GOS:anatomical structure formation involved in morphogenesis

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This page displays the top molecular interactions and top single events that were mentioned in the literature for anatomical structure formation involved in morphog. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for anatomical structure formation involved in morphog. They are ordered first by their pain relevance and then by number of times they were reported for anatomical structure formation involved in morphog. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Disease Relevance TM Confidence Documents Genes linked to anatomical structure formation involved in morphog Pain Relevance
1 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 0 0.35 1 1 1.04
2 INT165941 Bmp7 Positive_regulation of Penk 0.43 0.28 1 1 0.95
3 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 0 0.55 1 1 0.95
4 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 0.43 0.29 1 1 0.95
5 INT140985 Gli3 Regulation of Ihh 0.85 0.29 1 1 0.85
6 INT64067 Tp63 Negative_regulation of Localization of Gh1 0.07 0.08 1 2 0.76
7 INT64070 Tp63 Regulation of Ghrh 0.06 0.04 1 2 0.69
8 INT64068 Tp63 Regulation of Fdft1 0.06 0.00 1 2 0.69
9 INT68561 Binding of Gli3 and Ust 0.68 0.01 1 1 0.68
10 INT13077 Tac2 Positive_regulation of NKX2-1 0 0.00 1 1 0.39
11 INT353391 Binding of DRD4 and GRB2 0.62 0.37 1 1 0.37
12 INT318323 Binding of GRB2 and HSPA5 0.28 0.34 1 1 0.31
13 INT300752 GATA3 Regulation of Hand2 0.06 0.01 1 1 0.3
14 INT342164 Binding of Csf2 and Nkx2-1 0.52 0.01 1 1 0.26
15 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 0.69 0.23 1 1 0.25
16 INT317775 GATA3 Positive_regulation of HDAC1 0.69 0.23 1 1 0.25
17 INT118461 Bmp7 Positive_regulation of Th 0.06 0.31 1 1 0.25
18 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 0.51 0.06 1 1 0.2
19 INT291346 IL8 Positive_regulation of Binding of EGFR and GRB2 1.17 0.15 1 1 0.2
20 INT256629 Binding of Ptch1 and Shh 4.22 0.42 7 1 0.19
21 INT194829 Gata3 Positive_regulation of IL13 0.12 0.01 1 1 0.15
22 INT194835 Gata3 Positive_regulation of IL5 0.12 0.01 1 1 0.15
23 INT194833 Binding of IL5 and Gata3 0.12 0.01 1 1 0.15
24 INT213551 Proc Regulation of Bmp7 0.15 0.00 1 1 0.14
25 INT88410 BMP7 Negative_regulation of CDK2 0 0.35 1 1 0.14
26 INT338428 Il4 Positive_regulation of Gata3 0.75 0.06 1 1 0.13
27 INT280484 Bdnf Positive_regulation of Gene_expression of Lhx1 1.49 0.48 1 2 0.11
28 INT309371 Lhx1 Positive_regulation of Gene_expression of Pax2 0.07 0.08 1 2 0.11
29 INT191184 Binding of EGFR and GRB2 1.06 0.35 7 1 0.1
30 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 0.31 0.26 1 1 0.08
31 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 0.31 0.37 1 1 0.08
32 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 0.31 0.24 1 1 0.08
33 INT270464 Binding of Shh and Smo 1.3 0.07 1 1 0.08
34 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 0.31 0.25 1 1 0.08
35 INT290906 Shh Positive_regulation of Egfr 0 0.23 1 1 0.08
36 INT201173 Sox2 Positive_regulation of Localization of Ryr2 0.9 0.40 1 1 0.07
37 INT129627 Bmp7 Positive_regulation of Id2 0.25 0.24 1 1 0.07
38 INT129626 Bmp7 Positive_regulation of Id3 0.25 0.25 1 1 0.07
39 INT298349 HES3 Positive_regulation of Shh 0.14 0.12 1 1 0.07
40 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 0 0.14 1 1 0.06
41 INT201973 Bmp7 Positive_regulation of ap 0.18 0.00 1 1 0.06
42 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 0.07 0.35 1 1 0.05
43 INT73194 GRB2 Positive_regulation of Positive_regulation of PLCG2 0.81 0.19 1 1 0.05
44 INT235640 Binding of GATA3 and Mrgpre 0.8 0.01 1 1 0.04
45 INT352014 Shh Positive_regulation of Gene_expression of Pax1 0.07 0.29 1 1 0.03
46 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 0.12 0.14 1 1 0.03
47 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 0.18 0.31 1 1 0.03
48 INT270462 Shh Positive_regulation of Ccnd1 0.6 0.10 1 1 0.03
49 INT213559 Binding of Egf and Shh 0.07 0.17 1 1 0.03
50 INT348532 TP63 Positive_regulation of CASP3 0.55 0.04 1 1 0
51 INT262169 Binding of Foxa2 and Nr1i2 0.33 0.17 1 1 0
52 INT292882 Binding of S100A12 and TP63 0.51 0.06 1 1 0
53 INT290910 Pkm2 Negative_regulation of Shh 0.06 0.07 1 1 0
54 INT225909 Binding of GRB2 and SOS1 0.11 0.01 1 1 0
55 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 0.22 0.10 1 1 0
56 INT314850 Shh Regulation of Atoh7 0.22 0.45 1 1 0
57 INT290908 Regulation of Shh Positive_regulation of Ntn1 0 0.12 1 1 0
58 INT225905 Binding of GRB2 and SHC1 0 0.00 1 1 0
59 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 0 0.07 1 1 0
60 INT290904 Shh Positive_regulation of Prkcg 0.06 0.26 1 1 0
61 INT290900 Prkcg Regulation of Shh 0 0.23 1 1 0
62 INT191183 Binding of GRB2 and RECQL5 0.17 0.37 1 1 0
63 INT225906 Binding of GAB1 and GRB2 0.27 0.01 1 1 0
64 INT331611 NKX2-1 Regulation of Transcription of SFTPB 0.49 0.01 1 1 0
65 INT348540 TP63 Positive_regulation of CASP8 0.55 0.03 1 1 0
66 INT235647 TP63 Regulation of EPHA2 0.97 0.15 1 1 0
67 INT275974 Binding of Grb2 and Lat 0 0.33 1 1 0
68 INT290944 Shh Positive_regulation of VEGFA 0.05 0.04 1 1 0
69 INT270461 Shh Regulation of Gene_expression of Ptch1 0.07 0.48 1 1 0
70 INT275975 Grb2 Positive_regulation of Lcp2 0 0.24 1 1 0
71 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 0.07 0.09 1 1 0
72 INT303334 Binding of SOS1 and Grb2 0.11 0.00 1 1 0
73 INT269954 Sox17 Regulation of Gene_expression of Foxa2 0 0.43 1 1 0
74 INT196038 Gene_expression of Bmp7 Positive_regulation of ALPP 0.1 0.03 1 1 0
75 INT269933 Foxa2 Regulation of Gene_expression of Foxj1 0 0.27 1 1 0
76 INT185453 Binding of PRKCB and Lhx1 1.99 0.35 1 2 0
77 INT244857 Lbx1 Positive_regulation of Lhx1 0 0.37 1 2 0
78 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 0.08 0.09 1 1 0
79 INT171394 Binding of Grb2 and Shc1 0 0.05 1 1 0
80 INT235646 TP63 Regulation of EFNA1 0.97 0.09 1 1 0
81 INT280546 Binding of KIT and TP63 1.19 0.01 1 1 0
82 INT275979 Binding of Grb2 and Lcp2 0 0.23 1 1 0
83 INT270471 Shh Regulation of VEGFA 0.08 0.39 1 1 0
84 INT139032 Binding of Oprm1 and Tp63 0.05 0.25 1 2 0
85 INT290898 Shh Positive_regulation of Nos2 0.05 0.46 1 1 0
86 INT323500 Ghrl Positive_regulation of Grb2 0.5 0.13 1 1 0
87 INT88409 BMP7 Positive_regulation of Gene_expression of ACTA1 0 0.09 1 1 0
88 INT179699 LPCAT3 Regulation of LHX2 0.31 0.00 1 1 0
89 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1.55 0.00 1 1 0
90 INT270466 Ptch1 Regulation of Gene_expression of Shh 0.07 0.48 1 1 0
91 INT348536 Positive_regulation of TP63 Positive_regulation of Gene_expression of CASP9 0.55 0.02 1 1 0
92 INT196022 Bmp7 Regulation of Bmp4 0.06 0.06 1 2 0
93 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 0.08 0.04 1 1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for anatomical structure formation involved in morphog. They are ordered first by their pain relevance and then by number of times they were reported in anatomical structure formation involved in morphog. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Disease Relevance TM Confidence Documents Pain Relevance
1 INT111476 Gene_expression of TP63 61.08 0.76 88 11.64
2 INT116011 Positive_regulation of Gata3 3.17 0.31 5 4.21
3 INT202417 Gene_expression of Gata3 7.84 0.61 16 4.12
4 INT141148 Gene_expression of BMP7 14.34 0.71 24 3.44
5 INT12844 Binding of TP63 10.57 0.47 15 3.38
6 INT100295 Gene_expression of Bmp7 14.34 0.78 27 3.3
7 INT114295 Gene_expression of Gli2 7.58 0.54 10 2.95
8 INT133080 Gene_expression of GATA3 5.64 0.61 15 2.89
9 INT126581 Positive_regulation of Gli3 1.59 0.35 6 2.48
10 INT158442 Gene_expression of Nkx2-1 8.47 0.59 21 1.99
11 INT193823 Positive_regulation of Gene_expression of TP63 7.74 0.18 7 1.57
12 INT116014 Transcription of Gata3 2.24 0.63 4 1.46
13 INT140245 Binding of Gli3 2.65 0.36 3 1.46
14 INT116015 Regulation of Gata3 1.41 0.22 3 1.42
15 INT116008 Binding of Gata3 1.37 0.34 2 1.41
16 INT165538 Binding of Bmp7 1.87 0.37 5 1.39
17 INT287241 Positive_regulation of BMP7 2.68 0.43 10 1.38
18 INT237620 Binding of Nodal 0.4 0.12 1 1.36
19 INT116016 Positive_regulation of Positive_regulation of Gata3 0.5 0.21 2 1.28
20 INT355352 Gene_expression of NOG 24.11 0.36 1 1.23
21 INT253191 Positive_regulation of Gene_expression of Shh 2.57 0.66 2 1.14
22 INT278117 Negative_regulation of TP63 3.38 0.32 5 1.13
23 INT133079 Positive_regulation of Gene_expression of GATA3 1.03 0.50 3 1.11
24 INT165530 Positive_regulation of Shh 1.21 0.69 4 1.05
25 INT15040 Gene_expression of NKX2-1 3.95 0.65 8 1.02
26 INT44293 Regulation of TP63 2.88 0.24 6 0.76
27 INT141150 Localization of BMP7 2.84 0.56 4 0.76
28 INT15039 Negative_regulation of NKX2-1 0 0.21 3 0.72
29 INT355345 Localization of NOG 16.14 0.37 1 0.71
30 INT116012 Regulation of Positive_regulation of Gata3 0.07 0.20 1 0.71
31 INT116006 Positive_regulation of Transcription of Gata3 0.07 0.21 1 0.7
32 INT116010 Positive_regulation of Binding of Gata3 0.07 0.31 1 0.7
33 INT121609 Positive_regulation of Nog 0.1 0.49 1 0.69
34 INT68560 Regulation of Gli3 1.51 0.18 3 0.68
35 INT202416 Negative_regulation of Gata3 1.17 0.32 2 0.64
36 INT185244 Gene_expression of Sox2 4.71 0.65 27 0.61
37 INT100294 Positive_regulation of Gene_expression of Bmp7 5.41 0.46 8 0.61
38 INT89126 Regulation of BMP7 2.5 0.45 7 0.58
39 INT226481 Negative_regulation of Gene_expression of GATA3 1.41 0.06 1 0.57
40 INT144053 Transcription of GATA3 0.89 0.67 1 0.54
41 INT165537 Negative_regulation of Bmp7 0.55 0.43 2 0.52
42 INT135062 Transcription of Gli3 0 0.05 1 0.52
43 INT306741 Positive_regulation of Positive_regulation of TP63 1.16 0.05 2 0.49
44 INT237623 Localization of Nodal 0.25 0.25 1 0.48
45 INT278121 Negative_regulation of Negative_regulation of TP63 0 0.03 1 0.48
46 INT129620 Regulation of Gene_expression of Bmp7 3.2 0.42 3 0.47
47 INT299799 Negative_regulation of Negative_regulation of GATA3 1.32 0.09 1 0.47
48 INT206484 Localization of Shh 1.14 0.75 2 0.46
49 INT114291 Negative_regulation of Gene_expression of Gli2 0.99 0.01 1 0.45
50 INT142124 Binding of Bmp4 0.46 0.35 1 0.45
51 INT232798 Positive_regulation of Gene_expression of Shh 1.49 0.70 7 0.44
52 INT185255 Positive_regulation of Sox2 1.22 0.26 3 0.42
53 INT180688 Transcription of Bmp4 0.35 0.58 3 0.41
54 INT118460 Binding of Bmp7 1.3 0.46 3 0.4
55 INT177349 Regulation of Gene_expression of Gli2 0.65 0.01 1 0.4
56 INT208559 Negative_regulation of Gene_expression of Shh 1.58 0.43 8 0.38
57 INT355353 Binding of NOG 2.33 0.17 1 0.38
58 INT114740 Binding of GRB2 2.24 0.36 8 0.37
59 INT355346 Negative_regulation of Gene_expression of NOG 5.87 0.20 1 0.33
60 INT191211 Gene_expression of GRB2 0.96 0.62 5 0.32
61 INT196032 Positive_regulation of Gene_expression of Bmp7 1.31 0.17 10 0.31
62 INT185428 Gene_expression of Lhx1 2.6 0.75 4 0.28
63 INT232795 Positive_regulation of Shh 3.68 0.70 2 0.26
64 INT240034 Phosphorylation of GRB2 1.79 0.79 3 0.25
65 INT237630 Protein_catabolism of Nodal 0.08 0.22 1 0.22
66 INT355348 Transcription of NOG 1.71 0.33 1 0.22
67 INT294169 Gene_expression of Trp63 1.22 0.59 8 0.2
68 INT304145 Phosphorylation of Grb2 0.72 0.03 1 0.2
69 INT135060 Negative_regulation of Transcription of Gli3 0 0.03 1 0.19
70 INT120085 Negative_regulation of Gene_expression of Bmp4 0.61 0.55 5 0.17
71 INT185427 Negative_regulation of Lhx1 3.48 0.42 4 0.17
72 INT339267 Negative_regulation of BMP7 0.55 0.43 1 0.17
73 INT232799 Regulation of Gene_expression of Shh 1.04 0.27 3 0.16
74 INT253177 Negative_regulation of Gene_expression of Shh 0.63 0.55 2 0.16
75 INT139201 Localization of TP63 2.56 0.32 4 0.15
76 INT294867 Gene_expression of Sox2 0.43 0.21 4 0.15
77 INT118459 Regulation of Bmp7 0.25 0.43 3 0.15
78 INT230637 Gene_expression of HOXB1 0.06 0.57 1 0.15
79 INT201968 Positive_regulation of Bmp7 1.11 0.43 2 0.14
80 INT256864 Gene_expression of Tp63 0.47 0.14 1 0.14
81 INT253190 Localization of Shh 1.06 0.77 2 0.13
82 INT24324 Regulation of NKX2-1 0.1 0.03 1 0.13
83 INT253183 Negative_regulation of Shh 2.13 0.55 8 0.12
84 INT194746 Phosphorylation of Gata3 0.08 0.10 1 0.12
85 INT190068 Positive_regulation of Gata3 0.13 0.25 1 0.12
86 INT190071 Positive_regulation of Positive_regulation of Gata3 0.13 0.18 1 0.12
87 INT201144 Regulation of Gene_expression of Sox2 0.82 0.44 3 0.11
88 INT351385 Gene_expression of Wnt3 0.84 0.28 1 0.11
89 INT270451 Localization of Gli3 0.63 0.26 1 0.11
90 INT208645 Gene_expression of DLX5 0.28 0.58 1 0.1
91 INT196033 Negative_regulation of Gene_expression of Bmp4 0.45 0.21 3 0.09
92 INT355351 Positive_regulation of Localization of NOG 1.11 0.23 1 0.09
93 INT355349 Regulation of NOG 4.23 0.21 1 0.09
94 INT270442 Transcription of Shh 0.25 0.53 1 0.09
95 INT270453 Regulation of Shh 0.83 0.27 1 0.08
96 INT126375 Negative_regulation of Gene_expression of Gli3 0.79 0.58 1 0.08
97 INT256854 Regulation of Tp63 0.06 0.06 1 0.08
98 INT316570 Binding of BMP7 0.95 0.37 3 0.07
99 INT136890 Protein_catabolism of TP63 1.17 0.56 2 0.07
100 INT287244 Transcription of BMP7 0.15 0.66 1 0.07
101 INT355358 Positive_regulation of Gene_expression of NOG 5.75 0.20 1 0.07
102 INT256862 Regulation of Shh 0 0.25 1 0.07
103 INT355354 Negative_regulation of Transcription of NOG 0.49 0.23 1 0.07
104 INT355356 Positive_regulation of Transcription of NOG 0.32 0.32 1 0.06
105 INT355342 Negative_regulation of Localization of NOG 1.49 0.23 1 0.06
106 INT270445 Positive_regulation of Localization of Shh 0.13 0.44 1 0.05
107 INT185260 Positive_regulation of Positive_regulation of Sox2 0 0.15 1 0.05
108 INT196030 Positive_regulation of Bmp4 2.55 0.62 6 0.04
109 INT197017 Binding of GATA3 0.94 0.36 2 0.04
110 INT208560 Negative_regulation of Shh 2.22 0.59 2 0.04
111 INT213528 Negative_regulation of Gene_expression of Sox2 0.07 0.30 1 0.04
112 INT185429 Regulation of Lhx1 1.33 0.12 1 0.04
113 INT210238 Positive_regulation of Negative_regulation of Bmp4 0 0.47 1 0.04
114 INT217080 Gene_expression of Hoxa1 0.17 0.71 1 0.04
115 INT217103 Positive_regulation of Gene_expression of Hoxa1 0.17 0.63 1 0.04
116 INT253182 Positive_regulation of Positive_regulation of Bmp4 0.58 0.45 1 0.04
117 INT201965 Transcription of Bmp7 0.93 0.49 2 0.03
118 INT306559 Negative_regulation of Nog 0.08 0.42 1 0.03
119 INT253187 Negative_regulation of Transcription of Shh 0.55 0.41 1 0.03
120 INT294473 Gene_expression of GLI3 0.63 0.37 1 0.03
121 INT253181 Transcription of Shh 0.54 0.68 1 0.03
122 INT275931 Binding of Grb2 0 0.26 5 0
123 INT196034 Positive_regulation of Gene_expression of Bmp4 0.63 0.45 4 0
124 INT260779 Negative_regulation of Bmp4 0.94 0.23 4 0
125 INT201142 Negative_regulation of Sox2 0.59 0.57 4 0
126 INT209451 Regulation of Gene_expression of TP63 4.32 0.16 3 0
127 INT201141 Binding of Sox2 0.53 0.36 3 0
128 INT133629 Binding of GLI3 0 0.17 2 0
129 INT196027 Binding of Bmp4 0.97 0.13 2 0
130 INT142119 Regulation of Bmp4 0.29 0.58 2 0
131 INT311635 Negative_regulation of Gene_expression of Dlx6 0.23 0.39 1 0
132 INT185426 Binding of Lhx1 1.96 0.36 1 0
133 INT223596 Positive_regulation of Gene_expression of GRB2 0.51 0.03 1 0
134 INT260766 Negative_regulation of Gene_expression of Bmp7 0 0.35 1 0
135 INT311629 Negative_regulation of Gene_expression of Dlx5 0.42 0.39 1 0
136 INT221439 Regulation of GLI3 0.16 0.03 1 0
137 INT201591 Regulation of Grb2 1.18 0.20 1 0
138 INT242099 Binding of Nkx2-1 1.15 0.02 1 0
139 INT339667 Localization of Bmp4 0.27 0.38 1 0
140 INT201963 Positive_regulation of Binding of Bmp7 0 0.05 1 0
141 INT239582 Gene_expression of LHX2 0.39 0.03 1 0
142 INT275959 Localization of Grb2 0 0.51 1 0
143 INT314125 Regulation of Transcription of Bmp7 0.88 0.25 1 0
144 INT294866 Negative_regulation of Sox2 0.43 0.04 1 0
145 INT275932 Gene_expression of Grb2 0 0.53 1 0
146 INT235637 Localization of GATA3 0.55 0.73 1 0
147 INT201146 Negative_regulation of Binding of Sox2 0.28 0.41 1 0
148 INT290918 Negative_regulation of Positive_regulation of Shh 0.25 0.41 1 0
149 INT262045 Phosphorylation of Foxa2 0.08 0.34 1 0
150 INT280555 Regulation of Binding of TP63 0.93 0.12 1 0
151 INT314127 Regulation of Bmp7 0.88 0.25 1 0
152 INT201139 Localization of Sox2 0.15 0.73 1 0
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