GOS:histone binding

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This page displays the top molecular interactions and top single events that were mentioned in the literature for histone binding. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone binding. They are ordered first by their pain relevance and then by number of times they were reported for histone binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to histone binding Documents TM Confidence Disease Relevance Pain Relevance
1 INT275850 Binding of NDUFAB1 and SNCA 1 1 0.00 3.78 3.16
2 INT113337 EPO Positive_regulation of JAK2 1 1 0.76 2.8 1.55
3 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 1 0.08 1.68 1.49
4 INT168865 Cd38 Regulation of Wdtc1 1 1 0.03 0.12 1.35
5 INT90385 EXTL3 Regulation of Ctsl 2 1 0.00 1.1 0.98
6 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 1 0.00 0.66 0.83
7 INT340294 Ea1 Positive_regulation of Sirt1 1 1 0.06 0.53 0.83
8 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 2 1 0.34 0 0.8
9 INT278697 LEF1 Negative_regulation of STAT6 1 1 0.00 0.44 0.78
10 INT134049 Jak2 Positive_regulation of Gsk3b 2 1 0.37 0.22 0.77
11 INT134043 Jak2 Positive_regulation of Akt1 2 1 0.31 0.22 0.76
12 INT134051 Jak2 Positive_regulation of Stat3 2 1 0.44 0.22 0.76
13 INT40134 Binding of Pomc and Noc2l 2 1 0.01 0.08 0.7
14 INT184405 CRP Positive_regulation of Gene_expression of ASF1A 1 1 0.03 1.17 0.49
15 INT263977 PROC Negative_regulation of JAK2 1 1 0.00 0.93 0.47
16 INT134048 Jak2 Regulation of Pik3cb 2 1 0.23 0.13 0.47
17 INT134045 Jak2 Regulation of Stat3 2 1 0.26 0.13 0.47
18 INT134042 Jak2 Regulation of Akt1 2 1 0.18 0.13 0.47
19 INT134046 Jak2 Regulation of Gsk3b 2 1 0.22 0.13 0.47
20 INT134050 Positive_regulation of Jak2 Regulation of Stat3 2 1 0.44 0.13 0.47
21 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 1 0.08 0.15 0.46
22 INT135426 Binding of APBB1 and Dlg4 1 1 0.00 0.17 0.42
23 INT40208 Binding of Eef1a1 and Hils1 1 1 0.01 0.22 0.42
24 INT237414 Binding of Jak2 and Bace1 1 1 0.20 0.77 0.39
25 INT328828 Binding of Jak2 and Jak1 2 1 0.24 0 0.38
26 INT328827 Binding of Jak2 and Il6st 2 1 0.05 0 0.38
27 INT328820 Binding of Il6 and Jak2 2 1 0.09 0 0.38
28 INT303994 Il6 Positive_regulation of JAK2 1 1 0.03 0.41 0.37
29 INT231535 Binding of JAK2 and SOAT1 1 1 0.01 0.3 0.35
30 INT184084 Jak2 Positive_regulation of Stat1 1 1 0.33 0.3 0.33
31 INT243622 Twist1 Regulation of Jak2 1 1 0.30 0.2 0.32
32 INT28688 Binding of Kng1 and Ctsl1 1 1 0.15 0 0.31
33 INT328407 Nlrp1a Negative_regulation of Gene_expression of Snca 2 1 0.07 0.31 0.29
34 INT328410 Nlrp1a Negative_regulation of Snca 2 1 0.07 0.31 0.29
35 INT118842 Negative_regulation of JAK2 Negative_regulation of GNA14 Positive_regulation of STAT3 1 1 0.00 0.08 0.28
36 INT198926 Binding of Apbb1 and Lrp1 1 5 0.12 2.18 0.24
37 INT139050 Negative_regulation of AR Negative_regulation of Phosphorylation of PRKCB 1 1 0.02 0.34 0.23
38 INT223570 Binding of Mri1 and Uhrf2 1 1 0.02 0.56 0.22
39 INT240536 Il12a Positive_regulation of Jak2 1 1 0.10 0.74 0.21
40 INT45934 PKN1 Regulation of NOTCH2NL 1 1 0.01 0 0.2
41 INT45933 PKN1 Regulation of PKN3 1 1 0.05 0 0.2
42 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 1 0.33 0.62 0.17
43 INT317322 Snca Regulation of Positive_regulation of Th 2 1 0.01 0.23 0.17
44 INT190638 Binding of Rab7 and Sirt1 1 1 0.29 0.62 0.17
45 INT119561 TLE4 Negative_regulation of Positive_regulation of CD1D 1 1 0.00 0.68 0.16
46 INT119557 CD1D Positive_regulation of IL4 1 1 0.00 0.67 0.16
47 INT119564 TLE4 Negative_regulation of CD1D Positive_regulation of IL5 1 1 0.00 0.68 0.16
48 INT119558 CD1D Positive_regulation of TNF 1 1 0.00 0.67 0.15
49 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 1 0.32 0.86 0.15
50 INT182480 Binding of Cd1d1 and Cxcr6 1 1 0.27 0.25 0.15
51 INT119563 CD1D Positive_regulation of IL5 1 1 0.01 0.67 0.15
52 INT339116 CNA1 Regulation of RSF1 1 1 0.00 0.3 0.13
53 INT220639 Binding of Apbb1 and Ighd 1 1 0.12 0.31 0.12
54 INT158141 Binding of HOXD13 and SNCA 1 1 0.54 0.41 0.11
55 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 1 0.34 0.19 0.11
56 INT169340 Binding of UGT8 and Jak2 2 1 0.36 0.15 0.11
57 INT328413 Binding of Snca and Nlrp1a 2 1 0.06 0.75 0.1
58 INT213421 Binding of CXCL2 and SET 1 1 0.11 0.17 0.1
59 INT213417 Binding of CCL7 and SET 1 1 0.11 0.17 0.1
60 INT213414 Binding of CXCL1 and SET 1 1 0.10 0.17 0.1
61 INT213415 Binding of CCL8 and SET 1 1 0.11 0.17 0.1
62 INT213420 Binding of IL6 and SET 1 1 0.10 0.17 0.1
63 INT213416 Binding of CCL2 and SET 1 1 0.11 0.17 0.1
64 INT243652 Gk Negative_regulation of Gene_expression of Il12a 1 1 0.01 0 0.09
65 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 1 0.29 0.47 0.09
66 INT83270 Snca Regulation of Napepld 1 1 0.14 0 0.09
67 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 1 0.10 0.96 0.08
68 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 1 0.13 0.43 0.08
69 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 1 0.02 0.43 0.08
70 INT310113 Binding of SET and TP53INP2 1 1 0.15 0.05 0.08
71 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 1 0.03 0.43 0.08
72 INT273374 Binding of JAK2 and STAT3 1 1 0.24 0 0.07
73 INT273368 Negative_regulation of Binding of JAK2 and STAT3 1 1 0.28 0 0.07
74 INT289533 Sirt1 Negative_regulation of Pparg 1 1 0.18 0.42 0.07
75 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 1 0.55 0.21 0.07
76 INT289602 Sirt1 Negative_regulation of PPARG 1 1 0.02 0.37 0.07
77 INT256161 Binding of Pgc and Sirt1 1 1 0.38 0.21 0.07
78 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 1 0.27 1.05 0.07
79 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 1 0.01 0 0.06
80 INT200807 Jak2 Positive_regulation of Mvd 1 1 0.18 3.46 0.06
81 INT325769 Binding of EPOR and Positive_regulation of Phosphorylation of JAK2 1 1 0.66 0 0.06
82 INT273365 JAK2 Regulation of SOCS1 1 1 0.01 0 0.06
83 INT310110 SET Positive_regulation of Localization of POMT1 1 1 0.08 0 0.05
84 INT238117 Positive_regulation of STAT3 Positive_regulation of Gene_expression of JAK2 1 1 0.11 0 0.05
85 INT238116 STAT3 Positive_regulation of Gene_expression of JAK2 1 1 0.16 0 0.05
86 INT340293 Binding of Ins1 and Sirt1 1 1 0.25 1.25 0.05
87 INT180348 CYP2A6 Regulation of AIRE 1 1 0.01 2.01 0.05
88 INT354715 Binding of PKN1 and Pick1 1 1 0.01 0.19 0.04
89 INT253580 Csnk2a2 Negative_regulation of Jak2 Negative_regulation of Positive_regulation of Akt1 1 1 0.05 0 0.04
90 INT354682 Binding of ASIC1 and PKN1 1 1 0.01 0.19 0.04
91 INT210466 Negative_regulation of Binding of Gopc and Uhrf2 1 1 0.10 0.07 0.04
92 INT210465 Binding of Gopc and Uhrf2 1 1 0.09 0.07 0.04
93 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 1 0.41 0.52 0.04
94 INT274715 TBL1XR1 Positive_regulation of TIMP1 1 1 0.00 0.26 0.04
95 INT200821 Binding of Jak2 and Mvd 1 1 0.14 0.68 0.04
96 INT289538 Sirt1 Positive_regulation of Stat3 1 1 0.34 0.37 0.04
97 INT200813 Jak2 Positive_regulation of Akt1 1 1 0.26 1.46 0.03
98 INT253578 Csnk2a2 Negative_regulation of Jak2 1 1 0.09 0 0.03
99 INT253573 Binding of Jak2 and Pik3r1 1 1 0.06 0 0.03
100 INT200816 Jak2 Positive_regulation of Binding of Mvd and 1 1 0.19 1.51 0.03
101 INT289101 Binding of KCNA1 and LEF1 1 1 0.00 2.58 0.03
102 INT175946 RSF1 Positive_regulation of Positive_regulation of CASP3 1 1 0.01 0.41 0.03
103 INT200810 Jak2 Positive_regulation of Src 1 1 0.29 1.46 0.03
104 INT289542 Sirt1 Negative_regulation of Stat3 1 1 0.32 0.31 0.03
105 INT289606 Sirt1 Negative_regulation of Stat3 Positive_regulation of Stat3 1 1 0.28 0.31 0.03
106 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 1 0.20 0.13 0.03
107 INT253575 Binding of Jak2 and Pik3r2 1 1 0.00 0 0.03
108 INT289526 Binding of Arc and Sirt1 1 1 0.08 0.55 0.03
109 INT200815 Binding of Epo and Jak2 1 1 0.36 0.98 0.03
110 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 1 0.51 0.36 0.03
111 INT200822 Akt1 Regulation of Jak2 1 1 0.25 1.48 0.03
112 INT260342 Binding of Esr1 and Rcc1 1 1 0.05 0.99 0
113 INT180040 Binding of D7Cwr3P and Sirt1 1 1 0.00 0 0
114 INT300696 Sirt1 Regulation of Cyb5r3 1 1 0.03 0 0
115 INT356117 Binding of SORL1 and Apbb1 1 1 0.14 0.43 0
116 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 2 1 0.12 2.32 0
117 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 2 1 0.31 0.2 0
118 INT299444 Foxl2 Positive_regulation of Sirt1 1 1 0.24 0.31 0
119 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 2 1 0.47 1.17 0
120 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 1 0.25 0.32 0
121 INT222868 Binding of Chuk and Pkn1 1 1 0.00 0 0
122 INT337402 LEF1 Positive_regulation of E2F1 1 1 0.11 0 0
123 INT204318 NOS3 Regulation of NOS3 Regulation of SIRT1 1 1 0.20 0.1 0
124 INT317313 Atp13a2 Negative_regulation of Snca 2 1 0.13 0.59 0
125 INT204325 Binding of PPARGC1A and SIRT1 1 1 0.39 0.19 0
126 INT166237 NLRP1 Positive_regulation of Localization of CD1D 1 1 0.48 0 0
127 INT339096 Ezh2 Regulation of Rcc1 1 1 0.02 1.1 0
128 INT201541 Binding of NPC1 and BRD7 1 1 0.35 1.59 0
129 INT183648 Binding of Lef1 and Ctnnd2 1 1 0.07 1.05 0
130 INT337415 Negative_regulation of MIR203 Positive_regulation of Positive_regulation of LEF1 1 1 0.03 0.25 0
131 INT289534 Sirt1 Regulation of Regulation of Pomc 1 1 0.04 0.15 0
132 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 1 0.49 0.91 0
133 INT215243 Binding of Rab3a and Noc2l 2 1 0.00 0.26 0
134 INT337405 MIR203 Regulation of LEF1 1 1 0.02 0.31 0
135 INT256165 Binding of Sirt6 and Sirt1 1 1 0.13 0.58 0
136 INT332136 POGLUT1 Negative_regulation of HJURP 2 1 0.00 0.06 0
137 INT337411 Negative_regulation of MIR203 Positive_regulation of Gene_expression of LEF1 1 1 0.04 0.25 0
138 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 and 1 1 0.44 0.51 0
139 INT356100 Binding of Apbb1 and App 1 1 0.14 0.43 0
140 INT289518 Arc Regulation of Sirt1 1 1 0.10 0.56 0
141 INT274716 TBL1XR1 Positive_regulation of Gene_expression of MMP1 1 1 0.02 0.45 0
142 INT300081 Binding of JAK2 and TYK2 1 1 0.09 1.13 0
143 INT289537 Lep Negative_regulation of Sirt1 1 1 0.20 0.05 0
144 INT318219 SIRT1 Regulation of TBK1 1 1 0.03 0.43 0
145 INT185453 Binding of PRKCB and Lhx1 1 1 0.35 1.99 0
146 INT310115 Binding of NOVA2 and SET 1 1 0.12 0 0
147 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 1 0.00 0.44 0
148 INT289098 KCNA1 Regulation of LEF1 1 1 0.00 0.67 0
149 INT289517 Sirt1 Regulation of Prkag1 1 1 0.02 0.08 0
150 INT253630 Binding of HNRNPA1 and Npm1 1 1 0.00 0.19 0
151 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 1 0.51 0.19 0
152 INT318221 SIRT1 Positive_regulation of FOXO3 1 1 0.41 0.63 0
153 INT350503 Binding of HSP90AA1 and JAK2 1 1 0.06 1.39 0
154 INT317315 Gene_expression of Snca Negative_regulation of Psmb10 2 1 0.00 0.52 0
155 INT317320 Binding of Snca and Atp13a2 2 1 0.08 0.58 0
156 INT337637 SIRT1 Negative_regulation of TP53 1 1 0.23 1.49 0
157 INT289598 Binding of Sirt1 and Sirt1 2 1 0.41 1.15 0
158 INT337417 MIR203 Negative_regulation of LEF1 1 1 0.04 0.57 0
159 INT312304 Binding of JAK2 and VEGFA 1 1 0.30 0.82 0
160 INT220822 Binding of Myc and LEF1 1 1 0.26 0.08 0
161 INT300303 Binding of Gk and Foxo3 1 1 0.09 1.53 0
162 INT327872 Binding of Postn and Pkn1 1 1 0.03 0.21 0
163 INT298105 Ca2 Negative_regulation of Cd1d1 2 1 0.12 0.09 0
164 INT300307 Binding of Tp53 and Sirt1 1 1 0.24 0.98 0
165 INT289519 Sirt1 Regulation of Rps6kb1 1 1 0.25 0.13 0
166 INT220766 Binding of MAX and LEF1 1 1 0.40 0.08 0
167 INT289530 Sirt1 Regulation of Foxo1 1 1 0.25 0.42 0
168 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 1 0.36 0.13 0
169 INT204321 NOS3 Regulation of SIRT1 1 1 0.23 0.1 0
170 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 1 0.50 2.3 0
171 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 1 0.25 0.32 0
172 INT289531 Acsm3 Positive_regulation of Sirt1 1 1 0.01 0.27 0
173 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 1 0.10 0.53 0
174 INT215242 Binding of Rab27a and Noc2l 2 1 0.07 0.26 0
175 INT318683 ARPP21 Negative_regulation of SET 1 1 0.00 0.1 0
176 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 1 0.36 0.52 0
177 INT318217 SIRT1 Regulation of TP53 1 1 0.07 0.43 0
178 INT198026 JAK2 Positive_regulation of HCC 1 1 0.19 1.35 0
179 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 1 0.07 1.5 0
180 INT331090 Binding of Ctsl and Itga2 2 1 0.10 0.2 0
181 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 1 0.00 0.68 0
182 INT198928 Binding of Apbb1 and Lrp8 1 1 0.07 0.17 0
183 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 1 0.50 0.12 0
184 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 and 1 1 0.29 0.14 0
185 INT350504 ABL1 Negative_regulation of JAK2 1 1 0.20 2.18 0
186 INT289529 Lep Regulation of Sirt1 1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone binding. They are ordered first by their pain relevance and then by number of times they were reported in histone binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
2 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1
3 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
4 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
5 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
6 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
7 INT123594 Negative_regulation of Snca 19 0.59 4.43 4.59
8 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56
9 INT47298 Localization of Ctsl 13 0.79 3.77 4.08
10 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
11 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
12 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
13 INT174117 Gene_expression of Cd1d1 26 0.75 12.07 3.07
14 INT123595 Regulation of Snca 7 0.62 4.3 3.06
15 INT40128 Binding of Noc2l 7 0.27 0.67 3.03
16 INT82719 Positive_regulation of ASF1A 2 0.08 9.55 3
17 INT95778 Gene_expression of Prkcb 5 0.75 2.3 2.97
18 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
19 INT113339 Binding of JAK2 6 0.40 5.31 2.4
20 INT26696 Gene_expression of Hils1 4 0.21 1.18 2.38
21 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
22 INT156694 Binding of SET 10 0.36 3.77 2.21
23 INT95781 Positive_regulation of Gene_expression of Prkcb 3 0.07 1.86 2.17
24 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
25 INT190894 Gene_expression of Pkn1 6 0.04 3.12 2.15
26 INT13368 Binding of Hils1 5 0.23 0.46 2.14
27 INT94628 Gene_expression of CD1D 12 0.75 5.58 2.13
28 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
29 INT156720 Localization of CD1D 7 0.68 1.1 2.09
30 INT95780 Positive_regulation of Prkcb 3 0.50 0.48 2.06
31 INT47303 Regulation of Ctsl 10 0.56 2.64 2.04
32 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03
33 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
34 INT184410 Gene_expression of ASF1A 6 0.11 5.51 1.94
35 INT48850 Gene_expression of PKN1 16 0.52 1.93 1.92
36 INT58208 Negative_regulation of Ctsl 8 0.53 3.49 1.91
37 INT127125 Localization of Snca 6 0.81 8.24 1.88
38 INT80408 Negative_regulation of Prkcb 3 0.14 2.17 1.88
39 INT106153 Gene_expression of HJURP 5 0.04 2.33 1.85
40 INT265449 Gene_expression of Aire 10 0.67 9.18 1.8
41 INT47302 Regulation of Gene_expression of Ctsl 2 0.53 0.54 1.77
42 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74
43 INT127145 Gene_expression of SET 46 0.65 10.39 1.7
44 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
45 INT210455 Gene_expression of Noc2l 3 0.33 1.01 1.58
46 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
47 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
48 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
49 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
50 INT104941 Negative_regulation of Prkcb 4 0.39 2.94 1.47
51 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
52 INT201271 Phosphorylation of Snca 3 0.82 4.22 1.45
53 INT168863 Regulation of Wdtc1 3 0.08 1.88 1.45
54 INT200015 Gene_expression of Apbb1 1 0.05 0.4 1.45
55 INT124247 Negative_regulation of Gene_expression of Snca 12 0.59 3.87 1.39
56 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
57 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33
58 INT58761 Regulation of CD1D 3 0.26 1.54 1.33
59 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
60 INT265444 Negative_regulation of Aire 1 0.37 5.68 1.3
61 INT41698 Localization of Hils1 3 0.16 0.54 1.29
62 INT56385 Positive_regulation of Gk 11 0.22 15.07 1.28
63 INT18947 Negative_regulation of Hils1 3 0.04 1.11 1.27
64 INT314186 Gene_expression of Npm1 1 0.01 1.78 1.22
65 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19
66 INT283661 Positive_regulation of Gene_expression of Pkn1 1 0.02 1.22 1.19
67 INT23415 Regulation of Hils1 2 0.27 0.29 1.18
68 INT47305 Positive_regulation of Gene_expression of Ctsl 5 0.59 2.06 1.12
69 INT151753 Transcription of Snca 6 0.69 1.99 1.11
70 INT292945 Positive_regulation of Positive_regulation of Snca 4 0.69 2.42 1.05
71 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
72 INT223563 Gene_expression of Uhrf2 4 0.48 1.15 1.04
73 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
74 INT286344 Positive_regulation of Gene_expression of Snca 1 0.41 2.84 1.03
75 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
76 INT80409 Regulation of Prkcb 1 0.06 0 0.97
77 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
78 INT342642 Regulation of CTSL1 1 0.07 0.19 0.96
79 INT137807 Binding of Cd1d1 4 0.31 1.26 0.94
80 INT6534 Negative_regulation of Ctsl1 3 0.54 0.11 0.94
81 INT169336 Binding of Jak2 2 0.42 1.31 0.93
82 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
83 INT151752 Positive_regulation of Transcription of Snca 2 0.50 0.99 0.92
84 INT351587 Positive_regulation of Gene_expression of Uhrf2 1 0.29 0.81 0.92
85 INT124246 Binding of Snca 10 0.37 6.53 0.9
86 INT36494 Positive_regulation of Hils1 2 0.15 0.88 0.88
87 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
88 INT51790 Negative_regulation of ASF1A 2 0.17 2.73 0.86
89 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
90 INT24860 Positive_regulation of CD1D 6 0.49 2.13 0.83
91 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
92 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
93 INT80404 Negative_regulation of Negative_regulation of Prkcb 2 0.10 1.13 0.81
94 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
95 INT120046 Negative_regulation of Localization of Ctsl 2 0.40 0.31 0.8
96 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
97 INT48851 Positive_regulation of Gene_expression of PKN1 2 0.27 0.67 0.78
98 INT68307 Negative_regulation of Ncapd2 3 0.42 1.2 0.74
99 INT199812 Localization of CTSL1 2 0.30 0.16 0.73
100 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
101 INT179481 Positive_regulation of Wdtc1 8 0.67 7.11 0.71
102 INT76314 Gene_expression of CTSL1 3 0.65 1.26 0.68
103 INT40069 Negative_regulation of Binding of Hils1 1 0.03 0.09 0.67
104 INT26695 Positive_regulation of Binding of Hils1 2 0.11 0.2 0.66
105 INT274725 Regulation of TBL1XR1 5 0.11 2.08 0.64
106 INT139186 Positive_regulation of APBB1 1 0.00 0.31 0.62
107 INT114405 Regulation of Pkn1 1 0.44 1.58 0.61
108 INT104940 Gene_expression of Prkcb 2 0.03 0.9 0.58
109 INT119099 Positive_regulation of Pkn1 2 0.02 0.35 0.58
110 INT28687 Gene_expression of Ctsl1 4 0.61 0.48 0.57
111 INT132104 Positive_regulation of Gene_expression of CD1D 2 0.03 0.55 0.57
112 INT200020 Negative_regulation of Apbb1 1 0.03 0.34 0.55
113 INT267651 Positive_regulation of CTSL1 1 0.09 0.96 0.55
114 INT200016 Positive_regulation of Apbb1 1 0.04 0.08 0.55
115 INT51843 Localization of Ctsl1 3 0.62 0.54 0.54
116 INT184417 Positive_regulation of Positive_regulation of ASF1A 1 0.08 1.25 0.54
117 INT160148 Positive_regulation of Ctsl 2 0.43 0.74 0.52
118 INT172310 Positive_regulation of PKN1 6 0.12 2 0.51
119 INT184411 Negative_regulation of Positive_regulation of ASF1A 1 0.05 1.46 0.51
120 INT315427 Positive_regulation of Uhrf2 2 0.38 0.33 0.5
121 INT80411 Negative_regulation of Regulation of Prkcb 1 0.09 0 0.5
122 INT157772 Gene_expression of ASF1B 3 0.07 2.78 0.49
123 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
124 INT182468 Positive_regulation of Cd1d1 5 0.61 4.08 0.48
125 INT175960 Positive_regulation of RSF1 4 0.50 3.88 0.48
126 INT184414 Localization of ASF1A 1 0.08 1.01 0.48
127 INT184062 Binding of Jak2 5 0.37 3.13 0.47
128 INT216519 Gene_expression of Wdtc1 4 0.65 4.02 0.47
129 INT24859 Negative_regulation of CD1D 2 0.58 0.41 0.47
130 INT209432 Gene_expression of Rag1 5 0.55 1.69 0.46
131 INT274724 Positive_regulation of TBL1XR1 5 0.12 2.74 0.45
132 INT6533 Binding of Ctsl1 2 0.34 0 0.45
133 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
134 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
135 INT47895 Localization of Gk 3 0.22 2.35 0.42
136 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
137 INT343940 Binding of Uhrf2 2 0.30 0.06 0.42
138 INT148264 Transcription of SNCA 1 0.40 0.25 0.42
139 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
140 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
141 INT216873 Binding of TBL1XR1 3 0.36 4.44 0.4
142 INT107462 Localization of Jak2 2 0.60 0.78 0.4
143 INT174118 Regulation of Gene_expression of Cd1d1 1 0.44 1.42 0.4
144 INT348083 Positive_regulation of Ctsl1 1 0.08 0.21 0.4
145 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
146 INT314185 Localization of Npm1 1 0.02 0.44 0.39
147 INT343972 Negative_regulation of Binding of SNCA 1 0.36 0.2 0.39
148 INT255571 Gene_expression of Gk 15 0.26 15.42 0.38
149 INT224637 Protein_catabolism of Ctsl 1 0.12 0.76 0.37
150 INT169628 Binding of SNCA 4 0.47 3.53 0.36
151 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
152 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
153 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
154 INT129025 Positive_regulation of Prkcb 1 0.64 0.25 0.34
155 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
156 INT19783 Localization of Wdtc1 2 0.13 1.89 0.33
157 INT314188 Regulation of Npm1 1 0.01 0.33 0.33
158 INT222639 Gene_expression of Cd1d1 2 0.65 0.65 0.32
159 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
160 INT132184 Regulation of Binding of NASP 1 0.05 0 0.31
161 INT255551 Negative_regulation of Gene_expression of Rag1 1 0.35 0.81 0.31
162 INT132185 Binding of NASP 1 0.06 0 0.31
163 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
164 INT122139 Positive_regulation of Gene_expression of Prkcb 1 0.00 0.06 0.3
165 INT66060 Regulation of Gene_expression of PKN1 1 0.23 0 0.3
166 INT343973 Localization of SNCA 1 0.63 0.07 0.3
167 INT92859 Positive_regulation of Positive_regulation of Hils1 1 0.03 0 0.3
168 INT6536 Negative_regulation of Binding of Ctsl1 1 0.39 0 0.3
169 INT182465 Negative_regulation of Cd1d1 4 0.28 1.72 0.29
170 INT104939 Negative_regulation of Gene_expression of Prkcb 1 0.02 0.86 0.29
171 INT315428 Transcription of Uhrf2 1 0.38 0 0.28
172 INT127488 Negative_regulation of Pkn1 1 0.00 0.2 0.28
173 INT190895 Transcription of Pkn1 1 0.03 0.67 0.28
174 INT146319 Negative_regulation of Phosphorylation of Prkcb 1 0.14 1.13 0.27
175 INT146320 Phosphorylation of Prkcb 1 0.20 1.13 0.27
176 INT265442 Positive_regulation of Gene_expression of Aire 1 0.43 1.32 0.27
177 INT156707 Positive_regulation of SET 6 0.49 1.14 0.26
178 INT274742 Localization of TBL1XR1 2 0.24 1.4 0.26
179 INT352911 Gene_expression of HINFP 1 0.02 0.99 0.26
180 INT287251 Negative_regulation of PKN1 6 0.01 1.86 0.25
181 INT100277 Positive_regulation of Gene_expression of TBL1XR1 5 0.19 1.9 0.25
182 INT303972 Positive_regulation of Gene_expression of JAK2 2 0.63 1.3 0.24
183 INT220582 Binding of Apbb1 2 0.14 0.69 0.24
184 INT66230 Negative_regulation of Rcc1 1 0.28 0.75 0.24
185 INT200018 Localization of Apbb1 1 0.05 0 0.24
186 INT174116 Negative_regulation of Gene_expression of Cd1d1 1 0.31 0.51 0.24
187 INT139053 Phosphorylation of PRKCB 1 0.04 0.32 0.23
188 INT139051 Positive_regulation of Phosphorylation of PRKCB 1 0.02 0.33 0.23
189 INT184412 Positive_regulation of Gene_expression of ASF1A 1 0.06 1.01 0.23
190 INT139054 Negative_regulation of Phosphorylation of PRKCB 1 0.02 0.33 0.23
191 INT142052 Binding of Snca 4 0.47 1.02 0.22
192 INT36060 Protein_catabolism of Ctsl1 2 0.83 0.15 0.22
193 INT124178 Regulation of Ctsl1 1 0.23 0.19 0.22
194 INT182453 Positive_regulation of Gene_expression of Cd1d1 6 0.67 1.64 0.21
195 INT260340 Gene_expression of Rcc1 4 0.58 5.36 0.21
196 INT220862 Negative_regulation of Transcription of Ctsl 1 0.05 0.41 0.21
197 INT292944 Regulation of Positive_regulation of Snca 1 0.45 0.36 0.21
198 INT220859 Transcription of Ctsl 1 0.09 0.41 0.21
199 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
200 INT41699 Positive_regulation of Localization of Hils1 1 0.11 0 0.2
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