GOS:proteinaceous extracellular matrix

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This page displays the top molecular interactions and top single events that were mentioned in the literature for proteinaceous extracellular matrix. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for proteinaceous extracellular matrix. They are ordered first by their pain relevance and then by number of times they were reported for proteinaceous extracellular matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to proteinaceous extracellular matrix Documents TM Confidence Disease Relevance Pain Relevance
1 INT190167 Binding of JUN and MMP12 1 1 0.26 0.82 2.76
2 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 1 0.49 0.67 2.69
3 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 1 0.06 0.5 2.6
4 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 1 0.06 4.35 2.14
5 INT113550 Binding of FN1 and VTN 2 6 0.30 5.24 1.91
6 INT243043 Binding of Mmp9 and Timp1 2 1 0.05 0.25 1.86
7 INT205152 Binding of CD44 and MMP9 1 23 0.35 17.13 1.85
8 INT192161 Mmp14 Positive_regulation of Mmp2 1 2 0.19 1.23 1.81
9 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 1 0.13 5.83 1.8
10 INT302646 ARSA Positive_regulation of TGFB1 1 1 0.10 0.52 1.76
11 INT102160 Binding of Mmp2 and Mmp9 2 3 0.28 2.87 1.75
12 INT6407 Binding of Lama5 and Oprm1 1 1 0.02 0.08 1.72
13 INT24817 Binding of POMC and VTN 1 8 0.42 0.39 1.71
14 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 1 3 0.38 4.29 1.71
15 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 2 4 0.47 1.01 1.63
16 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 1 0.23 0.45 1.62
17 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 1 0.23 0.45 1.61
18 INT326509 Binding of ACE and VWF 1 1 0.05 2.07 1.59
19 INT168609 Binding of Itgb1 and Mmp9 1 1 0.02 0.41 1.58
20 INT168611 Binding of Mmp9 and Ndor1 1 1 0.29 0.41 1.57
21 INT168608 Binding of Grin2b and Mmp9 1 1 0.22 0.41 1.57
22 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 1 0.00 1.8 1.42
23 INT261831 Mapk1 Negative_regulation of Hspg2 1 1 0.00 1.26 1.42
24 INT158762 Binding of Vwf and Mthfr 1 1 0.05 1.85 1.37
25 INT60993 Ntf4 Negative_regulation of Positive_regulation of CRTAC1 1 1 0.00 0 1.37
26 INT60992 Ngf Regulation of CRTAC1 1 1 0.00 0 1.35
27 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 and 1 1 0.08 0.65 1.35
28 INT178986 Binding of MMP9 and TIMP1 1 4 0.47 2.58 1.33
29 INT194513 Timp1 Negative_regulation of Cpox 1 1 0.00 0.9 1.31
30 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 1 3 0.49 1.2 1.3
31 INT262377 Binding of Comt and Fmod 1 1 0.06 1.47 1.29
32 INT108386 IL1B Positive_regulation of MMP1 1 3 0.27 1.56 1.28
33 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 1 3 0.49 1.14 1.27
34 INT202042 CAMK2N2 Negative_regulation of MMP9 1 1 0.01 0.73 1.25
35 INT202039 CAMK2N2 Negative_regulation of MMP1 1 1 0.00 0.73 1.24
36 INT136257 Tff3 Regulation of SGCG 1 1 0.00 0.18 1.24
37 INT202036 CAMK2N2 Negative_regulation of MMP3 1 1 0.00 0.73 1.24
38 INT136255 Tff3 Regulation of GRIA1 1 1 0.00 0.18 1.24
39 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 1 0.02 0.18 1.24
40 INT202040 CAMK2N2 Negative_regulation of MMP7 1 1 0.00 0.73 1.24
41 INT108389 IL1B Positive_regulation of ADAMTS4 1 1 0.51 1.19 1.24
42 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 1 0.01 0.18 1.23
43 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 1 0.01 1.94 1.23
44 INT197092 TNF Regulation of VEGFA 1 4 0.21 2.78 1.22
45 INT187174 RPS3AP9 Negative_regulation of MMP2 1 1 0.00 0.9 1.22
46 INT187172 RPS3AP9 Negative_regulation of MMP9 1 1 0.00 0.89 1.2
47 INT299299 VEGFA Positive_regulation of SRC 1 1 0.20 0.91 1.2
48 INT75483 Binding of SGCG and TGFB1 1 1 0.52 2.27 1.19
49 INT142077 TGFB1 Negative_regulation of Binding of IDO1 and 1 1 0.15 2.07 1.19
50 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 1 0.25 0.15 1.15
51 INT72754 Adamts7 Negative_regulation of TNF 1 1 0.28 1.64 1.13
52 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 1 0.02 1.31 1.12
53 INT224728 Col7a1 Positive_regulation of Cia1 1 1 0.00 2.9 1.12
54 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 1 0.01 0.72 1.11
55 INT173059 Binding of KDR and VEGFA 1 43 0.43 29.63 1.1
56 INT187176 Binding of BSG and MMP1 1 1 0.09 1.18 1.08
57 INT91395 MMP2 Positive_regulation of CALCA 1 1 0.36 0.17 1.07
58 INT120313 Gnrhr Negative_regulation of Mmp2 1 1 0.03 0.85 1.07
59 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 3 1 0.13 0.81 1.07
60 INT139227 Icam1 Negative_regulation of Timp1 1 1 0.37 1.13 1.06
61 INT116777 Psma5 Positive_regulation of Binding of Fn1 and 2 1 0.01 1.24 1.06
62 INT139231 Calca Negative_regulation of Timp1 1 1 0.36 1.11 1.05
63 INT150787 ZNF398 Positive_regulation of Gene_expression of SPARC 1 1 0.13 1.02 1.05
64 INT144069 Positive_regulation of TRPV1 Positive_regulation of Gene_expression of MMP1 1 1 0.43 1.35 1.03
65 INT204551 Binding of Col2a1 and Positive_regulation of Cia1 1 1 0.03 1.74 1.03
66 INT106706 POMC Negative_regulation of Binding of FN1 and 1 1 0.19 0.79 1.02
67 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 1 0.02 0.51 1.01
68 INT238091 Binding of GRIP1 and Mmp24 1 1 0.00 0 0.98
69 INT238092 Binding of SHBG and Mmp24 1 1 0.04 0 0.98
70 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 1 0.06 1.56 0.98
71 INT187111 TIMP2 Regulation of MMP9 1 1 0.23 1.47 0.97
72 INT171264 TNF Positive_regulation of MMP1 1 2 0.10 2.05 0.95
73 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 1 0.67 0.16 0.95
74 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 1 0.00 1.04 0.95
75 INT351311 Has1 Regulation of Gene_expression of MMP3 1 1 0.11 1.15 0.95
76 INT137922 VEGFA Positive_regulation of Oprm1 1 1 0.06 0 0.94
77 INT266659 Binding of MMP9 and MOCS1 1 1 0.01 1.71 0.94
78 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 1 0.05 0 0.93
79 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 1 0.01 1.64 0.93
80 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 1 0.15 1.73 0.93
81 INT137921 VEGFA Positive_regulation of Ephb2 1 1 0.03 0 0.93
82 INT222978 Binding of COL1A1 and FN1 1 1 0.01 1.64 0.92
83 INT161455 Mmp7 Positive_regulation of Egfr 1 1 0.03 0.19 0.92
84 INT243044 Mmp8 Regulation of Mmp9 2 1 0.05 1.45 0.91
85 INT250976 Binding of FMOD and IL8 1 1 0.08 1.26 0.91
86 INT190147 MMP12 Positive_regulation of MMP2 Positive_regulation of Protein_catabolism of MMRN1 2 1 0.03 0.87 0.9
87 INT66334 Fgf2 Regulation of Fgf1 2 1 0.37 0.17 0.9
88 INT121700 IL12RB1 Positive_regulation of Gene_expression of MMP1 1 1 0.06 0.22 0.9
89 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 1 0.06 0.2 0.9
90 INT121701 HRAS Negative_regulation of MMP1 1 1 0.06 0.2 0.89
91 INT121704 HRAS Negative_regulation of MMP3 1 1 0.06 0.19 0.89
92 INT109103 MMP2 Positive_regulation of INS 1 1 0.33 1.07 0.89
93 INT167466 Ccdc80 Negative_regulation of Tnf 1 1 0.01 0.76 0.88
94 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 1 0.06 0.19 0.88
95 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 1 0.00 0 0.88
96 INT149562 Tgfb1 Positive_regulation of CXCL10 1 1 0.00 0 0.88
97 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 1 0.00 0 0.88
98 INT149560 Tgfb1 Positive_regulation of Ccr5 1 1 0.00 0 0.88
99 INT209881 Binding of TNFRSF11B and TNFSF11 1 8 0.36 8.92 0.86
100 INT196523 Binding of MMP2 and TIMP1 1 3 0.43 1.94 0.85
101 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 1 0.01 0.73 0.85
102 INT190165 MMP12 Positive_regulation of MMP2 2 1 0.13 0.72 0.85
103 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 1 0.00 1.57 0.85
104 INT260894 CRH Regulation of Localization of MMP3 1 1 0.21 0.36 0.85
105 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 1 0.13 0.26 0.84
106 INT215945 Binding of Mmp14 and Timp2 Positive_regulation of Mmp2 1 1 0.11 0.4 0.84
107 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 1 0.00 0 0.83
108 INT192158 Binding of Mmp2 and Mmp9 2 1 0.21 0.94 0.83
109 INT97058 Cpz Regulation of Gene_expression of Trp53 1 1 0.27 0.57 0.83
110 INT116108 VEGFA Positive_regulation of SEC23IP 1 1 0.10 0.3 0.83
111 INT106808 RECK Negative_regulation of MMP2 1 1 0.40 0.5 0.83
112 INT116109 VEGFA Positive_regulation of PTK2 1 1 0.13 0.3 0.83
113 INT309001 Ins1 Positive_regulation of Mmp9 1 1 0.20 1.96 0.83
114 INT149563 Tgfb1 Positive_regulation of CCL2 1 1 0.00 0 0.83
115 INT97056 Cpz Regulation of Gene_expression of Bcl2l1 1 1 0.22 0.57 0.83
116 INT116106 VEGFA Positive_regulation of AKT1 1 1 0.12 0.3 0.83
117 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 1 0.00 0 0.82
118 INT114844 Lgals1 Positive_regulation of TACR1 1 1 0.16 0.95 0.82
119 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 1 0.00 0 0.82
120 INT190182 JUN Positive_regulation of MMP12 1 1 0.34 0.08 0.8
121 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 1 0.01 0.78 0.8
122 INT21233 Ngf Regulation of Fgf1 2 1 0.46 0.09 0.79
123 INT209043 Binding of Fn1 and Slc11a1 2 3 0.03 1.91 0.78
124 INT196525 Binding of MMP2 and MMP9 2 2 0.32 2.49 0.78
125 INT172982 Binding of MUC1 and MUC4 1 1 0.30 2.46 0.78
126 INT102163 Binding of TNF and Mmp9 1 1 0.12 0.88 0.78
127 INT102161 Binding of TNF and Mmp2 1 1 0.10 0.88 0.78
128 INT113546 Binding of FN1 and ITGA3 1 1 0.03 2.12 0.77
129 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 1 0.47 1.21 0.77
130 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 1 0.14 1.21 0.77
131 INT102159 Binding of Adam17 and Mmp2 1 1 0.18 0.87 0.77
132 INT164227 Binding of PAEP and Tnfrsf11b 1 1 0.00 1.18 0.77
133 INT113549 Binding of VTN and alphavbeta3 integrin receptor 1 1 0.09 2.05 0.76
134 INT161482 Il1b Negative_regulation of TGFB1 1 1 0.45 1.17 0.76
135 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 1 0.44 1.5 0.75
136 INT150268 MMP8 Regulation of Transcription of SFTPA1 1 1 0.05 0.43 0.75
137 INT260895 CRH Regulation of MMP1 1 1 0.11 0.31 0.74
138 INT219685 Binding of MMP12 and COPD 1 1 0.27 5.59 0.74
139 INT295711 MMP9 Positive_regulation of Localization of VEGFA 2 1 0.06 0.29 0.74
140 INT316673 Binding of CALR and LRP1 1 1 0.39 1.89 0.74
141 INT190174 TNF Positive_regulation of MMP12 1 1 0.27 0.08 0.74
142 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 1 0.30 0.07 0.74
143 INT170992 Binding of FN1 and MMRN1 1 3 0.01 2.13 0.73
144 INT162241 Binding of COL7A1 and MMP13 1 2 0.03 0.86 0.73
145 INT162240 Binding of COL7A1 and MMP1 1 1 0.03 0.86 0.73
146 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 1 0.46 2.15 0.73
147 INT161484 Binding of TGFB1 and Il1b 1 1 0.37 1.16 0.73
148 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 1 0.46 2.15 0.73
149 INT162239 Binding of COL7A1 and MMP8 1 1 0.04 0.86 0.73
150 INT58870 Binding of ap and Bgn 1 1 0.13 0 0.72
151 INT262580 Ngf Positive_regulation of Hspg2 1 1 0.03 0.35 0.72
152 INT308167 Binding of Eln and Tnfrsf1b 2 1 0.01 0.94 0.71
153 INT107910 Binding of Tnfrsf11b and Tnfsf11 1 6 0.30 5.88 0.7
154 INT120018 VEGFA Positive_regulation of CCL3 1 1 0.01 1 0.7
155 INT120020 VEGFA Positive_regulation of CCL2 1 1 0.00 1 0.7
156 INT121697 IL4I1 Positive_regulation of Gene_expression of MMP3 1 1 0.06 0.27 0.7
157 INT295720 PTGER2 Regulation of MMP9 1 1 0.01 0.53 0.7
158 INT120036 VEGFA Positive_regulation of Prap1 1 1 0.00 1 0.7
159 INT348129 Bgn Regulation of Regulation of Hspg2 1 1 0.00 0.69 0.69
160 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 2 1 0.35 0.83 0.69
161 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 1 0.06 1.61 0.69
162 INT302642 Binding of ARSA and TGFB1 1 1 0.05 0.28 0.68
163 INT185802 Binding of MMP7 and SPP1 1 1 0.33 1.71 0.68
164 INT167355 VEGFA Regulation of RYBP 1 1 0.01 0.53 0.68
165 INT190172 Gene_expression of IL13 Regulation of MMP12 1 1 0.12 0.05 0.68
166 INT117677 Binding of MATN3 and OPRL1 1 1 0.26 0.07 0.68
167 INT157935 Negative_regulation of TRPV1 Negative_regulation of Gene_expression of MMP1 1 1 0.42 0.1 0.68
168 INT190164 Gene_expression of IL4 Regulation of MMP12 1 1 0.11 0.05 0.68
169 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 1 0.01 1.44 0.68
170 INT168295 PROC Regulation of Gene_expression of VEGFA 1 2 0.00 1.6 0.67
171 INT354913 VDR Positive_regulation of TGFB1 1 1 0.05 1.33 0.67
172 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 1 0.13 0.16 0.66
173 INT152299 Mmp2 Negative_regulation of Tsc22d1 1 1 0.16 0.16 0.66
174 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 1 0.06 0.84 0.66
175 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 1 0.08 0.16 0.66
176 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 1 0.00 1.42 0.66
177 INT152297 Mmp2 Negative_regulation of Mmp9 2 1 0.39 0.16 0.65
178 INT190178 PIK3CG Regulation of MMP12 1 1 0.09 0 0.65
179 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 1 0.44 0.06 0.65
180 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 and 1 1 0.01 0.81 0.65
181 INT224702 Timp2 Positive_regulation of Binding of Mmp14 and Mmp9 1 1 0.00 0.81 0.65
182 INT190211 Adm Regulation of MMP12 1 1 0.29 0 0.65
183 INT114845 RET Regulation of Gene_expression of Lgals1 1 1 0.02 0.84 0.65
184 INT224693 Timp2 Positive_regulation of Binding of Mmp9 and 1 1 0.01 0.81 0.65
185 INT149899 Ihh Positive_regulation of Mmp7 1 1 0.04 1.69 0.65
186 INT352462 Gse1 Positive_regulation of Gene_expression of Tnc 1 1 0.05 0.75 0.64
187 INT224684 Binding of Mmp14 and Mmp9 1 1 0.01 0.81 0.64
188 INT92045 Binding of ALB and SERPINA1 1 1 0.30 1.37 0.64
189 INT318981 Binding of CALR and GOPC 1 1 0.03 0.77 0.64
190 INT261830 Hspg2 Negative_regulation of Trpa1 1 1 0.01 0.58 0.63
191 INT333165 Binding of asa and Col7a1 1 1 0.03 0.94 0.63
192 INT99602 ZNF398 Negative_regulation of MMP2 1 1 0.14 0.85 0.63
193 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 1 0.35 2.03 0.63
194 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 1 0.21 1.68 0.63
195 INT239488 Spna1 Negative_regulation of Gene_expression of Timp1 1 1 0.00 0.94 0.62
196 INT7402 Positive_regulation of Ucma Positive_regulation of Localization of Gast 2 1 0.50 0 0.62
197 INT314051 THL Negative_regulation of Localization of Mmp2 1 1 0.14 1.1 0.62
198 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 1 0.29 0.99 0.62
199 INT8695 Binding of Calca and Lgals3 2 1 0.02 0.09 0.62
200 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 1 0.01 1.82 0.62

Single Events

The table below shows the top 100 pain related interactions that have been reported for proteinaceous extracellular matrix. They are ordered first by their pain relevance and then by number of times they were reported in proteinaceous extracellular matrix. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
2 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
3 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
4 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
5 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
6 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72
7 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
8 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9
9 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12
10 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
11 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
12 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78
13 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
14 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
15 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2
16 INT99610 Localization of MMP9 126 0.79 48.46 32.67
17 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
18 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
19 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
20 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
21 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
22 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71
23 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99
24 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
25 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
26 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
27 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
28 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
29 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16
30 INT34487 Localization of MMP2 56 0.81 31.41 23.61
31 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
32 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
33 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73
34 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72
35 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36
36 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
37 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
38 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
39 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
40 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86
41 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67
42 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99
43 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42
44 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13
45 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95
46 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
47 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
48 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
49 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
50 INT49379 Localization of MMP12 26 0.77 13.07 16.93
51 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17
52 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
53 INT81486 Localization of MMP3 31 0.81 12.94 15.21
54 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16
55 INT103210 Localization of MMP1 43 0.78 12.15 15.13
56 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
57 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06
58 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91
59 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
60 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
61 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31
62 INT302089 Localization of WNT2 1 0.17 0.15 14.05
63 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9
64 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85
65 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69
66 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
67 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53
68 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
69 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32
70 INT32054 Gene_expression of Tnc 14 0.59 9.36 12.22
71 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
72 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
73 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58
74 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
75 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
76 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
77 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74
78 INT34485 Negative_regulation of Localization of MMP2 17 0.50 9.96 10.49
79 INT94004 Negative_regulation of Lox 31 0.59 13.76 10.45
80 INT89282 Regulation of MMP9 39 0.60 25.45 10.34
81 INT262375 Binding of Fmod 1 0.20 12.37 10.1
82 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01
83 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98
84 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96
85 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93
86 INT82829 Gene_expression of COMP 104 0.78 57 9.81
87 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79
88 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
89 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7
90 INT102987 Regulation of MMP3 23 0.60 9.35 9.54
91 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42
92 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
93 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
94 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13
95 INT48233 Negative_regulation of Gene_expression of MMP1 34 0.58 12.94 9.08
96 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93
97 INT111397 Localization of Timp1 17 0.70 11.67 8.76
98 INT250978 Binding of FMOD 4 0.16 12.32 8.75
99 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57
100 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
101 INT302085 Negative_regulation of Localization of WNT2 1 0.12 0.15 8.52
102 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51
103 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17
104 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15
105 INT8694 Binding of Lgals3 38 0.48 14.82 8.05
106 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03
107 INT111903 Regulation of Mmp2 9 0.61 3.95 7.98
108 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88
109 INT74629 Gene_expression of Mmp7 17 0.55 12.78 7.58
110 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33
111 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26
112 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18
113 INT111398 Localization of Mmp2 37 0.76 23.78 7.17
114 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16
115 INT152030 Gene_expression of Postn 10 0.55 8.09 7.08
116 INT168381 Positive_regulation of Mmp3 24 0.58 19.12 7.03
117 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
118 INT168600 Binding of Mmp9 14 0.44 12.79 6.92
119 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88
120 INT81608 Gene_expression of Col11a1 13 0.15 1.58 6.87
121 INT67568 Positive_regulation of Localization of MMP2 14 0.31 8.58 6.79
122 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58
123 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39
124 INT171691 Protein_catabolism of Ecm1 31 0.20 11.57 6.38
125 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33
126 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32
127 INT60713 Binding of Col7a1 47 0.43 22.52 6.29
128 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27
129 INT47127 Gene_expression of BGN 11 0.75 17.09 6.25
130 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2
131 INT95607 Regulation of MMP1 19 0.60 7.86 6.18
132 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16
133 INT250982 Positive_regulation of FMOD 7 0.24 8.65 6.09
134 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08
135 INT108628 Regulation of MMP2 27 0.60 14.85 6.06
136 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02
137 INT14516 Positive_regulation of CRTAC1 14 0.37 4.6 6.01
138 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
139 INT132026 Gene_expression of Ntn1 7 0.78 5.97 6.01
140 INT123551 Regulation of Mmp2 17 0.57 11.6 6
141 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98
142 INT6913 Negative_regulation of Amelx 6 0.32 2.32 5.95
143 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88
144 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85
145 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78
146 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75
147 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68
148 INT65262 Gene_expression of Lox 47 0.74 36.59 5.65
149 INT4938 Localization of Tnc 5 0.65 1.73 5.64
150 INT13170 Gene_expression of Comp 25 0.74 8.68 5.62
151 INT32458 Gene_expression of VWF 57 0.78 28.97 5.56
152 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55
153 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
154 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54
155 INT15284 Positive_regulation of Lgals3 21 0.47 8.88 5.52
156 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47
157 INT90202 Protein_catabolism of MMP2 15 0.94 7.47 5.41
158 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36
159 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34
160 INT134966 Localization of Col7a1 23 0.42 16.4 5.24
161 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
162 INT10888 Binding of Vwf 32 0.46 22.87 5.21
163 INT89142 Gene_expression of Lox 28 0.67 15.36 5.2
164 INT65554 Positive_regulation of Hpse 13 0.69 8.16 5.17
165 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
166 INT351278 Regulation of FMOD 1 0.09 6.45 5.16
167 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
168 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12
169 INT107242 Binding of MMP3 14 0.47 12.06 5.11
170 INT90374 Positive_regulation of Positive_regulation of MMP2 14 0.50 10.12 5.08
171 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03
172 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95
173 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95
174 INT1285 Localization of Mmp13 12 0.78 8.98 4.93
175 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9
176 INT185877 Negative_regulation of Gene_expression of DCN 3 0.33 2.37 4.85
177 INT209893 Positive_regulation of Gene_expression of TNFRSF11B 31 0.68 11.77 4.8
178 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8
179 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79
180 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
181 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73
182 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71
183 INT79194 Positive_regulation of Tnc 5 0.41 2.25 4.69
184 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66
185 INT29502 Localization of Mmp2 18 0.79 3.49 4.64
186 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64
187 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6
188 INT73725 Positive_regulation of Tff3 3 0.40 0.51 4.59
189 INT115927 Negative_regulation of Hspg2 27 0.57 4.16 4.53
190 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52
191 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51
192 INT250981 Gene_expression of FMOD 2 0.20 7.3 4.47
193 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46
194 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43
195 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
196 INT28734 Gene_expression of Reln 7 0.74 5.76 4.33
197 INT134968 Localization of Ecm1 20 0.32 27.27 4.31
198 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22
199 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21
200 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2
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