GOS:enzyme binding

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This page displays the top molecular interactions and top single events that were mentioned in the literature for enzyme binding. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for enzyme binding. They are ordered first by their pain relevance and then by number of times they were reported for enzyme binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to enzyme binding Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 1 2 0.01 5.83 10.21
2 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 1 0.10 3.92 7.2
3 INT188692 Binding of Cd40 and Cd40lg 1 32 0.34 22.95 6.62
4 INT169218 Binding of EGFR and Coc 1 1 0.06 2.8 5.85
5 INT140935 Binding of Cd40lg and Cd40 1 1 0.30 6.34 5.61
6 INT164362 Binding of NLRP1 and VTA1 1 1 0.15 2.37 4.67
7 INT101942 Binding of CD40 and CD40LG 1 16 0.23 15.24 4.01
8 INT317517 Binding of Nos1 and Oprm1 1 1 0.17 0.22 3.85
9 INT220623 Binding of Stat1 and Bace1 2 11 0.25 10.33 3.81
10 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 1 0.34 1.96 3.6
11 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 2 1 0.18 1.57 3.59
12 INT349584 Binding of Cyp2e1 and Aap 2 1 0.10 1.56 3.24
13 INT108810 Esr1 Positive_regulation of Binding of Oprm1 and 1 1 0.51 1.79 3.22
14 INT251146 Binding of Grin1 and Dlg2 1 1 0.36 1.95 3.16
15 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 2 1 0.43 0.4 3.13
16 INT101408 Binding of Grin1 and Olr1469 1 1 0.03 0.86 3.1
17 INT101407 Binding of Grin1 and Spr 1 1 0.14 0.86 3.09
18 INT102284 Binding of Grin1 and Grin2a 1 5 0.27 1.79 3.01
19 INT118158 Binding of Prkca and Prkcz 1 1 0.07 1.14 2.98
20 INT156381 Binding of Grin1 and Dlg4 1 1 0.39 0.86 2.9
21 INT170367 Binding of Grin1 and Grin2a 1 5 0.23 1.72 2.79
22 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 1 2 0.02 0.44 2.79
23 INT317551 Binding of Akt1 and Oprm1 1 1 0.19 0.21 2.74
24 INT349589 Aap Positive_regulation of Cyp2e1 2 1 0.21 1.84 2.71
25 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 1 0.49 0.67 2.69
26 INT150457 Binding of Sort1 and Prss12 2 3 0.21 1.36 2.64
27 INT124547 Trib3 Regulation of Regulation of Th 2 1 0.02 0.79 2.64
28 INT351444 Grin1 Positive_regulation of Gria2 1 1 0.22 1.5 2.64
29 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 1 0.38 0.86 2.63
30 INT251150 Binding of Nos1 and Dlg2 1 1 0.30 1.98 2.62
31 INT356289 Binding of Egfr and Egf 1 1 0.13 3.02 2.52
32 INT317528 Ppp1r9b Regulation of Grin1 1 1 0.18 0.2 2.48
33 INT113715 Msh3 Positive_regulation of tf 1 1 0.11 0 2.47
34 INT147659 Prkce Positive_regulation of TRPV1 1 1 0.04 1.42 2.43
35 INT115367 Binding of IL6 and IL6R 1 12 0.07 8.16 2.36
36 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 1 0.37 1.4 2.34
37 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 2 1 0.23 1.41 2.3
38 INT317524 Binding of Camk2a and Grin1 1 1 0.17 0.06 2.21
39 INT114432 Oprl1 Positive_regulation of Akt1 1 1 0.18 0.08 2.2
40 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 1 0.06 4.35 2.14
41 INT319581 Binding of PIAS1 and TNFSF14 1 1 0.02 1.58 2.13
42 INT66157 Binding of ALB and BDP1 1 1 0.11 0 2.13
43 INT133946 Binding of DNM2 and OPRK1 1 1 0.11 0 2.1
44 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 1 0.33 0.53 2.1
45 INT117821 Binding of Tacr1 and Cd4 2 1 0.34 0.86 2.02
46 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 1 0.02 0.32 2.02
47 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 1 0.14 0.89 1.98
48 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 1 0.28 1.93 1.93
49 INT116815 Binding of Pias1 and Ppbp 1 1 0.36 0.86 1.92
50 INT112514 Binding of Prkaca and Trib3 2 1 0.03 1.18 1.9
51 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 2 3 0.08 1.33 1.89
52 INT169346 Nxn Negative_regulation of Dynll1 1 1 0.06 1.22 1.87
53 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 1 0.06 1.02 1.87
54 INT13940 DNM2 Regulation of Localization of CGA 1 1 0.11 0 1.86
55 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 1 0.63 2.86 1.84
56 INT169468 Binding of Egfr and Spink3 1 1 0.37 3.73 1.83
57 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 1 2 0.48 1.04 1.81
58 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 1 2 0.30 1.36 1.8
59 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 1 0.17 0.23 1.8
60 INT305741 Binding of Kcnk2 and Sort1 1 1 0.54 1.01 1.8
61 INT132229 Binding of Akt1 and Sh2d6 1 1 0.09 0.98 1.8
62 INT150456 Binding of Sort1 and Nts 2 3 0.45 0.64 1.79
63 INT302646 ARSA Positive_regulation of TGFB1 1 1 0.10 0.52 1.76
64 INT104709 Msh3 Positive_regulation of Rbm39 1 1 0.01 0.07 1.76
65 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 1 0.04 0.73 1.75
66 INT167765 Prkca Positive_regulation of Sigmar1 1 1 0.41 0.63 1.74
67 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 1 3 0.38 4.29 1.71
68 INT186433 Trib3 Regulation of Phosphorylation of Creb1 2 1 0.03 0.32 1.71
69 INT169464 Akt1 Positive_regulation of Egfr 2 1 0.28 1.63 1.7
70 INT139433 Binding of Prkaca and Prkca 1 1 0.37 0.13 1.67
71 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 1 0.01 0 1.65
72 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 1 4 0.47 1.01 1.63
73 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 1 0.03 0 1.63
74 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 1 0.12 0 1.62
75 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 1 0.23 0.45 1.62
76 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 1 0.27 0.92 1.62
77 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 1 0.23 0.45 1.61
78 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 1 0.27 0.56 1.58
79 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 1 0.28 0.31 1.58
80 INT315284 PRKG1 Positive_regulation of Nos1 1 1 0.33 0.85 1.56
81 INT148821 Binding of Oprm1 and Grin1 1 1 0.05 0.24 1.55
82 INT118157 Binding of Prkca and Prkcz Positive_regulation of Binding of Prkca Prkcz 1 1 0.02 0.58 1.55
83 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 1 0.22 1.11 1.54
84 INT118159 Binding of Prkca and Prkcz Positive_regulation of Prkcz 1 1 0.02 0.58 1.54
85 INT100784 RYBP Positive_regulation of CYP3A4 1 1 0.44 0 1.54
86 INT118160 Binding of Prkca and Prkcz Positive_regulation of Prkca 1 1 0.11 0.58 1.54
87 INT241750 Binding of CD4 and ITIH4 1 14 0.18 5.72 1.53
88 INT174508 Binding of CD4 and HLA-B 1 1 0.14 4.68 1.53
89 INT166676 Binding of PRKCA and UGT1A6 2 1 0.30 0 1.5
90 INT126718 Binding of Il6 and Il6r 2 3 0.09 2.33 1.49
91 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 1 0.08 1.68 1.49
92 INT136844 Binding of Prkca and Nrgn 1 1 0.33 0 1.47
93 INT140329 Grin1 Negative_regulation of Ltp 1 1 0.04 0.64 1.46
94 INT123899 Binding of CYP3A4 and UGT2B7 1 1 0.52 0 1.46
95 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 2 1 0.06 1.26 1.45
96 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 2 1 0.06 1.26 1.45
97 INT221242 Ros1 Positive_regulation of Prkca 1 1 0.02 0.39 1.44
98 INT214372 Ptprq Positive_regulation of Akt1 1 1 0.04 0.88 1.43
99 INT214369 Pik3cb Positive_regulation of Akt1 1 1 0.56 0.87 1.41
100 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 1 0.24 0.4 1.39
101 INT223156 Il6 Regulation of A2m 2 1 0.11 2.79 1.39
102 INT133933 Binding of DNM2 and TP53INP2 1 1 0.00 0 1.38
103 INT161191 CRX Regulation of Gene_expression of Trib3 2 1 0.00 2 1.38
104 INT50706 Phax Positive_regulation of Localization of Trib3 2 1 0.04 0.28 1.38
105 INT161185 NMS Regulation of Gene_expression of Trib3 2 1 0.03 2 1.38
106 INT158079 Binding of Esr1 and Gper 2 1 0.31 0.97 1.35
107 INT222182 Binding of ESR1 and HLA-DRB2 2 1 0.00 3.1 1.35
108 INT39950 Binding of ALB and PDYN 1 1 0.31 0 1.32
109 INT150890 Binding of Esr1 and Esr2 2 2 0.52 2.06 1.31
110 INT90221 Binding of CYP2D6 and Cyp1a2 1 1 0.03 0.09 1.31
111 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 1 0.14 0 1.31
112 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 2 1 0.38 0.94 1.31
113 INT148778 Binding of Usf1 and Rtn1 1 1 0.40 0.85 1.3
114 INT169297 TRPV1 Positive_regulation of EGFR 1 1 0.64 0.37 1.3
115 INT95406 Trib3 Positive_regulation of Ephb1 2 2 0.08 0.96 1.29
116 INT148775 Binding of Calca and Usf1 1 1 0.43 0.85 1.29
117 INT154203 Binding of Pick1 and Grm7 1 1 0.41 1.64 1.28
118 INT169289 CNR1 Positive_regulation of EGFR 1 1 0.62 0.36 1.28
119 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 1 0.15 1.14 1.27
120 INT317569 Prkca Positive_regulation of Phosphorylation of Src 2 1 0.11 0 1.25
121 INT132465 Ltf Positive_regulation of Nos1 1 1 0.35 0.05 1.24
122 INT249487 Binding of Ephb1 and Src 1 1 0.17 0.74 1.23
123 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 1 0.29 1.24 1.22
124 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 2 1 0.03 0 1.21
125 INT164365 Positive_regulation of Binding of NLRP1 and VTA1 1 1 0.14 0.6 1.21
126 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 2 1 0.03 0 1.21
127 INT228681 Fkbp4 Negative_regulation of Trib3 2 1 0.00 0.57 1.2
128 INT162419 Binding of Abpa and Cftr 2 1 0.04 1.66 1.19
129 INT75483 Binding of SGCG and TGFB1 1 1 0.52 2.27 1.19
130 INT142077 TGFB1 Negative_regulation of Binding of IDO1 and 1 1 0.15 2.07 1.19
131 INT116730 Rac1 Regulation of Localization of Calca 1 1 0.13 1.32 1.19
132 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 1 0.03 2.4 1.18
133 INT228680 Fkbp1a Negative_regulation of Trib3 3 1 0.01 0.56 1.18
134 INT150835 Gper Positive_regulation of Localization of Prkce 2 1 0.15 0.62 1.18
135 INT141246 Trib3 Regulation of Gene_expression of Th 2 1 0.02 0.17 1.17
136 INT111221 MMEL1 Negative_regulation of HMOX1 1 1 0.01 1 1.16
137 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 1 0.10 3.26 1.16
138 INT19535 Binding of ADRA1D and ALB 1 3 0.42 0.8 1.15
139 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 1 0.26 4.75 1.15
140 INT317553 Binding of Car2 and Grin1 1 1 0.07 0 1.14
141 INT348400 LPA Positive_regulation of Trib3 2 1 0.00 0.87 1.14
142 INT139188 Binding of Daxx and Fas 1 1 0.03 0.55 1.14
143 INT69504 Binding of Nos1 and Gatm 1 1 0.05 0 1.13
144 INT332776 FSCN1 Positive_regulation of Grin1 1 1 0.02 0.21 1.12
145 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 1 0.23 0.68 1.12
146 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 1 0.04 0.69 1.12
147 INT202620 Binding of Ppara and Rxra 1 15 0.09 2.63 1.11
148 INT142572 D5Pas1 Negative_regulation of Nos1 1 2 0.02 0.14 1.11
149 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 2 1 0.15 0 1.11
150 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 1 0.17 0.1 1.11
151 INT317527 Binding of Hint1 and Nos1 1 1 0.27 0.1 1.11
152 INT317512 Binding of Oprm1 and Prkca 1 1 0.07 0.13 1.1
153 INT323175 PRKCA Positive_regulation of Akt1 2 1 0.02 0 1.1
154 INT333966 Binding of Il6r and Il6st 2 1 0.01 1.74 1.1
155 INT269191 Binding of Grin1 and Grin3a 1 2 0.32 1.05 1.09
156 INT264988 Binding of CYP2C19 and CYP3A4 2 1 0.18 0.72 1.09
157 INT108547 AKT1 Regulation of MAPKAPK5 1 1 0.04 1.2 1.08
158 INT352453 Calca Positive_regulation of Trib3 2 1 0.00 0.8 1.08
159 INT305734 Binding of Sort1 and Trpv1 1 1 0.01 0.5 1.08
160 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 1 0.04 0.33 1.08
161 INT264987 Binding of CYP2C9 and CYP3A4 1 1 0.19 0.71 1.08
162 INT317561 Binding of Grin1 and Oprm1 1 1 0.14 0.09 1.08
163 INT296458 Binding of Gria2 and Pick1 1 3 0.24 1.86 1.07
164 INT96905 Plxna3 Regulation of Regulation of Prkce 2 1 0.18 0.71 1.07
165 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 1 0.13 0.81 1.07
166 INT77083 Das Negative_regulation of Cyp2e1 1 1 0.20 0.59 1.06
167 INT18828 DNM2 Positive_regulation of Localization of LTB4R 1 1 0.01 0.07 1.06
168 INT317531 Regulation of Binding of Grin1 and Mors1 1 1 0.08 0.06 1.05
169 INT317534 Regulation of Binding of Camk2a and Grin1 1 1 0.20 0.06 1.05
170 INT119887 Binding of Atf4 and Usf1 1 1 0.21 0.15 1.05
171 INT119888 Binding of Creb1 and Usf1 1 1 0.18 0.15 1.05
172 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 1 0.09 1.54 1.05
173 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 1 0.03 0.56 1.05
174 INT317535 Binding of Grin1 and Mors1 1 1 0.07 0.06 1.04
175 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 2 1 0.00 1.05 1.04
176 INT65986 IL1B Positive_regulation of PTGS2 1 3 0.32 2.05 1.03
177 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 1 0.00 0.26 1.03
178 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 1 0.33 0 1.03
179 INT269194 Ceacam3 Positive_regulation of Phosphorylation of Grin1 1 1 0.09 0.55 1.02
180 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 1 0.27 0 1.02
181 INT131889 gr Regulation of Gene_expression of Grin1 1 1 0.02 0 1.01
182 INT119914 Olr1714 Negative_regulation of Nos1 1 1 0.02 0.47 1.01
183 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 1 0.11 1.05 1.01
184 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 1 0.21 0.07 1
185 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 1 0.18 0.07 1
186 INT317518 Src Regulation of Negative_regulation of Oprm1 1 1 0.16 0.07 1
187 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 1 0.21 0.07 1
188 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 1 0.10 0.07 1
189 INT228498 Il10 Negative_regulation of Hand1 1 1 0.03 1.4 0.99
190 INT143915 Src Regulation of Rbm39 1 1 0.03 0.18 0.99
191 INT53750 Cyp2e1 Positive_regulation of RYBP 1 1 0.14 0.44 0.99
192 INT228496 Il4 Negative_regulation of Hand1 1 1 0.02 1.4 0.99
193 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 1 0.30 0.38 0.99
194 INT156510 Nfkb1 Regulation of Positive_regulation of Grin1 1 1 0.03 0.98 0.98
195 INT228495 Il13 Negative_regulation of Hand1 1 1 0.01 1.4 0.98
196 INT73680 KNG1 Positive_regulation of ALB 1 1 0.51 0.38 0.98
197 INT140934 Binding of Cd40 and Ean5 1 1 0.09 1.03 0.98
198 INT156508 Nfkb1 Regulation of Positive_regulation of Grin1 1 1 0.22 0.98 0.98
199 INT69506 CA2 Positive_regulation of PRKCA 1 1 0.50 0.42 0.98
200 INT353372 Dio1 Positive_regulation of Grin1 1 1 0.16 0 0.98

Single Events

The table below shows the top 100 pain related interactions that have been reported for enzyme binding. They are ordered first by their pain relevance and then by number of times they were reported in enzyme binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
2 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
3 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
4 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
5 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
6 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
7 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
8 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
9 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
10 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
11 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
12 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
13 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
14 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
15 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
16 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
17 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
18 INT546 Binding of ALB 311 0.48 85.98 60.14
19 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
20 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
21 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
22 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
23 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
24 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
25 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
26 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
27 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
28 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
29 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
30 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
31 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
32 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
33 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
34 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
35 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
36 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
37 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
38 INT613 Gene_expression of Alb 268 0.78 149.84 42.78
39 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
40 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
41 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
42 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75
43 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
44 INT11246 Binding of Grin1 65 0.48 14.53 36.93
45 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
46 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
47 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45
48 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
49 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
50 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05
51 INT234 Binding of Alb 151 0.48 52.34 32.97
52 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6
53 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
54 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
55 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
56 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
57 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
58 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
59 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
60 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
61 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65
62 INT106540 Negative_regulation of Phosphorylation of Grin1 15 0.58 9.32 29.13
63 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
64 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
65 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
66 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
67 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
68 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
69 INT37296 Binding of Esr1 117 0.43 62.51 27.33
70 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
71 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15
72 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7
73 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
74 INT20462 Binding of ESR1 210 0.44 102.7 26.34
75 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
76 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
77 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
78 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
79 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2
80 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
81 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
82 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
83 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
84 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57
85 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
86 INT7678 Localization of Alb 142 0.81 80.93 22.49
87 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
88 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
89 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
90 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19
91 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
92 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
93 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
94 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7
95 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
96 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
97 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
98 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
99 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
100 INT117527 Binding of Prkca 25 0.48 6.43 21.05
101 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
102 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
103 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
104 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
105 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
106 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53
107 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
108 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35
109 INT50420 Transcription of Grin1 30 0.71 13.21 18.28
110 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
111 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
112 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
113 INT63928 Negative_regulation of Grin1 51 0.56 11.81 17.57
114 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
115 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
116 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
117 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
118 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
119 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
120 INT16624 Localization of Grin1 38 0.79 8.46 17.15
121 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96
122 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
123 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
124 INT88356 Negative_regulation of Positive_regulation of Grin1 16 0.58 4.72 16.58
125 INT164366 Localization of NLRP1 26 0.71 5.9 16.54
126 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43
127 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4
128 INT104045 Regulation of Hand1 65 0.35 51.32 16.26
129 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
130 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
131 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79
132 INT79458 Localization of Prkca 30 0.81 11.13 15.78
133 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
134 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
135 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
136 INT92354 Localization of ESR1 77 0.75 33.04 15.51
137 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
138 INT38253 Localization of Trib3 35 0.63 10.28 15.42
139 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37
140 INT615 Regulation of Alb 66 0.62 33.43 15.33
141 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32
142 INT195414 Gene_expression of ALOX5AP 65 0.72 31.22 15.25
143 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
144 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
145 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
146 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
147 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
148 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
149 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
150 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
151 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
152 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
153 INT92513 Regulation of Grin1 26 0.59 9.12 13.94
154 INT18773 Localization of ALB 117 0.80 69.18 13.8
155 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
156 INT133156 Binding of Cd40 77 0.48 45.92 13.77
157 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76
158 INT27627 Binding of Rac1 41 0.41 22.88 13.68
159 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
160 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
161 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
162 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
163 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
164 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
165 INT20378 Localization of Hand1 53 0.71 41.96 13.31
166 INT2038 Localization of Esr1 104 0.79 40.12 13.27
167 INT59665 Positive_regulation of Ugt1a6 24 0.69 7.24 13.25
168 INT67611 Positive_regulation of Pparg 39 0.69 18.33 13.23
169 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
170 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
171 INT119089 Regulation of Phosphorylation of Grin1 17 0.61 3.1 12.82
172 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
173 INT84307 Binding of Cftr 31 0.47 26.19 12.8
174 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79
175 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75
176 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
177 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
178 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5
179 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
180 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39
181 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
182 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09
183 INT112103 Binding of Grin1 28 0.48 4.21 12.08
184 INT36287 Binding of CD4 96 0.47 58.93 11.88
185 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
186 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
187 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
188 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
189 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
190 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
191 INT80251 Binding of Nos1 21 0.30 8.24 11.31
192 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
193 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
194 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
195 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
196 INT79685 Positive_regulation of Gene_expression of Pparg 17 0.70 14.63 11.03
197 INT52918 Positive_regulation of Prkca 13 0.64 1.67 11
198 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
199 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88
200 INT8801 Gene_expression of Csf3 71 0.74 45.6 10.83
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