GOS:protein maturation

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This page displays the top molecular interactions and top single events that were mentioned in the literature for protein maturation. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein maturation. They are ordered first by their pain relevance and then by number of times they were reported for protein maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to protein maturation Documents TM Confidence Disease Relevance Pain Relevance
1 INT111076 Psen1 Regulation of Psenen 1 1 0.17 0.76 1.58
2 INT27871 Binding of FCGR1B and HSPD1 1 1 0.01 1.93 0.56
3 INT27872 Positive_regulation of Binding of FCGR1B and HSPD1 1 1 0.01 1.93 0.56
4 INT129640 Binding of Ambp and Oprd1 1 1 0.22 0.19 0.55
5 INT129639 Regulation of Binding of Ambp and Oprd1 1 1 0.17 0.19 0.55
6 INT15828 Ambp Regulation of Negative_regulation of Fn1 1 1 0.03 0 0.3
7 INT297547 Pou3f3 Regulation of Psen1 1 1 0.00 0.41 0.25
8 INT111909 Binding of HSPD1 and CCT4 1 1 0.29 0.48 0.25
9 INT111908 Binding of HSPD1 and AP4B1 1 1 0.03 0.48 0.25
10 INT243640 Binding of Twist1 and Stub1 1 1 0.08 0.34 0.24
11 INT15829 Ambp Regulation of Positive_regulation of ELANE 1 1 0.00 0 0.24
12 INT336738 S100a8 Regulation of Gene_expression of Ambp 1 1 0.02 2.15 0.24
13 INT46308 Asrgl1 Positive_regulation of Gene_expression of Serpinc1 1 1 0.01 1.07 0.19
14 INT46306 Asrgl1 Positive_regulation of Negative_regulation of Plg 1 1 0.01 1.07 0.19
15 INT46307 Asrgl1 Positive_regulation of Negative_regulation of Serpinc1 1 1 0.01 1.07 0.19
16 INT231763 Binding of HSPD1 and TLR2 1 1 0.12 2 0.19
17 INT251492 Binding of HSPD1 and SOD1 1 1 0.02 1.45 0.18
18 INT231765 Binding of HSPD1 and TLR4 1 1 0.13 1.94 0.16
19 INT21453 Ambp Regulation of ELANE 1 1 0.00 0 0.15
20 INT310626 Ambp Regulation of OTOR 1 1 0.15 1.04 0.14
21 INT209645 AR Regulation of STUB1 1 1 0.04 0.93 0.13
22 INT336740 Positive_regulation of Ambp Positive_regulation of Gene_expression of S100a8 1 1 0.02 1.3 0.12
23 INT297543 Neurod1 Regulation of Psen1 1 1 0.00 0.2 0.12
24 INT192358 CRP Regulation of Positive_regulation of HSPD1 1 1 0.15 2.46 0.1
25 INT192352 CRP Regulation of HSPD1 1 1 0.15 2.46 0.1
26 INT294608 Binding of Serpinh1 and Col5a1 1 1 0.03 0.45 0.09
27 INT193959 Psen1 Regulation of App 1 1 0.40 0.58 0.08
28 INT21452 Ambp Regulation of Gene_expression of ELANE 1 1 0.00 0 0.08
29 INT21446 Ambp Negative_regulation of Positive_regulation of Mpo 1 1 0.01 0 0.07
30 INT193954 Binding of App and Psen1 1 3 0.38 0.88 0.06
31 INT273288 Psen1 Regulation of Prdx2 1 1 0.01 0.7 0.06
32 INT298258 Binding of Runx3 and Stub1 1 1 0.11 0.18 0.06
33 INT193967 Binding of PSEN1 and Psen1 1 1 0.41 1.2 0.05
34 INT193970 Binding of PSEN1 and Psen2 1 1 0.36 2.06 0.05
35 INT213815 Binding of Tfeb and Stub1 1 1 0.13 0.09 0.04
36 INT356101 App Regulation of Negative_regulation of Psen1 1 1 0.23 0.31 0.04
37 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 1 0.00 0.15 0.03
38 INT354896 Binding of Psen2 and Fancd2 1 1 0.04 0.75 0.03
39 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 1 0.00 0.15 0.03
40 INT192354 Binding of CRP and HSPD1 1 1 0.12 1.28 0
41 INT226714 Binding of Ambp and Hivan1 1 1 0.00 0.32 0
42 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 1 0.03 0.06 0
43 INT313117 Binding of Stub1 and Carf 1 1 0.10 0 0
44 INT193962 Binding of Psen1 and Ncstn 1 1 0.13 0.08 0
45 INT273289 Binding of Psen2 and Ryr2 1 1 0.27 4.53 0
46 INT217398 Binding of Psen2 and Bace1 1 1 0.12 1.44 0
47 INT193955 Binding of Psen1 and Psen2 2 1 0.37 1.64 0
48 INT193948 Binding of Psen1 and Notch1 1 1 0.02 0 0
49 INT286331 Binding of Psen1 and Ror1 1 1 0.27 0 0
50 INT226711 Binding of Ambp and Tsg101 1 1 0.01 0.33 0
51 INT243635 Positive_regulation of Binding of Nfatc2 and Stub1 1 1 0.09 0 0
52 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 1 0.22 0.07 0
53 INT217400 Binding of Psen1 and Bace1 1 1 0.17 1.43 0
54 INT286337 PSENEN Regulation of Psen1 1 1 0.07 0.37 0
55 INT193958 Binding of Pld1 and Psen1 1 1 0.17 0 0
56 INT193953 Binding of Bcl2l1 and Psen1 1 1 0.07 0.66 0
57 INT193956 Binding of Psen1 and Rab6a 1 1 0.15 0 0
58 INT243628 Binding of Nfatc2 and Stub1 1 1 0.06 0 0
59 INT193957 Binding of Bcl2l1 and Psen2 1 1 0.07 0.66 0
60 INT331479 Binding of PSEN2 and Psen1 1 1 0.00 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein maturation. They are ordered first by their pain relevance and then by number of times they were reported in protein maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38
3 INT2802 Negative_regulation of Asrgl1 14 0.59 2.69 7.37
4 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
5 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
6 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
7 INT120372 Positive_regulation of Ambp 21 0.21 21.1 2.66
8 INT163544 Binding of Psen1 40 0.36 15.28 2.42
9 INT160673 Gene_expression of Ambp 16 0.49 19.49 2.3
10 INT27880 Positive_regulation of HSPD1 17 0.65 18.16 2.23
11 INT152436 Positive_regulation of Gene_expression of HSPD1 12 0.67 10.06 2.16
12 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
13 INT60723 Localization of Psen2 5 0.68 2.11 2.02
14 INT27881 Binding of HSPD1 10 0.31 9.2 1.78
15 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
16 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
17 INT162325 Negative_regulation of Psen1 1 0.01 0.55 1.43
18 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
19 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
20 INT112891 Regulation of Gene_expression of HSPD1 2 0.43 3.98 1.17
21 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
22 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
23 INT215363 Regulation of HSPD1 4 0.51 2.74 0.99
24 INT41307 Localization of Asrgl1 2 0.79 0.19 0.92
25 INT7702 Gene_expression of Asrgl1 5 0.77 3.33 0.89
26 INT41306 Positive_regulation of Negative_regulation of Asrgl1 1 0.48 0 0.88
27 INT17804 Negative_regulation of Ambp 2 0.31 2.03 0.85
28 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
29 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
30 INT51069 Negative_regulation of Asrgl1 1 0.59 0.08 0.8
31 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
32 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
33 INT78649 Binding of Psen2 7 0.36 5.9 0.73
34 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
35 INT303885 Negative_regulation of Serpinh1 5 0.05 1.68 0.7
36 INT73977 Gene_expression of Serpinh1 14 0.54 8.14 0.69
37 INT65521 Positive_regulation of Psen1 1 0.43 0 0.66
38 INT211782 Localization of Ambp 2 0.26 2.12 0.64
39 INT21663 Regulation of Negative_regulation of Asrgl1 1 0.03 0.21 0.6
40 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
41 INT15816 Negative_regulation of AGA 1 0.42 0.9 0.59
42 INT15815 Positive_regulation of AGA 1 0.45 0.85 0.56
43 INT41305 Transcription of Asrgl1 1 0.66 0 0.55
44 INT89258 Localization of STUB1 3 0.14 0.67 0.49
45 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
46 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
47 INT193856 Localization of Psen1 19 0.73 9.79 0.41
48 INT81310 Gene_expression of AGA 3 0.75 3.87 0.41
49 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
50 INT294604 Binding of Serpinh1 5 0.16 4.02 0.36
51 INT306291 Localization of HSPD1 1 0.31 0.81 0.36
52 INT46333 Positive_regulation of Asrgl1 3 0.49 2.71 0.33
53 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
54 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
55 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
56 INT273507 Gene_expression of Asrgl1 1 0.02 0.85 0.25
57 INT166356 Negative_regulation of HSPD1 4 0.55 3 0.23
58 INT203471 Localization of Stub1 1 0.23 0.5 0.21
59 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
60 INT46631 Regulation of Asrgl1 2 0.45 0.35 0.19
61 INT235538 Positive_regulation of Binding of HSPD1 1 0.08 1.15 0.19
62 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
63 INT96560 Binding of Asrgl1 2 0.26 1.07 0.16
64 INT208473 Positive_regulation of ASRGL1 1 0.04 0.54 0.15
65 INT239485 Regulation of Gene_expression of Serpinh1 1 0.02 0.35 0.14
66 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
67 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
68 INT303888 Positive_regulation of Serpinh1 1 0.06 0.56 0.13
69 INT336732 Transcription of Ambp 1 0.03 1.17 0.13
70 INT336733 Positive_regulation of Gene_expression of Ambp 1 0.02 1.1 0.12
71 INT256850 Regulation of Psen1 1 0.00 0.25 0.12
72 INT192360 Positive_regulation of Positive_regulation of HSPD1 1 0.29 0.77 0.11
73 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
74 INT73984 Positive_regulation of Serpinh1 2 0.35 5.92 0.1
75 INT277225 Gene_expression of Psen1 1 0.02 0.88 0.1
76 INT294606 Negative_regulation of Positive_regulation of Serpinh1 1 0.09 2.69 0.09
77 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
78 INT215368 Regulation of Positive_regulation of HSPD1 1 0.38 0.51 0.09
79 INT294605 Negative_regulation of Gene_expression of Serpinh1 1 0.13 2.68 0.09
80 INT184167 Binding of STUB1 5 0.07 0.72 0.08
81 INT243617 Binding of Stub1 3 0.09 0.16 0.08
82 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
83 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
84 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
85 INT197395 Positive_regulation of Gene_expression of Serpinh1 2 0.19 2.81 0.07
86 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
87 INT197397 Localization of Serpinh1 2 0.20 0.56 0.05
88 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
89 INT303884 Regulation of Positive_regulation of Serpinh1 1 0.04 0.3 0.05
90 INT303891 Positive_regulation of Positive_regulation of Serpinh1 1 0.04 0.07 0.05
91 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
92 INT182999 Negative_regulation of Gene_expression of STUB1 1 0.08 0.31 0.03
93 INT194536 Binding of ASRGL1 1 0.03 0.39 0.03
94 INT194535 Gene_expression of ASRGL1 1 0.05 0.39 0.03
95 INT200277 Positive_regulation of Gene_expression of Stub1 2 0.06 0 0
96 INT196230 Regulation of STUB1 2 0.05 0.8 0
97 INT209699 Negative_regulation of STUB1 1 0.07 0.41 0
98 INT303886 Gene_expression of Serpinh1 1 0.05 0 0
99 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
100 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
101 INT342089 Regulation of Gene_expression of Stub1 1 0.02 0.16 0
102 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
103 INT313091 Negative_regulation of Stub1 1 0.07 0.25 0
104 INT354892 Negative_regulation of Psen2 1 0.37 0.95 0
105 INT73985 Transcription of Serpinh1 1 0.37 0.08 0
106 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
107 INT303889 Regulation of Serpinh1 1 0.05 0.23 0
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