GOS:anatomical structure development

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This page displays the top molecular interactions and top single events that were mentioned in the literature for anatomical structure development. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for anatomical structure development. They are ordered first by their pain relevance and then by number of times they were reported for anatomical structure development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to anatomical structure development Documents TM Confidence Disease Relevance Pain Relevance
1 INT140985 Gli3 Regulation of Ihh 1 1 0.29 0.85 0.85
2 INT314203 Nos2 Positive_regulation of Gli3 1 1 0.19 1.27 0.73
3 INT68561 Binding of Gli3 and Ust 1 1 0.01 0.68 0.68
4 INT129270 Binding of Wnt4 and Efs 1 1 0.00 0 0.55
5 INT256629 Binding of Ptch1 and Shh 1 7 0.42 4.22 0.19
6 INT270464 Binding of Shh and Smo 1 1 0.07 1.3 0.08
7 INT290906 Shh Positive_regulation of Egfr 1 1 0.23 0 0.08
8 INT335890 Binding of Dkk1 and Lrp4 1 1 0.37 0.64 0.07
9 INT335886 Binding of Sost and Lrp4 1 1 0.28 0.65 0.07
10 INT298349 HES3 Positive_regulation of Shh 1 1 0.12 0.14 0.07
11 INT298350 HES3 Positive_regulation of HES3 Positive_regulation of Shh 1 1 0.09 0.14 0.07
12 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 1 0.14 0 0.06
13 INT312636 Negative_regulation of Binding of Musk and Lrp4 1 1 0.21 0.32 0.06
14 INT312639 Binding of Musk and Lrp4 1 1 0.23 0.91 0.06
15 INT312632 Binding of Agrn and Lrp4 1 1 0.17 0.32 0.06
16 INT213563 Binding of Ctnnd2 and Shh 1 1 0.27 0.09 0.04
17 INT270459 Binding of Shh and Gli1 1 1 0.02 0.65 0.04
18 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 1 0.29 0.07 0.03
19 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 1 0.31 0.18 0.03
20 INT270462 Shh Positive_regulation of Ccnd1 1 1 0.10 0.6 0.03
21 INT213559 Binding of Egf and Shh 1 1 0.17 0.07 0.03
22 INT290910 Pkm2 Negative_regulation of Shh 1 1 0.07 0.06 0
23 INT314850 Shh Regulation of Atoh7 1 1 0.45 0.22 0
24 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 1 0.12 0 0
25 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 1 0.07 0 0
26 INT290904 Shh Positive_regulation of Prkcg 1 1 0.26 0.06 0
27 INT290900 Prkcg Regulation of Shh 1 1 0.23 0 0
28 INT290944 Shh Positive_regulation of VEGFA 1 1 0.04 0.05 0
29 INT270461 Shh Regulation of Gene_expression of Ptch1 1 1 0.48 0.07 0
30 INT312628 Agrn Positive_regulation of Lrp4 1 1 0.22 0.66 0
31 INT314866 Binding of Six1 and Sall1 1 1 0.39 0.76 0
32 INT270471 Shh Regulation of VEGFA 1 1 0.39 0.08 0
33 INT290898 Shh Positive_regulation of Nos2 1 1 0.46 0.05 0
34 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 1 0.48 0.07 0
35 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 1 0.04 0.08 0
36 INT213556 Binding of Eya1 and Six1 2 1 0.41 0.48 0
37 INT270470 Shh Regulation of Gene_expression of VEGFA 1 1 0.39 0.15 0
38 INT290907 Shh Positive_regulation of Ntn1 1 1 0.32 0.05 0
39 INT270469 Shh Positive_regulation of VEGFA 1 1 0.29 0.12 0
40 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 1 0.44 0.08 0
41 INT264737 Hes1 Regulation of Shh 1 1 0.19 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for anatomical structure development. They are ordered first by their pain relevance and then by number of times they were reported in anatomical structure development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
2 INT114295 Gene_expression of Gli2 10 0.54 7.58 2.95
3 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
4 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
5 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
6 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
7 INT140245 Binding of Gli3 3 0.36 2.65 1.46
8 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
9 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
10 INT177347 Positive_regulation of Gene_expression of Gli2 3 0.25 2.61 0.69
11 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
12 INT135062 Transcription of Gli3 1 0.05 0 0.52
13 INT156254 Gene_expression of Six1 7 0.67 1.52 0.51
14 INT206484 Localization of Shh 2 0.75 1.14 0.46
15 INT114291 Negative_regulation of Gene_expression of Gli2 1 0.01 0.99 0.45
16 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
17 INT177349 Regulation of Gene_expression of Gli2 1 0.01 0.65 0.4
18 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
19 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38
20 INT38582 Binding of Wnt4 1 0.00 0.11 0.28
21 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
22 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
23 INT335874 Regulation of Lrp4 1 0.18 0 0.23
24 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21
25 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
26 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
27 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
28 INT253190 Localization of Shh 2 0.77 1.06 0.13
29 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
30 INT254428 Binding of Lrp4 4 0.44 1.52 0.11
31 INT270451 Localization of Gli3 1 0.26 0.63 0.11
32 INT143830 Gene_expression of Barx1 1 0.23 0.91 0.09
33 INT270442 Transcription of Shh 1 0.53 0.25 0.09
34 INT143832 Positive_regulation of Barx1 1 0.19 0.86 0.09
35 INT143831 Negative_regulation of Barx1 1 0.16 0.91 0.09
36 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
37 INT213515 Binding of Shh 8 0.37 1.92 0.08
38 INT270453 Regulation of Shh 1 0.27 0.83 0.08
39 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
40 INT256862 Regulation of Shh 1 0.25 0 0.07
41 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
42 INT208924 Gene_expression of Eya1 1 0.34 0.33 0.05
43 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
44 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
45 INT253181 Transcription of Shh 1 0.68 0.54 0.03
46 INT312607 Regulation of Binding of Lrp4 1 0.19 0.28 0
47 INT311627 Regulation of Barx1 1 0.56 0.88 0
48 INT213510 Localization of Eya1 1 0.65 0 0
49 INT203578 Localization of RPS19 1 0.32 0.32 0
50 INT312610 Positive_regulation of Lrp4 1 0.21 0.66 0
51 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
52 INT205585 Regulation of Wnt4 1 0.45 0.7 0
53 INT117892 Negative_regulation of LRP4 1 0.37 0.79 0
54 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0
55 INT213525 Regulation of Localization of Eya1 1 0.39 0 0
56 INT213526 Gene_expression of Six4 1 0.58 0.42 0
57 INT290929 Binding of Shh 1 0.31 0.1 0
58 INT205581 Regulation of Negative_regulation of Wnt4 1 0.27 0.7 0
59 INT304336 Gene_expression of Otx2 1 0.45 0 0
60 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
61 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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