GO:GO:0030104

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Name water homeostasis
Categary Process
Go Slim No
Go Link GO:0030104
Unique Molecular Interactions 269
Total Molecular Interactions 380
Total Single Events 4438
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for water homeostasis. They are ordered first by their pain relevance and then by number of times they were reported for water homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
3 INT130838 Gfap Positive_regulation of Aqp4 1 0.51 1.9 1.56
4 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
5 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
6 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
7 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
8 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
9 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
10 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
11 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
12 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
13 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
14 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
15 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
16 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
17 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
18 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
19 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
20 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
21 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
22 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
23 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
24 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
25 INT235956 Binding of Aqp4 and NMO-IgG 1 0.04 4.53 0.5
26 INT161166 Binding of Aqp4 and Igh-6 1 0.03 2.58 0.49
27 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
28 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
29 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
30 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
31 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
32 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
33 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
34 INT50553 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Tbxa2r 1 0.02 1.37 0.38
35 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
36 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
37 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
38 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
39 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
40 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
41 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
42 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
43 INT84600 Binding of Avp and Aqp2 1 0.17 0 0.35
44 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
45 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
46 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
47 INT235958 Binding of Ighg1 and Aqp4 1 0.14 1.32 0.3
48 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
49 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
50 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
51 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
52 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
53 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
54 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
55 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
56 INT293118 Avp Regulation of Aqp2 1 0.04 0.7 0.27
57 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
58 INT235959 Nqo1 Positive_regulation of Localization of Aqp4 1 0.02 1.39 0.26
59 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
60 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
61 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
62 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
63 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
64 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
65 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
66 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21
67 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
68 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
69 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
70 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
71 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
72 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19
73 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
74 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
75 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
76 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
77 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
78 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
79 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
80 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16
81 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15
82 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
83 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
84 INT247851 Negative_regulation of Aqp4 Negative_regulation of Positive_regulation of Narfl 1 0.09 1.78 0.15
85 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
86 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
87 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
88 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14
89 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
90 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
91 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
92 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
93 INT45371 IGF1 Regulation of Smc1b 1 0.08 0 0.14
94 INT293117 Agt Regulation of Gene_expression of Aqp2 1 0.23 0.36 0.14
95 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14
96 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14
97 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
98 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
99 INT45370 IGF1 Regulation of Gh1 1 0.13 0 0.14
100 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
101 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
102 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
103 INT57586 Tbxa2r Regulation of Positive_regulation of Uae1 1 0.08 0.52 0.13
104 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
105 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
106 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
107 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
108 INT44978 Gfra1 Negative_regulation of Tbxa2r 1 0.00 0.44 0.12
109 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
110 INT353318 NOS1 Positive_regulation of Localization of Tbxa2r 1 0.04 0.71 0.12
111 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 0.22 1.18 0.11
112 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
113 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
114 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
115 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
116 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
117 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
118 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
119 INT323875 Binding of BMI1 and IGF1 1 0.01 1.2 0.11
120 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11
121 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1
122 INT220149 Binding of IGF1 and IGFALS 2 0.39 0.44 0.1
123 INT267124 IGF1 Negative_regulation of Gene_expression of INS 2 0.14 0.18 0.1
124 INT277657 Igfbp1 Negative_regulation of Negative_regulation of Igf1 1 0.02 0.26 0.1
125 INT161741 Gh1 Positive_regulation of Gene_expression of Igf1 1 0.35 0.55 0.1
126 INT137368 Retn Positive_regulation of Gene_expression of IGF1 1 0.00 0.17 0.1
127 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
128 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
129 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
130 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09
131 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
132 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
133 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
134 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
135 INT192293 Binding of IGF1 and IL1B 1 0.15 0.08 0.08
136 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
137 INT235964 Binding of Atp9a and Aqp4 1 0.01 0.55 0.08
138 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
139 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
140 INT312219 Binding of IGF1 and IGFBP5 1 0.02 0.13 0.08
141 INT283126 Dag1 Positive_regulation of Localization of Aqp4 1 0.47 0.2 0.07
142 INT323872 LEP Positive_regulation of Gene_expression of IGF1 1 0.35 0.77 0.07
143 INT265883 IGF1 Positive_regulation of Transcription of FOXO1 1 0.17 1.14 0.07
144 INT70762 IGF1 Regulation of Gh 1 0.00 0.17 0.07
145 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07
146 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07
147 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
148 INT51273 IGF1 Positive_regulation of IGFBP2 1 0.37 0.13 0.06
149 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
150 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06
151 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
152 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
153 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
154 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06
155 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06
156 INT51276 IGF1 Negative_regulation of GH1 1 0.10 0.13 0.06
157 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06
158 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
159 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
160 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05
161 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05
162 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05
163 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
164 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
165 INT122713 Guca2b Positive_regulation of RTCA 1 0.03 0.16 0.05
166 INT112282 Ntf3 Regulation of Igf1 1 0.07 0.14 0.05
167 INT206619 Mtpn Positive_regulation of Igf1 1 0.04 0.17 0.05
168 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
169 INT235963 Snta1 Regulation of Gene_expression of Aqp4 1 0.41 0.23 0.05
170 INT293122 Avp Regulation of Gene_expression of Aqp2 1 0.04 0.81 0.05
171 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05
172 INT198358 GH1 Regulation of Igf1 1 0.00 0.09 0.05
173 INT315986 Igf1 Positive_regulation of Pik3c3 1 0.00 0.48 0.05
174 INT247843 Narfl Regulation of Aqp4 1 0.04 1.07 0.04
175 INT184083 Positive_regulation of Gh Positive_regulation of Igf1 1 0.09 0.7 0.04
176 INT184115 Igf1 Positive_regulation of Gene_expression of Socs2 1 0.16 0.62 0.04
177 INT202233 IGFBP1 Regulation of IGF1 1 0.22 0.19 0.04
178 INT206620 Gh1 Positive_regulation of Igf1 1 0.25 0.17 0.04
179 INT247855 Positive_regulation of Narfl Regulation of Aqp4 1 0.04 2.93 0.04
180 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03
181 INT265891 IGF1 Regulation of AKT1 1 0.05 1.24 0.03
182 INT265884 IGF1 Regulation of CREB1 1 0.13 1.31 0.03
183 INT265879 IGF1 Regulation of FOXO1 1 0.11 1.37 0.03
184 INT265880 IGF1 Regulation of PIK3CG 1 0.10 1.23 0.03
185 INT208410 IGF1 Positive_regulation of TXK 1 0.08 0.9 0.03
186 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
187 INT174532 PTH Positive_regulation of Transcription of IGF1 1 0.06 0.51 0
188 INT295573 Igf1 Positive_regulation of Gene_expression of Mstn 1 0.19 0 0
189 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
190 INT315984 Rhd Positive_regulation of Localization of Igf1 1 0.07 0.25 0
191 INT226190 Binding of Igf1 and Positive_regulation of Pik3cb 1 0.17 1.04 0
192 INT295868 Igf1 Positive_regulation of VEGFA 1 0.16 0.19 0
193 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0
194 INT206854 ESR1 Regulation of IGF1 1 0.01 0.33 0
195 INT278495 IGFBP2 Positive_regulation of Gene_expression of IGF1 1 0.20 0 0
196 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0
197 INT218952 Dlst Negative_regulation of Igf1 1 0.03 0.1 0
198 INT295574 Binding of Igf1 and Mstn 1 0.16 0.08 0
199 INT327830 Alms1 Positive_regulation of Aqp4 1 0.03 0.15 0
200 INT225969 Binding of Aqp4 and Nefl 1 0.07 0.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for water homeostasis. They are ordered first by their pain relevance and then by number of times they were reported in water homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
2 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
3 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
4 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63
5 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
6 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
7 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
8 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27
9 INT109650 Gene_expression of Aqp4 87 0.78 51.52 20.72
10 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
11 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
12 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
13 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
14 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
15 INT109651 Negative_regulation of Aqp4 23 0.53 8.5 10.7
16 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
17 INT5458 Negative_regulation of Tbxa2r 31 0.54 10.58 8.89
18 INT34777 Localization of IGF1 82 0.80 42.68 8.62
19 INT19107 Positive_regulation of Tbxa2r 23 0.62 12.54 8.44
20 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
21 INT136304 Negative_regulation of Aqp4 54 0.59 48.42 7.4
22 INT11042 Localization of Tbxa2r 26 0.76 10.15 7.24
23 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
24 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
25 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
26 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
27 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
28 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
29 INT151032 Localization of Igf1 49 0.76 26.32 5.71
30 INT155348 Positive_regulation of Aqp4 14 0.63 9.92 5.53
31 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
32 INT19639 Negative_regulation of Gene_expression of Tbxa2r 17 0.55 7.69 5.01
33 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
34 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
35 INT49360 Localization of Igf1 22 0.76 6.96 4.26
36 INT143337 Binding of Aqp4 30 0.40 23.73 4.24
37 INT160023 Regulation of Aqp4 9 0.45 8.41 4.19
38 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79
39 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
40 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77
41 INT225965 Localization of Aqp4 26 0.81 18.85 3.75
42 INT9077 Regulation of Tbxa2r 13 0.45 5.49 3.75
43 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
44 INT130836 Transcription of Aqp4 6 0.72 5.93 3.52
45 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
46 INT130835 Positive_regulation of Transcription of Aqp4 3 0.68 4.5 3.28
47 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
48 INT165821 Positive_regulation of Aqp4 27 0.70 24.37 3.22
49 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
50 INT16130 Binding of IGF1 67 0.48 27.43 2.95
51 INT155349 Positive_regulation of Gene_expression of Aqp4 8 0.70 6.26 2.94
52 INT152961 Negative_regulation of Gene_expression of Aqp4 13 0.59 10.01 2.92
53 INT84599 Gene_expression of Aqp2 31 0.77 22.58 2.54
54 INT104563 Localization of Aqp4 10 0.73 7.82 2.54
55 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
56 INT66544 Binding of Igf1 23 0.46 8.33 2.44
57 INT17243 Positive_regulation of Gene_expression of Tbxa2r 7 0.55 4.7 2.37
58 INT225966 Regulation of Gene_expression of Aqp4 18 0.62 20.39 2.3
59 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
60 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
61 INT155344 Phosphorylation of Aqp4 1 0.82 4 2.05
62 INT140171 Binding of Aqp4 7 0.36 11.63 1.98
63 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
64 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
65 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
66 INT9076 Regulation of Gene_expression of Tbxa2r 7 0.61 1.16 1.92
67 INT84595 Negative_regulation of Aqp2 11 0.58 4.88 1.78
68 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
69 INT164480 Negative_regulation of Gene_expression of Aqp4 14 0.58 10.84 1.52
70 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
71 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
72 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
73 INT155345 Negative_regulation of Phosphorylation of Aqp4 1 0.43 2.86 1.37
74 INT90491 Binding of Igf1 25 0.44 9.75 1.36
75 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
76 INT152964 Regulation of Gene_expression of Aqp4 3 0.56 4.18 1.34
77 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
78 INT79557 Localization of Aqp2 5 0.73 2 1.13
79 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
80 INT28212 Regulation of Localization of Tbxa2r 2 0.01 0.49 1.09
81 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
82 INT202378 Transcription of Aqp4 5 0.65 1.7 1.02
83 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
84 INT84597 Transcription of Aqp2 3 0.55 2.11 0.98
85 INT84598 Regulation of Aqp2 13 0.45 4.28 0.86
86 INT108348 Positive_regulation of Aqp2 10 0.68 4.94 0.82
87 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
88 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
89 INT235953 Regulation of Binding of Aqp4 4 0.45 4.4 0.76
90 INT235951 Positive_regulation of Positive_regulation of Aqp4 4 0.57 5.13 0.75
91 INT149238 Positive_regulation of Gene_expression of Aqp2 5 0.66 3.07 0.73
92 INT28211 Positive_regulation of Localization of Tbxa2r 4 0.44 1.73 0.7
93 INT202374 Negative_regulation of Transcription of Aqp4 2 0.37 1.34 0.69
94 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
95 INT61506 Localization of Ghrhr 1 0.51 0 0.61
96 INT84596 Negative_regulation of Gene_expression of Aqp2 3 0.58 8.49 0.6
97 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
98 INT84594 Negative_regulation of Transcription of Aqp2 1 0.43 0 0.59
99 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
100 INT131609 Binding of Tbxa2r 3 0.24 1.33 0.55
101 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
102 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
103 INT35872 Negative_regulation of Localization of Tbxa2r 5 0.56 1.38 0.52
104 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
105 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
106 INT110914 Negative_regulation of Protein_catabolism of Tbxa2r 1 0.00 0.28 0.42
107 INT110915 Protein_catabolism of Tbxa2r 1 0.01 0.28 0.42
108 INT131608 Negative_regulation of Negative_regulation of Tbxa2r 1 0.33 0 0.42
109 INT149235 Positive_regulation of Transcription of Aqp2 1 0.45 0.72 0.4
110 INT149244 Positive_regulation of Localization of Aqp2 1 0.49 0.72 0.4
111 INT131607 Positive_regulation of Binding of Tbxa2r 1 0.32 0 0.39
112 INT157836 Regulation of Gene_expression of Aqp2 9 0.57 8.37 0.37
113 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
114 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
115 INT299223 Negative_regulation of Transcription of Aqp4 3 0.59 1.36 0.35
116 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
117 INT235950 Regulation of Regulation of Aqp4 1 0.37 1.96 0.34
118 INT79558 Binding of Aqp2 2 0.31 0.25 0.33
119 INT49672 Regulation of Negative_regulation of IGF1 1 0.21 1.07 0.33
120 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
121 INT169405 Negative_regulation of Phosphorylation of IGF1 1 0.07 0.15 0.32
122 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
123 INT247863 Positive_regulation of Negative_regulation of Aqp4 3 0.45 2.63 0.25
124 INT235946 Positive_regulation of Localization of Aqp4 1 0.41 1.32 0.25
125 INT247870 Negative_regulation of Localization of Aqp4 3 0.43 2 0.24
126 INT283108 Regulation of Localization of Aqp4 1 0.41 0.44 0.23
127 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
128 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22
129 INT235947 Regulation of Localization of Aqp4 1 0.37 1.25 0.22
130 INT104568 Negative_regulation of Localization of Aqp1 1 0.36 2.47 0.2
131 INT70493 Positive_regulation of Negative_regulation of Tbxa2r 1 0.02 0.07 0.19
132 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
133 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18
134 INT159640 Negative_regulation of Regulation of Aqp4 1 0.42 0.78 0.18
135 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17
136 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
137 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
138 INT98625 Regulation of Aqp1 1 0.27 0.1 0.17
139 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
140 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
141 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
142 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
143 INT38920 Positive_regulation of Positive_regulation of Tbxa2r 1 0.01 0.25 0.13
144 INT332570 Phosphorylation of Aqp4 1 0.59 0.9 0.13
145 INT212553 Negative_regulation of Transcription of IGF1 1 0.39 0.3 0.12
146 INT48615 Positive_regulation of Binding of IGF1 5 0.50 0.54 0.11
147 INT327825 Positive_regulation of Binding of Aqp4 1 0.42 1.5 0.11
148 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
149 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1
150 INT262892 Gene_expression of Ghrhr 1 0.20 1.93 0.1
151 INT157832 Phosphorylation of Aqp2 2 0.77 2.04 0.08
152 INT327827 Negative_regulation of Gene_expression of Aqp1 1 0.45 0.8 0.08
153 INT318819 Positive_regulation of Transcription of IGF1 1 0.33 1.94 0.07
154 INT262510 Regulation of Gene_expression of Aqp1 1 0.33 1.18 0.07
155 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
156 INT202238 Regulation of Transcription of IGF1 1 0.38 0 0.06
157 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
158 INT293110 Positive_regulation of Phosphorylation of Aqp2 1 0.47 1.39 0.05
159 INT293105 Positive_regulation of Positive_regulation of Aqp2 1 0.47 0.72 0.03
160 INT235949 Regulation of Positive_regulation of Aqp4 1 0.37 0 0.03
161 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
162 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0
163 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
164 INT202239 Negative_regulation of Negative_regulation of IGF1 2 0.39 0.53 0
165 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
166 INT262504 Positive_regulation of Aqp1 1 0.25 0.43 0
167 INT202372 Positive_regulation of Transcription of Aqp4 1 0.28 0.07 0
168 INT157833 Negative_regulation of Negative_regulation of Aqp2 1 0.36 0 0
169 INT262513 Negative_regulation of Binding of Aqp1 1 0.23 0.64 0
170 INT247864 Positive_regulation of Protein_catabolism of Aqp4 1 0.45 0.41 0
171 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
172 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
173 INT283116 Regulation of Negative_regulation of Aqp4 1 0.41 0.32 0
174 INT341042 Positive_regulation of Protein_catabolism of Aqp2 1 0.34 0.07 0
175 INT262891 Positive_regulation of Ghrhr 1 0.15 0.33 0
176 INT262514 Binding of Aqp1 1 0.20 0.64 0
177 INT242407 Negative_regulation of Positive_regulation of Aqp4 1 0.09 0 0
178 INT341039 Protein_catabolism of Aqp2 1 0.47 0.06 0
179 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
180 INT274266 Regulation of Positive_regulation of IGF1 1 0.35 0.17 0
181 INT264308 Negative_regulation of Regulation of IGF1 1 0.39 0.23 0
182 INT299193 Transcription of Aqp1 1 0.56 0.62 0
183 INT247880 Protein_catabolism of Aqp4 1 0.64 1.35 0
184 INT262511 Positive_regulation of Gene_expression of Aqp1 1 0.37 1.78 0
185 INT269768 Negative_regulation of Negative_regulation of Igf1 1 0.08 0.96 0
186 INT147064 Protein_catabolism of Aqp4 1 0.94 0 0
187 INT112083 Negative_regulation of Negative_regulation of Igf1 1 0.31 0.22 0
188 INT262512 Localization of Aqp1 1 0.40 0.7 0
189 INT246771 Negative_regulation of Phosphorylation of Igf1 1 0.09 0.37 0
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