GOS:pigmentation

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This page displays the top molecular interactions and top single events that were mentioned in the literature for pigmentation. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pigmentation. They are ordered first by their pain relevance and then by number of times they were reported for pigmentation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to pigmentation Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 1 52 0.54 8.87 18.3
2 INT338167 Binding of CDKN2A and MC1R 1 1 0.42 6.14 5.76
3 INT211710 Binding of Mc1r and a 2 7 0.44 0.37 4.78
4 INT111758 Binding of Drd2 and Insrr 1 1 0.01 0.94 4.33
5 INT113223 POMC Regulation of MC1R 1 6 0.68 0.39 4.24
6 INT104977 MITF Regulation of Gene_expression of MC1R 1 1 0.69 0.91 3.71
7 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 1 0.02 0.64 2.89
8 INT107723 POMC Positive_regulation of MC1R 1 7 0.68 0.71 2.82
9 INT49242 Binding of Mc1r and Pomc 1 10 0.38 3.79 2.15
10 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 1 0.04 0.64 2.07
11 INT163266 Crh Negative_regulation of Tyr 2 1 0.01 0.45 1.98
12 INT110525 Binding of MC1R and OCA2 1 1 0.41 1.08 1.97
13 INT101926 Binding of Dio1 and Drd2 1 4 0.28 0.39 1.66
14 INT191618 Binding of App and Nf1 2 1 0.35 3.77 1.65
15 INT145072 ASIP Negative_regulation of MC1R 2 1 0.29 0 1.52
16 INT61443 Binding of KNG1 and Tyr 2 1 0.00 0 1.46
17 INT104972 MITF Regulation of Transcription of TYR 1 1 0.20 0.35 1.45
18 INT111759 Binding of Cpe and Drd2 1 1 0.01 0.32 1.42
19 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 1 0.02 0.33 1.42
20 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 1 0.13 0.15 1.36
21 INT131888 gr Positive_regulation of Gene_expression of Prkcg 1 1 0.00 0 1.32
22 INT281479 Drd2 Positive_regulation of Penk 1 1 0.23 0.4 1.3
23 INT276282 Binding of Atrn and Mc1r 2 1 0.32 0.41 1.29
24 INT71109 Binding of INSRR and MC1R 1 1 0.01 0 1.27
25 INT98833 Th Regulation of Gene_expression of Drd2 2 1 0.19 0.64 1.27
26 INT46022 tp Positive_regulation of SERPINB1 1 1 0.04 0 1.26
27 INT46021 tp Positive_regulation of Oprl1 1 1 0.22 0 1.26
28 INT140238 HELQ Regulation of MC1R 1 1 0.01 0.5 1.2
29 INT281373 Tcf21 Regulation of Fig4 2 1 0.03 0.67 1.2
30 INT108469 Tacr1 Regulation of Transcription of Drd2 2 1 0.07 0.14 1.2
31 INT281383 FSCN1 Positive_regulation of Fig4 2 1 0.02 0.44 1.19
32 INT209132 Binding of Drd2 and Riok3 1 1 0.01 1.57 1.16
33 INT106069 TH Positive_regulation of Th 1 1 0.07 0.16 1.14
34 INT99577 Binding of KITLG and Kit 1 3 0.34 2.33 1.11
35 INT69874 POMC Negative_regulation of TYRP1 1 1 0.13 0 1.07
36 INT69871 ASIP Negative_regulation of TYRP1 2 1 0.36 0 1.07
37 INT331108 Mc1r Positive_regulation of Mc4r 1 1 0.44 1.05 1.06
38 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 1 0.05 0.5 1.05
39 INT88971 Binding of Sult4a1 and Atrn 2 1 0.02 0.54 1.03
40 INT255335 Fig4 Regulation of Phosphorylation of Nav1 2 1 0.01 0 1.03
41 INT127997 Binding of MC1R and RHCE 1 2 0.28 0.41 1.02
42 INT131889 gr Regulation of Gene_expression of Grin1 1 1 0.02 0 1.01
43 INT21332 Binding of Drd2 and Gm5195 2 1 0.01 0.26 1
44 INT201614 Mc1r Regulation of Uvbi1 1 1 0.04 1.42 0.98
45 INT163265 Sst Negative_regulation of Tyr 2 1 0.00 0.22 0.95
46 INT77859 EDN1 Positive_regulation of MC1R 1 2 0.64 0.34 0.94
47 INT73467 PTPLA Positive_regulation of Transcription of Myc 2 1 0.29 0.97 0.94
48 INT77253 Binding of gr and Creb1 1 1 0.03 0.4 0.9
49 INT77254 Binding of gr and Sp1 1 1 0.04 0.4 0.9
50 INT69870 ASIP Negative_regulation of Binding of MC1R and POMC 2 1 0.37 0 0.9
51 INT116269 Binding of Myc and Mycbp2 2 1 0.19 0.5 0.87
52 INT281482 Drd2 Positive_regulation of Drd2 Positive_regulation of Penk 1 1 0.21 0.27 0.87
53 INT202254 Binding of COMT and DRD2 1 1 0.41 0.23 0.86
54 INT311612 Binding of Drd2 and Sert1 2 1 0.12 0.65 0.86
55 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 1 0.01 2.11 0.85
56 INT261479 Fig4 Positive_regulation of Ephb1 2 1 0.07 0.79 0.83
57 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 1 0.41 0.34 0.82
58 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 1 0.22 0 0.82
59 INT99578 Binding of CEL and Kit 1 1 0.04 1.07 0.81
60 INT140922 Btnl2 Negative_regulation of EDA 1 1 0.00 0.88 0.8
61 INT276283 Atrn Positive_regulation of Binding of Mc1r and a 3 1 0.38 0.26 0.8
62 INT130286 MC1R Positive_regulation of Localization of IL10 1 1 0.24 0.07 0.79
63 INT151453 Gtf3a Regulation of Kit 1 1 0.04 0.25 0.78
64 INT239638 Sst Regulation of Fig4 2 1 0.12 0.39 0.78
65 INT164364 Binding of DRD2 and SUGT1 1 2 0.06 0.33 0.77
66 INT121647 Binding of Oprm1 and Atrn 2 1 0.01 0.12 0.77
67 INT124385 GRK6 Negative_regulation of MC1R 1 1 0.42 0.42 0.77
68 INT124384 ADRBK1 Negative_regulation of MC1R 1 1 0.40 0.42 0.77
69 INT99335 Binding of Agrp and Mc1r 1 1 0.30 0 0.77
70 INT215630 Fig4 Regulation of Npy 2 1 0.01 0.26 0.76
71 INT334833 Binding of Drd2 and Ncs1 1 1 0.05 1.11 0.76
72 INT113222 POMC Regulation of Gene_expression of MC1R 1 1 0.06 0 0.76
73 INT37439 Binding of Shbdp1 and Tyr 2 1 0.01 0 0.76
74 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 1 0.11 0.22 0.76
75 INT151340 Binding of Drd2 and P9Ehs1 1 1 0.09 0.22 0.75
76 INT113224 Binding of ASIP and MC1R 2 1 0.00 0 0.75
77 INT266108 Binding of COMT and HPS1 1 1 0.23 1.21 0.74
78 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 1 0.00 0 0.74
79 INT327702 Binding of Comt and Drd2 1 1 0.28 0.27 0.74
80 INT202909 Binding of Tacr1 and Fig4 2 1 0.03 0.33 0.74
81 INT113225 POMC Regulation of Transcription of MC1R 1 1 0.03 0 0.74
82 INT288371 Binding of Atrn and a 2 1 0.39 0 0.74
83 INT104974 MITF Positive_regulation of MC1R 1 1 0.52 0.16 0.74
84 INT46917 Binding of Tyr and Positive_regulation of Penk 2 1 0.02 0 0.73
85 INT46919 Binding of Tyr and Positive_regulation of Vom1r1 2 1 0.00 0 0.73
86 INT155139 Binding of MC1R and PTGES 1 3 0.09 0 0.7
87 INT99172 Pomc Positive_regulation of Tyr 2 1 0.35 0.17 0.69
88 INT102762 Binding of POMC and TYR 1 1 0.12 0.35 0.69
89 INT81787 Binding of AGRP and MC1R 1 1 0.53 0 0.69
90 INT134652 Binding of MC1R and SUGT1 1 1 0.02 0.84 0.68
91 INT140235 ADRBK1 Positive_regulation of Binding of MC1R and 1 1 0.46 0.31 0.68
92 INT140236 GRK6 Positive_regulation of Binding of MC1R and 1 1 0.52 0.31 0.68
93 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 1 0.52 0.31 0.68
94 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 1 0.46 0.31 0.68
95 INT246335 Fig4 Regulation of Localization of P2rx7 2 1 0.01 0 0.67
96 INT211915 Fig4 Positive_regulation of Mapk3 2 1 0.12 0.25 0.66
97 INT211916 Fig4 Positive_regulation of Mapk1 2 1 0.13 0.25 0.66
98 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 2 1 0.01 0 0.66
99 INT246336 Fig4 Regulation of Localization of Nts 2 1 0.18 0 0.66
100 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 2 1 0.01 1.05 0.66
101 INT222253 Binding of Cxcl10 and Fig4 2 1 0.09 0.66 0.65
102 INT313702 Binding of Edn1 and Fig4 2 1 0.16 0 0.65
103 INT27526 Binding of Sdcbp and Eda 2 1 0.13 0 0.65
104 INT313703 Binding of Calca and Fig4 2 1 0.11 0 0.65
105 INT110526 OCA2 Regulation of MC1R 1 1 0.49 0.43 0.65
106 INT233669 gr Positive_regulation of Transcription of Nfkbia 1 1 0.26 0.33 0.64
107 INT99170 Binding of Mc1r and Tyr 3 1 0.11 0.2 0.64
108 INT233671 gr Positive_regulation of Transcription of Tsc22d3 1 1 0.44 0.33 0.64
109 INT30130 Binding of TYRP1 and Gast 1 1 0.06 0.09 0.63
110 INT104973 SGCG Regulation of Gene_expression of MC1R 1 1 0.67 0.17 0.63
111 INT209131 Binding of Bcl2a1a and Drd2 1 1 0.22 0.45 0.62
112 INT148352 Binding of MC1R and XRCC3 1 1 0.36 0.34 0.62
113 INT70811 Penk Negative_regulation of Binding of Tyr and 2 1 0.01 0 0.6
114 INT75040 Binding of GHSR and MC1R 1 1 0.02 0.34 0.6
115 INT37034 PLAT Positive_regulation of PLDN 1 1 0.08 0.15 0.58
116 INT93063 Binding of gr and Jun 1 3 0.14 0.79 0.57
117 INT136682 Binding of BRAF and MC1R 1 2 0.49 3.16 0.57
118 INT71110 Binding of MC1R and NDP 1 1 0.10 0 0.57
119 INT66020 Binding of Mc1r and RBM25 1 1 0.00 0.42 0.57
120 INT261496 Binding of Bdnf and Bdnf Positive_regulation of Positive_regulation of Fig4 2 1 0.04 0.21 0.57
121 INT281378 FSCN1 Positive_regulation of Gene_expression of Fig4 2 1 0.02 0.22 0.56
122 INT45258 SLAMF6 Positive_regulation of Drd2 2 1 0.00 0 0.55
123 INT281648 Negative_regulation of Binding of Trpv1 and Fig4 2 1 0.14 0.69 0.55
124 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 2 1 0.16 0.67 0.55
125 INT215644 Binding of Drd2 and Adora2a 1 1 0.03 0.23 0.55
126 INT271889 Binding of DRD2 and ANKK1 1 1 0.23 0.36 0.55
127 INT271888 Binding of DRD2 and DNAJC7 1 1 0.14 0.36 0.55
128 INT281647 Binding of Trpv1 and Fig4 2 1 0.12 0.68 0.55
129 INT222245 Binding of Ccr2 and Fig4 2 1 0.12 0.67 0.55
130 INT303653 Binding of DRD2 and SST 1 1 0.18 0.45 0.54
131 INT32908 Binding of ADCY1 and Drd2 1 1 0.00 0 0.54
132 INT208984 Binding of Ca2 and Fig4 2 1 0.02 0 0.54
133 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 2 1 0.38 0 0.53
134 INT309953 Binding of Atrn and Nav1 2 1 0.00 0.23 0.53
135 INT160829 Tyr Regulation of RYBP 2 1 0.04 0.75 0.53
136 INT165045 Drd2 Regulation of Cpe 1 1 0.07 0 0.52
137 INT165042 Drd2 Regulation of Tac1 1 1 0.22 0 0.52
138 INT130157 Pomc Regulation of Gene_expression of Ednrb 2 1 0.14 0 0.52
139 INT165043 Drd2 Regulation of Cck 1 1 0.20 0 0.52
140 INT343838 EDA Positive_regulation of TLR4 1 1 0.11 0.87 0.51
141 INT20580 Drd2 Regulation of Akr1d1 2 1 0.02 0.26 0.51
142 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 1 0.13 0.97 0.51
143 INT31531 Mif-ps1 Regulation of TYR 1 1 0.11 0 0.49
144 INT93508 Binding of ASIP and Mc1r 2 1 0.02 0 0.47
145 INT168699 Binding of Nedd4 and Tyr 2 1 0.02 0.45 0.46
146 INT32662 Hps1 Negative_regulation of Localization of CGB 1 1 0.00 0 0.46
147 INT73831 Binding of Mc1r and Pld1 1 1 0.00 0.16 0.45
148 INT69873 ASIP Negative_regulation of Binding of POMC and 1 1 0.35 0 0.45
149 INT335594 Myo5a Regulation of Hmmr 2 1 0.00 0.39 0.45
150 INT147404 NDP Positive_regulation of MC1R 1 1 0.22 0.25 0.45
151 INT288370 a Positive_regulation of Mc1r 2 1 0.39 0 0.44
152 INT232293 Abat Regulation of Binding of Fig4 and 2 1 0.11 0 0.43
153 INT16586 Binding of Drd2 and Nts 2 1 0.12 0 0.43
154 INT228323 PYCARD Positive_regulation of FIG4 1 1 0.17 0 0.42
155 INT201610 Binding of Mc1r and Braf 1 1 0.31 0.75 0.42
156 INT89666 Binding of Adora2a and Drd2 1 1 0.54 0.4 0.42
157 INT36009 Binding of Drd2 and Prl 1 1 0.01 1.05 0.42
158 INT159439 sea Positive_regulation of Gene_expression of Il1a 1 1 0.07 0 0.41
159 INT327727 Atp6v0a2 Negative_regulation of Gene_expression of Kit 1 1 0.05 0.83 0.41
160 INT55588 Drd2 Regulation of Transcription of Gad1 2 1 0.15 0.07 0.4
161 INT330598 Binding of Il6 and Fig4 2 1 0.11 1.78 0.4
162 INT232292 Abat Positive_regulation of Fig4 2 1 0.12 0 0.4
163 INT55589 Drd2 Regulation of Gad1 2 1 0.15 0.07 0.4
164 INT215629 Binding of Kcnj5 and Fig4 2 1 0.00 0.37 0.39
165 INT303444 Timp1 Regulation of Fig4 2 1 0.15 0.43 0.39
166 INT10825 Binding of PDYN and Tyr 2 1 0.01 0 0.39
167 INT321292 Fig4 Negative_regulation of Pck1 2 1 0.10 0.33 0.39
168 INT321301 Fig4 Negative_regulation of G6pc 2 1 0.07 0.33 0.39
169 INT148246 Binding of KITLG and Positive_regulation of Kit 1 1 0.04 0.43 0.38
170 INT31794 Hps6 Positive_regulation of Th 2 1 0.03 0 0.38
171 INT117361 Binding of Esr1 and sea 1 1 0.02 1.38 0.38
172 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 1 0.11 0.9 0.38
173 INT266553 Ppp2r1a Positive_regulation of Fig4 2 1 0.00 0 0.38
174 INT266530 Ppyr1 Positive_regulation of Fig4 2 1 0.01 0 0.38
175 INT148247 KITLG Positive_regulation of Kit 1 1 0.03 0.43 0.38
176 INT215655 Fig4 Regulation of REG1A 2 1 0.00 0.13 0.38
177 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 1 0.04 0.56 0.38
178 INT204905 Tlr4 Positive_regulation of gr 1 1 0.18 0.9 0.38
179 INT288545 Gsk3b Negative_regulation of gr 1 1 0.25 0.38 0.38
180 INT37247 Binding of Drd1a and Drd2 2 1 0.20 0 0.37
181 INT327708 Binding of Drd1a and Drd2 1 1 0.12 0.12 0.37
182 INT119319 Binding of Atrn and Rhox3h 2 1 0.00 0.3 0.37
183 INT35685 TYR Regulation of Oxt 1 1 0.14 0.32 0.36
184 INT152315 Ifng Regulation of Ednrb 2 1 0.19 0.22 0.36
185 INT152313 Il18 Regulation of Ednrb 2 1 0.30 0.22 0.36
186 INT227943 Binding of Vip and Mlph 1 1 0.01 0.33 0.36
187 INT201068 Binding of Edn1 and Ednrb 2 2 0.18 1.23 0.35
188 INT99171 Negative_regulation of Pomc Positive_regulation of Tyr 2 1 0.22 0.08 0.35
189 INT148243 Binding of Akt1 and Kit 1 1 0.03 0.44 0.35
190 INT107726 BIRC2 Regulation of ASIP 1 1 0.03 0.24 0.35
191 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 1 0.21 0.49 0.35
192 INT148240 Binding of Kit and Ret 1 1 0.24 0.44 0.35
193 INT148241 Binding of Kit and Ntrk1 1 1 0.25 0.44 0.35
194 INT99173 Pomc Positive_regulation of Pomc Positive_regulation of Tyr 2 1 0.25 0.08 0.35
195 INT127887 SLC6A3 Regulation of Drd2 2 1 0.34 0.68 0.34
196 INT177426 Izumo1 Positive_regulation of Positive_regulation of Fig4 2 1 0.16 0.59 0.34
197 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 1 0.17 0.82 0.34
198 INT280838 Binding of Crh and gr 1 1 0.06 0 0.33
199 INT334836 Ncs1 Regulation of Drd2 1 1 0.02 0.48 0.33
200 INT109894 Drd2 Positive_regulation of FOS 1 1 0.01 0 0.33

Single Events

The table below shows the top 100 pain related interactions that have been reported for pigmentation. They are ordered first by their pain relevance and then by number of times they were reported in pigmentation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32
2 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
3 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81
4 INT21737 Binding of MC1R 129 0.48 45.45 56.54
5 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
6 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92
7 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
8 INT13501 Binding of Drd2 65 0.48 23.76 35.6
9 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
10 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
11 INT177581 Regulation of Fig4 113 0.41 39.26 27.75
12 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
13 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
14 INT13995 Gene_expression of gr 96 0.74 48.21 26.54
15 INT12484 Binding of Drd2 45 0.48 15.17 24.72
16 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
17 INT55251 Gene_expression of a 142 0.67 81.21 23.03
18 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
19 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
20 INT171820 Localization of Fig4 144 0.65 27.38 20.88
21 INT49774 Binding of DRD2 48 0.48 17.42 20.73
22 INT7561 Positive_regulation of gr 70 0.57 31.92 20.22
23 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
24 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69
25 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59
26 INT13716 Positive_regulation of TH 33 0.68 19.11 16
27 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
28 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
29 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
30 INT174844 Binding of Fig4 81 0.41 18.03 12.87
31 INT222660 Phosphorylation of Tyr 2 0.06 5.31 12.33
32 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
33 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
34 INT173272 Phosphorylation of Fig4 45 0.48 13.85 11.42
35 INT2260 Gene_expression of Tyr 30 0.49 7.05 11.31
36 INT85631 Positive_regulation of Tyrp1 40 0.64 18.73 10.84
37 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
38 INT53201 Negative_regulation of gr 35 0.50 17.76 10.62
39 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
40 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
41 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
42 INT96319 Negative_regulation of Gene_expression of gr 16 0.56 12.82 9.4
43 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
44 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
45 INT43811 Positive_regulation of Tyr 14 0.45 2.52 8.86
46 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84
47 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
48 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17
49 INT77249 Positive_regulation of Gene_expression of gr 24 0.67 16.09 8.17
50 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
51 INT5481 Binding of TYR 26 0.47 1.3 7.95
52 INT22491 Binding of Atrn 23 0.30 4.51 7.79
53 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
54 INT93507 Gene_expression of ASIP 14 0.60 3.98 7.55
55 INT171146 Negative_regulation of Gene_expression of Fig4 38 0.37 11.41 7.42
56 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
57 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
58 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
59 INT195442 Gene_expression of FIG4 23 0.65 5.13 6.92
60 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
61 INT4431 Negative_regulation of Eda 10 0.46 3.53 6.81
62 INT3438 Negative_regulation of Dock7 11 0.00 1.03 6.72
63 INT98310 Regulation of gr 21 0.39 15.04 6.68
64 INT3506 Localization of TH 12 0.81 0.78 6.66
65 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
66 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
67 INT24460 Localization of Drd2 12 0.73 2.96 6.46
68 INT93061 Binding of gr 31 0.48 10.93 6.45
69 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
70 INT218698 Negative_regulation of Positive_regulation of Fig4 11 0.20 6.01 6.32
71 INT86772 Localization of Drd2 14 0.80 1.93 6.17
72 INT40436 Positive_regulation of Eda 21 0.70 8.09 6.15
73 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06
74 INT131884 Positive_regulation of Positive_regulation of gr 3 0.03 2.31 6.03
75 INT103918 Phosphorylation of Tyr 12 0.47 10.12 5.96
76 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
77 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
78 INT8157 Binding of Tyr 14 0.09 0.64 5.89
79 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84
80 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
81 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
82 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
83 INT51411 Negative_regulation of EDAR 8 0.41 1.05 5.49
84 INT114993 Binding of Myo5a 15 0.30 11.46 5.48
85 INT94652 Binding of a 15 0.48 4.18 5.4
86 INT30317 Regulation of TH 14 0.43 7.27 5.38
87 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
88 INT68591 Regulation of TYRP1 14 0.44 3.93 5.05
89 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92
90 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
91 INT32324 Gene_expression of Eda 20 0.75 6.43 4.66
92 INT173273 Positive_regulation of Phosphorylation of Fig4 16 0.30 7.3 4.62
93 INT68216 Binding of NF1 40 0.48 51.24 4.59
94 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
95 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54
96 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
97 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
98 INT278362 Negative_regulation of Hps5 2 0.21 15.71 4.44
99 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
100 INT32446 Localization of Tyr 11 0.68 1.31 4.25
101 INT56404 Gene_expression of EDA 16 0.75 7.09 4.24
102 INT88278 Binding of Kit 33 0.37 24.45 4.13
103 INT7560 Transcription of gr 14 0.69 4.21 4.09
104 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07
105 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
106 INT142501 Transcription of Tyrp1 4 0.18 2.09 3.71
107 INT173751 Transcription of Fig4 31 0.46 8.28 3.7
108 INT31528 Regulation of TYR 6 0.44 0.83 3.63
109 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61
110 INT42943 Positive_regulation of Atrn 9 0.18 2.68 3.43
111 INT3478 Phosphorylation of Atrn 5 0.53 0.16 3.39
112 INT18073 Positive_regulation of TYRP1 11 0.67 1.98 3.36
113 INT148892 Binding of HPS1 13 0.37 19.21 3.35
114 INT59447 Negative_regulation of Tyr 12 0.56 4.57 3.32
115 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
116 INT187505 Positive_regulation of Localization of Fig4 16 0.24 1.21 3.17
117 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
118 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16
119 INT211708 Regulation of a 4 0.42 1.92 3.15
120 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06
121 INT45179 Gene_expression of sea 8 0.58 3.4 2.99
122 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
123 INT113029 Negative_regulation of Myo5a 7 0.48 0.97 2.95
124 INT37435 Negative_regulation of Tyr 6 0.14 0.96 2.94
125 INT36886 Transcription of Myc 6 0.69 3.16 2.86
126 INT61136 Localization of MC1R 8 0.75 2.8 2.85
127 INT32787 Positive_regulation of Gene_expression of Tyr 5 0.38 0.37 2.77
128 INT5460 Positive_regulation of EDAR 10 0.23 8.18 2.71
129 INT47503 Gene_expression of HPS1 12 0.58 7.96 2.7
130 INT187499 Positive_regulation of Positive_regulation of Fig4 9 0.21 3.28 2.69
131 INT49020 Negative_regulation of TYR 11 0.58 1.97 2.68
132 INT83073 Negative_regulation of Tyrp1 10 0.23 4.4 2.65
133 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
134 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
135 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
136 INT97398 Localization of gr 12 0.36 6.88 2.59
137 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
138 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
139 INT128774 Regulation of Gene_expression of Ednrb 3 0.46 1 2.56
140 INT30040 Negative_regulation of TYRP1 11 0.51 2.72 2.54
141 INT46020 Binding of tp 1 0.35 0 2.53
142 INT178291 Gene_expression of Hps1 26 0.67 8.2 2.52
143 INT174876 Regulation of Gene_expression of Fig4 18 0.39 7.83 2.44
144 INT37341 Regulation of Tyrp1 4 0.29 4.53 2.42
145 INT61441 Negative_regulation of Gene_expression of Tyr 3 0.10 0.69 2.4
146 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
147 INT59287 Positive_regulation of Eda 5 0.40 1.25 2.36
148 INT155045 Negative_regulation of Gene_expression of Mc1r 7 0.43 1.04 2.33
149 INT92791 Negative_regulation of Szt2 1 0.03 2.4 2.33
150 INT85630 Positive_regulation of Tyr 11 0.56 3.07 2.31
151 INT64700 Binding of Nf1 14 0.45 15.24 2.29
152 INT53202 Negative_regulation of Positive_regulation of gr 6 0.46 2.35 2.27
153 INT74241 Positive_regulation of Gene_expression of EDA 3 0.49 4.93 2.24
154 INT151449 Negative_regulation of Gene_expression of Kit 18 0.45 12.05 2.23
155 INT39679 Regulation of Atrn 8 0.11 1.29 2.22
156 INT178246 Negative_regulation of Gene_expression of a 8 0.43 4.27 2.19
157 INT266121 Transcription of HPS1 1 0.50 7.79 2.19
158 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
159 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16
160 INT131883 Phosphorylation of gr 3 0.45 2.41 2.14
161 INT178260 Positive_regulation of a 6 0.50 3.09 2.08
162 INT114768 Regulation of Eda 6 0.62 1.8 2.08
163 INT91608 Negative_regulation of ASIP 3 0.40 0.51 2.04
164 INT43044 Gene_expression of Eda 3 0.75 0.69 2
165 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
166 INT7562 Positive_regulation of Transcription of gr 8 0.48 2.47 1.97
167 INT32133 Gene_expression of Cited1 3 0.51 0.31 1.97
168 INT99572 Localization of Kit 13 0.75 5.23 1.95
169 INT183047 Gene_expression of EN1 9 0.60 1.72 1.94
170 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
171 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
172 INT68181 Binding of Nf1 6 0.48 8.14 1.88
173 INT167057 Binding of Myo5a 1 0.46 0.37 1.88
174 INT71762 Negative_regulation of sea 6 0.36 1.73 1.86
175 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
176 INT10426 Regulation of Myo5a 3 0.60 0.85 1.85
177 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
178 INT88269 Binding of ASIP 4 0.19 0.41 1.82
179 INT3505 Binding of TH 5 0.39 2.6 1.8
180 INT140175 Regulation of Kit 23 0.62 8.59 1.79
181 INT39677 Negative_regulation of Atrn 6 0.17 2.17 1.79
182 INT162871 Localization of Mc1r 6 0.75 0.61 1.72
183 INT201475 Negative_regulation of Positive_regulation of Ednrb 6 0.42 3.74 1.66
184 INT300417 Localization of Tyr 5 0.11 0.26 1.65
185 INT145545 Transcription of TH 3 0.67 1.48 1.64
186 INT26393 Localization of Eda 4 0.60 0.18 1.63
187 INT3479 Regulation of Phosphorylation of Atrn 3 0.23 0.17 1.63
188 INT71780 Phosphorylation of TYR 12 0.34 17.21 1.62
189 INT30037 Binding of TYRP1 9 0.36 0.45 1.6
190 INT25678 Negative_regulation of Binding of Atrn 3 0.17 0.16 1.53
191 INT186022 Negative_regulation of Transcription of Fig4 6 0.28 2.09 1.5
192 INT145177 Positive_regulation of Gene_expression of Tyrp1 5 0.30 3.31 1.46
193 INT93505 Positive_regulation of Positive_regulation of Mc1r 2 0.70 0.33 1.45
194 INT32072 Positive_regulation of sea 7 0.40 0.91 1.44
195 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43
196 INT49402 Positive_regulation of EDA 6 0.61 4.23 1.43
197 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42
198 INT62425 Regulation of Gene_expression of Tyrp1 7 0.29 1.44 1.41
199 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41
200 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
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