GO:GO:0010642

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Name negative regulation of platelet-derived growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0010642
Unique Molecular Interactions 158
Total Molecular Interactions 226
Total Single Events 1961
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of platelet-derived growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of platelet-derived growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
2 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
3 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
4 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
5 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
6 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
7 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
8 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
9 INT130975 Binding of ASIC3 and Slc9a3r1 1 0.06 0.26 0.43
10 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
11 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
12 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
13 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
14 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
15 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
16 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
17 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
18 INT130974 Slc9a3r1 Positive_regulation of ASIC3 1 0.08 0.29 0.36
19 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
20 INT328407 Nlrp1a Negative_regulation of Gene_expression of Snca 1 0.07 0.31 0.29
21 INT328410 Nlrp1a Negative_regulation of Snca 1 0.07 0.31 0.29
22 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28
23 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
24 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23
25 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22
26 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
27 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21
28 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
29 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
30 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
31 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2
32 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
33 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
34 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
35 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
36 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
37 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
38 INT256987 Binding of Cd81 and Slc9a3r1 1 0.43 0.06 0.17
39 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15
40 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
41 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
42 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
43 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12
44 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
45 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
46 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
47 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12
48 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
49 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12
50 INT257467 Fat1 Regulation of Gene_expression of Adipoq 1 0.08 0.56 0.11
51 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
52 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1
53 INT328413 Binding of Snca and Nlrp1a 1 0.06 0.75 0.1
54 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
55 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
56 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
57 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09
58 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
59 INT83270 Snca Regulation of Napepld 1 0.14 0 0.09
60 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08
61 INT257466 Psd Negative_regulation of Gene_expression of Adipoq 1 0.22 0.66 0.08
62 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
63 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
64 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
65 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
66 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07
67 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06
68 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
69 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
70 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05
71 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
72 INT236590 Binding of Adipoq and Ncoa2 1 0.15 0.2 0.03
73 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
74 INT234978 Binding of Dsg3 and Positive_regulation of Inppl1 1 0.00 0.32 0.03
75 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
76 INT236592 Positive_regulation of Binding of Adipoq and Ncoa2 1 0.19 0.2 0.03
77 INT227305 Zbp1 Regulation of Gene_expression of Adipoq 1 0.21 1.27 0
78 INT256997 Binding of RLBP1 and Slc9a3r1 1 0.44 0 0
79 INT317313 Atp13a2 Negative_regulation of Snca 1 0.13 0.59 0
80 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0
81 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 0.08 0.12 0
82 INT352516 Binding of POMT1 and Adipoq 1 0.01 0.4 0
83 INT204322 Binding of ADIPOQ and Positive_regulation of Gene_expression of PPARGC1A 1 0.30 0.07 0
84 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
85 INT256979 Binding of Slc9a3r1 and Rlbp1 1 0.03 0 0
86 INT140814 Adipoq Regulation of Retn 1 0.03 0.8 0
87 INT227302 Zbp1 Regulation of Transcription of Adipoq 1 0.09 1.27 0
88 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
89 INT317315 Gene_expression of Snca Negative_regulation of Psmb10 1 0.00 0.52 0
90 INT317320 Binding of Snca and Atp13a2 1 0.08 0.58 0
91 INT256980 Binding of Slc9a3r1 and Rpe 1 0.08 0.13 0
92 INT350254 Slc12a6 Regulation of Gene_expression of Adipoq 1 0.02 0.63 0
93 INT197915 Des Positive_regulation of Adipoq 1 0.07 0 0
94 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0
95 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0
96 INT256992 Binding of Slc9a3r1 and Hspb6 1 0.09 0 0
97 INT256981 Binding of Dlg1 and Slc9a3r1 1 0.22 0 0
98 INT256989 Binding of Ezr and Slc9a3r1 1 0.10 0 0
99 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of platelet-derived growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of platelet-derived growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
2 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
3 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
4 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
5 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1
6 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
7 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
8 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
9 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
10 INT123594 Negative_regulation of Snca 19 0.59 4.43 4.59
11 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56
12 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
13 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
14 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
15 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
16 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
17 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
18 INT123595 Regulation of Snca 7 0.62 4.3 3.06
19 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
20 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
21 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
22 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
23 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
24 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
25 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
26 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03
27 INT127125 Localization of Snca 6 0.81 8.24 1.88
28 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74
29 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
30 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
31 INT201271 Phosphorylation of Snca 3 0.82 4.22 1.45
32 INT124247 Negative_regulation of Gene_expression of Snca 12 0.59 3.87 1.39
33 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19
34 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
35 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
36 INT151753 Transcription of Snca 6 0.69 1.99 1.11
37 INT292945 Positive_regulation of Positive_regulation of Snca 4 0.69 2.42 1.05
38 INT286344 Positive_regulation of Gene_expression of Snca 1 0.41 2.84 1.03
39 INT151752 Positive_regulation of Transcription of Snca 2 0.50 0.99 0.92
40 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
41 INT124246 Binding of Snca 10 0.37 6.53 0.9
42 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
43 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
44 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
45 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
46 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
47 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
48 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
49 INT130971 Binding of Slc9a3r1 2 0.39 0.32 0.59
50 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
51 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
52 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
53 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
54 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
55 INT130969 Positive_regulation of Binding of Slc9a3r1 1 0.09 0.26 0.43
56 INT148264 Transcription of SNCA 1 0.40 0.25 0.42
57 INT160053 Gene_expression of INPPL1 1 0.55 0.6 0.42
58 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
59 INT343972 Negative_regulation of Binding of SNCA 1 0.36 0.2 0.39
60 INT130972 Gene_expression of Slc9a3r1 2 0.63 0.36 0.37
61 INT169628 Binding of SNCA 4 0.47 3.53 0.36
62 INT179491 Transcription of Adipoq 4 0.51 0.98 0.32
63 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3
64 INT343973 Localization of SNCA 1 0.63 0.07 0.3
65 INT142052 Binding of Snca 4 0.47 1.02 0.22
66 INT253941 Positive_regulation of Localization of Adipoq 5 0.24 2.59 0.21
67 INT292944 Regulation of Positive_regulation of Snca 1 0.45 0.36 0.21
68 INT257418 Negative_regulation of Transcription of Snca 1 0.43 0.93 0.19
69 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18
70 INT197872 Regulation of Regulation of Adipoq 3 0.35 1.11 0.17
71 INT28026 Positive_regulation of Binding of Adipoq 1 0.27 0 0.17
72 INT137455 Protein_catabolism of ADIPOQ 1 0.66 0.25 0.17
73 INT228162 Negative_regulation of Localization of Adipoq 1 0.38 1.29 0.17
74 INT166361 Phosphorylation of SNCA 1 0.70 0.72 0.17
75 INT308978 Negative_regulation of Regulation of Adipoq 1 0.28 0.92 0.17
76 INT263001 Regulation of Gene_expression of ADIPOQ 5 0.45 3.77 0.16
77 INT157084 Localization of Snca 1 0.51 0.17 0.16
78 INT343974 Negative_regulation of Gene_expression of SNCA 1 0.31 0.09 0.16
79 INT319289 Protein_catabolism of Snca 1 0.35 0.93 0.15
80 INT286343 Negative_regulation of Gene_expression of Snca 1 0.26 0.65 0.15
81 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14
82 INT262999 Negative_regulation of Gene_expression of ADIPOQ 7 0.43 9.52 0.12
83 INT157267 Negative_regulation of Localization of Adipoq 1 0.24 0.94 0.09
84 INT288642 Negative_regulation of Positive_regulation of Snca 1 0.07 0.93 0.09
85 INT327816 Regulation of Positive_regulation of ADIPOQ 1 0.04 1.2 0.09
86 INT292946 Positive_regulation of Localization of Snca 1 0.50 0.52 0.06
87 INT353069 Positive_regulation of Positive_regulation of ADIPOQ 1 0.13 1.75 0.05
88 INT245905 Negative_regulation of Transcription of ADIPOQ 1 0.42 1.26 0.05
89 INT267251 Gene_expression of Ptprj 1 0.12 2.02 0.05
90 INT228584 Phosphorylation of Adipoq 1 0.38 0.61 0.04
91 INT251940 Positive_regulation of Transcription of ADIPOQ 1 0.01 0 0.04
92 INT240621 Negative_regulation of Localization of ADIPOQ 1 0.39 0.64 0.03
93 INT267249 Positive_regulation of Gene_expression of Ptprj 1 0.08 0.39 0.03
94 INT256965 Positive_regulation of Slc9a3r1 1 0.38 0 0
95 INT317275 Positive_regulation of Binding of Snca 1 0.37 0.53 0
96 INT257464 Negative_regulation of Transcription of Adipoq 1 0.41 0.45 0
97 INT263530 Negative_regulation of Positive_regulation of ADIPOQ 1 0.31 1.43 0
98 INT330881 Regulation of Inppl1 1 0.13 0 0
99 INT267250 Positive_regulation of Ptprj 1 0.08 1.31 0
100 INT256950 Negative_regulation of Gene_expression of Slc9a3r1 1 0.35 0 0
101 INT256962 Positive_regulation of Gene_expression of Slc9a3r1 1 0.38 0 0
102 INT227262 Regulation of Transcription of Adipoq 1 0.35 0.47 0
103 INT256968 Localization of Slc9a3r1 1 0.57 0 0
104 INT343971 Positive_regulation of Positive_regulation of SNCA 1 0.42 0.35 0
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