GOS:neurological system process

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This page displays the top molecular interactions and top single events that were mentioned in the literature for neurological system process. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neurological system process. They are ordered first by their pain relevance and then by number of times they were reported for neurological system process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to neurological system process Documents TM Confidence Disease Relevance Pain Relevance
1 INT276678 Nkx1-1 Regulation of Nav1 1 1 0.15 0.88 3.31
2 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 1 0.07 0.94 3.08
3 INT140347 Binding of ATP1A2 and Cacna1a 1 1 0.11 2.88 2.73
4 INT74840 Binding of Cacna1a and Cacna1a 2 5 0.00 4.24 2.36
5 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 1 0.01 0.06 1.86
6 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 1 0.04 0.06 1.86
7 INT276674 Negative_regulation of Nkx1-1 Regulation of Nav1 1 1 0.11 0.68 1.81
8 INT276680 Binding of Prkcg and Nkx1-1 1 1 0.05 0.18 1.66
9 INT276670 Binding of Trpv1 and Nkx1-1 1 1 0.07 0.68 1.6
10 INT355254 Ltp Regulation of Cacna1a 1 1 0.04 0 1.58
11 INT74843 Binding of Cacna1a and Ea2 1 3 0.13 3.29 1.55
12 INT276687 Pax3 Positive_regulation of Nkx1-1 1 1 0.00 0.59 1.47
13 INT276688 Positive_regulation of Prkcg Positive_regulation of Nkx1-1 Regulation of Trpv1 1 1 0.05 0.16 1.46
14 INT276675 Binding of Nkx1-1 and Nav1 1 1 0.09 0.21 1.46
15 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 1 0.04 0 1.39
16 INT276673 Nkx1-1 Regulation of Trpv1 1 1 0.05 0.16 1.37
17 INT355253 Ltp Positive_regulation of Cacna1a 1 1 0.05 0 1.34
18 INT355252 Binding of Cacna1a and Cnr1 1 1 0.04 0 1.31
19 INT154203 Binding of Pick1 and Grm7 1 1 0.41 1.64 1.28
20 INT74841 Binding of Cacna1a and Ea2 1 2 0.01 2.33 1.27
21 INT206766 Positive_regulation of Ltp Positive_regulation of Positive_regulation of Nkx1-1 1 1 0.01 0.22 1.16
22 INT73679 Nkx1-1 Positive_regulation of Tacr3 1 1 0.22 0.26 1.12
23 INT108729 Binding of CACNA1A and Cacna1a 1 3 0.13 1.21 0.95
24 INT219035 Nkx1-1 Regulation of Gene_expression of Bdnf 1 1 0.13 0.88 0.7
25 INT81769 Binding of Chrna4 and Neurod1 2 1 0.35 0.07 0.69
26 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 1 0.03 0 0.65
27 INT354986 Cacna1a Regulation of Localization of Mpo 1 1 0.01 1.15 0.49
28 INT88080 Binding of Chrna4 and Psmb6 2 1 0.03 0.56 0.46
29 INT12677 Sepp1 Positive_regulation of Localization of Nkx1-1 1 1 0.06 0.1 0.46
30 INT12678 Sepp1 Regulation of Nkx1-1 1 1 0.03 0.1 0.45
31 INT12675 Nka1 Regulation of Nkx1-1 1 1 0.03 0.1 0.45
32 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 1 0.01 0.99 0.45
33 INT12676 Sepp1 Positive_regulation of Nkx1-1 1 1 0.02 0.1 0.45
34 INT12674 Nka1 Positive_regulation of Nkx1-1 1 1 0.03 0.1 0.45
35 INT296477 Binding of Cacng2 and Dlg4 1 1 0.04 0.22 0.42
36 INT160971 Gm2111 Positive_regulation of Grm7 1 1 0.01 0.16 0.41
37 INT354984 Binding of Cacna1a and Tnf 1 1 0.01 0.83 0.4
38 INT158355 Cacna1a Regulation of Alox5 1 1 0.01 0.7 0.37
39 INT354985 Cacna1a Regulation of Nos2 1 1 0.01 0.73 0.34
40 INT354982 Cacna1a Regulation of Tnf 1 1 0.00 0.73 0.34
41 INT198566 Ddit4l Regulation of Axin1 2 1 0.03 1 0.31
42 INT151258 Binding of Cacna1a and FCMTE1 1 1 0.00 0.57 0.3
43 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 2 1 0.01 0.43 0.3
44 INT349951 Grm7 Regulation of pcp 1 1 0.00 0.56 0.28
45 INT208499 Positive_regulation of Nkx1-1 Positive_regulation of Npr1 1 1 0.00 0 0.27
46 INT142003 Binding of Cacna1a and Etax2 1 1 0.00 1.02 0.26
47 INT296450 Cacng2 Regulation of Gria2 1 1 0.13 0.24 0.26
48 INT142004 Binding of Cacna1a and TGM6 1 1 0.00 1.02 0.26
49 INT346745 Binding of Cacng2 and Grip2 1 1 0.01 0 0.25
50 INT70660 Binding of Hrasls and Nkx1-1 1 1 0.01 0 0.24
51 INT281798 CFD Regulation of Positive_regulation of Chrna4 2 1 0.01 0.24 0.24
52 INT296470 Binding of Cacng2 and Myo18a 1 1 0.00 0.22 0.24
53 INT296467 Binding of Cacng2 and Gria1 1 1 0.12 0.25 0.23
54 INT296464 Binding of Cacng2 and Tinagl1 1 1 0.06 0.25 0.23
55 INT296474 Binding of Cacng2 and Gria2 1 1 0.18 0.26 0.23
56 INT87169 Creb1 Positive_regulation of Gene_expression of Nkx1-1 1 1 0.11 0.17 0.21
57 INT256706 Binding of Hsp90b1 and Wfs1 1 1 0.43 5.02 0.2
58 INT217074 Binding of Acsm3 and Axin1 2 1 0.00 5.37 0.17
59 INT296469 Gene_expression of Cacng2 Positive_regulation of Gria2 1 1 0.15 0 0.16
60 INT296461 Gene_expression of Cacng2 Positive_regulation of Rbm39 1 1 0.00 0 0.16
61 INT241967 Binding of Grm7 and Acpt 1 1 0.17 0 0.16
62 INT71329 Cacna1a Regulation of Ea2 1 1 0.01 0.71 0.15
63 INT71328 Cacna1a Regulation of Atxn2 1 1 0.00 0.71 0.15
64 INT296468 Cacng2 Regulation of Regulation of Gria2 1 1 0.10 0 0.11
65 INT139558 Chrna4 Regulation of Neurod1 2 1 0.17 0 0.1
66 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 2 1 0.17 0 0.1
67 INT120559 Binding of Cacna1a and FCMTE1 1 1 0.02 0.25 0.1
68 INT163473 Binding of GM2A and GRDX 1 1 0.27 0.35 0.08
69 INT292816 Binding of KCNJ11 and FTO 1 1 0.46 0.49 0.05
70 INT354983 Cacna1a Regulation of Mpo 1 1 0.02 0.41 0.04
71 INT354987 Cacna1a Regulation of Localization of LDHA 1 1 0.00 0.23 0.03
72 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 1 0.10 0.78 0.03
73 INT346742 Binding of Cacng2 and Dlg4 1 1 0.03 0 0
74 INT256703 Negative_regulation of Hsp90b1 Positive_regulation of Wfs1 1 1 0.42 0.24 0
75 INT256700 Negative_regulation of Binding of Hsp90b1 and Wfs1 1 1 0.52 0 0
76 INT261963 Binding of Cacna1a and Tgm2 1 1 0.08 1.19 0
77 INT287885 Binding of DVL1 and AXIN1 1 1 0.02 0 0
78 INT346746 Binding of Cacng2 and Gria2 1 1 0.21 0.18 0
79 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 1 0.37 0 0
80 INT236724 Binding of AXIN1 and Ctnnd2 1 1 0.39 1.03 0
81 INT256705 Binding of Wfs1 and Xbp1 1 1 0.19 0.39 0
82 INT256704 Xbp1 Positive_regulation of Positive_regulation of Wfs1 1 1 0.26 0.4 0
83 INT256702 Binding of Wfs1 and Tmed4 1 1 0.01 0.61 0
84 INT246649 Binding of Kcnj11 and Krt23 1 1 0.01 0.53 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neurological system process. They are ordered first by their pain relevance and then by number of times they were reported in neurological system process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88
2 INT13938 Positive_regulation of Nkx1-1 64 0.68 30.83 58.75
3 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
4 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
5 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
6 INT7039 Regulation of Nkx1-1 22 0.44 10.51 20.89
7 INT15370 Binding of Nkx1-1 24 0.29 5.84 18.16
8 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
9 INT74465 Negative_regulation of Nkx1-1 22 0.46 8.51 13.63
10 INT58596 Positive_regulation of Gene_expression of Nkx1-1 21 0.49 14.05 13.53
11 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
12 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
13 INT12663 Localization of Nkx1-1 16 0.74 3.77 8.74
14 INT73544 Gene_expression of Grm7 34 0.64 31.28 8.04
15 INT104508 Regulation of Gene_expression of Nkx1-1 9 0.30 4.55 7.36
16 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98
17 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
18 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
19 INT84676 Regulation of Positive_regulation of Nkx1-1 1 0.12 1.58 5.1
20 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
21 INT79682 Gene_expression of Grm7 6 0.75 4.74 4.5
22 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
23 INT79680 Binding of Grm7 6 0.47 2.83 3.58
24 INT58595 Transcription of Nkx1-1 7 0.47 2.53 3.54
25 INT24959 Negative_regulation of Gene_expression of Nkx1-1 4 0.20 2.64 3.4
26 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
27 INT91979 Positive_regulation of Positive_regulation of Nkx1-1 3 0.23 2.06 3.06
28 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
29 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
30 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
31 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36
32 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
33 INT276682 Negative_regulation of Positive_regulation of Nkx1-1 1 0.11 1.07 2
34 INT123253 Localization of Chrna4 4 0.44 1.31 1.99
35 INT106869 Positive_regulation of Binding of Nkx1-1 2 0.13 0.21 1.85
36 INT122435 Positive_regulation of Grm7 3 0.00 1.89 1.79
37 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
38 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
39 INT79683 Negative_regulation of Grm7 3 0.41 2.22 1.75
40 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
41 INT276684 Regulation of Binding of Nkx1-1 1 0.11 0.18 1.61
42 INT287528 Gene_expression of WFS1 1 0.75 2.74 1.55
43 INT106865 Negative_regulation of Binding of Nkx1-1 3 0.11 0.14 1.48
44 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
45 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
46 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
47 INT79681 Localization of Grm7 5 0.78 2.57 1.34
48 INT95694 Gene_expression of Chrnb1 6 0.36 4.27 1.33
49 INT74927 Gene_expression of Cacna1e 4 0.51 0.7 1.25
50 INT267107 Binding of CHRNB2 2 0.07 1.33 1.25
51 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
52 INT130323 Regulation of Grm7 3 0.26 1.9 1.21
53 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2
54 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
55 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
56 INT218977 Negative_regulation of Localization of Nkx1-1 1 0.03 0.84 1.09
57 INT45084 Positive_regulation of Chrnb1 4 0.40 1.32 0.99
58 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
59 INT87768 Binding of Chrnb1 4 0.26 0.18 0.94
60 INT158378 Transcription of Grm7 1 0.00 0.65 0.94
61 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
62 INT296844 Gene_expression of Atg7 1 0.62 10.64 0.86
63 INT287524 Regulation of WFS1 1 0.40 1.34 0.78
64 INT123254 Regulation of Chrna4 3 0.27 0.84 0.76
65 INT146020 Negative_regulation of Transcription of Nkx1-1 1 0.28 0.39 0.75
66 INT146019 Regulation of Transcription of Nkx1-1 1 0.18 0.41 0.72
67 INT146018 Positive_regulation of Transcription of Nkx1-1 1 0.31 0.41 0.72
68 INT91056 Negative_regulation of Gene_expression of Grm7 2 0.18 1.21 0.69
69 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
70 INT123251 Regulation of Gene_expression of Chrna4 2 0.27 0.36 0.67
71 INT345211 Positive_regulation of Grm7 1 0.02 0.64 0.66
72 INT154199 Regulation of Localization of Grm7 1 0.60 0.92 0.62
73 INT99329 Binding of Chrna4 3 0.37 0.45 0.6
74 INT272575 Binding of Cacng2 3 0.36 0.54 0.58
75 INT123256 Regulation of Localization of Chrna4 1 0.27 0.28 0.58
76 INT120995 Positive_regulation of Gene_expression of Grm7 1 0.00 0.57 0.57
77 INT296850 Positive_regulation of Gene_expression of Atg7 1 0.40 4.41 0.54
78 INT135449 Transcription of Kcnj11 1 0.06 0.64 0.53
79 INT90479 Negative_regulation of CHRNA4 2 0.57 0.37 0.51
80 INT55538 Positive_regulation of Gm2a 1 0.22 0 0.48
81 INT95695 Transcription of Chrnb1 2 0.19 0.8 0.47
82 INT77748 Localization of Chrna4 1 0.15 0 0.46
83 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
84 INT96576 Transcription of Cacna1e 1 0.58 0.28 0.42
85 INT281775 Regulation of Positive_regulation of Chrna4 1 0.02 0.98 0.41
86 INT256681 Regulation of Wfs1 8 0.43 4.72 0.36
87 INT90497 Positive_regulation of Gene_expression of Cacna1e 1 0.01 0.17 0.36
88 INT90498 Positive_regulation of Cacna1e 1 0.01 0.17 0.35
89 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
90 INT221224 Gene_expression of KCNJ11 2 0.61 5.83 0.33
91 INT254881 Negative_regulation of Atg7 9 0.34 5.69 0.32
92 INT223646 Regulation of Gene_expression of Grm7 1 0.01 4.41 0.32
93 INT190521 Regulation of Positive_regulation of Chrnb1 1 0.09 0.35 0.31
94 INT264110 Regulation of Chrnb1 1 0.03 0.82 0.31
95 INT264108 Positive_regulation of Gene_expression of Chrnb1 1 0.03 1.06 0.31
96 INT264112 Regulation of Gene_expression of Chrnb1 1 0.04 1.07 0.31
97 INT268029 Gene_expression of Kcnj11 1 0.02 0.23 0.29
98 INT311615 Binding of CHRNB1 1 0.01 0.24 0.28
99 INT256682 Gene_expression of Wfs1 1 0.74 6.63 0.25
100 INT320250 Regulation of Cacnb4 1 0.31 0.16 0.24
101 INT223645 Positive_regulation of Gene_expression of Grm7 2 0.25 1.16 0.21
102 INT296852 Negative_regulation of Gene_expression of Atg7 1 0.47 4.67 0.19
103 INT296853 Positive_regulation of Atg7 4 0.37 1.45 0.18
104 INT170513 Gene_expression of Cacng2 3 0.65 0.06 0.18
105 INT256696 Positive_regulation of Wfs1 1 0.66 9.14 0.17
106 INT210123 Localization of Axin1 1 0.04 0.84 0.17
107 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
108 INT296433 Positive_regulation of Gene_expression of Cacng2 1 0.18 0 0.16
109 INT256684 Positive_regulation of Gene_expression of Wfs1 1 0.66 3.62 0.16
110 INT95697 Positive_regulation of Transcription of Chrnb1 1 0.14 0 0.16
111 INT241959 Binding of Grm7 1 0.23 0 0.15
112 INT246309 Negative_regulation of Chrnb1 2 0.09 0.09 0.14
113 INT296851 Localization of Atg7 1 0.60 0.82 0.14
114 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
115 INT260482 Localization of Grm7 1 0.18 0.11 0.13
116 INT250219 Positive_regulation of KCNJ11 3 0.68 2.5 0.12
117 INT139554 Positive_regulation of Gene_expression of Chrna4 2 0.25 0 0.1
118 INT139553 Transcription of Chrna4 1 0.27 0 0.1
119 INT168525 Localization of GPR98 1 0.21 0.17 0.1
120 INT139555 Positive_regulation of Positive_regulation of Chrna4 1 0.25 0 0.1
121 INT338884 Regulation of Grm7 1 0.13 0.42 0.09
122 INT338883 Positive_regulation of Regulation of Grm7 1 0.22 0.42 0.09
123 INT256675 Regulation of Gene_expression of Wfs1 1 0.43 2.33 0.09
124 INT256687 Positive_regulation of Transcription of Wfs1 1 0.44 1.95 0.09
125 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
126 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
127 INT347113 Protein_catabolism of Axin1 1 0.43 0.68 0.08
128 INT256693 Transcription of Wfs1 1 0.68 2.44 0.08
129 INT58644 Negative_regulation of KCNJ11 1 0.24 0 0.08
130 INT163475 Binding of GM2A 1 0.28 0.3 0.08
131 INT347115 Negative_regulation of Protein_catabolism of Axin1 1 0.25 0.2 0.08
132 INT204808 Binding of Kcnj11 3 0.04 3.28 0.07
133 INT207818 Positive_regulation of Kcnj11 2 0.48 1.67 0.07
134 INT300139 Positive_regulation of WFS1 1 0.36 1.32 0.07
135 INT296861 Regulation of Atg7 1 0.19 0.43 0.07
136 INT346730 Positive_regulation of Cacng2 1 0.49 0 0.06
137 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
138 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
139 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
140 INT346727 Regulation of Cacng2 1 0.26 0 0.03
141 INT268030 Positive_regulation of Gene_expression of Kcnj11 1 0.02 0 0.03
142 INT204807 Negative_regulation of Binding of Kcnj11 1 0.03 1.9 0.03
143 INT268039 Positive_regulation of Kcnj11 1 0.02 0.07 0.03
144 INT207834 Negative_regulation of Localization of KCNJ11 1 0.41 0 0.03
145 INT207832 Localization of KCNJ11 1 0.73 0 0.03
146 INT105164 Negative_regulation of Axin1 2 0.14 0.17 0
147 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
148 INT245105 Binding of Axin1 2 0.06 0.65 0
149 INT256676 Regulation of Binding of Wfs1 1 0.43 0.35 0
150 INT246313 Localization of Chrnb1 1 0.17 0.28 0
151 INT268034 Regulation of Kcnj11 1 0.00 0.08 0
152 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
153 INT256692 Negative_regulation of Wfs1 1 0.41 0 0
154 INT256671 Regulation of Positive_regulation of Wfs1 1 0.59 1.77 0
155 INT329212 Phosphorylation of KCNJ11 1 0.80 1.07 0
156 INT246320 Regulation of Localization of Chrnb1 1 0.10 0.19 0
157 INT256686 Binding of Wfs1 1 0.46 0.91 0
158 INT235673 Positive_regulation of Gene_expression of Axin1 1 0.16 0 0
159 INT256677 Regulation of Transcription of Wfs1 1 0.59 0.5 0
160 INT347116 Localization of Axin1 1 0.28 0.53 0
161 INT339052 Binding of KCNJ11 1 0.34 1.16 0
162 INT329213 Positive_regulation of Phosphorylation of KCNJ11 1 0.45 1.14 0
163 INT346728 Localization of Cacng2 1 0.73 0 0
164 INT347114 Positive_regulation of Protein_catabolism of Axin1 1 0.19 0.48 0
165 INT315419 Protein_catabolism of Chrnb1 1 0.03 0.14 0
166 INT148141 Negative_regulation of Negative_regulation of Nkx1-1 1 0.34 0.08 0
167 INT235671 Gene_expression of Axin1 1 0.22 0 0
168 INT256672 Positive_regulation of Positive_regulation of Wfs1 1 0.44 0.24 0
169 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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