GOS:ribosome biogenesis

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This page displays the top molecular interactions and top single events that were mentioned in the literature for ribosome biogenesis. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ribosome biogenesis. They are ordered first by their pain relevance and then by number of times they were reported for ribosome biogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to ribosome biogenesis Documents TM Confidence Disease Relevance Pain Relevance
1 INT103724 Oprd1 Positive_regulation of Gtpbp4 1 3 0.30 0.91 4.18
2 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 1 3 0.23 0 2.35
3 INT350148 Binding of IL12A and ERAL1 1 1 0.21 8.23 2.26
4 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 1 2 0.12 0 2.19
5 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 1 0.17 0.38 1.65
6 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 1 0.10 0.38 1.64
7 INT106751 Pes1 Negative_regulation of Casp3 1 2 0.23 0 1.54
8 INT21425 Binding of Pomc and Gtpbp4 1 1 0.01 0.1 1.45
9 INT117871 Sct Positive_regulation of Pes1 1 1 0.10 0 1.36
10 INT51388 Binding of CSF2 and RPLP0 1 1 0.11 1.8 1.27
11 INT21424 Binding of Penk and Gtpbp4 1 1 0.02 0.16 1.2
12 INT207437 Binding of PLA2G7 and ERAL1 1 1 0.14 3.64 1.11
13 INT64259 Binding of Gtpbp4 and Ptprg 1 1 0.06 0 1.1
14 INT230019 Binding of HLA-B and ERAL1 1 1 0.00 2.23 1.1
15 INT61637 Binding of P2ry2 and Gtpbp4 1 1 0.02 0.1 0.99
16 INT153685 Binding of Bcl2l11 and Gtpbp4 1 1 0.08 0.76 0.93
17 INT207439 Binding of HCRT and ERAL1 1 1 0.00 3.06 0.87
18 INT122728 Pes1 Positive_regulation of Transcription of Penk 1 1 0.07 0 0.81
19 INT122727 Pes1 Positive_regulation of Penk 1 1 0.07 0 0.81
20 INT142454 Npff Positive_regulation of Gtpbp4 1 1 0.56 0 0.78
21 INT142455 Binding of Npff and Gtpbp4 1 1 0.40 0 0.78
22 INT117870 Positive_regulation of Sct Positive_regulation of Pes1 1 1 0.09 0 0.71
23 INT113931 Mors1 Positive_regulation of Gtpbp4 1 1 0.02 0 0.67
24 INT117872 Negative_regulation of Sct Positive_regulation of Pes1 1 1 0.10 0 0.66
25 INT106754 Pes1 Positive_regulation of Casp3 1 1 0.13 0 0.63
26 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 1 0.12 0 0.63
27 INT161387 Binding of PNOC and GTPBP4 1 1 0.03 1.05 0.59
28 INT97635 ABCF1 Positive_regulation of Localization of CCR1 1 1 0.05 0.51 0.55
29 INT310701 RPLP0 Regulation of Positive_regulation of PGR 1 1 0.01 0.49 0.53
30 INT97636 ABCF1 Positive_regulation of Localization of CXCR1 1 1 0.35 0.45 0.51
31 INT97634 ABCF1 Positive_regulation of Localization of CCL16 1 1 0.11 0.44 0.51
32 INT81004 Htr1a Positive_regulation of Gtpbp4 1 1 0.20 0 0.5
33 INT310711 Binding of RPLP0 and Gabrg1 1 1 0.04 0.37 0.45
34 INT139683 Binding of Cldn11 and 2410016O06Rik 1 1 0.02 1.06 0.4
35 INT139684 Binding of Cd4 and 2410016O06Rik 1 1 0.02 1.05 0.4
36 INT56876 Regulation of Binding of Cd36 and Gtpbp4 1 1 0.00 0 0.4
37 INT56875 Binding of Cd36 and Gtpbp4 1 1 0.00 0 0.4
38 INT109282 Gdi2 Negative_regulation of Gtpbp4 1 1 0.01 0.13 0.32
39 INT278693 ERAL1 Positive_regulation of CD4 1 1 0.05 1.1 0.31
40 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 1 0.05 1.1 0.31
41 INT71550 GTPBP4 Regulation of Localization of INS 1 1 0.00 0.16 0.28
42 INT350145 Binding of SNRNP70 and ERAL1 1 1 0.05 1.29 0.28
43 INT64892 ANTXR1 Regulation of Gtpbp4 1 1 0.00 0.47 0.28
44 INT310700 PGR Regulation of Gene_expression of RPLP0 1 1 0.01 0.37 0.25
45 INT207438 Binding of OLR1 and ERAL1 1 1 0.08 0.5 0.25
46 INT146826 Binding of Galr1 and Gtpbp4 1 1 0.03 0.17 0.22
47 INT95896 Npy Positive_regulation of Positive_regulation of Gtpbp4 1 1 0.12 0 0.2
48 INT249412 Frg1 Positive_regulation of Binding of Napa and 1 1 0.02 0.13 0.13
49 INT292555 Binding of MAPK8 and GTPBP4 1 1 0.00 0.36 0.09
50 INT209706 Binding of GTPBP4 and MRGPRX1 1 1 0.01 0 0.08
51 INT201611 Uvbi1 Negative_regulation of Bop1 1 1 0.03 0.3 0.08
52 INT223521 Li Regulation of Imp3 1 1 0.03 0.82 0.06
53 INT223524 Erv4 Regulation of Imp3 1 1 0.02 0.82 0.06
54 INT251892 Binding of Plau and Naf1 1 1 0.07 0.06 0.04
55 INT258203 S1PR1 Positive_regulation of GTPBP4 1 1 0.00 0.29 0
56 INT331118 Regulation of Binding of KIF22 and EBNA1BP2 1 1 0.04 0.16 0
57 INT337708 Naf1 Regulation of Gene_expression of Tp53 2 1 0.09 0.22 0
58 INT258204 LPA Positive_regulation of GTPBP4 1 1 0.00 0.29 0
59 INT171991 Binding of DMD and ERAL1 1 1 0.01 0.54 0
60 INT331115 Binding of KIF22 and EBNA1BP2 1 1 0.07 0.49 0
61 INT315073 DROSHA Regulation of PAR4 1 1 0.36 0.13 0
62 INT337707 Naf1 Regulation of Gene_expression of Bcl2 2 1 0.11 0.57 0
63 INT59458 GTPBP4 Positive_regulation of Gene_expression of ISYNA1 1 1 0.02 0.14 0
64 INT315059 PAR4 Regulation of DROSHA 1 1 0.19 0.52 0
65 INT91095 Naf1 Positive_regulation of Npr1 2 1 0.01 0.18 0
66 INT283718 Binding of Id2 and Aatf 1 1 0.03 0.19 0
67 INT331116 Binding of BLVRB and EBNA1BP2 1 1 0.04 0.38 0
68 INT223528 Binding of Erv4 and Imp3 1 1 0.01 0.45 0
69 INT209708 Binding of GABBR1 and GTPBP4 1 1 0.00 0 0
70 INT91096 Naf1 Positive_regulation of Binding of Npr1 and 2 1 0.02 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ribosome biogenesis. They are ordered first by their pain relevance and then by number of times they were reported in ribosome biogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9298 Positive_regulation of Gtpbp4 64 0.69 12.29 41.97
2 INT21421 Regulation of Gtpbp4 15 0.30 2.7 13.49
3 INT67915 Negative_regulation of Gtpbp4 18 0.33 6.31 10.17
4 INT68434 Gene_expression of Gtpbp4 15 0.54 5.5 7.91
5 INT6341 Binding of Gtpbp4 11 0.44 1.54 7.3
6 INT77756 Positive_regulation of GTPBP4 16 0.11 2.6 7.29
7 INT103723 Regulation of Positive_regulation of Gtpbp4 5 0.22 1.56 6.35
8 INT74203 Positive_regulation of Positive_regulation of Gtpbp4 6 0.50 0.33 4.13
9 INT223495 Gene_expression of Imp3 1 0.05 13.54 2.71
10 INT68435 Regulation of Gene_expression of Gtpbp4 4 0.34 0.96 1.89
11 INT9297 Localization of Gtpbp4 4 0.17 0.88 1.89
12 INT57618 Binding of GTPBP4 9 0.43 1.61 1.87
13 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67
14 INT96823 Positive_regulation of Positive_regulation of GTPBP4 3 0.05 0.41 1.67
15 INT130765 Positive_regulation of ERAL1 7 0.49 7.07 1.54
16 INT117858 Positive_regulation of Pes1 4 0.19 0.09 1.48
17 INT207443 Binding of ERAL1 5 0.19 3.69 1.47
18 INT79099 Negative_regulation of Positive_regulation of Gtpbp4 4 0.20 0.06 1.31
19 INT52079 Negative_regulation of Mrto4 1 0.12 0.14 1.28
20 INT117862 Negative_regulation of Pes1 2 0.15 0.28 1.27
21 INT67254 Gene_expression of RPLP0 6 0.38 2.7 1.24
22 INT278722 Phosphorylation of ERAL1 1 0.10 3.19 1.21
23 INT57619 Gene_expression of GTPBP4 3 0.04 0.22 1.2
24 INT74521 Negative_regulation of ERAL1 3 0.42 2.78 1.13
25 INT81440 Regulation of GTPBP4 3 0.02 0.09 1.1
26 INT311605 Positive_regulation of AATF 5 0.06 6.72 1.05
27 INT86798 Positive_regulation of Binding of Gtpbp4 1 0.29 0 1.01
28 INT97639 Localization of ABCF1 1 0.51 0.78 1
29 INT21109 Phosphorylation of Gtpbp4 2 0.22 0.28 0.97
30 INT7080 Positive_regulation of Mrto4 2 0.06 0.1 0.81
31 INT152530 Regulation of ZNHIT6 1 0.08 0.62 0.75
32 INT117859 Localization of Pes1 1 0.13 0 0.7
33 INT53067 Gene_expression of Pes1 1 0.53 1.54 0.67
34 INT103237 Regulation of Localization of Gtpbp4 2 0.03 0.19 0.64
35 INT42348 Regulation of Pes1 1 0.23 0 0.62
36 INT223518 Regulation of Gene_expression of Imp3 1 0.02 2.46 0.61
37 INT340209 Negative_regulation of Frg1 1 0.01 0.52 0.6
38 INT91896 Negative_regulation of Gene_expression of Gtpbp4 2 0.13 1.33 0.58
39 INT165456 Positive_regulation of NAF1 3 0.42 0.77 0.56
40 INT311604 Gene_expression of AATF 3 0.06 2.9 0.55
41 INT185916 Gene_expression of NAF1 16 0.65 4.27 0.53
42 INT97641 Negative_regulation of Localization of ABCF1 1 0.27 0.44 0.51
43 INT112575 Negative_regulation of Sbds 1 0.01 1.1 0.49
44 INT215149 Binding of Sbds 5 0.22 0.44 0.48
45 INT46376 Negative_regulation of Positive_regulation of Pes1 1 0.38 0 0.48
46 INT46377 Positive_regulation of Pes1 1 0.41 0 0.47
47 INT63904 Regulation of BOP1 1 0.02 0 0.45
48 INT160456 Positive_regulation of Localization of Gtpbp4 1 0.03 0.19 0.4
49 INT275312 Positive_regulation of Utp14b 1 0.24 1.08 0.39
50 INT275311 Positive_regulation of Gene_expression of Utp14b 1 0.26 1.08 0.39
51 INT275313 Gene_expression of Utp14b 1 0.34 1.08 0.39
52 INT45288 Positive_regulation of Naf1 3 0.29 0.64 0.34
53 INT207453 Localization of ERAL1 1 0.28 0.89 0.34
54 INT165454 Regulation of NAF1 2 0.15 1.13 0.33
55 INT340202 Gene_expression of Frg1 1 0.01 0.13 0.29
56 INT215152 Regulation of Sbds 2 0.16 0.11 0.27
57 INT165455 Negative_regulation of NAF1 2 0.24 1.26 0.26
58 INT91549 Regulation of Binding of GTPBP4 1 0.05 0.09 0.26
59 INT172003 Regulation of ERAL1 2 0.07 0.62 0.25
60 INT165096 Positive_regulation of Binding of GTPBP4 1 0.11 0 0.25
61 INT17737 Regulation of Pes1 1 0.19 0 0.23
62 INT223493 Negative_regulation of Gene_expression of Imp3 1 0.03 0.84 0.23
63 INT310703 Negative_regulation of Gene_expression of RPLP0 1 0.04 0.68 0.21
64 INT223513 Positive_regulation of Imp3 1 0.03 3.52 0.21
65 INT311603 Transcription of AATF 1 0.06 1 0.2
66 INT185915 Binding of NAF1 1 0.31 0.36 0.19
67 INT153070 Negative_regulation of Bop1 1 0.11 0.92 0.19
68 INT153076 Negative_regulation of Phosphorylation of Bop1 1 0.15 0.92 0.19
69 INT153072 Phosphorylation of Bop1 1 0.21 0.91 0.19
70 INT185913 Positive_regulation of Binding of NAF1 1 0.42 0.36 0.19
71 INT43569 Negative_regulation of Naf1 2 0.34 5.21 0.16
72 INT21978 Gene_expression of EFTUD1 1 0.65 0.25 0.15
73 INT153071 Gene_expression of Bop1 1 0.20 0.94 0.15
74 INT311601 Binding of AATF 1 0.03 0.99 0.15
75 INT186837 Gene_expression of EBNA1BP2 9 0.64 8.66 0.13
76 INT77286 Binding of RPLP0 2 0.21 0.58 0.1
77 INT249374 Binding of Frg1 1 0.02 0.16 0.1
78 INT153079 Positive_regulation of Phosphorylation of Bop1 1 0.12 0.46 0.1
79 INT263282 Binding of EIF6 1 0.08 0.51 0.09
80 INT127998 Negative_regulation of GTPBP4 1 0.03 0.17 0.08
81 INT76801 Negative_regulation of Gar1 1 0.51 0 0.08
82 INT253329 Negative_regulation of Rrs1 1 0.05 0.18 0.06
83 INT251883 Positive_regulation of Naf1 1 0.08 0.52 0.04
84 INT251888 Gene_expression of Naf1 1 0.11 0.69 0.04
85 INT251882 Negative_regulation of Gene_expression of Naf1 1 0.07 0.69 0.04
86 INT194250 Gene_expression of Rrs1 4 0.58 0.12 0.03
87 INT185914 Positive_regulation of Gene_expression of NAF1 1 0.59 0 0.03
88 INT251889 Regulation of Naf1 1 0.07 0 0.03
89 INT198378 Regulation of Naf1 1 0.26 1.98 0.03
90 INT322593 Gene_expression of RPS18 1 0.05 2.51 0.03
91 INT189926 Gene_expression of Drosha 1 0.32 0.55 0.03
92 INT186850 Binding of EBNA1BP2 10 0.39 2.9 0
93 INT188124 Gene_expression of Sbds 6 0.24 0.68 0
94 INT197607 Gene_expression of Rplp0 4 0.40 0.12 0
95 INT245960 Localization of DROSHA 4 0.61 0.41 0
96 INT194249 Positive_regulation of Rrs1 4 0.60 0.7 0
97 INT198379 Binding of Naf1 3 0.21 2.17 0
98 INT232211 Transcription of Rplp0 3 0.67 0.51 0
99 INT260476 Transcription of Rplp0 2 0.30 1.5 0
100 INT232209 Gene_expression of Rplp0 2 0.75 0.38 0
101 INT194247 Regulation of Rrs1 2 0.24 0 0
102 INT283691 Binding of Aatf 2 0.03 0.19 0
103 INT194248 Positive_regulation of Gene_expression of Rrs1 2 0.44 0.05 0
104 INT223508 Binding of Imp3 1 0.03 2.01 0
105 INT315125 Regulation of Gene_expression of DROSHA 1 0.44 0.74 0
106 INT351507 Localization of RPLP0 1 0.38 0.1 0
107 INT315121 Regulation of DROSHA 1 0.32 3.15 0
108 INT189910 Negative_regulation of Gene_expression of Drosha 1 0.24 0.2 0
109 INT337705 Gene_expression of Naf1 1 0.43 1.24 0
110 INT198380 Negative_regulation of Binding of Naf1 1 0.25 2.13 0
111 INT283704 Phosphorylation of Aatf 1 0.05 0.19 0
112 INT266265 Localization of Rrs1 1 0.09 0 0
113 INT253330 Binding of Rrs1 1 0.04 0 0
114 INT223492 Regulation of Transcription of Imp3 1 0.03 0.12 0
115 INT315095 Positive_regulation of Gene_expression of DROSHA 1 0.56 1.58 0
116 INT256679 Gene_expression of Aatf 1 0.65 0.71 0
117 INT197605 Regulation of Gene_expression of Rplp0 1 0.16 0 0
118 INT266266 Positive_regulation of Localization of Rrs1 1 0.06 0 0
119 INT294466 Positive_regulation of Rplp0 1 0.49 0 0
120 INT351496 Positive_regulation of RPLP0 1 0.25 0.52 0
121 INT301999 Binding of Rplp0 1 0.09 0.28 0
122 INT189917 Negative_regulation of Drosha 1 0.18 0.22 0
123 INT189919 Transcription of Drosha 1 0.30 0.22 0
124 INT188048 Transcription of Gtpbp4 1 0.02 0.39 0
125 INT286557 Regulation of Binding of Aatf 1 0.02 0 0
126 INT294465 Regulation of Rplp0 1 0.26 0.48 0
127 INT219447 Regulation of MRTO4 1 0.03 1.7 0
128 INT186854 Regulation of EBNA1BP2 1 0.03 1.5 0
129 INT294464 Binding of Rplp0 1 0.36 0.73 0
130 INT189921 Negative_regulation of Transcription of Drosha 1 0.24 0.22 0
131 INT315106 Gene_expression of DROSHA 1 0.63 3.24 0
132 INT228292 Localization of RCL1 1 0.07 0 0
133 INT351495 Positive_regulation of Gene_expression of RPLP0 1 0.25 0.54 0
134 INT247795 Positive_regulation of Bop1 1 0.01 0.8 0
135 INT197600 Positive_regulation of Gene_expression of Rplp0 1 0.30 0 0
136 INT223490 Regulation of Imp3 1 0.03 0.12 0
137 INT188061 Regulation of Transcription of Gtpbp4 1 0.01 0.39 0
138 INT247792 Regulation of Bop1 1 0.00 0.6 0
139 INT315129 Negative_regulation of DROSHA 1 0.31 2.01 0
140 INT223501 Transcription of Imp3 1 0.04 0.12 0
141 INT226279 Localization of NAF1 1 0.21 0.47 0
142 INT337704 Regulation of Gene_expression of Naf1 1 0.25 0.06 0
143 INT281662 Binding of Drosha 1 0.36 0.27 0
144 INT171993 Regulation of Gene_expression of ERAL1 1 0.07 0.06 0
145 INT315131 Negative_regulation of Gene_expression of DROSHA 1 0.30 0.29 0
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