GOS:lyase activity

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This page displays the top molecular interactions and top single events that were mentioned in the literature for lyase activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lyase activity. They are ordered first by their pain relevance and then by number of times they were reported for lyase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to lyase activity Documents TM Confidence Disease Relevance Pain Relevance
1 INT259228 Binding of Oprm1 and Glul 1 1 0.00 0.08 7.22
2 INT259209 Binding of Glul and Flna 1 1 0.03 0 4.2
3 INT48162 RIMS3 Regulation of Localization of LTC4S 1 1 0.10 2.14 3.25
4 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 1 0.17 0.55 2.7
5 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 1 0.12 0 2.53
6 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 1 0.17 0.46 2.13
7 INT64750 Binding of Oprm1 and Pck1 1 2 0.41 0.51 2.07
8 INT296277 Binding of Car2 and Kcnip3 1 5 0.18 1.09 2.06
9 INT283050 Binding of Gad2 and Trpm8 1 1 0.23 2.02 1.93
10 INT145940 Binding of Gad1 and Abat 1 2 0.14 1.44 1.78
11 INT296280 Binding of Car2 and Dlg4 1 1 0.19 0.45 1.71
12 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 1 0.21 0 1.64
13 INT45816 Binding of Car2 and Gabrg1 1 2 0.28 0.15 1.63
14 INT208991 Binding of CALM1 and Ca2 1 10 0.06 1.34 1.55
15 INT208980 Binding of Ca2 and Trpv1 1 4 0.32 0.67 1.55
16 INT69709 NPL Positive_regulation of Localization of POMC 1 2 0.36 1.22 1.51
17 INT256360 Car2 Positive_regulation of Localization of Rela 1 1 0.14 0 1.51
18 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 1 0.04 0.66 1.49
19 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 1 0.12 0.66 1.49
20 INT26893 OGG1 Negative_regulation of Gh1 1 1 0.12 0 1.37
21 INT281382 FSCN1 Positive_regulation of Sds 1 1 0.02 0.84 1.33
22 INT63407 Binding of Oprl1 and Pck1 1 1 0.40 0 1.29
23 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 1 0.47 0.21 1.27
24 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 1 0.58 0.81 1.23
25 INT147033 Positive_regulation of Binding of Sds and Accn3 1 1 0.13 0.73 1.23
26 INT147032 Binding of Sds and Accn3 1 1 0.09 0.73 1.22
27 INT285185 Binding of Ca2 and Cd2 1 1 0.25 0.24 1.21
28 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 1 0.38 0 1.21
29 INT317553 Binding of Car2 and Grin1 1 1 0.07 0 1.14
30 INT1619 Binding of Gad1 and Oprl1 1 1 0.14 0 1.13
31 INT1620 Negative_regulation of Binding of Gad1 and Oprl1 1 1 0.16 0 1.13
32 INT270053 HOXD12 Positive_regulation of Gene_expression of GAD1 1 1 0.03 0.68 1.12
33 INT270052 GAD1 Positive_regulation of Gene_expression of SFTPA1 1 1 0.03 0.68 1.11
34 INT61053 Adarb1 Positive_regulation of Pomc Negative_regulation of Odc1 1 1 0.01 0 1.1
35 INT317552 Binding of Calm3 and Car2 1 2 0.06 0.07 1.05
36 INT33142 Pck1 Positive_regulation of Npr1 1 4 0.01 0.5 1.02
37 INT293014 IRF6 Positive_regulation of Localization of CA2 1 1 0.04 0.71 1.02
38 INT293008 IL8 Positive_regulation of Localization of CA2 1 1 0.11 0.71 1.01
39 INT153727 Sds Negative_regulation of RYBP Positive_regulation of Slc17a5 1 1 0.02 0.68 1.01
40 INT353690 Binding of Grin2b and Ca2 1 1 0.14 1.17 1.01
41 INT71000 Positive_regulation of Adarb1 Positive_regulation of Odc1 1 1 0.01 0 1
42 INT69506 CA2 Positive_regulation of PRKCA 1 1 0.50 0.42 0.98
43 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 1 0.06 0.99 0.96
44 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 1 0.21 0.98 0.95
45 INT88583 Hal Positive_regulation of Prl 1 1 0.15 0.44 0.95
46 INT60827 Ddc Positive_regulation of Localization of Abat 1 1 0.12 0.34 0.94
47 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 1 0.29 0.97 0.94
48 INT60828 Ddc Positive_regulation of Abat 1 1 0.13 0.34 0.93
49 INT56779 Pomc Negative_regulation of Gene_expression of Odc1 1 2 0.31 0 0.89
50 INT57746 Il1 Regulation of Gene_expression of Ltc4s 1 1 0.36 0.33 0.88
51 INT272039 Ddc Positive_regulation of Gene_expression of Aanat 1 1 0.00 0.26 0.87
52 INT330630 Binding of TP53 and Car1 1 1 0.23 1.56 0.86
53 INT110236 Hk1 Regulation of CSAD 1 1 0.01 1.57 0.84
54 INT12137 Ngf Regulation of Gad1 1 1 0.27 0.67 0.83
55 INT73462 PTPLA Regulation of Gene_expression of SART1 1 1 0.00 0.79 0.82
56 INT110118 A630055G03Rik Regulation of Car2 1 1 0.01 0.35 0.81
57 INT61052 Binding of Adarb1 and Negative_regulation of Gene_expression of Odc1 1 1 0.02 0 0.81
58 INT270217 Binding of C2 and Ca2 1 1 0.03 1.63 0.81
59 INT251172 Trpv1 Regulation of Gene_expression of Ca2 1 1 0.13 0.7 0.81
60 INT317705 Gad2 Regulation of Gene_expression of Gabrg1 1 1 0.28 0.53 0.8
61 INT77526 Oprd1 Regulation of Positive_regulation of Odc1 1 1 0.01 0.12 0.78
62 INT296279 Positive_regulation of Rbm39 Positive_regulation of Positive_regulation of Car2 1 1 0.01 0.58 0.78
63 INT69225 Pnoc Negative_regulation of Car1 1 1 0.42 0 0.78
64 INT296297 Positive_regulation of Cysltr1 Positive_regulation of Positive_regulation of Car2 1 1 0.01 0.59 0.77
65 INT305034 Adcy8 Regulation of Localization of Adcy1 2 1 0.35 1.51 0.77
66 INT305033 Adcy1 Regulation of Localization of Adcy8 2 1 0.35 1.51 0.77
67 INT190788 Adcy8 Positive_regulation of Adcy1 2 1 0.23 0.77 0.77
68 INT170369 Binding of Car2 and Nono 1 1 0.01 0 0.76
69 INT49585 Binding of Glul and Selenbp2 1 1 0.20 0.19 0.76
70 INT322128 Binding of Ca2 and Trpv4 1 1 0.03 1.1 0.75
71 INT111194 Binding of NEUROD1 and Pck1 1 1 0.39 0 0.75
72 INT61050 Oprd1 Positive_regulation of Odc1 1 1 0.25 0 0.74
73 INT111080 Binding of CA1 and CA2 2 2 0.02 1.62 0.73
74 INT136538 Nrgn Regulation of Car2 1 1 0.33 0 0.73
75 INT296285 Binding of Car1 and Grin2b 1 1 0.14 0.32 0.72
76 INT296292 Binding of Car1 and Grin2a 1 1 0.14 0.32 0.72
77 INT288323 Glyr1 Regulation of Sds 1 1 0.05 0.2 0.72
78 INT317586 Binding of SCLY and Ppap2b 1 1 0.00 0.78 0.72
79 INT296290 Binding of Car1 and Grin1 1 1 0.11 0.32 0.72
80 INT272147 PTAFR Positive_regulation of CA2 1 1 0.13 0 0.71
81 INT208978 Ca2 Positive_regulation of Trpv1 1 1 0.22 0.29 0.71
82 INT130356 Adcy10 Negative_regulation of Positive_regulation of Crp 1 1 0.13 0.23 0.71
83 INT328625 NPL Regulation of Phosphorylation of Ephb1 1 1 0.04 0.42 0.7
84 INT251169 Clu Regulation of Ca2 1 1 0.03 0.66 0.7
85 INT335596 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Car2 1 1 0.12 0.19 0.69
86 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 1 0.10 0 0.69
87 INT253759 Hmgb1 Positive_regulation of Apex1 1 1 0.09 4.53 0.69
88 INT99937 Ddc Regulation of Transcription of Qrfp 1 1 0.02 0 0.69
89 INT82311 Binding of HADHA and Gast 1 1 0.03 0.37 0.68
90 INT288326 Sds Positive_regulation of Glyr1 1 1 0.10 0.12 0.68
91 INT82312 Negative_regulation of Binding of HADHA and Gast 1 1 0.04 0.37 0.68
92 INT288324 Sds Positive_regulation of Gene_expression of Glyr1 1 1 0.10 0.12 0.68
93 INT99940 Ddc Regulation of Drd1a Regulation of Qrfp 1 1 0.01 0 0.68
94 INT146375 Sds Negative_regulation of Positive_regulation of Cysltr1 1 1 0.02 0.32 0.67
95 INT151252 CSAD Positive_regulation of Positive_regulation of Ltp 1 1 0.06 0.81 0.67
96 INT283049 Car2 Positive_regulation of Trpa1 1 1 0.20 1.33 0.67
97 INT41224 Pdyn Positive_regulation of Car1 1 1 0.19 0 0.66
98 INT326586 SLC18A2 Negative_regulation of DDC 1 1 0.28 0.91 0.66
99 INT130357 Adcy10 Regulation of Fgg 1 1 0.03 0.2 0.66
100 INT130354 Adcy10 Regulation of Serpine1 1 1 0.17 0.2 0.66
101 INT309123 Edc4 Positive_regulation of Car1 1 1 0.02 0.51 0.66
102 INT151251 CSAD Regulation of Positive_regulation of Ltp 1 1 0.04 0.82 0.65
103 INT308484 Car2 Positive_regulation of Pla2g4a 1 1 0.03 1.23 0.65
104 INT251165 Trpv1 Positive_regulation of Gene_expression of Ca2 1 1 0.15 0.54 0.65
105 INT50634 Ddc Regulation of Gene_expression of Glul 2 1 0.02 0 0.65
106 INT253935 Binding of PTPLA and Trpv1 1 1 0.14 1.25 0.65
107 INT169293 PTPLA Positive_regulation of AKT1 1 1 0.10 0.15 0.64
108 INT34099 Hal Positive_regulation of Localization of Gnrh1 1 1 0.00 0 0.64
109 INT235082 CA2 Positive_regulation of NOS1 1 2 0.11 0.62 0.63
110 INT169285 PTPLA Positive_regulation of GRAP2 1 1 0.03 0.15 0.63
111 INT281081 Prkaca Positive_regulation of Gene_expression of Adcy1 1 1 0.12 0 0.63
112 INT169296 PTPLA Positive_regulation of MAPK3 1 1 0.10 0.15 0.63
113 INT127057 Ddc Positive_regulation of Gene_expression of Slc1a2 1 1 0.01 0.06 0.63
114 INT169295 PTPLA Positive_regulation of MAPK8 1 1 0.10 0.15 0.63
115 INT77529 PDYN Positive_regulation of Odc1 1 1 0.02 0 0.63
116 INT281092 Adcy1 Positive_regulation of Mapk1 1 1 0.21 0 0.63
117 INT113146 Ddc Positive_regulation of Gene_expression of Nr4a1 1 1 0.06 0.1 0.63
118 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 1 0.10 0.06 0.63
119 INT281078 Prkacb Positive_regulation of Gene_expression of Adcy1 1 1 0.03 0 0.63
120 INT326193 Bdnf Positive_regulation of Car2 1 2 0.14 0.11 0.62
121 INT9163 Tnf Regulation of Gene_expression of Glul 1 1 0.12 1.99 0.62
122 INT98386 GAD1 Positive_regulation of Gene_expression of Abat 1 1 0.30 1.67 0.62
123 INT281076 Adcy1 Positive_regulation of Mdk 1 1 0.07 0 0.62
124 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 1 0.10 0 0.62
125 INT50816 Penk Positive_regulation of Localization of Ca2 1 1 0.32 0 0.62
126 INT164285 Ltc4s Positive_regulation of Cysltr2 1 1 0.20 1.11 0.61
127 INT123301 Car2 Positive_regulation of Creb1 1 1 0.21 0.28 0.61
128 INT164283 Ltb4r Positive_regulation of Ltc4s 1 1 0.37 1.1 0.6
129 INT70254 Binding of Htr1a and Ca2 1 1 0.31 0.5 0.6
130 INT169291 CNR1 Positive_regulation of Gene_expression of PTPLA 1 1 0.19 0.11 0.59
131 INT321300 Ins1 Negative_regulation of Pck1 1 1 0.09 0.52 0.59
132 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 1 0.01 0 0.59
133 INT169298 TRPV1 Positive_regulation of Gene_expression of PTPLA 1 1 0.20 0.11 0.59
134 INT240070 KCNIP3 Regulation of CA2 1 1 0.02 0.72 0.59
135 INT169292 Positive_regulation of CNR1 Positive_regulation of Gene_expression of PTPLA 1 1 0.19 0.11 0.59
136 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 1 0.10 3.53 0.58
137 INT335432 Ltc4s Regulation of Cysltr2 1 1 0.11 0.38 0.58
138 INT37035 PLAT Negative_regulation of ODC1 1 1 0.45 0.15 0.58
139 INT335436 Ltc4s Regulation of Gene_expression of Cysltr2 1 1 0.18 0.38 0.58
140 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 1 0.01 0.52 0.57
141 INT218844 Cysltr1 Regulation of Car1 1 1 0.01 1.42 0.55
142 INT218839 Ppp1r9a Regulation of Car1 1 1 0.12 1.42 0.55
143 INT218841 Ltp Regulation of Car1 1 1 0.15 1.42 0.55
144 INT281124 Tcf21 Positive_regulation of Binding of Ddc and 1 1 0.04 1.21 0.54
145 INT61051 Pomc Negative_regulation of Odc1 1 1 0.22 0 0.54
146 INT209591 Car2 Positive_regulation of Positive_regulation of Ltp 1 1 0.05 0 0.54
147 INT208984 Binding of Ca2 and Fig4 1 1 0.02 0 0.54
148 INT56733 Ddc Positive_regulation of Localization of GLUL 2 1 0.00 0 0.54
149 INT209592 Car2 Positive_regulation of Localization of Ltp 1 1 0.05 0 0.54
150 INT216918 Binding of Ca2 and Abat 1 1 0.01 0.45 0.53
151 INT118138 Binding of Ca2 and Mgat4a 1 1 0.01 0 0.53
152 INT333309 Binding of Htr1b and Adcy1 1 1 0.01 0 0.53
153 INT187333 Binding of C4bpa and Car1 1 1 0.08 0 0.52
154 INT297479 Ryr2 Positive_regulation of Ca2 1 1 0.22 0 0.52
155 INT30028 Ins1 Regulation of Odc1 1 2 0.11 0 0.51
156 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 1 0.03 0 0.51
157 INT318472 CA2 Regulation of OPRM1 1 1 0.17 0 0.51
158 INT37583 Naga Regulation of Odc1 1 1 0.20 0 0.51
159 INT261498 CBS Positive_regulation of DSE 1 1 0.00 0 0.5
160 INT330796 P2ry1 Positive_regulation of Ca2 1 1 0.05 0.06 0.5
161 INT93740 Ddc Positive_regulation of Tnf 1 1 0.00 1.45 0.5
162 INT39248 NPL Regulation of PLOD1 1 1 0.14 0.16 0.49
163 INT103535 Obfc1 Negative_regulation of Positive_regulation of Gad1 1 1 0.03 0.07 0.49
164 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 1 0.08 0.71 0.49
165 INT65007 DAK Negative_regulation of CTSA 1 1 0.03 0.35 0.48
166 INT250077 Positive_regulation of Ltp Positive_regulation of Localization of Ca2 1 1 0.10 0 0.48
167 INT280189 Binding of Cbs and P2rx3 1 1 0.01 1.03 0.47
168 INT65006 DAK Negative_regulation of ELANE 1 1 0.05 0.35 0.47
169 INT280188 Binding of Cbs and Trpv1 1 1 0.26 1.03 0.47
170 INT39181 NPL Regulation of Prl 1 1 0.16 0 0.47
171 INT338447 GAD1 Negative_regulation of Slc32a1 1 1 0.04 0.59 0.47
172 INT117531 Twist1 Regulation of CSAD 1 1 0.00 0.85 0.47
173 INT39870 Odc1 Negative_regulation of Tk1 1 1 0.36 0.8 0.46
174 INT39178 NPL Regulation of FSHR 1 1 0.03 0 0.46
175 INT72203 GH1 Regulation of OGG1 1 1 0.10 0 0.46
176 INT117890 Positive_regulation of Gfap Regulation of Glul 1 1 0.51 0.36 0.46
177 INT310769 Pam Regulation of Tlr4 1 1 0.01 0.69 0.46
178 INT117887 Glul Regulation of Arc 1 1 0.02 0.37 0.46
179 INT117889 Gfap Regulation of Glul 1 1 0.30 0.36 0.46
180 INT237810 Itpr3 Positive_regulation of Localization of Car2 1 2 0.08 0.68 0.45
181 INT261839 Binding of Car2 and Trpv1 1 1 0.03 0 0.45
182 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 1 0.05 1.24 0.45
183 INT265359 Efs Positive_regulation of Car2 1 1 0.19 0.42 0.45
184 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 1 0.04 0 0.45
185 INT185191 Binding of Car9 and Pif 1 1 0.01 2.33 0.45
186 INT309136 Dlat Positive_regulation of Gene_expression of Car1 1 1 0.03 0.99 0.45
187 INT193219 Binding of LTC4S and CYSLTR2 1 2 0.28 2.2 0.44
188 INT254460 Binding of Calm2 and Ca2 1 5 0.03 0.48 0.43
189 INT257806 Binding of Car1 and Gopc 1 1 0.13 0 0.43
190 INT12139 Ins1 Regulation of Gad1 1 1 0.15 0.33 0.42
191 INT33380 Binding of PTPLA and NPL 2 1 0.23 0.27 0.41
192 INT250975 Binding of FMOD and CSAD 1 1 0.01 0.86 0.41
193 INT140140 Adcy1 Regulation of Regulation of Atf6b 1 1 0.14 0.34 0.41
194 INT161074 Ccbl1 Negative_regulation of Gsr 1 1 0.00 0 0.41
195 INT66660 Pck1 Positive_regulation of Localization of Ptprg 1 1 0.07 0 0.4
196 INT37584 Naga Positive_regulation of Odc1 1 1 0.51 0 0.4
197 INT55588 Drd2 Regulation of Transcription of Gad1 1 1 0.15 0.07 0.4
198 INT37582 Pomc Regulation of Odc1 1 1 0.31 0 0.4
199 INT325701 Aacs Regulation of Car3 1 1 0.17 0 0.4
200 INT148514 Binding of Gad2 and Penk 1 1 0.25 0 0.4

Single Events

The table below shows the top 100 pain related interactions that have been reported for lyase activity. They are ordered first by their pain relevance and then by number of times they were reported in lyase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
2 INT4822 Localization of Ca2 417 0.80 99.57 96.45
3 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35
4 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
5 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
6 INT12717 Binding of Pck1 85 0.47 12.49 54.81
7 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
8 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76
9 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11
10 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97
11 INT17561 Localization of Car2 303 0.79 60.95 44.52
12 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71
13 INT12029 Gene_expression of Car1 143 0.67 29.69 36.39
14 INT5489 Localization of CA2 172 0.80 39.46 33.56
15 INT10453 Positive_regulation of Gad1 65 0.70 10.75 31.9
16 INT2671 Positive_regulation of Odc1 82 0.70 11.03 29
17 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96
18 INT1616 Regulation of Gad1 46 0.61 10.2 28.64
19 INT111081 Gene_expression of CA1 19 0.75 51.09 26.64
20 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95
21 INT13145 Positive_regulation of Car1 60 0.70 16.32 23.23
22 INT11829 Negative_regulation of Odc1 54 0.59 7.03 23.03
23 INT82461 Gene_expression of Gad2 40 0.78 19.12 22.79
24 INT17962 Regulation of Car2 124 0.41 33.98 22.71
25 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68
26 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07
27 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86
28 INT6230 Localization of Ddc 40 0.79 13.11 20.88
29 INT16326 Transcription of Gad1 58 0.71 15.78 20.45
30 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4
31 INT12031 Negative_regulation of Car1 44 0.59 20.46 19.36
32 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72
33 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45
34 INT19948 Gene_expression of Sds 34 0.63 14.69 15.44
35 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4
36 INT24798 Negative_regulation of Glul 52 0.55 27.25 15.17
37 INT6869 Positive_regulation of Car3 34 0.61 5.15 14.21
38 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07
39 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8
40 INT21937 Positive_regulation of Scly 16 0.39 22.34 13.76
41 INT3112 Regulation of Odc1 39 0.62 4.73 13.69
42 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6
43 INT19799 Binding of Ca2 71 0.48 13.69 12.92
44 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35
45 INT3969 Positive_regulation of Sds 27 0.69 7.52 12.31
46 INT107539 Gene_expression of Csad 7 0.66 8.32 12.13
47 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63
48 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24
49 INT311552 Positive_regulation of Gene_expression of CA1 3 0.67 21.83 11.2
50 INT3535 Regulation of CA2 61 0.32 16.48 10.8
51 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19
52 INT29967 Positive_regulation of Positive_regulation of Car2 40 0.40 8.03 10.13
53 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96
54 INT14881 Gene_expression of Car3 49 0.73 14.89 9.94
55 INT36212 Positive_regulation of Csad 11 0.61 12.31 9.94
56 INT55038 Gene_expression of Adcy8 10 0.77 28.79 9.8
57 INT32239 Gene_expression of Car3 38 0.67 6.86 9.76
58 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63
59 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62
60 INT130280 Positive_regulation of Gene_expression of Gad2 7 0.69 8.13 9.55
61 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53
62 INT336 Negative_regulation of Gad1 19 0.58 7.71 9.51
63 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43
64 INT179696 Negative_regulation of DAK 5 0.02 16.79 9.42
65 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35
66 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34
67 INT1129 Binding of Car2 69 0.35 14.01 9.2
68 INT26789 Positive_regulation of Gene_expression of Gad1 22 0.70 7.39 9.02
69 INT63739 Regulation of Gad2 15 0.58 3.44 8.86
70 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
71 INT220 Negative_regulation of Ddc 16 0.59 2.94 8.66
72 INT7663 Positive_regulation of Pck1 15 0.67 3.05 8.63
73 INT170504 Positive_regulation of Gene_expression of Car2 60 0.41 19.1 8.45
74 INT106719 Gene_expression of Adcy1 18 0.77 12.18 8.42
75 INT46112 Regulation of GAD1 15 0.52 11.09 8.37
76 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35
77 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17
78 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07
79 INT24799 Regulation of Glul 22 0.45 8.3 8
80 INT12028 Regulation of Car1 28 0.43 9.01 7.84
81 INT139493 Gene_expression of Scly 11 0.57 16.96 7.61
82 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6
83 INT29142 Positive_regulation of Binding of Pck1 10 0.67 1.48 7.6
84 INT4807 Localization of LTC4S 23 0.58 6.89 7.59
85 INT97068 Gene_expression of PISD 1 0.07 4.2 7.59
86 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47
87 INT202868 Positive_regulation of Car1 30 0.44 15.48 7.42
88 INT4284 Regulation of Ddc 17 0.43 8.17 7.31
89 INT98205 Gene_expression of PCBD1 10 0.61 14.78 7.27
90 INT261511 Localization of CBS 1 0.02 5.06 7.27
91 INT53685 Regulation of Sds 10 0.39 5.39 7.22
92 INT12032 Negative_regulation of Gene_expression of Car1 16 0.34 7.23 7.03
93 INT20840 Negative_regulation of Car3 14 0.47 4.35 6.83
94 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79
95 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76
96 INT29845 Positive_regulation of Sds 11 0.62 3.69 6.63
97 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61
98 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59
99 INT50633 Regulation of Gene_expression of Glul 12 0.60 1.64 6.59
100 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54
101 INT65480 Gene_expression of Pts 15 0.66 7.53 6.46
102 INT30025 Negative_regulation of Positive_regulation of Odc1 14 0.59 0.89 6.34
103 INT96164 Positive_regulation of CA1 8 0.67 10.99 6.23
104 INT19110 Gene_expression of Odc1 19 0.78 4.51 6.11
105 INT49011 Regulation of Gene_expression of Gad1 10 0.62 0.55 6.07
106 INT25193 Negative_regulation of Pck1 20 0.57 5.66 6.05
107 INT20839 Regulation of Car3 12 0.45 4.13 5.97
108 INT157121 Gene_expression of GAD2 15 0.67 7.21 5.91
109 INT86799 Gene_expression of Pck1 20 0.65 6.22 5.8
110 INT39436 Positive_regulation of PISD 4 0.26 3.16 5.78
111 INT245587 Regulation of Car1 13 0.27 4.68 5.72
112 INT93387 Gene_expression of Sds 9 0.65 2.58 5.72
113 INT75978 Transcription of Gad2 11 0.69 2.28 5.68
114 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59
115 INT5490 Binding of CA2 52 0.36 9.73 5.53
116 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53
117 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51
118 INT170516 Negative_regulation of Gene_expression of Car2 35 0.35 9.4 5.48
119 INT22160 Negative_regulation of Positive_regulation of Car2 18 0.38 4.94 5.45
120 INT55037 Positive_regulation of Adcy8 7 0.61 5.92 5.36
121 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31
122 INT12030 Positive_regulation of Gene_expression of Car1 15 0.50 3.98 5.27
123 INT74394 Negative_regulation of Gad2 6 0.42 1.96 5.26
124 INT30800 Localization of Car3 11 0.80 0.5 5.21
125 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1
126 INT158668 Positive_regulation of Gene_expression of Sgpl1 1 0.05 1.15 5.09
127 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07
128 INT10606 Localization of Ltc4s 16 0.75 10.14 5.05
129 INT1317 Negative_regulation of Sds 23 0.48 6.97 5.03
130 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03
131 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02
132 INT35990 Negative_regulation of Sds 8 0.49 4.47 4.96
133 INT28449 Binding of Car3 10 0.36 0.89 4.95
134 INT131176 Gene_expression of Srr 8 0.64 3.29 4.81
135 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8
136 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8
137 INT66388 Positive_regulation of Transcription of Gad1 14 0.67 2.45 4.67
138 INT128353 Negative_regulation of Car3 16 0.37 4.93 4.61
139 INT131808 Localization of Apex1 2 0.16 13.46 4.61
140 INT106971 Positive_regulation of Gene_expression of GAD1 19 0.58 10.89 4.59
141 INT25146 Negative_regulation of Positive_regulation of Glul 5 0.43 0.91 4.53
142 INT158664 Gene_expression of Sgpl1 5 0.20 1.8 4.47
143 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44
144 INT50631 Positive_regulation of Gene_expression of Glul 9 0.43 3 4.37
145 INT119785 Localization of GAD1 7 0.63 5.99 4.34
146 INT63740 Positive_regulation of Gad2 11 0.66 0.78 4.32
147 INT333923 Gene_expression of GLO1 1 0.43 3.26 4.27
148 INT76467 Regulation of Gene_expression of Car2 41 0.37 12.88 4.21
149 INT106721 Regulation of Adcy1 6 0.45 2.32 4.17
150 INT50646 Transcription of Glul 12 0.38 3.59 4.07
151 INT35992 Regulation of Sds 7 0.52 1.14 4.04
152 INT159119 Negative_regulation of Car1 17 0.37 6.6 4.01
153 INT38285 Positive_regulation of SCLY 8 0.36 3.32 3.96
154 INT252884 Positive_regulation of Gene_expression of PISD 1 0.05 1.15 3.92
155 INT131178 Positive_regulation of Srr 4 0.56 4.78 3.91
156 INT20743 Positive_regulation of Gene_expression of Ltc4s 13 0.60 12.3 3.86
157 INT2073 Regulation of CA1 5 0.26 4.9 3.86
158 INT151427 Gene_expression of ADC 31 0.55 21.86 3.81
159 INT280193 Positive_regulation of Gene_expression of Cbs 1 0.69 6.59 3.81
160 INT34441 Negative_regulation of Binding of Pck1 6 0.42 0.76 3.8
161 INT11261 Positive_regulation of PTPLA 3 0.50 4.4 3.74
162 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73
163 INT54116 Negative_regulation of Eno2 6 0.41 2.78 3.71
164 INT35634 Positive_regulation of Gene_expression of Sds 10 0.37 3.23 3.69
165 INT26891 Gene_expression of OGG1 21 0.74 2.08 3.64
166 INT141125 Regulation of Gene_expression of GAD1 5 0.52 8.81 3.63
167 INT200385 Negative_regulation of ADC 19 0.18 16.56 3.6
168 INT50648 Negative_regulation of Gene_expression of Glul 9 0.58 2.7 3.53
169 INT41541 Regulation of Gene_expression of Car1 9 0.41 3.82 3.52
170 INT76468 Regulation of Positive_regulation of Car2 13 0.29 4.54 3.46
171 INT42251 Regulation of Gad1 10 0.44 5.25 3.45
172 INT66570 Localization of Glul 4 0.78 0.37 3.45
173 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32
174 INT131748 Binding of Csad 5 0.32 5.23 3.32
175 INT23376 Localization of NPL 7 0.47 2.59 3.29
176 INT128138 Positive_regulation of Positive_regulation of Adcy1 5 0.45 2.67 3.25
177 INT218814 Negative_regulation of Gene_expression of Car1 12 0.24 3.95 3.24
178 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23
179 INT35009 Binding of CSAD 12 0.41 10.74 3.21
180 INT16159 Regulation of Ltc4s 11 0.38 2.52 3.21
181 INT12843 Regulation of Pck1 13 0.60 3.46 3.18
182 INT39249 Positive_regulation of NPL 5 0.41 2.72 3.18
183 INT30024 Regulation of Positive_regulation of Odc1 3 0.50 0.19 3.17
184 INT64748 Regulation of Binding of Pck1 4 0.44 0.45 3.15
185 INT67770 Regulation of NPL 4 0.18 0.85 3.13
186 INT149795 Gene_expression of Ddc 8 0.73 1.5 3.06
187 INT82462 Positive_regulation of Transcription of Gad2 5 0.49 1.03 3.01
188 INT67952 Regulation of Transcription of Gad1 6 0.51 1.23 2.98
189 INT151947 Positive_regulation of MVD 3 0.67 1.53 2.97
190 INT120201 Gene_expression of Aco1 54 0.35 26.29 2.95
191 INT15549 Regulation of Positive_regulation of Ca2 11 0.38 2.55 2.92
192 INT91520 Negative_regulation of Positive_regulation of CA2 7 0.30 0.99 2.92
193 INT4811 Positive_regulation of Gene_expression of LTC4S 5 0.65 3.29 2.92
194 INT31111 Negative_regulation of Positive_regulation of Car3 4 0.38 0.52 2.91
195 INT220335 Gene_expression of UROD 34 0.54 24.53 2.89
196 INT50535 Gene_expression of CA3 25 0.51 9.25 2.89
197 INT11920 Regulation of ENO2 18 0.55 11.51 2.89
198 INT54170 Positive_regulation of Positive_regulation of Gad1 5 0.69 0 2.89
199 INT65481 Positive_regulation of Gene_expression of Pts 5 0.48 0.57 2.85
200 INT82841 Localization of Car1 11 0.68 3.91 2.84
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