GOS:nuclease activity

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This page displays the top molecular interactions and top single events that were mentioned in the literature for nuclease activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nuclease activity. They are ordered first by their pain relevance and then by number of times they were reported for nuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to nuclease activity Documents TM Confidence Disease Relevance Pain Relevance
1 INT117535 SND1 Positive_regulation of Gene_expression of TNF 1 1 0.06 0.29 0.71
2 INT117534 TNF Positive_regulation of Positive_regulation of SND1 1 1 0.06 0.29 0.7
3 INT253759 Hmgb1 Positive_regulation of Apex1 1 1 0.09 4.53 0.69
4 INT255994 Binding of Ang and Il1rn 1 1 0.09 1.21 0.63
5 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 1 0.10 3.53 0.58
6 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 1 0.01 0.52 0.57
7 INT255999 Binding of Ang and H7 1 1 0.00 0.38 0.54
8 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 1 0.08 0.71 0.49
9 INT326473 Positive_regulation of PGAP1 Positive_regulation of ROS1 1 1 0.00 0.07 0.41
10 INT326470 PGAP1 Positive_regulation of ROS1 1 1 0.00 0.07 0.4
11 INT326472 AGXT Negative_regulation of PGAP1 1 1 0.00 0.05 0.39
12 INT203151 Binding of Rnase1 and Trav6-3 1 1 0.03 1.51 0.36
13 INT253766 Binding of Apex1 and Tlr4 1 1 0.03 0.53 0.32
14 INT253762 Binding of Apex1 and Hmgb1 1 1 0.09 1.29 0.32
15 INT40219 Ang Negative_regulation of REN 1 1 0.00 0 0.3
16 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 1 0.01 0.29 0.28
17 INT256001 Ang Negative_regulation of Il1rn 1 1 0.11 0.25 0.27
18 INT253765 Apex1 Positive_regulation of Hmgb1 1 1 0.09 1.27 0.24
19 INT316375 Ang Positive_regulation of Nfkb1 1 1 0.08 0.73 0.23
20 INT316370 Ang Positive_regulation of Xdh 1 1 0.07 0.62 0.2
21 INT218937 Akt1 Positive_regulation of Parn 1 1 0.01 0.65 0.16
22 INT316376 Binding of Ang and Atp6ap2 1 1 0.06 0.87 0.16
23 INT307814 Ace Positive_regulation of Ace Positive_regulation of Ang 1 1 0.30 3.05 0.15
24 INT304187 Ang Negative_regulation of Gene_expression of VEGFA 1 1 0.05 0.16 0.13
25 INT306921 Ang Positive_regulation of Gene_expression of Ephx2 1 1 0.15 0.79 0.12
26 INT161174 Binding of Ang and Trpc6 1 1 0.29 0.74 0.11
27 INT204993 Eri1 Positive_regulation of Gene_expression of Pink1 1 1 0.22 0.61 0.08
28 INT320881 Ang Positive_regulation of Agtrap 1 1 0.12 1.35 0.08
29 INT253764 Atp9a Positive_regulation of Apex1 1 1 0.00 0.39 0.08
30 INT307805 Ace Positive_regulation of Ang 1 1 0.32 1.52 0.07
31 INT304186 Ang Positive_regulation of Gene_expression of VEGFA 1 2 0.05 2.5 0.06
32 INT204998 Hmmr Positive_regulation of Eri1 1 1 0.00 0.58 0.06
33 INT172349 Eri1 Regulation of Gene_expression of Agrp 1 1 0.03 0.28 0.05
34 INT316371 Ang Negative_regulation of Ren1 1 1 0.16 0.64 0.05
35 INT172348 Eri1 Negative_regulation of Gene_expression of Agrp 1 1 0.07 0.28 0.05
36 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 1 0.03 0.15 0.03
37 INT315263 Eri1 Regulation of Rela 1 1 0.00 0.49 0
38 INT161177 Ang Positive_regulation of Trpc6 1 1 0.31 0.5 0
39 INT315271 Eri1 Regulation of Nfe2l2 1 1 0.00 0.48 0
40 INT172347 Eri1 Negative_regulation of Hras1 1 1 0.00 0.76 0
41 INT325607 Positive_regulation of Gopc Regulation of Ang 1 1 0.15 0.26 0
42 INT315265 Eri1 Negative_regulation of Keap1 1 1 0.01 0.26 0
43 INT325602 Binding of Ang and Pde2a 1 1 0.07 0.15 0
44 INT161176 Ang Positive_regulation of Positive_regulation of Trpc6 1 1 0.31 0.5 0
45 INT325590 Gopc Regulation of Ang 1 1 0.13 0.25 0
46 INT325595 Nppa Negative_regulation of Ang 1 1 0.25 0.46 0
47 INT315260 Eri1 Regulation of Keap1 1 1 0.00 0.48 0
48 INT218973 Gen1 Regulation of Gene_expression of Pgr 1 1 0.06 0.09 0
49 INT325587 Binding of Ang and Nppa 1 1 0.21 0.24 0
50 INT185353 Eri1 Negative_regulation of Transcription of Egfr 1 1 0.01 0.5 0
51 INT325594 Binding of Ang and Olfml3 1 1 0.01 0.1 0
52 INT328422 Protein_catabolism of Neu1 Positive_regulation of Dnase2b 1 1 0.01 0.67 0
53 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 1 0.25 0.46 0
54 INT172345 Eri1 Negative_regulation of Gene_expression of Hras1 1 1 0.00 0.76 0
55 INT325598 Ang Positive_regulation of Camk2a 1 1 0.21 0.29 0
56 INT161179 Positive_regulation of Ang Positive_regulation of Trpc6 1 1 0.31 0.5 0
57 INT172344 Eri1 Negative_regulation of Positive_regulation of Hras1 1 1 0.00 0.76 0
58 INT109815 Ace2 Positive_regulation of Ang 1 1 0.06 0.3 0
59 INT245039 Binding of Xrcc1 and Tdp1 1 1 0.39 0.77 0
60 INT244063 Binding of Gabarap and Eri3 1 1 0.00 0 0
61 INT218974 Gen1 Negative_regulation of Gnrh1 1 1 0.13 0.16 0
62 INT325601 Ang Positive_regulation of Phosphorylation of Camk2a 1 1 0.21 0.29 0
63 INT185357 Eri1 Negative_regulation of Gene_expression of Egfr 1 1 0.01 0.57 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for nuclease activity. They are ordered first by their pain relevance and then by number of times they were reported in nuclease activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
2 INT142694 Positive_regulation of PGAP1 3 0.08 2.78 8.68
3 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
4 INT322474 Regulation of PGAP1 1 0.38 4.82 5.06
5 INT322475 Negative_regulation of PGAP1 9 0.36 4.78 4.69
6 INT131808 Localization of Apex1 2 0.16 13.46 4.61
7 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
8 INT46687 Negative_regulation of Snd1 7 0.38 2.47 2.59
9 INT40992 Binding of Xrn1 2 0.46 0 2.33
10 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
11 INT70600 Positive_regulation of Exo1 9 0.39 4.36 2.05
12 INT40993 Negative_regulation of Binding of Xrn1 2 0.41 0 1.99
13 INT253756 Gene_expression of Apex1 1 0.14 7.47 1.84
14 INT261613 Gene_expression of Tsen2 1 0.01 0.05 1.84
15 INT133138 Regulation of Dnase1 1 0.62 2.86 1.8
16 INT133139 Localization of Dnase1 2 0.80 2.6 1.74
17 INT137639 Localization of Endog 1 0.78 1.94 1.62
18 INT133137 Gene_expression of Dnase1 1 0.68 1.76 1.19
19 INT154057 Gene_expression of Ear1 14 0.41 9.72 1.12
20 INT96861 Binding of Ang 11 0.32 4.46 1.1
21 INT87637 Localization of Ang 11 0.63 4.42 1.03
22 INT38172 Regulation of Ang 8 0.31 4.13 0.9
23 INT97051 Positive_regulation of Dffb 1 0.45 0.53 0.82
24 INT326487 Positive_regulation of Positive_regulation of PGAP1 1 0.01 0.07 0.8
25 INT44685 Gene_expression of Snd1 3 0.53 2.13 0.79
26 INT117427 Gene_expression of Parn 1 0.44 1.18 0.79
27 INT26041 Binding of Tdp2 1 0.06 0.15 0.78
28 INT81325 Transcription of Ang 2 0.52 1.43 0.76
29 INT81327 Positive_regulation of Transcription of Ang 1 0.45 1.32 0.76
30 INT117547 Gene_expression of SND1 2 0.57 1.27 0.71
31 INT79428 Regulation of Snd1 3 0.11 0.87 0.69
32 INT117542 Positive_regulation of SND1 2 0.34 2.19 0.69
33 INT100856 Negative_regulation of Positive_regulation of Exo1 1 0.07 0.24 0.67
34 INT217986 Negative_regulation of Ear11 1 0.40 1.59 0.65
35 INT253750 Positive_regulation of Gene_expression of Apex1 1 0.10 1.43 0.64
36 INT19606 Negative_regulation of Ear1 3 0.22 3.25 0.61
37 INT64453 Positive_regulation of Ear2 1 0.21 0.31 0.6
38 INT43343 Positive_regulation of Binding of Xrn1 1 0.26 0 0.58
39 INT73524 Positive_regulation of Ear1 7 0.27 4.82 0.54
40 INT96919 Positive_regulation of Snd1 3 0.41 0.94 0.53
41 INT326485 Negative_regulation of Positive_regulation of PGAP1 1 0.01 0.08 0.49
42 INT62300 Regulation of SND1 1 0.47 1.07 0.48
43 INT209432 Gene_expression of Rag1 5 0.55 1.69 0.46
44 INT97171 Localization of Ear1 7 0.43 4.25 0.44
45 INT183162 Localization of Snd1 1 0.04 1.44 0.44
46 INT183160 Positive_regulation of Localization of Snd1 1 0.03 1.45 0.44
47 INT169943 Gene_expression of Eri1 22 0.35 10.45 0.41
48 INT137635 Gene_expression of Endog 1 0.58 0.46 0.4
49 INT92197 Gene_expression of PGAP1 1 0.00 0.3 0.4
50 INT137637 Negative_regulation of Localization of Endog 1 0.41 0.39 0.39
51 INT164413 Gene_expression of Dffb 1 0.01 0.78 0.39
52 INT89262 Positive_regulation of Snd1 1 0.19 0.47 0.39
53 INT98745 Regulation of Ear1 2 0.51 0.36 0.38
54 INT46103 Gene_expression of Tdp2 1 0.01 0 0.36
55 INT352280 Binding of Ear2 1 0.00 0 0.35
56 INT255551 Negative_regulation of Gene_expression of Rag1 1 0.35 0.81 0.31
57 INT89261 Gene_expression of Snd1 3 0.27 1.17 0.29
58 INT200 Positive_regulation of Rnase1 6 0.44 0.19 0.28
59 INT217982 Regulation of Ear11 2 0.33 0.86 0.28
60 INT322476 Positive_regulation of Negative_regulation of PGAP1 1 0.29 0.46 0.28
61 INT217988 Gene_expression of Ear11 1 0.56 0.81 0.26
62 INT227426 Positive_regulation of Apex1 2 0.08 1.98 0.23
63 INT199 Negative_regulation of Rnase1 5 0.59 0.58 0.22
64 INT161779 Positive_regulation of Gene_expression of Ear1 3 0.27 1.91 0.22
65 INT96860 Positive_regulation of Binding of Ang 3 0.33 1.4 0.21
66 INT184353 Binding of Pgap1 1 0.01 0.82 0.21
67 INT253752 Negative_regulation of Localization of Apex1 1 0.08 1.26 0.2
68 INT350380 Negative_regulation of Localization of Ear1 1 0.01 0.92 0.2
69 INT181059 Gene_expression of Rnase1 5 0.25 0.98 0.19
70 INT21055 Positive_regulation of Tdp2 1 0.03 0 0.19
71 INT161173 Negative_regulation of Localization of Ang 3 0.39 2.19 0.18
72 INT135762 Binding of Ear1 2 0.41 1.6 0.18
73 INT218968 Positive_regulation of Gen1 1 0.26 1.15 0.18
74 INT218902 Phosphorylation of Parn 1 0.03 0.64 0.16
75 INT324893 Positive_regulation of Localization of Ang 1 0.10 0.59 0.16
76 INT243345 Positive_regulation of TDP2 1 0.20 1.37 0.16
77 INT190110 Positive_regulation of Eri1 2 0.27 3.47 0.15
78 INT197894 Binding of Gen1 2 0.20 0.09 0.14
79 INT313864 Negative_regulation of Tdp2 1 0.02 2.14 0.14
80 INT235935 Gene_expression of Cpsf3 1 0.04 1.5 0.14
81 INT3162 Gene_expression of TDP2 1 0.16 0.29 0.14
82 INT3855 Transcription of Rnasel 1 0.55 0 0.14
83 INT167442 Localization of RAD50 1 0.60 0.61 0.14
84 INT255552 Negative_regulation of Rag1 1 0.31 0.33 0.13
85 INT204967 Negative_regulation of Eri1 2 0.17 1.41 0.12
86 INT237631 Regulation of Exosc9 1 0.13 0.09 0.12
87 INT248550 Gene_expression of Rexo1 1 0.04 0.09 0.12
88 INT307797 Negative_regulation of Gene_expression of Ang 2 0.39 1.3 0.11
89 INT273334 Positive_regulation of Rnaseh2a 1 0.09 0.51 0.11
90 INT46878 Positive_regulation of Rnasel 3 0.27 2.13 0.1
91 INT190501 Regulation of Apex1 1 0.12 0.32 0.1
92 INT253923 Binding of Trex1 1 0.29 1.59 0.1
93 INT132754 Regulation of Wrn 1 0.39 0.8 0.1
94 INT273338 Protein_catabolism of Apex1 4 0.05 0.57 0.09
95 INT169935 Positive_regulation of Gene_expression of Eri1 3 0.19 2.46 0.09
96 INT79424 Gene_expression of Exo1 3 0.19 2.04 0.08
97 INT172342 Regulation of Eri1 2 0.03 0.3 0.08
98 INT240587 Gene_expression of Slk 1 0.58 0.6 0.08
99 INT89260 Positive_regulation of Gene_expression of Snd1 1 0.20 0.3 0.08
100 INT161777 Regulation of Gene_expression of Ear1 1 0.28 0.6 0.08
101 INT169876 Negative_regulation of Ercc4 1 0.42 1.34 0.08
102 INT216243 Binding of Dis3 1 0.04 0.05 0.08
103 INT320864 Negative_regulation of Positive_regulation of Ang 1 0.19 1.37 0.08
104 INT167443 Regulation of RAD50 2 0.22 0.34 0.07
105 INT291675 Positive_regulation of Pnpt1 1 0.01 0.6 0.05
106 INT344422 Regulation of Localization of Ear1 1 0.07 0.41 0.05
107 INT190102 Protein_catabolism of Eri1 3 0.25 1.69 0.04
108 INT65171 Negative_regulation of Rnasel 2 0.05 0.73 0.04
109 INT218758 Gene_expression of Isg20 1 0.10 0.48 0.04
110 INT189926 Gene_expression of Drosha 1 0.32 0.55 0.03
111 INT2851 Gene_expression of Xrn1 1 0.52 0 0.03
112 INT273823 Gene_expression of Gen1 2 0.10 0.92 0
113 INT251064 Gene_expression of Exosc10 2 0.19 0.25 0
114 INT100857 Negative_regulation of Exo1 1 0.10 0 0
115 INT44684 Regulation of Gene_expression of Snd1 1 0.01 0.48 0
116 INT230298 Negative_regulation of MRE11A 1 0.18 0 0
117 INT251044 Negative_regulation of Exosc10 1 0.06 0 0
118 INT204991 Positive_regulation of Positive_regulation of Eri1 1 0.19 0.96 0
119 INT297783 Gene_expression of Ang3 1 0.55 0.09 0
120 INT189910 Negative_regulation of Gene_expression of Drosha 1 0.24 0.2 0
121 INT218967 Gene_expression of Gen1 1 0.25 0.45 0
122 INT349152 Negative_regulation of Dnase1 1 0.14 0.34 0
123 INT336973 Positive_regulation of Gene_expression of Exo1 1 0.05 0.77 0
124 INT230325 Transcription of MRE11A 1 0.69 0 0
125 INT35638 Localization of PGAP1 1 0.01 0.69 0
126 INT279861 Positive_regulation of Gene_expression of Rnase1 1 0.15 0 0
127 INT230303 Regulation of Transcription of RAD50 1 0.04 0 0
128 INT350661 Binding of Eif2c2 1 0.18 0.15 0
129 INT309506 Positive_regulation of Tdp1 1 0.23 1.19 0
130 INT343722 Binding of Exosc10 1 0.11 0.27 0
131 INT178865 Positive_regulation of PARN 1 0.01 1.48 0
132 INT328418 Protein_catabolism of Dnase2b 1 0.42 0.72 0
133 INT265908 Positive_regulation of Positive_regulation of Exo1 1 0.01 0.65 0
134 INT189917 Negative_regulation of Drosha 1 0.18 0.22 0
135 INT189919 Transcription of Drosha 1 0.30 0.22 0
136 INT283730 Binding of Eri1 1 0.01 0.26 0
137 INT125029 Binding of PARN 1 0.36 0.18 0
138 INT316365 Positive_regulation of Negative_regulation of Ang 1 0.33 0.76 0
139 INT219055 Regulation of Gene_expression of Eri1 1 0.00 0.1 0
140 INT218966 Regulation of Gen1 1 0.17 0.15 0
141 INT303276 Regulation of Gene_expression of Ang 1 0.24 0.89 0
142 INT349163 Positive_regulation of Dnase1 1 0.12 0 0
143 INT209441 Positive_regulation of Gene_expression of Rag1 1 0.41 0 0
144 INT189921 Negative_regulation of Transcription of Drosha 1 0.24 0.22 0
145 INT297813 Negative_regulation of Gene_expression of Ang3 1 0.35 0.09 0
146 INT325550 Positive_regulation of Regulation of Ang 1 0.33 0.27 0
147 INT335903 Regulation of Gene_expression of Gen1 1 0.07 0.14 0
148 INT349149 Positive_regulation of Gene_expression of Dnase1 1 0.12 0 0
149 INT198 Regulation of Rnase1 1 0.39 0 0
150 INT349157 Negative_regulation of Gene_expression of Dnase1 1 0.10 0 0
151 INT251061 Positive_regulation of Exosc10 1 0.08 0.07 0
152 INT291673 Gene_expression of Pnpt1 1 0.02 0.74 0
153 INT335898 Binding of Gen1 1 0.06 0.38 0
154 INT297786 Positive_regulation of Ang3 1 0.38 0.09 0
155 INT337668 Positive_regulation of Gene_expression of SND1 1 0.51 0.99 0
156 INT525 Negative_regulation of Xrn1 1 0.37 0 0
157 INT335904 Positive_regulation of Gen1 1 0.08 0.2 0
158 INT171531 Protein_catabolism of Xrn1 1 0.01 0 0
159 INT65170 Gene_expression of Rnasel 1 0.31 1.84 0
160 INT273818 Negative_regulation of Gen1 1 0.01 0.14 0
161 INT218969 Negative_regulation of Gen1 1 0.16 0.18 0
162 INT319024 Protein_catabolism of Dnase1 1 0.09 0 0
163 INT281662 Binding of Drosha 1 0.36 0.27 0
164 INT230295 Transcription of RAD50 1 0.08 0 0
165 INT230299 Gene_expression of RAD50 1 0.11 0 0
166 INT204984 Transcription of Eri1 1 0.21 0.78 0
167 INT279157 Gene_expression of TATDN1 1 0.49 0.57 0
168 INT273815 Localization of Gen1 1 0.01 0.22 0
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