GOS:cellular nitrogen compound metabolic process

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This page displays the top molecular interactions and top single events that were mentioned in the literature for cellular nitrogen compound metabolic process. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular nitrogen compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for cellular nitrogen compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to cellular nitrogen compound metabolic process Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 1 52 0.54 8.87 18.3
2 INT10268 Binding of PDYN and POMC 1 11 0.39 0.08 10.36
3 INT29206 Crh Regulation of Localization of POMC 1 4 0.64 0.96 4.68
4 INT113223 POMC Regulation of MC1R 1 6 0.68 0.39 4.24
5 INT29240 Binding of POMC and YY1 1 5 0.40 0.17 4.06
6 INT34220 Binding of POMC and Oprl1 1 4 0.01 0.25 4.05
7 INT24388 CRH Positive_regulation of Localization of POMC 1 8 0.51 5.67 3.35
8 INT7436 CFP Positive_regulation of Binding of POMC and 1 1 0.02 0.18 3.35
9 INT17456 Binding of CSF2 and POMC 1 3 0.32 4.06 3.15
10 INT81708 POMC Regulation of Gene_expression of ITGAM 1 1 0.53 0.72 3.1
11 INT134212 CRH Regulation of Localization of POMC 1 1 0.47 2.89 2.9
12 INT107723 POMC Positive_regulation of MC1R 1 7 0.68 0.71 2.82
13 INT31513 Crh Regulation of POMC 1 3 0.29 5.06 2.78
14 INT29446 Crh Positive_regulation of Localization of POMC 1 8 0.38 1.87 2.58
15 INT51317 Binding of POMC and OR5D2P 1 1 0.00 0.6 2.23
16 INT34310 CRH Positive_regulation of POMC 1 3 0.42 0.62 2.21
17 INT349608 Binding of DIO2 and LMOD1 1 1 0.23 0.41 2.01
18 INT264953 Binding of POMC and TLR4 1 1 0.03 0.89 1.96
19 INT264947 Binding of POMC and TLR2 1 1 0.03 0.89 1.95
20 INT91607 Binding of EDN1 and POMC 1 1 0.12 0 1.9
21 INT13940 DNM2 Regulation of Localization of CGA 1 1 0.11 0 1.86
22 INT57249 GNRH1 Regulation of Regulation of CGA 1 1 0.20 0 1.74
23 INT24817 Binding of POMC and VTN 1 8 0.42 0.39 1.71
24 INT56134 CALCA Positive_regulation of POMC 1 2 0.71 0.72 1.68
25 INT32442 POMC Positive_regulation of POMC Positive_regulation of ELANE 1 1 0.15 0.18 1.66
26 INT86637 POMC Regulation of Gene_expression of KRT16 1 2 0.47 1.22 1.61
27 INT254243 Binding of HOMER1 and MRI1 1 1 0.03 1.99 1.57
28 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 1 0.50 0.34 1.57
29 INT81709 POMC Regulation of Gene_expression of ITGB2 1 1 0.40 0.34 1.57
30 INT81719 POMC Regulation of Gene_expression of ITGAL 1 1 0.35 0.34 1.57
31 INT81712 POMC Regulation of FCGR3B 1 1 0.16 0.34 1.56
32 INT81715 POMC Regulation of ITGB2 1 1 0.40 0.34 1.55
33 INT81721 POMC Regulation of ITGAM 1 1 0.39 0.34 1.55
34 INT81714 POMC Regulation of ITGAL 1 1 0.15 0.34 1.54
35 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 1 2 0.67 0 1.53
36 INT23546 Negative_regulation of CNDP2 Negative_regulation of POMC Positive_regulation of POMC 2 1 0.04 0 1.52
37 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 2 1 0.03 0 1.52
38 INT69709 NPL Positive_regulation of Localization of POMC 1 2 0.36 1.22 1.51
39 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 1 0.03 0 1.51
40 INT40209 TNS3 Regulation of POMC 1 1 0.16 0.27 1.47
41 INT12691 SST Negative_regulation of Localization of POMC 1 3 0.24 1.24 1.45
42 INT154111 POMC Positive_regulation of Localization of PENK 1 1 0.34 0.05 1.41
43 INT154110 PENK Positive_regulation of Localization of POMC 1 1 0.34 0.05 1.41
44 INT154113 POMC Positive_regulation of YY1 1 1 0.70 0.06 1.41
45 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 1 0.13 0.15 1.36
46 INT19633 GNRH1 Regulation of Localization of CGA 1 4 0.44 0.82 1.33
47 INT86636 POMC Positive_regulation of Gene_expression of KRT16 1 2 0.39 0.83 1.28
48 INT48117 GH1 Positive_regulation of CGA 1 1 0.10 0 1.28
49 INT42579 SOD1 Negative_regulation of POMC 1 1 0.16 0.43 1.27
50 INT34052 POMC Regulation of Gene_expression of IFNG 1 1 0.11 0 1.27
51 INT42580 CAT Negative_regulation of POMC 1 1 0.20 0.42 1.26
52 INT46853 POMC Regulation of GAST 1 1 0.11 0.07 1.26
53 INT45269 POMC Negative_regulation of Penk 1 1 0.01 0 1.24
54 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 1 0.58 0.81 1.23
55 INT123453 Binding of POMC and Penk 1 1 0.01 0.31 1.23
56 INT40900 PDYN Regulation of Localization of POMC 1 2 0.07 0.56 1.22
57 INT17601 Binding of POMC and Oprl1 1 1 0.01 0 1.2
58 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 1 0.45 0 1.19
59 INT142075 IL4 Negative_regulation of Binding of IDO1 and 1 1 0.02 2.07 1.19
60 INT142077 TGFB1 Negative_regulation of Binding of IDO1 and 1 1 0.15 2.07 1.19
61 INT43509 Avp Positive_regulation of Localization of POMC 1 2 0.13 1.26 1.16
62 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 1 0.07 1.18 1.16
63 INT106069 TH Positive_regulation of Th 1 1 0.07 0.16 1.14
64 INT13098 POMC Regulation of Localization of CGA 2 1 0.58 0 1.14
65 INT59035 Binding of CPB1 and POMC 1 1 0.00 0 1.12
66 INT102421 POMC Regulation of Gene_expression of Fos 1 1 0.12 0.34 1.11
67 INT29874 OXTR Negative_regulation of POMC 1 1 0.22 0 1.1
68 INT168185 Binding of PLXNA2 and MRI1 1 1 0.25 0.78 1.08
69 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 1 0.42 1.09 1.07
70 INT69874 POMC Negative_regulation of TYRP1 1 1 0.13 0 1.07
71 INT101381 POMC Regulation of Localization of IL8 1 1 0.28 1.49 1.02
72 INT160879 POMC Positive_regulation of DECR1 1 1 0.04 0.08 1.02
73 INT106706 POMC Negative_regulation of Binding of FN1 and 1 1 0.19 0.79 1.02
74 INT79602 Binding of PSMA5 and Oprd1 1 2 0.19 1.05 1.01
75 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 1 0.00 0.27 1
76 INT32327 POMC Positive_regulation of Localization of PRL 1 4 0.45 0 0.99
77 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 1 0.12 1.07 0.99
78 INT38579 Binding of POMC and Hps4 1 1 0.00 0.32 0.99
79 INT1415 Binding of OPRM1 and POMC 1 3 0.16 0.3 0.98
80 INT106707 POMC Regulation of Binding of LAMB2 and 1 1 0.03 0.7 0.94
81 INT20888 POMC Positive_regulation of Localization of PDYN 1 1 0.40 0 0.92
82 INT34457 AGT Positive_regulation of POMC 1 1 0.01 0 0.91
83 INT48113 GH1 Positive_regulation of Localization of CGA 1 1 0.07 0 0.9
84 INT69870 ASIP Negative_regulation of Binding of MC1R and POMC 1 1 0.37 0 0.9
85 INT161916 Binding of POMC and Oprd1 1 1 0.01 0 0.89
86 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 1 0.01 0 0.89
87 INT264944 Binding of POMC and BOC 1 1 0.07 0.44 0.89
88 INT161915 Negative_regulation of Binding of POMC and YY1 1 1 0.33 0 0.88
89 INT59497 Adh1 Regulation of POMC 1 1 0.03 0 0.86
90 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 1 0.12 0.27 0.86
91 INT5451 CRH Regulation of POMC 1 2 0.28 0.39 0.85
92 INT161306 POMC Negative_regulation of Transcription of IL2 1 1 0.24 0.27 0.85
93 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 1 0.54 0.5 0.85
94 INT110236 Hk1 Regulation of CSAD 1 1 0.01 1.57 0.84
95 INT32441 POMC Positive_regulation of ELANE 1 1 0.13 0.09 0.83
96 INT1583 PENK Negative_regulation of Binding of PENK and POMC 1 1 0.08 0 0.83
97 INT1582 Binding of PENK and POMC 1 1 0.16 0 0.83
98 INT79617 Htr1a Positive_regulation of Localization of POMC 1 1 0.38 0 0.83
99 INT12883 Binding of IL2 and POMC 1 1 0.01 0 0.81
100 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 1 0.28 0.82 0.81
101 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 1 0.45 0.39 0.78
102 INT97863 Binding of NOS1 and GRHPR 1 1 0.05 0.23 0.77
103 INT18099 POMC Positive_regulation of Binding of Prl and 1 1 0.00 0 0.76
104 INT113222 POMC Regulation of Gene_expression of MC1R 1 1 0.06 0 0.76
105 INT32163 Binding of CALM1 and POMC 1 4 0.46 0 0.75
106 INT164055 POMC Regulation of Agrp 1 1 0.29 0.3 0.75
107 INT164057 POMC Regulation of Pomc 1 1 0.09 0.3 0.75
108 INT124404 Binding of POMC and Oprm1 1 1 0.00 0.25 0.75
109 INT164056 Agrp Regulation of POMC 1 1 0.29 0.3 0.75
110 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 1 0.00 0 0.74
111 INT113225 POMC Regulation of Transcription of MC1R 1 1 0.03 0 0.74
112 INT31642 POMC Regulation of GCG 1 1 0.41 0.62 0.73
113 INT31643 POMC Regulation of INS 1 1 0.59 0.62 0.73
114 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 1 0.01 0.16 0.73
115 INT26872 ABAT Positive_regulation of Localization of POMC 1 1 0.03 0 0.71
116 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 1 0.49 0.06 0.71
117 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 1 0.31 0 0.7
118 INT12711 POMC Regulation of Prl 1 1 0.04 1.25 0.7
119 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 1 0.24 0.49 0.7
120 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 1 0.38 0 0.7
121 INT102762 Binding of POMC and TYR 1 1 0.12 0.35 0.69
122 INT76655 POMC Positive_regulation of Transcription of Il6 1 1 0.01 0 0.68
123 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 1 0.34 0.33 0.68
124 INT40471 GH1 Positive_regulation of POMC 1 1 0.25 0 0.67
125 INT56308 POMC Negative_regulation of Gene_expression of Il2 1 1 0.01 0.1 0.67
126 INT151252 CSAD Positive_regulation of Positive_regulation of Ltp 1 1 0.06 0.81 0.67
127 INT61798 Binding of NDP and POMC 1 2 0.22 0 0.66
128 INT326586 SLC18A2 Negative_regulation of DDC 1 1 0.28 0.91 0.66
129 INT28079 POMC Regulation of ANPEP 1 1 0.08 0.16 0.66
130 INT151251 CSAD Regulation of Positive_regulation of Ltp 1 1 0.04 0.82 0.65
131 INT28080 POMC Negative_regulation of Gene_expression of ITGAM 1 1 0.00 0.16 0.65
132 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 1 0.06 0.24 0.65
133 INT38820 Binding of MTR and PDYN 1 1 0.03 0.19 0.65
134 INT72146 POMC Positive_regulation of Phosphorylation of MYOT 1 1 0.00 0.25 0.65
135 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 1 0.06 0.24 0.65
136 INT33561 Crh Positive_regulation of POMC 1 3 0.45 1.19 0.64
137 INT23555 POMC Positive_regulation of Penk 1 1 0.56 0 0.63
138 INT23554 POMC Positive_regulation of Localization of Penk 1 1 0.56 0 0.63
139 INT25248 GNRH1 Regulation of CGA 1 4 0.30 1.22 0.62
140 INT11558 POMC Positive_regulation of CASP3 1 1 0.05 0 0.62
141 INT152766 TAT Positive_regulation of Positive_regulation of MYLK 1 1 0.44 0.67 0.61
142 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 1 0.15 1.66 0.61
143 INT144256 CGA Regulation of Gene_expression of NFKB1 1 1 0.21 1.66 0.61
144 INT42269 POMC Negative_regulation of Localization of AVP 1 1 0.09 0 0.61
145 INT47461 PDYN Regulation of POMC 1 1 0.01 0 0.6
146 INT40901 Trf Regulation of Localization of POMC 1 1 0.07 0.56 0.6
147 INT152765 TAT Regulation of Positive_regulation of MYLK 1 1 0.40 0.66 0.6
148 INT13238 POMC Regulation of Gene_expression of IL2 1 1 0.09 0.26 0.59
149 INT130288 POMC Regulation of Gene_expression of VTCN1 1 1 0.01 0.1 0.59
150 INT34311 Regulation of CRH Positive_regulation of POMC 1 1 0.24 0 0.59
151 INT60538 Gnrh1 Positive_regulation of Localization of LHB 1 1 0.00 0.19 0.59
152 INT130287 POMC Regulation of Localization of IL10 1 1 0.12 0.1 0.59
153 INT31640 POMC Regulation of POMC Regulation of GCG 1 1 0.19 0.38 0.58
154 INT37035 PLAT Negative_regulation of ODC1 1 1 0.45 0.15 0.58
155 INT62034 POMC Regulation of Positive_regulation of IL4 1 1 0.44 0 0.58
156 INT35181 Binding of STT3A and POMC 1 1 0.29 0.75 0.57
157 INT93541 Ntsr1 Regulation of POMC 1 1 0.00 0 0.57
158 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 1 0.00 0 0.56
159 INT350169 Binding of DMD and MRI1 1 1 0.11 3.08 0.54
160 INT102422 POMC Regulation of Gene_expression of Sst 1 1 0.14 0.24 0.54
161 INT23486 HBE1 Positive_regulation of Localization of FSHB 1 1 0.03 0 0.54
162 INT56733 Ddc Positive_regulation of Localization of GLUL 1 1 0.00 0 0.54
163 INT5112 DIO2 Positive_regulation of Positive_regulation of Gal 1 1 0.27 0 0.53
164 INT5111 DIO2 Positive_regulation of Drd1a 1 1 0.04 0 0.53
165 INT70244 POMC Positive_regulation of Localization of PLOD1 1 1 0.21 0 0.53
166 INT23483 HBE1 Positive_regulation of FSHB 1 1 0.01 0 0.53
167 INT56390 CCK Positive_regulation of Localization of POMC 1 1 0.14 0.06 0.52
168 INT57248 ELANE Regulation of Gene_expression of CGA 1 1 0.05 0 0.52
169 INT119030 Binding of POMC and Ighg1 1 1 0.06 0 0.52
170 INT18248 Binding of CGA and GNRH1 1 1 0.15 0.92 0.52
171 INT33505 Oprd1 Regulation of Localization of CGA 1 1 0.00 0 0.52
172 INT150243 POMC Positive_regulation of Mc3r 1 1 0.05 0.88 0.52
173 INT150244 POMC Positive_regulation of Mc3r Regulation of POMC 1 1 0.03 0.88 0.52
174 INT261498 CBS Positive_regulation of DSE 1 1 0.00 0 0.5
175 INT55323 GNRH1 Regulation of POMC 1 1 0.35 0 0.49
176 INT179237 Binding of SERPINA6 and POMC 1 1 0.03 1.15 0.49
177 INT48114 GHRH Positive_regulation of Localization of CGB 1 1 0.05 0 0.48
178 INT90252 Binding of PPBP and TAT 1 1 0.39 5.55 0.48
179 INT90262 Binding of TAT and Pf4 1 1 0.03 5.64 0.48
180 INT92802 Binding of PPIG and GRHPR 1 1 0.03 0.11 0.47
181 INT92801 Binding of CYP2B6 and GRHPR 1 1 0.03 0.1 0.47
182 INT117531 Twist1 Regulation of CSAD 1 1 0.00 0.85 0.47
183 INT177784 PDCD2 Positive_regulation of ASNS 1 1 0.04 0.76 0.46
184 INT72088 IL10 Positive_regulation of POMC 1 1 0.15 0 0.46
185 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 1 0.11 0.77 0.46
186 INT72087 IL4 Positive_regulation of POMC 1 1 0.16 0 0.46
187 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 1 0.41 1 0.46
188 INT28081 POMC Regulation of Gene_expression of VIM 1 1 0.13 0.09 0.46
189 INT177780 BUB1B Positive_regulation of ASNS 1 1 0.05 0.76 0.46
190 INT72089 TGFB2 Positive_regulation of POMC 1 1 0.11 0 0.46
191 INT32662 Hps1 Negative_regulation of Localization of CGB 1 1 0.00 0 0.46
192 INT48116 Negative_regulation of GH1 Positive_regulation of CGA 1 1 0.06 0 0.45
193 INT69873 ASIP Negative_regulation of Binding of POMC and 1 1 0.35 0 0.45
194 INT28082 POMC Regulation of PDYN 1 1 0.04 0.09 0.45
195 INT80053 Negative_regulation of Binding of ACAT1 and NA 1 1 0.01 0.25 0.45
196 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 1 0.13 0.79 0.45
197 INT56132 CALCA Positive_regulation of Localization of POMC 1 1 0.51 0.16 0.44
198 INT80052 Binding of ACAT1 and NA 1 1 0.01 0.24 0.44
199 INT100282 TXN Negative_regulation of Transcription of POMC 1 1 0.54 0.39 0.43
200 INT23481 POMC Regulation of Localization of PLOD1 1 1 0.20 0 0.42

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular nitrogen compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in cellular nitrogen compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT738 Regulation of POMC 459 0.62 111.19 243.74
5 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
6 INT695 Binding of POMC 304 0.48 56.66 126.85
7 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
8 INT1793 Localization of CGA 379 0.81 67.38 114.69
9 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
10 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
11 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
12 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
13 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98
14 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
15 INT7035 Regulation of CGA 87 0.45 29.04 28.45
16 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
17 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
18 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68
19 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
20 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
21 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
22 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
23 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
24 INT5372 Localization of LHB 55 0.68 9.47 19
25 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
26 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
27 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
28 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
29 INT13716 Positive_regulation of TH 33 0.68 19.11 16
30 INT1416 Transcription of POMC 40 0.72 10.71 15.38
31 INT11918 Localization of CGB 35 0.51 8.21 15.01
32 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94
33 INT180497 Binding of MRI1 45 0.42 28.35 14.77
34 INT70265 Regulation of MRI1 42 0.39 30.95 14.18
35 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
36 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
37 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23
38 INT9946 Regulation of Localization of LHB 27 0.52 2.47 11.08
39 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18
40 INT31780 Binding of DIO2 17 0.36 10.07 10
41 INT1648 Regulation of LHB 21 0.61 3.32 9.6
42 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96
43 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
44 INT156827 Localization of MRI1 25 0.65 16.06 8.33
45 INT13346 Regulation of Localization of CGB 18 0.30 1.29 8.32
46 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07
47 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
48 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91
49 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47
50 INT98205 Gene_expression of PCBD1 10 0.61 14.78 7.27
51 INT261511 Localization of CBS 1 0.02 5.06 7.27
52 INT321907 Negative_regulation of DAO 1 0.51 9.08 7.07
53 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
54 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
55 INT3506 Localization of TH 12 0.81 0.78 6.66
56 INT142082 Positive_regulation of IDO1 17 0.60 9.46 6.33
57 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14
58 INT138671 Gene_expression of TPH2 35 0.78 7.34 6.03
59 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88
60 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
61 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6
62 INT8866 Positive_regulation of TAT 30 0.67 18.06 5.57
63 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47
64 INT30317 Regulation of TH 14 0.43 7.27 5.38
65 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
66 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31
67 INT95759 Gene_expression of DIO3 5 0.51 2.55 5.28
68 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05
69 INT94095 Negative_regulation of BCAT1 9 0.49 0.97 4.91
70 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81
71 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8
72 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76
73 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
74 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67
75 INT9729 Negative_regulation of LHB 14 0.42 1.86 4.63
76 INT14580 Regulation of Regulation of POMC 8 0.44 1.49 4.63
77 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6
78 INT30444 Negative_regulation of Protein_catabolism of POMC 4 0.51 2.11 4.53
79 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
80 INT27316 Negative_regulation of TPO 7 0.38 7.26 4.42
81 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
82 INT16235 Positive_regulation of CGB 27 0.70 15.71 4.06
83 INT11370 Positive_regulation of LHB 15 0.28 5.45 4.01
84 INT504 Gene_expression of GPT 42 0.75 27.54 3.99
85 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
86 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88
87 INT151427 Gene_expression of ADC 31 0.55 21.86 3.81
88 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66
89 INT200385 Negative_regulation of ADC 19 0.18 16.56 3.6
90 INT4632 Regulation of CGB 9 0.38 1.81 3.53
91 INT4771 Gene_expression of CGB 23 0.67 14.22 3.42
92 INT5400 Positive_regulation of DBH 6 0.70 2.02 3.38
93 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
94 INT124569 Transcription of HPD 6 0.15 1.25 3.32
95 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23
96 INT35009 Binding of CSAD 12 0.41 10.74 3.21
97 INT15837 Binding of CGA 31 0.41 12.06 3.17
98 INT15253 Binding of DBH 7 0.36 3.21 3.17
99 INT9110 Binding of PAH 32 0.41 42.1 3.1
100 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09
101 INT109411 Gene_expression of SAT1 61 0.77 67.99 3.08
102 INT124570 Gene_expression of HPD 14 0.78 6.76 3.07
103 INT30077 Positive_regulation of Localization of CGB 5 0.34 0.42 3.07
104 INT12796 Binding of DLD 20 0.36 6.71 3.02
105 INT137301 Negative_regulation of Gene_expression of TPH1 5 0.12 1.49 2.98
106 INT202577 Localization of DIO2 9 0.56 1.3 2.97
107 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
108 INT11371 Positive_regulation of Localization of LHB 8 0.47 1.4 2.93
109 INT51993 Gene_expression of PSMA5 5 0.75 2.59 2.92
110 INT140547 Negative_regulation of PSMB10 3 0.02 2.33 2.92
111 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91
112 INT16015 Negative_regulation of Localization of LHB 10 0.37 2.95 2.9
113 INT4147 Gene_expression of LHB 8 0.49 3.94 2.88
114 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84
115 INT173336 Gene_expression of GLUL 16 0.27 6.74 2.78
116 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
117 INT7142 Positive_regulation of DLD 22 0.60 7.69 2.76
118 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71
119 INT7976 Regulation of Gene_expression of CGA 8 0.19 1.09 2.71
120 INT1586 Regulation of Binding of POMC 7 0.45 1.14 2.61
121 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
122 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
123 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
124 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53
125 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53
126 INT15606 Localization of FSHB 24 0.78 9.16 2.49
127 INT53447 Negative_regulation of DLD 17 0.54 12.9 2.48
128 INT2695 Regulation of DBH 5 0.45 1.09 2.48
129 INT238712 Positive_regulation of PCBD1 1 0.55 3.49 2.48
130 INT200217 Localization of PAH 10 0.36 15.51 2.46
131 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45
132 INT56918 Negative_regulation of TAT 11 0.57 5.92 2.44
133 INT68367 Negative_regulation of PCBD1 4 0.59 2.8 2.42
134 INT200384 Regulation of ADC 12 0.25 5.46 2.41
135 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35
136 INT138672 Transcription of TPH2 5 0.69 2.99 2.34
137 INT115298 Regulation of Gene_expression of TPH1 1 0.22 2.36 2.33
138 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31
139 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29
140 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
141 INT7034 Regulation of Regulation of CGA 5 0.16 0.17 2.29
142 INT27315 Positive_regulation of TPO 17 0.45 9.84 2.28
143 INT66451 Negative_regulation of ASL 4 0.32 0.14 2.26
144 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
145 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16
146 INT281928 Gene_expression of ARG2 3 0.77 63.17 2.14
147 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12
148 INT49723 Localization of GLUL 5 0.27 0.67 2.1
149 INT61011 Regulation of TPH1 4 0.22 1.17 2.09
150 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02
151 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99
152 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
153 INT66082 Regulation of CSAD 5 0.27 4.72 1.99
154 INT42497 Regulation of Negative_regulation of POMC 4 0.44 0.63 1.99
155 INT243846 Localization of DDC 3 0.63 0.66 1.99
156 INT25952 Negative_regulation of Regulation of POMC 4 0.36 0.76 1.96
157 INT69027 Binding of PSMA5 4 0.47 1.08 1.93
158 INT8785 Gene_expression of ALDH7A1 16 0.75 5.55 1.92
159 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9
160 INT37041 Positive_regulation of ODC1 8 0.70 4.04 1.9
161 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
162 INT22087 Negative_regulation of DBH 3 0.59 1.45 1.84
163 INT77523 Positive_regulation of ADC 14 0.63 13.81 1.81
164 INT3505 Binding of TH 5 0.39 2.6 1.8
165 INT321910 Positive_regulation of DAO 1 0.60 3.96 1.8
166 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79
167 INT41580 Negative_regulation of Negative_regulation of POMC 5 0.50 0.46 1.79
168 INT8556 Positive_regulation of NQO1 12 0.70 5.11 1.78
169 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
170 INT191342 Positive_regulation of Gene_expression of IDO1 4 0.36 3.5 1.75
171 INT22632 Positive_regulation of HDC 2 0.69 2.28 1.75
172 INT142081 Binding of IDO1 4 0.21 2.55 1.73
173 INT122895 Transcription of DIO2 3 0.52 0.91 1.73
174 INT6130 Positive_regulation of Regulation of POMC 6 0.69 3.57 1.7
175 INT138670 Negative_regulation of Gene_expression of TPH2 3 0.42 0.91 1.69
176 INT145545 Transcription of TH 3 0.67 1.48 1.64
177 INT105658 Regulation of PAOX 2 0.00 0.25 1.64
178 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
179 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61
180 INT53451 Regulation of TAT 6 0.44 3.07 1.61
181 INT76633 Regulation of BCAT1 2 0.04 0.79 1.61
182 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59
183 INT40453 Regulation of ODC1 7 0.45 1.08 1.58
184 INT99720 Positive_regulation of SAT1 21 0.69 26.55 1.56
185 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
186 INT43019 Regulation of PHGDH 4 0.26 2.46 1.53
187 INT66450 Binding of ASL 1 0.00 0 1.52
188 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46
189 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46
190 INT292298 Positive_regulation of GOT2 5 0.45 3.7 1.46
191 INT69513 Regulation of PSMA5 2 0.60 1.04 1.43
192 INT146303 Binding of PHGDH 7 0.36 4.7 1.42
193 INT4486 Regulation of TSHB 5 0.28 0.99 1.42
194 INT138673 Regulation of Gene_expression of TPH2 3 0.62 1.23 1.42
195 INT108587 Negative_regulation of PSMA5 1 0.57 1.73 1.42
196 INT10062 Positive_regulation of PSMB5 6 0.45 3.88 1.41
197 INT238709 Binding of PCBD1 1 0.34 2.37 1.41
198 INT255702 Positive_regulation of TPH2 4 0.50 1.43 1.37
199 INT333291 Positive_regulation of Gene_expression of DDC 1 0.49 0.13 1.35
200 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33
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