GOS:protein binding transcription factor activity

This page displays the top molecular interactions and top single events that were mentioned in the literature for protein binding transcription factor activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein binding transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported for protein binding transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Genes linked to protein binding transcription factor activity	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT249013	Gabrg1 Negative_regulation of Per2	1	1	0.34	0.07	2.31
2	INT249005	Gabrg1 Positive_regulation of Per2	1	1	0.39	0	1.7
3	INT249014	Gabrg1 Regulation of Per2	1	1	0.31	0	1.24
4	INT249002	Gabrg1 Positive_regulation of Protein_catabolism of Per1	1	1	0.35	0.09	1.15
5	INT187290	Binding of HEY1 and Gtf3a	1	1	0.00	6.18	0.83
6	INT190986	Per1 Positive_regulation of Scn2a1	1	1	0.17	0	0.74
7	INT190979	Per2 Positive_regulation of Scn2a1	1	1	0.20	0	0.74
8	INT249018	Gabrg1 Regulation of Localization of Per2	1	1	0.35	0	0.69
9	INT249010	Gabrg1 Regulation of Positive_regulation of Per1	1	1	0.33	0	0.67
10	INT249008	Gabrg1 Regulation of Per1	1	1	0.33	0	0.67
11	INT249009	Gabrg1 Regulation of Gene_expression of Per2	1	1	0.40	0	0.56
12	INT249024	Gabrg1 Positive_regulation of Transcription of Per1	1	1	0.59	0	0.55
13	INT249020	Gabrg1 Positive_regulation of Per1	1	1	0.40	0	0.55
14	INT249007	Gabrg1 Regulation of Transcription of Per2	1	1	0.35	0	0.54
15	INT248996	Gabrg1 Negative_regulation of Gene_expression of Per2	1	1	0.33	0	0.51
16	INT329587	Binding of PTX3 and HEY1	1	1	0.00	2.03	0.5
17	INT249000	Helt Negative_regulation of Per2	1	1	0.01	0	0.48
18	INT135176	Myst2 Regulation of Gene_expression of Hif1a	1	1	0.24	0.47	0.47
19	INT135178	Myst2 Regulation of Hif1a	1	1	0.24	0.44	0.44
20	INT337890	Per1 Regulation of Nr2f2	1	1	0.08	0	0.37
21	INT128046	Per1 Regulation of Fos	1	1	0.41	0	0.29
22	INT128048	Per1 Regulation of Gene_expression of Fos	1	1	0.41	0	0.29
23	INT180570	Binding of HEYL and Positive_regulation of DMD	1	1	0.00	1.08	0.28
24	INT180564	HEYL Regulation of Regulation of DMD	1	1	0.00	0.88	0.28
25	INT190983	Vip Positive_regulation of Gene_expression of Per1	1	1	0.13	0.51	0.27
26	INT190978	Vip Positive_regulation of Gene_expression of Per2	1	1	0.22	0.51	0.27
27	INT190996	ADCYAP1 Positive_regulation of Per1	1	1	0.06	0.45	0.27
28	INT190997	ADCYAP1 Positive_regulation of Per2	1	1	0.07	0.45	0.27
29	INT52459	Binding of SUCLA2 and HEY2	2	1	0.01	0.09	0.21
30	INT5874	Pitx1 Positive_regulation of Ina	1	1	0.17	0	0.21
31	INT5873	Pitx1 Negative_regulation of Ina	1	1	0.15	0	0.21
32	INT339336	Binding of NKX3-1 and TAC4	1	1	0.03	0.08	0.18
33	INT333449	Binding of SMAD2 and SMAD4	1	1	0.23	0	0.17
34	INT180562	Binding of CYP27A1 and HEYL	1	1	0.02	0.29	0.16
35	INT237419	Binding of Hif1a and Bace1 Positive_regulation of Bace1	1	1	0.06	1.2	0.15
36	INT237418	Binding of Hif1a and Bace1	1	1	0.06	1.18	0.15
37	INT237420	Binding of Hif1a and Bace1 Positive_regulation of Positive_regulation of Bace1	1	1	0.06	1.2	0.15
38	INT323434	Osr1 Regulation of Hif1a	1	1	0.01	0.79	0.13
39	INT323433	Osr1 Regulation of Protein_catabolism of Hif1a	1	1	0.01	0.8	0.13
40	INT180567	HEYL Regulation of Positive_regulation of IBSP	1	1	0.01	0.18	0.12
41	INT232787	CYBB Positive_regulation of Positive_regulation of Hif1a	1	1	0.01	0.66	0.12
42	INT323438	Binding of Hif1a and Vhl Positive_regulation of Positive_regulation of Hif1a	1	1	0.05	0.74	0.12
43	INT323431	Binding of Hif1a and Vhl	1	1	0.07	0.68	0.12
44	INT249923	Binding of Pah and Hif1a	1	1	0.31	1.16	0.12
45	INT281022	Clock Negative_regulation of Per1	1	1	0.26	0.09	0.11
46	INT281023	Clock Negative_regulation of Per2	1	1	0.31	0.09	0.11
47	INT332891	Per2 Positive_regulation of Ppara	1	1	0.43	0	0.1
48	INT147669	Binding of GRP and Per1 Positive_regulation of Per1	1	1	0.06	0	0.09
49	INT147671	Tg(CAG-EGFP)D4Nagy Positive_regulation of Per1	1	1	0.05	0	0.09
50	INT147673	SRI Positive_regulation of Per1	1	1	0.03	0	0.09
51	INT147672	Binding of GRP and SRI Positive_regulation of Per1	1	1	0.00	0	0.09
52	INT180561	HEYL Negative_regulation of IBSP	1	1	0.01	0.19	0.09
53	INT249920	Negative_regulation of Binding of Pah and Hif1a	1	1	0.37	0.76	0.08
54	INT141997	HEY1 Negative_regulation of CDC42BPA	1	1	0.00	0	0.08
55	INT147674	Binding of GRP and Per1	1	1	0.04	0	0.08
56	INT269569	MAPKAP1 Positive_regulation of PER1	1	1	0.01	0	0.08
57	INT269566	MAPKAP1 Positive_regulation of Localization of PER1	1	1	0.01	0	0.08
58	INT247578	Hif1a Regulation of VEGFA	1	1	0.02	1.59	0.07
59	INT248999	Binding of Per2 and Luc7l3	1	1	0.05	0	0.05
60	INT206675	Adcyap1 Positive_regulation of Gene_expression of Per1	1	1	0.05	0	0.05
61	INT308328	Hif1a Regulation of Positive_regulation of Trib3	1	1	0.02	0.89	0.05
62	INT304322	Hif1a Positive_regulation of Positive_regulation of VEGFA	1	1	0.11	0.39	0.05
63	INT213608	Binding of PER2 and CLOCK	1	1	0.22	0.65	0.04
64	INT266445	Binding of HEY1 and GOPC	1	1	0.00	2.92	0.04
65	INT249921	Binding of Hif1a and Asph	1	1	0.05	0.41	0.04
66	INT349339	Rpe Regulation of Per2	1	1	0.30	0	0.04
67	INT266454	Binding of HEY1 and Acot1	1	1	0.00	1.19	0.04
68	INT297159	Gsta3 Negative_regulation of Hif1a	1	1	0.00	0.54	0.03
69	INT322471	Hif1a Positive_regulation of VEGFA	1	1	0.05	0.26	0.03
70	INT345183	Binding of Lhx3 and Trip6	1	1	0.03	0.66	0.03
71	INT349338	Regulation of Rpe Regulation of Gene_expression of Per2	1	1	0.21	0.06	0.03
72	INT180565	HEYL Positive_regulation of Negative_regulation of COL1A1	1	1	0.01	0	0.03
73	INT180571	HEYL Positive_regulation of Protein_catabolism of COL1A1	1	1	0.01	0	0.03
74	INT345188	Binding of Lhx3 and Lpar2	1	1	0.06	0.66	0.03
75	INT277927	WIF1 Negative_regulation of SMAD4	1	1	0.23	0.37	0
76	INT247576	Binding of Hif1a and Vbp1	1	1	0.01	0.6	0
77	INT328898	hb Regulation of Gene_expression of Per2	1	1	0.16	0	0
78	INT135174	Myst2 Positive_regulation of Binding of Hif1a and	1	1	0.41	0	0
79	INT247660	PER1 Positive_regulation of TNNI3	1	1	0.01	0.35	0
80	INT217918	Binding of PER2 and Per2	2	1	0.27	0	0
81	INT247574	Ube2e3 Positive_regulation of Hif1a	1	1	0.04	0.62	0
82	INT336537	Binding of Clock and Cry2	1	1	0.32	0	0
83	INT349987	Per1 Positive_regulation of Gene_expression of Diap1	1	1	0.08	0	0
84	INT247575	Binding of Epo and Hif1a	1	1	0.09	1.24	0
85	INT135175	Myst2 Positive_regulation of Hif1a	1	1	0.41	0	0
86	INT217915	Binding of Cry1 and Per2	2	1	0.28	0	0
87	INT268341	SMAD2 Positive_regulation of SMAD4	1	1	0.31	0.56	0
88	INT260496	Hif1a Regulation of Gene_expression of VEGFA	1	1	0.12	0.93	0
89	INT282328	Negative_regulation of Gopc Regulation of Per2	1	1	0.19	0.23	0
90	INT336536	Binding of Arntl and Cry1	1	1	0.37	0	0
91	INT233401	COPD Regulation of HEY1	1	1	0.07	1.67	0
92	INT249924	Cpox Positive_regulation of Hif1a	1	1	0.01	0.68	0
93	INT300164	Npas2 Positive_regulation of Transcription of Per1	1	1	0.13	0.23	0
94	INT175729	Binding of ARNTL and PER1	1	1	0.19	0.07	0
95	INT278752	Binding of NUP98 and HEY1	1	1	0.48	0	0
96	INT262710	Binding of Crem and Hif1a	1	1	0.00	1.85	0
97	INT278773	NUP98 Regulation of HEY1	1	1	0.45	0	0
98	INT218665	Olr811 Negative_regulation of Phosphorylation of Smad3	1	1	0.01	0.33	0
99	INT337891	Per1 Positive_regulation of Nr2f2	1	1	0.08	0.16	0
100	INT217876	Binding of CSNK1A1 and PER2	1	1	0.18	0.08	0
101	INT217151	Gene_expression of MIR98 Negative_regulation of HMGA2	1	1	0.24	1.08	0
102	INT179699	LPCAT3 Regulation of LHX2	1	1	0.00	0.31	0
103	INT278775	Binding of HOXA9 and HEY1	1	1	0.44	0	0
104	INT268600	Mirlet7a-1 Regulation of HMGA2	1	1	0.01	0.72	0
105	INT282325	Gopc Regulation of Per2	1	1	0.20	0.23	0
106	INT322470	Binding of Bcl6 and Hif1a	1	1	0.06	0.52	0
107	INT328895	hb Regulation of Per1	1	1	0.05	0	0
108	INT208139	Binding of PITX1 and URI1	1	1	0.01	0.62	0
109	INT247661	PER1 Positive_regulation of Positive_regulation of TNNI3	1	1	0.01	0.41	0
110	INT336533	Binding of Clock and Cry1	1	1	0.32	0	0
111	INT337886	Per1 Positive_regulation of Gene_expression of Nr2f2	1	1	0.09	0.16	0
112	INT217142	MIR98 Regulation of Gene_expression of HMGA2	1	1	0.40	2.22	0
113	INT247577	Binding of Epo and Hif1a Positive_regulation of Positive_regulation of Hif1a	1	1	0.05	0.63	0
114	INT175728	Binding of PER1 and CLOCK	1	1	0.18	0.07	0
115	INT268344	SMAD3 Positive_regulation of SMAD4	2	1	0.17	0.56	0
116	INT172981	PAN3 Negative_regulation of SMAD4	1	1	0.01	0.98	0
117	INT336534	Binding of Arntl and Cry2	1	1	0.37	0	0
118	INT328894	hb Regulation of Gene_expression of Per1	1	1	0.05	0	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein binding transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported in protein binding transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT127435	Gene_expression of Per1	89	0.77	13.94	22.31
2	INT128319	Gene_expression of Per2	105	0.78	14.69	15.13
3	INT128054	Gene_expression of Per1	15	0.61	2.12	11.84
4	INT118755	Gene_expression of Per2	12	0.68	2.81	11.41
5	INT130117	Regulation of Per1	26	0.53	3.25	7.63
6	INT17041	Gene_expression of PER1	24	0.66	5.31	7.12
7	INT135170	Positive_regulation of Hif1a	86	0.67	99.4	6.07
8	INT148384	Positive_regulation of HEY1	19	0.43	29.76	5.89
9	INT128045	Positive_regulation of Per1	29	0.69	5.32	5.5
10	INT196972	Regulation of Per2	23	0.62	2.22	5.46
11	INT112713	Gene_expression of Hif1a	24	0.75	20.48	5.45
12	INT135172	Gene_expression of Hif1a	56	0.76	46.49	5.44
13	INT128324	Regulation of Gene_expression of Per1	11	0.61	1.95	5.22
14	INT138216	Negative_regulation of PER1	13	0.37	9.66	4.55
15	INT187286	Binding of HEY1	17	0.32	31.21	4.52
16	INT176618	Gene_expression of HEY1	29	0.59	36	4.37
17	INT139252	Negative_regulation of Per2	15	0.52	0.91	4.24
18	INT112704	Positive_regulation of Hif1a	25	0.67	21.49	4.23
19	INT127434	Negative_regulation of Gene_expression of Per1	12	0.58	2.58	4.2
20	INT204020	Negative_regulation of Gene_expression of Per2	16	0.52	2.56	3.99
21	INT204007	Localization of Per2	21	0.75	1.94	3.98
22	INT130119	Transcription of Per1	28	0.67	1.92	3.56
23	INT147664	Positive_regulation of Per2	19	0.63	1.07	3.56
24	INT118761	Positive_regulation of Per2	9	0.42	0.68	3.33
25	INT137532	Negative_regulation of HEY2	1	0.31	1.69	3.18
26	INT118762	Transcription of Per2	1	0.08	0	3.09
27	INT161812	Positive_regulation of PER1	17	0.56	5.64	2.93
28	INT134756	Positive_regulation of Gene_expression of Hif1a	8	0.50	11.14	2.68
29	INT185407	Binding of PER1	13	0.42	9.32	2.6
30	INT196971	Positive_regulation of Gene_expression of Per1	8	0.69	1.23	2.44
31	INT171070	Positive_regulation of Hey2	8	0.05	10.12	1.96
32	INT204004	Transcription of Per2	30	0.72	5.05	1.91
33	INT121337	Negative_regulation of HEY1	7	0.20	12.91	1.89
34	INT128058	Regulation of PER1	6	0.43	1.82	1.89
35	INT128053	Positive_regulation of Per1	5	0.35	0.54	1.83
36	INT128060	Regulation of Gene_expression of PER1	4	0.52	2.41	1.72
37	INT204017	Positive_regulation of Gene_expression of Per2	14	0.61	2.82	1.71
38	INT128327	Regulation of Gene_expression of Per2	9	0.45	1.11	1.66
39	INT122597	Transcription of Hif1a	5	0.69	5.56	1.63
40	INT139254	Negative_regulation of Per1	12	0.56	3.17	1.62
41	INT153723	Negative_regulation of Gene_expression of Hif1a	2	0.41	1.25	1.58
42	INT135171	Positive_regulation of Gene_expression of Hif1a	15	0.68	16.95	1.51
43	INT188683	Binding of Per1	10	0.37	0.9	1.47
44	INT128322	Gene_expression of Cry1	11	0.60	1.03	1.4
45	INT128057	Positive_regulation of Gene_expression of PER1	7	0.59	1.21	1.39
46	INT128321	Regulation of Gene_expression of Cry1	2	0.34	0.09	1.38
47	INT232785	Localization of Hif1a	8	0.46	10.37	1.33
48	INT118758	Negative_regulation of Positive_regulation of Per2	3	0.09	0.07	1.23
49	INT118764	Regulation of Per2	2	0.16	0	1.21
50	INT180588	Gene_expression of HEYL	13	0.52	8.37	1.19
51	INT180580	Binding of HEYL	7	0.17	4.49	1.15
52	INT128052	Positive_regulation of Gene_expression of Per1	1	0.05	0	1.14
53	INT118757	Positive_regulation of Positive_regulation of Per2	1	0.07	0	1.11
54	INT160319	Negative_regulation of Gene_expression of Per1	1	0.41	0	1.09
55	INT187289	Regulation of HEY1	5	0.39	7.8	1.03
56	INT217879	Protein_catabolism of Per1	2	0.54	0.09	1.03
57	INT206672	Positive_regulation of Transcription of Per1	8	0.55	0.61	1
58	INT147665	Positive_regulation of Positive_regulation of Per1	2	0.49	0.57	0.99
59	INT204003	Binding of Per2	9	0.42	0.82	0.94
60	INT335360	Positive_regulation of Gene_expression of Per2	1	0.49	1.03	0.92
61	INT351261	Regulation of Binding of PER1	1	0.40	0	0.91
62	INT351262	Binding of PER2	1	0.31	0	0.91
63	INT351264	Regulation of Binding of PER2	1	0.37	0	0.91
64	INT187288	Positive_regulation of Gene_expression of HEY1	5	0.17	8.42	0.89
65	INT196974	Regulation of Regulation of Per1	2	0.34	0.52	0.87
66	INT206670	Localization of Per1	4	0.75	0.96	0.83
67	INT135169	Binding of Hif1a	22	0.47	12.48	0.79
68	INT135488	Localization of Smad4	2	0.61	0.74	0.77
69	INT84726	Gene_expression of NKX3-1	4	0.75	2.1	0.75
70	INT157238	Transcription of PER1	3	0.50	0.21	0.74
71	INT190968	Regulation of Per1	1	0.14	0	0.74
72	INT208142	Gene_expression of PITX1	3	0.65	9.36	0.73
73	INT121333	Localization of HEY1	11	0.65	18.17	0.72
74	INT147214	Negative_regulation of Gene_expression of Per2	1	0.37	0.1	0.7
75	INT174537	Positive_regulation of HEYL	7	0.39	3.07	0.68
76	INT128314	Gene_expression of Cry2	2	0.46	0.18	0.68
77	INT128326	Regulation of Gene_expression of Cry2	1	0.03	0.09	0.68
78	INT204011	Phosphorylation of Per2	23	0.72	1.25	0.67
79	INT233837	Negative_regulation of Hif1a	9	0.26	12.72	0.65
80	INT88987	Gene_expression of HMGA2	8	0.77	10.46	0.64
81	INT112708	Negative_regulation of Hif1a	5	0.38	2.7	0.64
82	INT267096	Positive_regulation of Localization of Smad4	1	0.27	0.67	0.63
83	INT136465	Regulation of Hif1a	5	0.39	7.05	0.62
84	INT148385	Positive_regulation of HEY2	1	0.38	1.09	0.62
85	INT248974	Negative_regulation of Transcription of Per1	2	0.48	0.33	0.6
86	INT248977	Negative_regulation of Localization of Per2	1	0.37	0	0.58
87	INT134308	Positive_regulation of Nkx3-1	1	0.67	0.48	0.55
88	INT217886	Positive_regulation of Transcription of Per2	5	0.55	0.61	0.54
89	INT135173	Regulation of Gene_expression of Hif1a	3	0.44	2.49	0.53
90	INT134758	Positive_regulation of Transcription of Hif1a	2	0.33	2.44	0.53
91	INT153065	Regulation of Hif1a	8	0.28	8.57	0.51
92	INT160320	Regulation of Gene_expression of Per2	1	0.24	0	0.5
93	INT181281	Localization of NKX3-1	1	0.12	0.3	0.5
94	INT180578	Regulation of HEYL	3	0.06	3.15	0.49
95	INT88170	Positive_regulation of HMGA2	2	0.69	2	0.48
96	INT171071	Negative_regulation of Hey2	1	0.03	1.31	0.48
97	INT153067	Positive_regulation of Positive_regulation of Hif1a	10	0.49	11.83	0.47
98	INT148976	Regulation of PER2	2	0.47	0.22	0.46
99	INT118765	Regulation of Transcription of Per2	1	0.04	0	0.46
100	INT170454	Gene_expression of Nkx3-1	3	0.58	2.54	0.45
101	INT187287	Negative_regulation of Gene_expression of HEY1	2	0.16	2.96	0.45
102	INT171073	Regulation of Positive_regulation of Hey2	1	0.03	1.22	0.45
103	INT128059	Regulation of Regulation of PER1	1	0.20	0	0.44
104	INT84724	Negative_regulation of Gene_expression of NKX3-1	1	0.41	0.43	0.44
105	INT71019	Negative_regulation of SMAD4	12	0.42	6.88	0.43
106	INT204009	Positive_regulation of Binding of Per2	2	0.43	0.57	0.38
107	INT218691	Phosphorylation of Smad3	1	0.28	3	0.38
108	INT117564	Gene_expression of SMAD4	12	0.71	8.7	0.37
109	INT118759	Positive_regulation of Transcription of Per2	1	0.07	0	0.37
110	INT247549	Transcription of Hif1a	7	0.42	8.77	0.36
111	INT88167	Negative_regulation of Positive_regulation of HMGA2	1	0.41	0.16	0.35
112	INT320784	Protein_catabolism of Hif1a	3	0.61	2.41	0.34
113	INT217889	Binding of Cry1	4	0.32	0	0.33
114	INT248970	Positive_regulation of Localization of Per2	1	0.43	0	0.32
115	INT247563	Negative_regulation of Positive_regulation of Hif1a	1	0.16	9.12	0.32
116	INT181918	Positive_regulation of SMAD3	6	0.35	2.62	0.31
117	INT148980	Negative_regulation of Gene_expression of PER1	1	0.49	0.08	0.3
118	INT88988	Positive_regulation of Gene_expression of HMGA2	1	0.69	4.05	0.29
119	INT120958	Protein_catabolism of HEY1	1	0.44	0.14	0.28
120	INT204010	Regulation of Transcription of Per2	5	0.62	1.23	0.27
121	INT232786	Positive_regulation of Localization of Hif1a	2	0.31	2.63	0.27
122	INT157244	Localization of PER1	8	0.50	2.4	0.26
123	INT241389	Negative_regulation of Heyl	1	0.03	1.38	0.21
124	INT247564	Positive_regulation of Transcription of Hif1a	1	0.19	2.05	0.2
125	INT130118	Regulation of Transcription of Per1	2	0.43	0.11	0.19
126	INT269637	Positive_regulation of Phosphorylation of PER1	1	0.04	0	0.19
127	INT339342	Binding of NKX3-1	1	0.04	0.08	0.18
128	INT277935	Binding of SMAD4	4	0.28	1.12	0.17
129	INT175737	Gene_expression of PER2	4	0.68	0.3	0.16
130	INT180592	Negative_regulation of Gene_expression of HEYL	1	0.03	0.3	0.15
131	INT171074	Gene_expression of Hey2	2	0.44	0.83	0.14
132	INT249919	Regulation of Regulation of Hif1a	2	0.29	1.81	0.14
133	INT249908	Binding of Hif1a	2	0.31	1.48	0.14
134	INT208140	Localization of PITX1	2	0.73	6.18	0.14
135	INT158903	Gene_expression of Smad3	2	0.56	0.54	0.13
136	INT249913	Regulation of Gene_expression of Hif1a	2	0.32	1.82	0.13
137	INT158890	Negative_regulation of Gene_expression of Smad3	1	0.42	0.13	0.13
138	INT206779	Regulation of Positive_regulation of PER1	1	0.03	0.18	0.13
139	INT180593	Positive_regulation of Gene_expression of HEYL	1	0.03	0.18	0.12
140	INT281017	Regulation of Regulation of Per2	1	0.41	0.09	0.11
141	INT217884	Transcription of Cry1	9	0.55	1.82	0.1
142	INT293961	Binding of PITX1	1	0.31	1.73	0.1
143	INT153064	Positive_regulation of Regulation of Hif1a	1	0.45	1.52	0.1
144	INT260478	Negative_regulation of Positive_regulation of Hif1a	2	0.30	1.23	0.09
145	INT271380	Regulation of Cry1	2	0.25	0.59	0.09
146	INT289450	Regulation of Gene_expression of PITX1	1	0.04	0.71	0.09
147	INT260462	Negative_regulation of Binding of Hif1a	1	0.30	1.13	0.09
148	INT266451	Regulation of Gene_expression of HEY1	1	0.02	2.03	0.09
149	INT217893	Phosphorylation of Per1	1	0.70	0	0.09
150	INT269661	Phosphorylation of PER1	1	0.07	0	0.09
151	INT332857	Binding of Cry2	2	0.32	0	0.08
152	INT267097	Gene_expression of Smad4	2	0.36	1.35	0.08
153	INT260451	Positive_regulation of Positive_regulation of Hif1a	1	0.36	1.01	0.08
154	INT332841	Negative_regulation of Binding of Cry1	1	0.29	0	0.08
155	INT332843	Negative_regulation of Binding of Cry2	1	0.33	0	0.08
156	INT332850	Negative_regulation of Binding of Per2	1	0.40	0	0.08
157	INT297157	Negative_regulation of Negative_regulation of Hif1a	1	0.03	0.54	0.07
158	INT247560	Negative_regulation of Negative_regulation of Hif1a	1	0.16	2.06	0.07
159	INT88990	Binding of HMGA2	1	0.48	0.95	0.07
160	INT248969	Transcription of Cry2	2	0.59	0.56	0.06
161	INT247553	Regulation of Negative_regulation of Hif1a	1	0.17	1.36	0.06
162	INT297158	Regulation of Localization of Hif1a	1	0.03	0.32	0.06
163	INT205201	Gene_expression of Hey1	1	0.46	0	0.06
164	INT235742	Regulation of Smad4	1	0.04	1.66	0.06
165	INT203988	Localization of Per1	1	0.68	0.14	0.06
166	INT175757	Positive_regulation of PER2	6	0.67	0.44	0.05
167	INT247559	Regulation of Positive_regulation of Hif1a	2	0.23	1.64	0.05
168	INT247555	Positive_regulation of Binding of Hif1a	2	0.31	1.15	0.05
169	INT217881	Positive_regulation of Phosphorylation of Per1	1	0.40	0	0.05
170	INT297156	Localization of Hif1a	1	0.06	0.32	0.05
171	INT322464	Regulation of Localization of Hif1a	1	0.28	0.59	0.05
172	INT217887	Regulation of Transcription of Cry1	2	0.46	0.06	0.04
173	INT290790	Phosphorylation of Cry2	1	0.46	0.29	0.04
174	INT290783	Protein_catabolism of Cry2	1	0.48	0.19	0.04
175	INT249918	Regulation of Protein_catabolism of Hif1a	1	0.29	0.4	0.04
176	INT249916	Protein_catabolism of Hif1a	1	0.64	0.39	0.04
177	INT290799	Positive_regulation of Protein_catabolism of Cry2	1	0.34	0.19	0.04
178	INT334291	Positive_regulation of Gene_expression of SMAD4	1	0.18	0	0.04
179	INT268360	Positive_regulation of SMAD4	3	0.55	1.55	0.03
180	INT300146	Transcription of Per1	2	0.18	0.52	0.03
181	INT271419	Localization of SMAD3	2	0.11	0.13	0.03
182	INT277248	Localization of HEY2	1	0.73	0.5	0.03
183	INT312133	Positive_regulation of Positive_regulation of PER1	1	0.05	0.06	0.03
184	INT117563	Negative_regulation of Gene_expression of SMAD4	6	0.54	3.87	0
185	INT244743	Gene_expression of Lhx3	2	0.70	0.74	0
186	INT217890	Positive_regulation of Transcription of Cry1	2	0.38	0.49	0
187	INT334327	Regulation of SMAD4	2	0.35	1.73	0
188	INT204000	Negative_regulation of Transcription of Per2	2	0.37	0.46	0
189	INT157242	Localization of PER2	2	0.68	0.3	0
190	INT218693	Negative_regulation of Phosphorylation of Smad3	1	0.19	0.32	0
191	INT157239	Transcription of PER2	1	0.01	0.08	0
192	INT268368	Transcription of SMAD4	1	0.54	1.7	0
193	INT329784	Gene_expression of SMAD3	1	0.31	0.41	0
194	INT180583	Negative_regulation of HEYL	1	0.03	0	0
195	INT217891	Positive_regulation of Phosphorylation of Per2	1	0.61	0.08	0
196	INT268384	Positive_regulation of Phosphorylation of SMAD3	1	0.29	1.22	0
197	INT208141	Positive_regulation of PITX1	1	0.30	1.46	0
198	INT249915	Regulation of Positive_regulation of Hif1a	1	0.29	0.85	0
199	INT294019	Regulation of Protein_catabolism of PER1	1	0.15	0.86	0
200	INT300344	Localization of HMGA2	1	0.42	1.75	0