expression of Src 3 0.09 1.29 0.58
58 INT86246 Binding of Bcl2l1 8 0.37 6.67 0.57
59 INT143910 Negative_regulation of Positive_regulation of Src 1 0.27 0.14 0.56
60 INT152057 Negative_regulation of Transcription of Bcl2l1 3 0.43 1 0.55
61 INT117998 Positive_regulation of Gene_expression of Src 4 0.36 1.45 0.51
62 INT152058 Regulation of Transcription of Bcl2l1 2 0.32 0.53 0.5
63 INT82608 Positive_regulation of Phosphorylation of SRC 3 0.49 1.28 0.48
64 INT165799 Negative_regulation of Gene_expression of Bcl2l1 6 0.41 5.12 0.47
65 INT106415 Positive_regulation of Transcription of Bcl2l1 1 0.20 0.49 0.46
66 INT249504 Localization of Src 1 0.36 0.32 0.46
67 INT152056 Negative_regulation of Regulation of Bcl2l1 1 0.58 0.07 0.45
68 INT98456 Negative_regulation of Src 17 0.42 8.3 0.42
69 INT105885 Binding of Bcl2l1 2 0.05 1.13 0.35
70 INT279985 Transcription of BCL2L1 5 0.69 3.76 0.34
71 INT138051 Negative_regulation of Positive_regulation of SRC 3 0.57 0.84 0.33
72 INT249533 Regulation of Localization of Src 1 0.22 0.22 0.32
73 INT149998 Positive_regulation of Positive_regulation of Bcl2l1 1 0.05 1.73 0.28
74 INT180186 Localization of BCL2L1 2 0.33 3.86 0.24
75 INT171374 Binding of Src 2 0.13 0.44 0.24
76 INT164162 Negative_regulation of Phosphorylation of SRC 3 0.29 2.12 0.21
77 INT235725 Regulation of SRC 7 0.44 4.71 0.19
78 INT227671 Protein_catabolism of Bcl2l1 2 0.18 0.96 0.19
79 INT356122 Regulation of Phosphorylation of Bcl2l1 1 0.09 0.69 0.19
80 INT249526 Positive_regulation of Localization of Src 1 0.24 0.1 0.16
81 INT285904 Positive_regulation of Transcription of BCL2L1 1 0.05 0.95 0.13
82 INT113990 Regulation of Gene_expression of BCL2L1 3 0.32 2.58 0.1
83 INT299357 Localization of SRC 1 0.51 0 0.09
84 INT338740 Transcription of Src 1 0.43 1.24 0.07
85 INT238187 Regulation of Positive_regulation of SRC 2 0.26 1.37 0.05
86 INT254082 Positive_regulation of Localization of Bcl2l1 1 0.09 0.16 0.05
87 INT254081 Localization of Bcl2l1 1 0.13 0 0.04
88 INT238193 Regulation of Gene_expression of SRC 1 0.44 0 0.03
89 INT225256 Positive_regulation of Gene_expression of Src 3 0.20 0.75 0
90 INT124649 Transcription of Bcl2l1 2 0.65 0.16 0
91 INT315141 Localization of Bcl2l1 2 0.36 2.39 0
92 INT200798 Positive_regulation of Phosphorylation of Bcl2l1 1 0.34 0.25 0
93 INT330044 Regulation of Regulation of Bcl2l1 1 0.16 0.76 0
94 INT338741 Negative_regulation of Binding of Src 1 0.30 0.75 0
95 INT285019 Positive_regulation of Negative_regulation of Bcl2l1 1 0.28 0.06 0
96 INT225249 Negative_regulation of Phosphorylation of Src 1 0.16 1.51 0
97 INT284070 Negative_regulation of Phosphorylation of Bcl2l1 1 0.10 1.07 0
98 INT191053 Positive_regulation of Transcription of Bcl2l1 1 0.47 0.08 0
99 INT124648 Regulation of Transcription of Bcl2l1 1 0.31 0.09 0
100 INT185889 Phosphorylation of BCL2L1 1 0.58 0.99 0
101 INT200801 Positive_regulation of Localization of Src 1 0.28 1.92 0
102 INT124647 Negative_regulation of Negative_regulation of Bcl2l1 1 0.29 0.08 0
103 INT171689 Protein_catabolism of Bcl2l1 1 0.38 0.67 0
104 INT191057 Regulation of Binding of Bcl2l1 1 0.37 0.74 0
105 INT238185 Regulation of Binding of SRC 1 0.44 0.06 0
106 INT315142 Negative_regulation of Localization of Bcl2l1 1 0.20 1.2 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox