GOS:ligase activity

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This page displays the top molecular interactions and top single events that were mentioned in the literature for ligase activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ligase activity. They are ordered first by their pain relevance and then by number of times they were reported for ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to ligase activity Documents TM Confidence Disease Relevance Pain Relevance
1 INT259228 Binding of Oprm1 and Glul 1 1 0.00 0.08 7.22
2 INT51497 Cck Negative_regulation of Localization of Trim13 1 1 0.34 0 4.53
3 INT259209 Binding of Glul and Flna 1 1 0.03 0 4.2
4 INT42727 Binding of Oprm1 and Trim13 1 1 0.14 0 2.54
5 INT334136 Binding of IFNA1 and Acsm3 1 1 0.01 4.52 2.19
6 INT319581 Binding of PIAS1 and TNFSF14 1 1 0.02 1.58 2.13
7 INT213973 Binding of Pax3 and Mthfd1 1 1 0.00 0.16 1.99
8 INT213968 Binding of Calca and Mthfd1 1 1 0.05 0.16 1.99
9 INT116815 Binding of Pias1 and Ppbp 1 1 0.36 0.86 1.92
10 INT278223 Binding of NOS3 and ACSM3 1 1 0.41 6.32 1.65
11 INT48790 Negative_regulation of Rtcd1 Negative_regulation of Pax3 1 1 0.02 0 1.59
12 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 1 0.01 0.58 1.51
13 INT63489 Dio1 Positive_regulation of Rtcd1 1 1 0.01 0.58 1.51
14 INT334131 Acsm3 Positive_regulation of Mip 1 1 0.13 3.12 1.48
15 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 1 0.05 1.65 1.42
16 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 1 0.08 1.64 1.42
17 INT116827 Binding of UCHL1 and TRPV1 1 1 0.41 0.88 1.39
18 INT86518 Ass1 Positive_regulation of Hmox2 1 1 0.03 0.08 1.27
19 INT334129 Acsm3 Positive_regulation of Gene_expression of Icam1 1 1 0.22 2.89 1.22
20 INT139191 Binding of Fas and RFFL 1 1 0.00 0.61 1.22
21 INT159837 Trim2 Negative_regulation of Transcription of Fos 1 1 0.10 1.92 1.22
22 INT7202 Uba3 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 1 0.00 0 1.2
23 INT57824 Binding of Trim13 and Slc25a2 1 1 0.01 0.08 1.19
24 INT20929 Binding of Trim13 and Vas1 1 1 0.10 0 1.18
25 INT57823 Binding of Trim13 and Atxn2l 1 1 0.00 0.08 1.17
26 INT59203 ecs Positive_regulation of Negative_regulation of Ube2d3 1 1 0.00 1.93 1.15
27 INT35399 Binding of Alox5 and Mthfs 1 1 0.01 0 1.14
28 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 1 0.00 0.64 1.13
29 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 1 0.00 0.64 1.13
30 INT68154 Mthfs Positive_regulation of Pdpk1 1 1 0.01 0.63 1.12
31 INT68161 Mthfs Positive_regulation of Positive_regulation of Pla2g1b 1 1 0.03 0.64 1.12
32 INT68155 Pla2g1b Positive_regulation of Positive_regulation of Mthfs 1 1 0.03 0.64 1.12
33 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 1 0.01 0.64 1.12
34 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 1 0.20 0.2 1.1
35 INT12684 Binding of Bcar3 and Trim13 1 1 0.03 0 1.08
36 INT60047 Oprl1 Negative_regulation of Phosphorylation of Syn1 1 1 0.05 0.17 1.05
37 INT197241 Kars Regulation of Localization of Gabrg1 1 1 0.23 0 1.02
38 INT36597 Hrh1 Regulation of Rtcd1 1 1 0.04 0.36 1.01
39 INT278224 Binding of ACSM3 and SNRNP70 1 1 0.04 3.76 1.01
40 INT47163 Penk Regulation of Rtcd1 1 1 0.00 0 1.01
41 INT144902 Binding of Trpv1 and Pars2 1 1 0.17 0 0.95
42 INT103933 Cps1 Negative_regulation of Gene_expression of Cd69 1 1 0.03 0.25 0.93
43 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 1 0.02 0.25 0.93
44 INT25110 RYBP Negative_regulation of MTHFS 1 1 0.02 0 0.92
45 INT63488 Sptan1 Positive_regulation of Rtcd1 1 1 0.03 0.34 0.91
46 INT112153 Regulation of Binding of Oprm1 and Rtcd1 1 1 0.00 0.09 0.87
47 INT129881 Binding of Calr and Cbll1 1 1 0.00 0.58 0.84
48 INT334132 Acsm3 Positive_regulation of Gene_expression of Cxcl2 1 1 0.13 2.26 0.83
49 INT46540 TRIM13 Positive_regulation of GPANK1 1 1 0.05 0 0.83
50 INT322266 Binding of LIG4 and NOS3 1 1 0.02 2.35 0.82
51 INT334130 Negative_regulation of Acsm3 Positive_regulation of Mip 1 1 0.12 1.48 0.81
52 INT112154 Binding of Oprm1 and Rtcd1 1 1 0.00 0.09 0.81
53 INT213972 Calca Regulation of Mthfd1 1 1 0.05 0.19 0.8
54 INT334134 Acsm3 Positive_regulation of Gene_expression of Mip 1 1 0.13 1.4 0.77
55 INT49585 Binding of Glul and Selenbp2 1 1 0.20 0.19 0.76
56 INT117412 RYBP Negative_regulation of LIG4 1 1 0.00 0.42 0.76
57 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 1 0.29 0.19 0.75
58 INT72229 Binding of NFKBIL1 and BTRC 1 1 0.00 0 0.73
59 INT296097 Acsm3 Negative_regulation of SOD1 1 1 0.01 1.3 0.72
60 INT57094 Oprl1 Positive_regulation of Negative_regulation of Rtcd1 1 1 0.01 0.1 0.71
61 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 1 0.00 0.14 0.68
62 INT334128 Acsm3 Positive_regulation of Sele 1 1 0.16 1.6 0.66
63 INT334133 Acsm3 Positive_regulation of Icam1 1 1 0.23 1.61 0.66
64 INT334127 Acsm3 Positive_regulation of Vcam1 1 1 0.24 1.61 0.66
65 INT50634 Ddc Regulation of Gene_expression of Glul 1 1 0.02 0 0.65
66 INT76761 Kctd1 Negative_regulation of RFFL 1 1 0.00 0.5 0.63
67 INT311466 Binding of Acsl1 and Il1 1 1 0.00 2.46 0.63
68 INT192332 UBR7 Negative_regulation of TXK 1 1 0.00 1.38 0.63
69 INT330104 Binding of Sh3rf1 and Rac1 1 1 0.13 2.41 0.62
70 INT9163 Tnf Regulation of Gene_expression of Glul 1 1 0.12 1.99 0.62
71 INT112701 Bid Regulation of RFFL 1 1 0.00 0.52 0.62
72 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 1 0.01 0.71 0.62
73 INT139192 RFFL Positive_regulation of Fas 1 1 0.00 0.3 0.61
74 INT311467 Binding of Crp and Acsl1 1 1 0.00 2.31 0.61
75 INT343365 Acsf2 Negative_regulation of Gabrd 1 1 0.04 0 0.61
76 INT29803 Binding of Rtcd1 and Rbm39 1 1 0.00 0.14 0.59
77 INT65285 TGFBI Negative_regulation of Pc 1 1 0.20 0.79 0.59
78 INT59202 ecs Positive_regulation of Ube2d3 1 1 0.00 0.98 0.59
79 INT35400 Fnd3c2 Negative_regulation of Binding of Alox5 and Mthfs 1 1 0.00 0 0.58
80 INT35397 Fnd3c2 Negative_regulation of Binding of Mthfs and 1 1 0.00 0 0.58
81 INT112700 Aap Positive_regulation of RFFL 1 1 0.00 0.5 0.57
82 INT42300 Guca2a Negative_regulation of Rtcd1 1 1 0.00 0.79 0.56
83 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 1 0.02 0.88 0.56
84 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 1 0.03 0.87 0.56
85 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 1 0.01 0.88 0.56
86 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 1 0.01 1 0.55
87 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 1 0.32 0.09 0.54
88 INT69177 UBA7 Negative_regulation of Igk 1 1 0.00 0.15 0.54
89 INT56733 Ddc Positive_regulation of Localization of GLUL 1 1 0.00 0 0.54
90 INT160779 Cps1 Positive_regulation of ATM 1 1 0.01 0.94 0.53
91 INT69179 Binding of UBA7 and Adarb1 1 1 0.00 0.16 0.53
92 INT240192 RBX1 Negative_regulation of BDNF 1 1 0.08 0.13 0.52
93 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 1 0.03 0.19 0.51
94 INT103932 Cps1 Negative_regulation of Gene_expression of Trav6-3 1 1 0.01 0.19 0.5
95 INT17622 Ass1 Positive_regulation of Lhb 1 1 0.02 1.22 0.49
96 INT103934 Cps1 Negative_regulation of Positive_regulation of Nfkb1 1 1 0.02 0.2 0.49
97 INT72230 Binding of BTRC and EMID1 1 1 0.00 0 0.49
98 INT72227 Binding of BTRC and AP1M2 1 1 0.00 0 0.49
99 INT215543 Negative_regulation of Trim33 Negative_regulation of Gopc 1 1 0.15 0.35 0.48
100 INT338940 Fpgs Positive_regulation of Mtx1 1 1 0.32 0.32 0.47
101 INT118396 Nfe2l2 Positive_regulation of Gene_expression of Cars 1 1 0.05 0.26 0.47
102 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 1 0.01 0.13 0.47
103 INT177784 PDCD2 Positive_regulation of ASNS 1 1 0.04 0.76 0.46
104 INT103936 Cps1 Negative_regulation of Il2ra 1 1 0.02 0.07 0.46
105 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 1 0.11 0.77 0.46
106 INT103931 Cps1 Negative_regulation of Icam1 1 1 0.01 0.07 0.46
107 INT103935 Cps1 Negative_regulation of Cd69 1 1 0.03 0.07 0.46
108 INT117890 Positive_regulation of Gfap Regulation of Glul 1 1 0.51 0.36 0.46
109 INT346913 Binding of Kars and Positive_regulation of Gene_expression of Ros1 1 1 0.03 1.25 0.46
110 INT177780 BUB1B Positive_regulation of ASNS 1 1 0.05 0.76 0.46
111 INT168699 Binding of Nedd4 and Tyr 1 1 0.02 0.45 0.46
112 INT117887 Glul Regulation of Arc 1 1 0.02 0.37 0.46
113 INT117889 Gfap Regulation of Glul 1 1 0.30 0.36 0.46
114 INT135389 4930519F16Rik Positive_regulation of Pars2 1 1 0.01 0.78 0.45
115 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 1 0.05 1.24 0.45
116 INT235404 Positive_regulation of RTCA Positive_regulation of Positive_regulation of Prkaca 1 1 0.00 0.22 0.45
117 INT24336 Negative_regulation of Binding of PRB1 and RTCA 1 1 0.00 0.1 0.45
118 INT24334 Binding of PRB1 and RTCA 1 1 0.00 0.09 0.44
119 INT80231 PCDHB17 Negative_regulation of Positive_regulation of RTCA 1 1 0.00 0 0.44
120 INT24335 Positive_regulation of Binding of PRB1 and RTCA 1 1 0.00 0.09 0.44
121 INT80230 PCDHB17 Negative_regulation of RTCA 1 1 0.00 0 0.44
122 INT90079 Ass1 Positive_regulation of Casp1 1 1 0.02 0.99 0.43
123 INT240193 RBX1 Positive_regulation of Gene_expression of BDNF 1 1 0.10 0 0.43
124 INT53470 Acsm3 Regulation of Ptgs1 1 1 0.15 0 0.42
125 INT121378 Fancl Positive_regulation of MIF 1 1 0.01 0.92 0.42
126 INT53469 Negative_regulation of Acsm3 Regulation of Ptgs1 1 1 0.24 0 0.42
127 INT128287 POMC Positive_regulation of RTCA 1 1 0.04 0.13 0.42
128 INT290269 KNG1 Positive_regulation of Binding of MID1 and 1 1 0.02 1.06 0.41
129 INT53471 Binding of Ptgs1 and Acsm3 1 1 0.17 0 0.41
130 INT290270 KNG1 Positive_regulation of MID1 1 1 0.02 1.06 0.41
131 INT351237 HRAS Regulation of CBL 1 1 0.00 0.48 0.4
132 INT325701 Aacs Regulation of Car3 1 1 0.17 0 0.4
133 INT204793 T Positive_regulation of Mthfd1 1 1 0.00 1.32 0.39
134 INT20949 Binding of HTN1 and PC 1 1 0.27 0 0.38
135 INT339511 Binding of Tlr4 and Traf6 1 1 0.05 0.12 0.38
136 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 1 0.05 0.17 0.38
137 INT148465 Positive_regulation of Ccl4 Positive_regulation of Gclc 1 1 0.32 0.06 0.38
138 INT339506 Binding of Irak1 and Traf6 1 1 0.03 0.12 0.37
139 INT151698 Binding of RNF130 and Vwf 1 1 0.04 0.29 0.37
140 INT148467 Ccl4 Positive_regulation of Gclc 1 1 0.32 0.05 0.37
141 INT187837 Ass1 Regulation of Mcpt1 1 1 0.00 1.29 0.37
142 INT151694 Binding of FBL and RNF130 1 1 0.40 0.23 0.36
143 INT353454 Binding of BRCA1 and IL17A 1 1 0.00 2.55 0.36
144 INT263359 Dlat Negative_regulation of Gars 1 1 0.15 0.31 0.35
145 INT353452 Binding of AGRP and BRCA1 1 1 0.00 3.89 0.34
146 INT141848 Mthfs Negative_regulation of Cpox 1 1 0.01 0 0.34
147 INT324690 Binding of Traf6 and Ticam1 1 2 0.07 0.23 0.33
148 INT252292 CCL21 Regulation of Binding of Mthfd1 and 1 1 0.03 0.41 0.33
149 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 1 0.03 1.46 0.33
150 INT263978 Binding of ADRB2 and TNFAIP3 1 1 0.01 0.5 0.32
151 INT42422 Pomc Positive_regulation of Rtcd1 1 1 0.07 0.35 0.32
152 INT203089 Binding of Il1a and Traf6 1 1 0.04 0.66 0.32
153 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 1 0.06 0.67 0.32
154 INT343366 Acsf2 Negative_regulation of Acot1 1 1 0.05 0 0.31
155 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 1 0.09 0.45 0.31
156 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 1 0.06 0.37 0.31
157 INT330100 Binding of Sh3rf1 and Map3k11 1 1 0.08 1.21 0.31
158 INT276602 Paf Positive_regulation of Gene_expression of Mthfd1 1 1 0.13 0.37 0.31
159 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 1 0.01 1.23 0.3
160 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 1 0.27 0.86 0.3
161 INT191240 SAE1 Regulation of Localization of INS 1 1 0.08 1.15 0.3
162 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 1 0.40 0.86 0.3
163 INT239324 Nr1h2 Positive_regulation of Hltf 1 1 0.04 0.78 0.29
164 INT239329 Nr1h2 Positive_regulation of Gene_expression of Hltf 1 1 0.04 0.84 0.29
165 INT109711 Mip Positive_regulation of Rtcd1 1 1 0.00 0 0.29
166 INT133109 Pc Positive_regulation of Pla2g6 1 1 0.34 0.28 0.28
167 INT323710 TRAF6 Regulation of MIR146A 1 1 0.06 0.55 0.28
168 INT170719 Binding of Grm5 and Siah1a 1 1 0.01 1.1 0.28
169 INT283743 Positive_regulation of Ptger2 Positive_regulation of Rtcd1 1 1 0.00 0.12 0.27
170 INT180246 Binding of Tbca and Uchl1 1 1 0.00 0.47 0.27
171 INT180245 Binding of Plp1 and Uchl1 1 1 0.03 0.47 0.27
172 INT290957 Lsd Positive_regulation of Gene_expression of Egr2 1 1 0.11 0.1 0.26
173 INT353448 BRCA1 Positive_regulation of CCL2 1 1 0.01 1.37 0.26
174 INT35021 Ptz1b Regulation of Phosphorylation of Syn1 1 1 0.01 0 0.26
175 INT273935 Crem Regulation of Gene_expression of Egr2 1 1 0.05 0.16 0.26
176 INT353449 BRCA1 Positive_regulation of IL4 1 1 0.00 1.37 0.26
177 INT353455 BRCA1 Positive_regulation of IL13 1 1 0.00 1.37 0.26
178 INT180718 Binding of SARS and ACE2 1 3 0.12 7.76 0.25
179 INT252349 Binding of Cd70 and Mthfd1 Positive_regulation of Cd27 1 1 0.03 1.07 0.25
180 INT197235 Binding of Grik1 and Kars 1 1 0.32 0.1 0.25
181 INT197237 Binding of Kars and Grik4 1 1 0.17 0.1 0.25
182 INT197232 Binding of Grik5 and Kars 1 1 0.17 0.1 0.25
183 INT243640 Binding of Twist1 and Stub1 1 1 0.08 0.34 0.24
184 INT191687 Igh-Dex Positive_regulation of Gene_expression of Xiap 1 1 0.01 0.63 0.24
185 INT311989 Binding of Chuk and Mthfd1 1 1 0.05 0.56 0.24
186 INT334256 Binding of Tlr9 and Iars 1 1 0.02 0.68 0.24
187 INT297376 Binding of RARS and Rxra 1 1 0.01 3.27 0.24
188 INT191689 Igh-Dex Positive_regulation of Xiap 1 1 0.01 0.63 0.24
189 INT55903 Negative_regulation of Mthfs Negative_regulation of Localization of Ptafr 1 1 0.01 0.35 0.24
190 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 1 0.00 0 0.24
191 INT252340 Binding of Cd70 and Mthfd1 1 1 0.03 1.05 0.24
192 INT333927 GLUL Positive_regulation of HSPA5 1 1 0.17 0.78 0.24
193 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 1 0.00 0.41 0.23
194 INT334269 Iars Negative_regulation of Gene_expression of IFNA1 1 1 0.03 0.62 0.23
195 INT192331 UBR7 Negative_regulation of INSRR 1 1 0.00 0.54 0.23
196 INT143628 MTHFS Positive_regulation of Gene_expression of MRXS5 1 1 0.01 0.55 0.23
197 INT316111 APC Negative_regulation of SAE1 1 1 0.04 1.21 0.22
198 INT242094 Binding of ACLY and Pts 1 1 0.01 0 0.22
199 INT32735 ADRA2A Regulation of RTCA 1 1 0.07 0 0.22
200 INT35023 Ptz1b Positive_regulation of Phosphorylation of Syn1 1 1 0.01 0 0.22

Single Events

The table below shows the top 100 pain related interactions that have been reported for ligase activity. They are ordered first by their pain relevance and then by number of times they were reported in ligase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66
2 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43
3 INT5069 Negative_regulation of Mthfs 69 0.57 22.54 31.36
4 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11
5 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
6 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74
7 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95
8 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07
9 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54
10 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
11 INT15102 Gene_expression of Trim13 18 0.67 0.43 15.49
12 INT24798 Negative_regulation of Glul 52 0.55 27.25 15.17
13 INT60044 Gene_expression of Syn1 38 0.78 4.98 14.61
14 INT60046 Positive_regulation of Syn1 16 0.70 2 13.9
15 INT1491 Regulation of Rtcd1 33 0.53 5.17 13.4
16 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
17 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
18 INT20131 Negative_regulation of Mthfs 18 0.57 7.93 10.54
19 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43
20 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
21 INT76759 Positive_regulation of RFFL 31 0.35 29.15 9.9
22 INT1567 Binding of TRIM13 10 0.47 0.24 9.16
23 INT21438 Binding of Trim13 10 0.47 0.26 8.76
24 INT85651 Positive_regulation of ACACA 17 0.67 4.73 8.63
25 INT86792 Gene_expression of Kars 17 0.77 4.24 8.58
26 INT13435 Positive_regulation of RTCA 31 0.60 7.19 8.5
27 INT90020 Gene_expression of SUCLG1 8 0.75 1.61 8.34
28 INT116121 Binding of Nfx1 1 0.41 0 8.06
29 INT24799 Regulation of Glul 22 0.45 8.3 8
30 INT35584 Binding of ACLY 22 0.35 31.78 7.17
31 INT90715 Gene_expression of Egr2 12 0.73 1.64 7.17
32 INT104909 Binding of Pias1 11 0.37 3.67 6.72
33 INT50633 Regulation of Gene_expression of Glul 12 0.60 1.64 6.59
34 INT48270 Negative_regulation of RNF130 44 0.57 21.31 6.14
35 INT63728 Transcription of Syn1 6 0.72 0.38 6.07
36 INT63726 Positive_regulation of Transcription of Syn1 1 0.70 0.39 5.99
37 INT3905 Positive_regulation of Positive_regulation of Rtcd1 10 0.27 1.76 5.82
38 INT25802 Positive_regulation of Negative_regulation of Rtcd1 7 0.11 2.66 5.57
39 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4
40 INT157076 Gene_expression of Acsf2 23 0.56 0.84 5.39
41 INT201477 Positive_regulation of Acsm3 8 0.31 15 5.38
42 INT111470 Positive_regulation of EPRS 18 0.44 11.42 5.29
43 INT38251 Negative_regulation of Gclc 7 0.57 1.37 5.06
44 INT126405 Negative_regulation of Syn2 5 0.43 4.66 5.03
45 INT94103 Gene_expression of EPRS 13 0.54 11.47 4.99
46 INT197229 Positive_regulation of Kars 5 0.54 1.89 4.81
47 INT12726 Gene_expression of Rtcd1 17 0.32 2.55 4.76
48 INT165058 Negative_regulation of MID1 14 0.37 10.82 4.67
49 INT97878 Positive_regulation of Pias1 6 0.50 2.73 4.65
50 INT25146 Negative_regulation of Positive_regulation of Glul 5 0.43 0.91 4.53
51 INT26787 Localization of Uchl1 10 0.60 5.9 4.48
52 INT44805 Positive_regulation of Mthfs 9 0.49 2.32 4.48
53 INT94277 Positive_regulation of Gene_expression of Egr2 7 0.49 0.69 4.4
54 INT36237 Gene_expression of Ass1 11 0.24 2.31 4.38
55 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37
56 INT50631 Positive_regulation of Gene_expression of Glul 9 0.43 3 4.37
57 INT51494 Localization of Trim13 1 0.60 0 4.36
58 INT35019 Phosphorylation of Syn1 11 0.82 0.33 4.28
59 INT27158 Negative_regulation of Positive_regulation of Rtcd1 7 0.13 1.84 4.25
60 INT117495 Gene_expression of Pars2 13 0.38 7.93 4.24
61 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
62 INT71441 Positive_regulation of Pars2 12 0.69 5.75 4.13
63 INT50646 Transcription of Glul 12 0.38 3.59 4.07
64 INT29453 Negative_regulation of Negative_regulation of RTCA 8 0.37 2.28 3.97
65 INT2677 Regulation of Trim13 3 0.44 0.5 3.91
66 INT217102 Gene_expression of Egr2 50 0.78 10.91 3.89
67 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86
68 INT17444 Gene_expression of MTHFS 14 0.66 5.17 3.85
69 INT199692 Gene_expression of Mkrn1 48 0.75 15.2 3.84
70 INT143082 Positive_regulation of Gene_expression of ACACA 5 0.67 5.36 3.83
71 INT51495 Positive_regulation of Trim13 3 0.41 0.08 3.81
72 INT165277 Negative_regulation of Acsf2 8 0.36 1.99 3.79
73 INT96071 Localization of PIAS1 6 0.71 4.44 3.79
74 INT116119 Gene_expression of Nfx1 1 0.75 0 3.72
75 INT75869 Gene_expression of Acsl1 24 0.45 27.76 3.66
76 INT66960 Negative_regulation of ACACA 4 0.57 1.21 3.59
77 INT50648 Negative_regulation of Gene_expression of Glul 9 0.58 2.7 3.53
78 INT24160 Gene_expression of TRIM13 7 0.65 1.42 3.46
79 INT66570 Localization of Glul 4 0.78 0.37 3.45
80 INT8481 Regulation of PIAS1 4 0.45 0.47 3.44
81 INT76758 Positive_regulation of Positive_regulation of RFFL 6 0.35 6.29 3.34
82 INT63727 Positive_regulation of Gene_expression of Syn1 4 0.50 2.1 3.31
83 INT36115 Transcription of Uchl1 7 0.60 3.24 3.25
84 INT246333 Localization of Sars 1 0.51 1.02 3.24
85 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23
86 INT35017 Negative_regulation of Phosphorylation of Syn1 5 0.59 0.24 3.22
87 INT197220 Positive_regulation of Gene_expression of Kars 3 0.39 0.29 3.15
88 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12
89 INT165057 Binding of MID1 7 0.32 4.13 3.12
90 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11
91 INT53468 Binding of Acsm3 26 0.24 20.87 2.95
92 INT25801 Negative_regulation of Negative_regulation of Rtcd1 6 0.05 0.82 2.95
93 INT54749 Binding of BTRC 7 0.09 0.88 2.9
94 INT61311 Negative_regulation of Gene_expression of Syn1 4 0.59 0.48 2.85
95 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84
96 INT173336 Gene_expression of GLUL 16 0.27 6.74 2.78
97 INT71442 Negative_regulation of Pars2 9 0.58 6.53 2.78
98 INT25128 Gene_expression of Mthfs 9 0.25 2.38 2.75
99 INT40772 Localization of Iars 7 0.25 0.49 2.75
100 INT54331 Positive_regulation of Glul 8 0.67 3.55 2.74
101 INT53020 Positive_regulation of ACSM3 9 0.58 11.03 2.73
102 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
103 INT154375 Gene_expression of Gars 12 0.37 1.28 2.69
104 INT71946 Negative_regulation of Ass1 7 0.41 1.9 2.68
105 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
106 INT5863 Positive_regulation of Egr2 7 0.40 1.44 2.64
107 INT141255 Regulation of Gars 6 0.22 0.49 2.59
108 INT197225 Regulation of Positive_regulation of Kars 1 0.35 0 2.56
109 INT249036 Gene_expression of Rnf103 1 0.78 7.53 2.42
110 INT39798 Negative_regulation of Gss 5 0.51 2.51 2.38
111 INT32923 Negative_regulation of Binding of TRIM13 2 0.57 0 2.38
112 INT127141 Negative_regulation of SUCLG2 1 0.49 0.57 2.34
113 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
114 INT229200 Gene_expression of Pc 13 0.65 8.96 2.32
115 INT13684 Positive_regulation of Gss 5 0.40 0.44 2.32
116 INT165059 Gene_expression of MID1 11 0.58 3.68 2.31
117 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
118 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26
119 INT65284 Regulation of Pc 7 0.52 5.93 2.24
120 INT86184 Negative_regulation of Acsl1 10 0.34 20.45 2.23
121 INT96070 Negative_regulation of PIAS1 3 0.35 1.08 2.23
122 INT207082 Positive_regulation of Pars2 10 0.14 5.45 2.22
123 INT30385 Protein_catabolism of Trim13 2 0.97 0 2.22
124 INT161500 Gene_expression of PC 42 0.67 9.02 2.2
125 INT97876 Gene_expression of Pias1 4 0.59 1.62 2.18
126 INT51496 Negative_regulation of Localization of Trim13 1 0.32 0 2.18
127 INT117415 Negative_regulation of LIG4 4 0.04 1.59 2.17
128 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14
129 INT58843 Positive_regulation of Sars 8 0.39 1.09 2.14
130 INT48858 Gene_expression of Gmps 8 0.52 0.36 2.13
131 INT126407 Positive_regulation of Syn2 1 0.50 2.17 2.13
132 INT49723 Localization of GLUL 5 0.27 0.67 2.1
133 INT132568 Negative_regulation of Positive_regulation of RFFL 1 0.33 4.86 2.09
134 INT121126 Positive_regulation of RNF34 9 0.04 6.83 2.05
135 INT35109 Binding of SUCLA2 6 0.32 5.79 2.01
136 INT69588 Regulation of Gars 4 0.13 0.42 2.01
137 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
138 INT124051 Regulation of ACACA 4 0.60 1.1 1.98
139 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94
140 INT57431 Binding of PIAS1 4 0.30 4.35 1.94
141 INT296095 Negative_regulation of Positive_regulation of Acsm3 1 0.14 4.41 1.94
142 INT43926 Gene_expression of SUCLA2 6 0.65 5.01 1.93
143 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93
144 INT49521 Binding of Rtcd1 5 0.04 0.22 1.9
145 INT34633 Positive_regulation of Rars 9 0.69 3.23 1.88
146 INT49584 Negative_regulation of Glul 3 0.52 1.16 1.88
147 INT217094 Positive_regulation of Egr2 17 0.69 5.31 1.87
148 INT27646 Regulation of Acsf2 6 0.41 1.32 1.87
149 INT50921 Phosphorylation of SYN1 4 0.38 0.08 1.86
150 INT18758 Positive_regulation of Gmps 4 0.41 0.36 1.86
151 INT104756 Gene_expression of ACSM3 8 0.58 8.76 1.83
152 INT126404 Gene_expression of Syn2 3 0.78 2.39 1.82
153 INT115674 Negative_regulation of Syn1 3 0.41 1.22 1.81
154 INT101148 Gene_expression of UCHL1 20 0.70 9.61 1.8
155 INT45064 Protein_catabolism of TRIM13 6 0.86 0 1.8
156 INT259220 Binding of Glul 3 0.36 0.61 1.78
157 INT217070 Gene_expression of Acsm3 8 0.25 6.27 1.75
158 INT157762 Localization of EPRS 6 0.60 5.29 1.73
159 INT5068 Binding of Mthfs 4 0.44 1.26 1.7
160 INT224975 Gene_expression of Ube3a 5 0.76 7.18 1.69
161 INT56201 Negative_regulation of Negative_regulation of Glul 2 0.31 0.97 1.69
162 INT29836 Regulation of MTHFS 6 0.33 1.43 1.67
163 INT41395 Positive_regulation of Gclc 9 0.61 1.34 1.66
164 INT50645 Positive_regulation of Positive_regulation of Glul 2 0.21 0.42 1.66
165 INT70595 Regulation of Pias1 1 0.53 0.34 1.66
166 INT24238 Phosphorylation of Syn1 11 0.45 2.97 1.65
167 INT41820 Positive_regulation of TRIM13 3 0.49 0.46 1.65
168 INT25981 Regulation of RTCA 7 0.26 2.07 1.64
169 INT107012 Binding of EPRS 5 0.30 2.92 1.63
170 INT25131 Localization of Mthfs 5 0.34 2.09 1.63
171 INT87100 Gene_expression of ACSL1 10 0.58 1.56 1.62
172 INT234116 Positive_regulation of MID1 9 0.03 3.78 1.61
173 INT129053 Regulation of EPRS 3 0.17 2.79 1.6
174 INT217072 Negative_regulation of Acsm3 5 0.29 6.15 1.59
175 INT161371 Gene_expression of Glul 7 0.61 2.44 1.58
176 INT66942 Negative_regulation of Protein_catabolism of Trim13 1 0.50 0 1.58
177 INT8480 Gene_expression of PIAS1 3 0.78 1.73 1.57
178 INT247752 Gene_expression of Ears2 2 0.25 4.65 1.57
179 INT72377 Phosphorylation of Trim13 1 0.79 0.27 1.57
180 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
181 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
182 INT81222 Binding of RNF130 9 0.47 5.38 1.54
183 INT60483 Negative_regulation of Phosphorylation of SYN1 2 0.07 0.08 1.54
184 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
185 INT214123 Negative_regulation of Gene_expression of Uchl1 3 0.06 4.52 1.52
186 INT40775 Positive_regulation of Localization of Iars 1 0.14 0 1.5
187 INT325697 Localization of Aacs 1 0.59 0.12 1.5
188 INT38043 Gene_expression of Cps1 6 0.56 0.82 1.46
189 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46
190 INT125871 Gene_expression of XIAP 5 0.65 11.46 1.46
191 INT135712 Positive_regulation of Positive_regulation of RNF34 2 0.03 2.21 1.45
192 INT69401 Gene_expression of Syn2 3 0.47 0.14 1.44
193 INT17219 Localization of Trim28 1 0.51 0 1.43
194 INT57524 Gene_expression of Sars 5 0.43 2.09 1.41
195 INT66372 Localization of RTCA 3 0.27 1.84 1.41
196 INT181868 Localization of ACLY 5 0.62 6.36 1.4
197 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4
198 INT259222 Positive_regulation of Binding of Glul 1 0.05 0 1.39
199 INT69400 Regulation of Gene_expression of Syn2 1 0.31 0 1.38
200 INT191678 Gene_expression of Xiap 60 0.71 57.25 1.37
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