GOS:signal transducer activity

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This page displays the top molecular interactions and top single events that were mentioned in the literature for signal transducer activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for signal transducer activity. They are ordered first by their pain relevance and then by number of times they were reported for signal transducer activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to signal transducer activity Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 2 1 0.03 0.25 25.89
3 INT69872 Binding of MC1R and POMC 1 52 0.54 8.87 18.3
4 INT221180 Binding of OPRM1 and Flna 2 1 0.09 0.22 12.65
5 INT68514 Pnoc Positive_regulation of Oprl1 1 10 0.59 3.56 9.57
6 INT65724 Binding of Pnoc and Oprl1 1 8 0.33 2.94 8.82
7 INT21276 Binding of Oprd1 and Penk 1 9 0.54 1.14 8.28
8 INT51205 Binding of OPRK1 and PDYN 1 7 0.00 2.01 7.8
9 INT259228 Binding of Oprm1 and Glul 1 1 0.00 0.08 7.22
10 INT254001 Binding of Cxcr4 and Mif 1 1 0.52 14.17 7.18
11 INT140015 Avp Positive_regulation of Localization of Penk 2 3 0.63 3.48 6.63
12 INT176477 Binding of CXCR3 and CXCL10 1 14 0.25 10.61 5.87
13 INT169218 Binding of EGFR and Coc 1 1 0.06 2.8 5.85
14 INT338167 Binding of CDKN2A and MC1R 1 1 0.42 6.14 5.76
15 INT211710 Binding of Mc1r and a 1 7 0.44 0.37 4.78
16 INT125407 Binding of OPRL1 and PTPRM 1 1 0.03 0.72 4.67
17 INT351352 Binding of Trpv1 and Lpar1 1 1 0.21 5.86 4.62
18 INT34444 Binding of Oprl1 and Ptprg 1 4 0.03 0.18 4.58
19 INT51497 Cck Negative_regulation of Localization of Trim13 1 1 0.34 0 4.53
20 INT38217 Penk Regulation of Localization of Avp 2 2 0.38 0.56 4.45
21 INT64480 Binding of OPRL1 and PNOC 1 2 0.33 0.23 4.38
22 INT111758 Binding of Drd2 and Insrr 1 1 0.01 0.94 4.33
23 INT7022 Drd1a Positive_regulation of Npr1 1 6 0.05 0.26 4.32
24 INT40114 Binding of OPRD1 and Oprm1 2 2 0.00 0 4.29
25 INT113223 POMC Regulation of MC1R 1 6 0.68 0.39 4.24
26 INT259209 Binding of Glul and Flna 1 1 0.03 0 4.2
27 INT161109 Avp Positive_regulation of Chkb 2 1 0.12 0.18 4.19
28 INT143270 Binding of Cnr1 and Gprasp1 1 4 0.54 0.64 4.18
29 INT103724 Oprd1 Positive_regulation of Gtpbp4 1 3 0.30 0.91 4.18
30 INT182194 Binding of IL8 and CXCR2 1 10 0.56 7.14 4.16
31 INT259230 Negative_regulation of Binding of Oprm1 and Flna 2 1 0.02 0 4.15
32 INT34220 Binding of POMC and Oprl1 1 4 0.01 0.25 4.05
33 INT101942 Binding of CD40 and CD40LG 1 16 0.23 15.24 4.01
34 INT127128 Binding of CNR1 and CNR2 2 8 0.39 3.98 3.97
35 INT136514 Binding of Grm1 and Grm5 2 4 0.12 1.8 3.9
36 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 1 2 0.27 0.43 3.88
37 INT317511 Ppp1r9b Regulation of Oprm1 1 3 0.27 0.33 3.85
38 INT317517 Binding of Nos1 and Oprm1 1 1 0.17 0.22 3.85
39 INT249566 Binding of Oprd1 and Psmd1 1 1 0.01 0.82 3.8
40 INT136525 Binding of Prokr1 and Trpv1 1 1 0.39 2.9 3.76
41 INT134284 Binding of OPRM1 and PLD2 1 1 0.52 0 3.72
42 INT104977 MITF Regulation of Gene_expression of MC1R 1 1 0.69 0.91 3.71
43 INT181455 Binding of Ccr5 and Ccl5 1 11 0.39 12.13 3.66
44 INT15984 Binding of Avp and Oxt 2 11 0.32 1.33 3.64
45 INT34534 Binding of Penk and Oprl1 1 4 0.37 0 3.64
46 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 1 0.03 0.13 3.64
47 INT64883 Ptger2 Positive_regulation of Ina 1 1 0.03 1.26 3.64
48 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 1 0.00 1.25 3.63
49 INT140011 Avp Positive_regulation of Dbi 2 2 0.07 0.93 3.61
50 INT18026 Binding of Oprd1 and Oprm1 2 4 0.40 0.83 3.53
51 INT121651 Binding of CXCL12 and CXCR4 1 13 0.48 17.61 3.52
52 INT85743 Pdyn Positive_regulation of Oprk1 1 3 0.32 2.12 3.52
53 INT302118 Binding of Oprm1 and Ppp1r9b 1 2 0.24 0.26 3.45
54 INT195931 Binding of OPRM1 and Trpv1 1 1 0.07 0.87 3.43
55 INT137918 Oprm1 Positive_regulation of Pdgfrb 2 1 0.41 0 3.31
56 INT189488 Binding of Ccr1 and Ccl5 1 8 0.40 9.26 3.27
57 INT108810 Esr1 Positive_regulation of Binding of Oprm1 and 1 1 0.51 1.79 3.22
58 INT166134 Binding of Cxcl12 and Cxcr4 1 3 0.49 5.69 3.17
59 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 1 3 0.00 0.63 3.1
60 INT101408 Binding of Grin1 and Olr1469 1 1 0.03 0.86 3.1
61 INT208572 Binding of IL8 and CXCR1 1 6 0.33 5.2 3.08
62 INT317563 Binding of Hint1 and Oprm1 1 1 0.20 0.25 3.03
63 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 1 5 0.34 0 3.01
64 INT106837 Binding of Oprm1 and Arrb2 1 3 0.32 0.83 3.01
65 INT37162 Binding of Calca and Cckar 1 1 0.04 0.55 3.01
66 INT182635 Binding of CCR5 and CCL5 1 2 0.09 4.19 3
67 INT123451 Binding of YY1 and Adra2a 1 1 0.37 0 2.98
68 INT324927 Syt17 Positive_regulation of Bdkrb1 1 1 0.04 4.29 2.96
69 INT113234 Binding of Pax3 and Tacr1 1 3 0.12 1.54 2.93
70 INT318996 Binding of CCR3 and CCL5 1 1 0.07 3.39 2.9
71 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 1 0.02 0.64 2.89
72 INT319003 Binding of CCR1 and CCL5 1 1 0.08 3.38 2.89
73 INT264929 Binding of Cnr1 and Gnaz 2 1 0.18 1.71 2.89
74 INT140014 Avp Negative_regulation of Chkb 2 1 0.04 1.58 2.86
75 INT114126 Binding of APLNR and OPRL1 2 1 0.01 0.47 2.85
76 INT107723 POMC Positive_regulation of MC1R 1 7 0.68 0.71 2.82
77 INT351349 Prkcg Positive_regulation of Binding of Lpar1 and 1 1 0.15 2 2.82
78 INT137230 Trh Regulation of Gene_expression of Oprd1 1 1 0.01 1.62 2.75
79 INT317551 Binding of Akt1 and Oprm1 1 1 0.19 0.21 2.74
80 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 1 0.17 0.55 2.7
81 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 1 0.09 4.04 2.69
82 INT114134 Penk Positive_regulation of Oprm1 1 2 0.24 1.48 2.68
83 INT182564 Binding of Ptger2 and Trpv1 1 1 0.18 1.77 2.67
84 INT259231 Binding of Oprm1 and Ppp1r9b 1 1 0.01 0 2.67
85 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 2 1 0.00 0 2.64
86 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 2 1 0.01 0 2.64
87 INT7888 Oprl1 Regulation of Localization of Avp 3 4 0.49 0.25 2.63
88 INT25708 Oprl1 Positive_regulation of Adra2a 2 1 0.25 0.15 2.63
89 INT152113 Binding of NTSR1 and Ngf 1 3 0.33 2.09 2.62
90 INT189490 Binding of Ccr3 and Ccl5 1 1 0.33 8.54 2.6
91 INT150596 Binding of Oprd1 and Oprk1 2 1 0.08 0.14 2.59
92 INT70757 Binding of Oprl1 and Pnoc 1 5 0.03 0.23 2.55
93 INT104219 SCD Positive_regulation of Cnr1 1 1 0.00 2.67 2.54
94 INT42727 Binding of Oprm1 and Trim13 2 1 0.14 0 2.54
95 INT104218 SCD Positive_regulation of CNR2 1 1 0.01 2.67 2.54
96 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 1 0.78 0.16 2.53
97 INT356289 Binding of Egfr and Egf 1 1 0.13 3.02 2.52
98 INT69665 Binding of Oprd1 and Pnoc 1 5 0.35 0.4 2.5
99 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 1 0.44 5.57 2.5
100 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 1 0.01 0.66 2.5
101 INT314141 Binding of Tacr3 and SFTPA1 1 1 0.00 3.02 2.48
102 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 1 0.07 1.72 2.46
103 INT156799 Gria1 Regulation of Grm8 1 1 0.11 1.29 2.45
104 INT143272 Binding of CNR1 and Gprasp1 1 1 0.01 0.17 2.42
105 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 1 0.19 3.22 2.35
106 INT96461 Pnoc Positive_regulation of Oprm1 1 1 0.09 0.73 2.34
107 INT88730 Binding of OPRM1 and Mop3 1 1 0.00 0 2.34
108 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 2 1 0.28 0.07 2.32
109 INT249013 Gabrg1 Negative_regulation of Per2 1 1 0.34 0.07 2.31
110 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 1 0.00 0.08 2.31
111 INT96652 F2rl1 Positive_regulation of Tac1 1 1 0.47 2.62 2.25
112 INT91860 Npy Regulation of Npy1r 1 2 0.28 1.13 2.24
113 INT198958 Cnr1 Positive_regulation of Kcnj9 1 1 0.00 0.15 2.24
114 INT114432 Oprl1 Positive_regulation of Akt1 1 1 0.18 0.08 2.2
115 INT1315 Pomc Positive_regulation of Localization of Gnrhr 1 3 0.38 0.16 2.16
116 INT5486 Oprd1 Regulation of Cck 1 1 0.21 0 2.16
117 INT49242 Binding of Mc1r and Pomc 1 10 0.38 3.79 2.15
118 INT66803 Oxt Regulation of Avp 2 7 0.16 0.19 2.15
119 INT134583 Arrb2 Regulation of Oprm1 1 1 0.41 1.23 2.15
120 INT229394 TPSD1 Positive_regulation of F2RL1 1 2 0.00 3.11 2.14
121 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 1 0.06 4.35 2.14
122 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 1 0.17 0.46 2.13
123 INT140019 Avp Positive_regulation of Localization of Kitl 2 1 0.00 1 2.13
124 INT133946 Binding of DNM2 and OPRK1 1 1 0.11 0 2.1
125 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 1 2 0.18 0.3 2.08
126 INT51199 Binding of OPRM1 and PDYN 1 2 0.13 0.3 2.08
127 INT221181 Binding of GOPC and Flna 1 1 0.03 0.06 2.08
128 INT64750 Binding of Oprm1 and Pck1 1 2 0.41 0.51 2.07
129 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 1 0.04 0.64 2.07
130 INT182200 Binding of CXCR5 and CXCL13 1 1 0.37 2.89 2.07
131 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 1 0.17 0.28 2.07
132 INT114923 Binding of Oprm1 and Creb1 1 1 0.16 0.28 2.06
133 INT117821 Binding of Tacr1 and Cd4 1 1 0.34 0.86 2.02
134 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 1 0.02 0.32 2.02
135 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 1 0.41 0 2.01
136 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 1 7 0.57 0.18 2
137 INT138960 Dbi Positive_regulation of Avp 2 1 0.02 1.53 2
138 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 2 1 0.02 1.53 2
139 INT179443 Vta1 Positive_regulation of Gpr156 1 1 0.20 0 1.99
140 INT45423 Avp Positive_regulation of Localization of Prl 2 4 0.67 1.37 1.98
141 INT137917 Oprm1 Positive_regulation of Kdr 1 1 0.43 0 1.98
142 INT317540 Camk2a Negative_regulation of Oprm1 1 1 0.19 0 1.98
143 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 1 0.47 2.37 1.98
144 INT110525 Binding of MC1R and OCA2 1 1 0.41 1.08 1.97
145 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 1 0.36 1.11 1.96
146 INT146099 Binding of Oprm1 and Rgs9 2 1 0.48 0 1.95
147 INT97208 Binding of Gabrg1 and Gabbr1 1 2 0.07 0.31 1.94
148 INT68272 Binding of Oprd1 and G2e3 1 1 0.00 0.11 1.93
149 INT68273 G2e3 Negative_regulation of Binding of Oprd1 and G2e3 1 1 0.00 0.11 1.93
150 INT107738 Binding of Pld2 and Oprm1 1 1 0.23 0 1.93
151 INT65025 Binding of Oprm1 and Hps4 1 1 0.01 0 1.93
152 INT6931 Binding of Oprk1 and Pdyn 1 2 0.24 0.92 1.92
153 INT149470 Oxt Regulation of Gene_expression of Avp 1 1 0.46 1.2 1.92
154 INT264928 Binding of Cnr1 and Hrh1 2 1 0.01 1.61 1.92
155 INT83418 Binding of OPRL1 and Ntrk1 1 1 0.02 0 1.91
156 INT169498 Binding of Oprm1 and Mirlet7a-1 1 1 0.32 0 1.9
157 INT113572 Binding of DMRT1 and OPRM1 1 1 0.01 0 1.9
158 INT161224 Ccl2 Positive_regulation of Ccr2 1 1 0.52 2.09 1.88
159 INT161225 Ccl2 Positive_regulation of Ccl2 Positive_regulation of Ccr2 1 1 0.57 2.09 1.88
160 INT153582 Binding of Oprm1 and Hint1 1 1 0.01 0 1.87
161 INT203044 Binding of PDCD1 and DTHD1 1 1 0.02 3.19 1.87
162 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 1 0.09 0 1.86
163 INT29996 Binding of Oprm1 and Penk 1 2 0.36 0.4 1.85
164 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 2 1 0.02 0.49 1.84
165 INT40239 Penk Regulation of Avp 2 1 0.07 0 1.84
166 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 1 0.40 0 1.83
167 INT169468 Binding of Egfr and Spink3 1 1 0.37 3.73 1.83
168 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 1 0.01 0 1.82
169 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 1 2 0.05 0.1 1.81
170 INT169502 Mirlet7a-1 Regulation of Oprm1 1 1 0.53 0 1.81
171 INT199287 TNF Positive_regulation of Transcription of Oprm1 1 2 0.02 1.86 1.8
172 INT117269 Binding of Avp and Prl 2 1 0.25 0.47 1.8
173 INT70225 oh Regulation of Oprd1 1 1 0.20 0.13 1.8
174 INT179444 Hmmr Negative_regulation of Gpr156 1 1 0.03 0 1.79
175 INT66504 Binding of Agt and Agtr1a 1 8 0.39 3.78 1.78
176 INT168925 Binding of Oprm1 and Imraq2 1 1 0.04 0.13 1.78
177 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 1 0.06 0.13 1.78
178 INT211746 Binding of Oprm1 and Mors1 1 1 0.08 0 1.78
179 INT167319 Binding of OPRM1 and PCSK2 1 1 0.22 0.63 1.77
180 INT167320 Binding of CPE and OPRM1 1 1 0.14 0.63 1.77
181 INT167321 Binding of ENG and OPRM1 1 1 0.27 0.63 1.76
182 INT266764 TPSD1 Positive_regulation of F2RL1 Positive_regulation of Localization of SFTPA1 1 1 0.00 1.55 1.76
183 INT276863 Gpr65 Regulation of Trpv1 1 1 0.25 1.78 1.75
184 INT168715 Mapk8 Negative_regulation of Oprk1 1 1 0.18 0.26 1.75
185 INT168717 Mapk8 Positive_regulation of Mapk8 Negative_regulation of Oprk1 1 1 0.19 0.26 1.75
186 INT31534 Binding of Sst and Oprl1 1 2 0.16 0.53 1.74
187 INT129953 Oprd1 Regulation of Cspg5 1 1 0.17 0.15 1.74
188 INT157524 Binding of GRM5 and OPRM1 2 1 0.36 0 1.74
189 INT253895 Binding of Htr1b and Htr1d 2 1 0.40 0.52 1.74
190 INT37840 Binding of Cyp27b1 and Oprd1 1 1 0.01 0 1.73
191 INT14910 Binding of GPR182 and SIT1 1 1 0.02 1.87 1.73
192 INT182565 Ptger2 Regulation of Trpv1 1 1 0.25 1.34 1.73
193 INT79365 Pnoc Negative_regulation of Oprl1 1 2 0.41 0.16 1.72
194 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 1 2 0.39 0.39 1.72
195 INT6407 Binding of Lama5 and Oprm1 1 1 0.02 0.08 1.72
196 INT264922 Binding of Cnr1 and Mors1 1 1 0.14 0.1 1.71
197 INT18786 Binding of Adra2a and Nisch 1 2 0.19 0 1.7
198 INT169464 Akt1 Positive_regulation of Egfr 1 1 0.28 1.63 1.7
199 INT200335 Binding of Oprm1 and Rest 1 1 0.40 0.07 1.7
200 INT249005 Gabrg1 Positive_regulation of Per2 1 1 0.39 0 1.7

Single Events

The table below shows the top 100 pain related interactions that have been reported for signal transducer activity. They are ordered first by their pain relevance and then by number of times they were reported in signal transducer activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
3 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
4 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
5 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
6 INT477 Localization of Avp 813 0.81 131.58 300.4
7 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
8 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
9 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
10 INT1212 Binding of Oprl1 312 0.48 28.6 225.15
11 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
12 INT767 Localization of Gnrhr 565 0.80 106.68 214.57
13 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
14 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
15 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
16 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
17 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
18 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
19 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93
20 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
21 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69
22 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99
23 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7
24 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
25 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74
26 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
27 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
28 INT4207 Regulation of Avp 267 0.62 63.72 115.33
29 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
30 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
31 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
32 INT114 Binding of Oprl1 139 0.48 23 103.35
33 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
34 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
35 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
36 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4
37 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
38 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49
39 INT214 Localization of AVP 370 0.81 208.51 91.09
40 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
41 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7
42 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
43 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
44 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56
45 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
46 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
47 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64
48 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58
49 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
50 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99
51 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68
52 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
53 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17
54 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
55 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
56 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
57 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84
58 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42
59 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
60 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23
61 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
62 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
63 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
64 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
65 INT21737 Binding of MC1R 129 0.48 45.45 56.54
66 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66
67 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
68 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
69 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
70 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
71 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
72 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
73 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
74 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
75 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
76 INT221172 Binding of Flna 32 0.42 1.37 51.59
77 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51
78 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14
79 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
80 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
81 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
82 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
83 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
84 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
85 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
86 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
87 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
88 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
89 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
90 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
91 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
92 INT685 Regulation of AVP 124 0.62 34.9 39.91
93 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
94 INT16194 Binding of CNR1 82 0.48 20.75 39.59
95 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
96 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
97 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
98 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
99 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
100 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
101 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
102 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
103 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
104 INT12608 Regulation of CNR1 62 0.60 24.36 36.02
105 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
106 INT13501 Binding of Drd2 65 0.48 23.76 35.6
107 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54
108 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
109 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
110 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
111 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93
112 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
113 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
114 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
115 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
116 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
117 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
118 INT50308 Binding of Cnr1 61 0.48 14.41 33.52
119 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
120 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
121 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
122 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
123 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
124 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
125 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72
126 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
127 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
128 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
129 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
130 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62
131 INT6177 Binding of Htr1a 65 0.47 17.65 30.59
132 INT29477 Transcription of Oprl1 52 0.72 5.05 30.52
133 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
134 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
135 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
136 INT894 Binding of Avp 84 0.48 29.16 29.63
137 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
138 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
139 INT6765 Localization of Oprl1 49 0.81 5.11 28.87
140 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58
141 INT182223 Gene_expression of CXCR5 57 0.76 51.49 28.4
142 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
143 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
144 INT233457 Gene_expression of Gpr65 56 0.68 26.57 27.94
145 INT5097 Localization of Sstr1 30 0.64 0.38 27.92
146 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
147 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
148 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
149 INT111359 Localization of Cnr1 55 0.81 11.25 27.41
150 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
151 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
152 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28
153 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19
154 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13
155 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27
156 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
157 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
158 INT28834 Positive_regulation of Bdkrb1 38 0.69 30.48 26.89
159 INT22764 Localization of Ptger2 81 0.64 24.38 26.77
160 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
161 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61
162 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57
163 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
164 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41
165 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26
166 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
167 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
168 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47
169 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92
170 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89
171 INT6179 Binding of Oprk1 37 0.48 9.24 24.83
172 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77
173 INT12484 Binding of Drd2 45 0.48 15.17 24.72
174 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
175 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
176 INT12441 Positive_regulation of Gpr156 29 0.67 5.7 24.44
177 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
178 INT18400 Localization of Glp1r 97 0.80 11.96 24.32
179 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14
180 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91
181 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88
182 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8
183 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56
184 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
185 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11
186 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
187 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
188 INT6270 Binding of HTR1D 55 0.47 9.54 22.86
189 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
190 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
191 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
192 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
193 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31
194 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
195 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
196 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14
197 INT9988 Regulation of Hrh1 22 0.46 12.87 22.13
198 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92
199 INT1644 Regulation of FSHR 77 0.55 15.62 21.49
200 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38
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