GOS:small molecule metabolic process

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This page displays the top molecular interactions and top single events that were mentioned in the literature for small molecule metabolic process. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for small molecule metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for small molecule metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to small molecule metabolic process Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 1 0.01 28.19 40.6
2 INT69872 Binding of MC1R and POMC 1 52 0.54 8.87 18.3
3 INT10268 Binding of PDYN and POMC 1 11 0.39 0.08 10.36
4 INT98346 Negative_regulation of Binding of CPOX and PTGS1 2 1 0.10 2.91 6.54
5 INT29206 Crh Regulation of Localization of POMC 1 4 0.64 0.96 4.68
6 INT113223 POMC Regulation of MC1R 1 6 0.68 0.39 4.24
7 INT29240 Binding of POMC and YY1 1 5 0.40 0.17 4.06
8 INT34220 Binding of POMC and Oprl1 1 4 0.01 0.25 4.05
9 INT24388 CRH Positive_regulation of Localization of POMC 1 8 0.51 5.67 3.35
10 INT7436 CFP Positive_regulation of Binding of POMC and 1 1 0.02 0.18 3.35
11 INT48162 RIMS3 Regulation of Localization of LTC4S 1 1 0.10 2.14 3.25
12 INT275850 Binding of NDUFAB1 and SNCA 1 1 0.00 3.78 3.16
13 INT17456 Binding of CSF2 and POMC 1 3 0.32 4.06 3.15
14 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 1 0.02 2.15 3.12
15 INT81708 POMC Regulation of Gene_expression of ITGAM 1 1 0.53 0.72 3.1
16 INT134212 CRH Regulation of Localization of POMC 1 1 0.47 2.89 2.9
17 INT107723 POMC Positive_regulation of MC1R 1 7 0.68 0.71 2.82
18 INT31513 Crh Regulation of POMC 1 3 0.29 5.06 2.78
19 INT29446 Crh Positive_regulation of Localization of POMC 1 8 0.38 1.87 2.58
20 INT81657 Binding of CPOX and PTGS1 2 5 0.15 1.9 2.37
21 INT51317 Binding of POMC and OR5D2P 1 1 0.00 0.6 2.23
22 INT34310 CRH Positive_regulation of POMC 1 3 0.42 0.62 2.21
23 INT209924 IL1B Negative_regulation of PPARA 1 1 0.20 4.38 2.17
24 INT66157 Binding of ALB and BDP1 1 1 0.11 0 2.13
25 INT135868 Zfp821 Positive_regulation of Binding of ACAA1 and 1 1 0.00 0 2.11
26 INT122660 Binding of CACNA1A and DNAH8 1 2 0.28 2.68 2.08
27 INT349608 Binding of DIO2 and LMOD1 1 1 0.23 0.41 2.01
28 INT264953 Binding of POMC and TLR4 1 1 0.03 0.89 1.96
29 INT264947 Binding of POMC and TLR2 1 1 0.03 0.89 1.95
30 INT279359 Binding of ADA and TNF 1 1 0.20 2.61 1.91
31 INT91607 Binding of EDN1 and POMC 1 1 0.12 0 1.9
32 INT351281 AP1M2 Regulation of NCOR2 1 1 0.00 0.85 1.9
33 INT183781 Binding of IL6 and INS 1 6 0.22 8.97 1.87
34 INT13940 DNM2 Regulation of Localization of CGA 1 1 0.11 0 1.86
35 INT302646 ARSA Positive_regulation of TGFB1 1 1 0.10 0.52 1.76
36 INT57249 GNRH1 Regulation of Regulation of CGA 1 1 0.20 0 1.74
37 INT92369 Binding of CYP2D6 and RYBP 1 1 0.25 0.15 1.73
38 INT24817 Binding of POMC and VTN 1 8 0.42 0.39 1.71
39 INT148090 Binding of CALCA and NCOR2 1 1 0.00 0.65 1.71
40 INT134363 Prkcg Regulation of ADCY2 1 1 0.00 0.14 1.7
41 INT56134 CALCA Positive_regulation of POMC 1 2 0.71 0.72 1.68
42 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 1 0.01 0.95 1.67
43 INT32442 POMC Positive_regulation of POMC Positive_regulation of ELANE 1 1 0.15 0.18 1.66
44 INT236491 GCH1 Regulation of Pain1 1 1 0.01 0.89 1.65
45 INT278223 Binding of NOS3 and ACSM3 1 1 0.41 6.32 1.65
46 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 1 0.19 1.52 1.64
47 INT187175 Binding of BSG and PPIA 1 1 0.14 2.23 1.64
48 INT119918 Zfp821 Positive_regulation of Binding of ACAA1 and 1 1 0.00 0 1.64
49 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 1 0.12 0 1.62
50 INT86637 POMC Regulation of Gene_expression of KRT16 1 2 0.47 1.22 1.61
51 INT73116 TYMS Negative_regulation of DNMT3B 1 1 0.24 0 1.6
52 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 1 0.24 0 1.6
53 INT209853 TNF Regulation of Gene_expression of CD36 1 1 0.61 3.41 1.59
54 INT149632 Binding of HK1 and NCOR2 2 1 0.01 0.13 1.58
55 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 1 0.27 0.56 1.58
56 INT254243 Binding of HOMER1 and MRI1 1 1 0.03 1.99 1.57
57 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 1 0.50 0.34 1.57
58 INT81709 POMC Regulation of Gene_expression of ITGB2 1 1 0.40 0.34 1.57
59 INT81719 POMC Regulation of Gene_expression of ITGAL 1 1 0.35 0.34 1.57
60 INT81712 POMC Regulation of FCGR3B 1 1 0.16 0.34 1.56
61 INT74937 IL1B Positive_regulation of CPOX 1 5 0.18 1.13 1.55
62 INT81715 POMC Regulation of ITGB2 1 1 0.40 0.34 1.55
63 INT81721 POMC Regulation of ITGAM 1 1 0.39 0.34 1.55
64 INT41100 Mdk Positive_regulation of Localization of INS 1 1 0.01 0 1.55
65 INT81714 POMC Regulation of ITGAL 1 1 0.15 0.34 1.54
66 INT100784 RYBP Positive_regulation of CYP3A4 1 1 0.44 0 1.54
67 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 1 6 0.17 3.36 1.53
68 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 1 2 0.67 0 1.53
69 INT111828 UPB1 Positive_regulation of Oprm1 1 1 0.00 0.85 1.53
70 INT351366 LPA Positive_regulation of Rab38 1 1 0.00 0.95 1.53
71 INT23546 Negative_regulation of CNDP2 Negative_regulation of POMC Positive_regulation of POMC 2 1 0.04 0 1.52
72 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 2 1 0.03 0 1.52
73 INT69709 NPL Positive_regulation of Localization of POMC 1 2 0.36 1.22 1.51
74 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 1 0.03 0 1.51
75 INT253863 Binding of LBP and PNP 1 1 0.13 1.5 1.5
76 INT166676 Binding of PRKCA and UGT1A6 2 1 0.30 0 1.5
77 INT322812 Binding of SLC12A1 and MOCOS 1 1 0.00 1.69 1.49
78 INT27932 Binding of CCK and NCOR2 1 1 0.01 0.91 1.47
79 INT40209 TNS3 Regulation of POMC 1 1 0.16 0.27 1.47
80 INT123899 Binding of CYP3A4 and UGT2B7 1 1 0.52 0 1.46
81 INT12691 SST Negative_regulation of Localization of POMC 1 3 0.24 1.24 1.45
82 INT351246 Binding of OPN1LW and NNT 1 1 0.03 0.53 1.45
83 INT154111 POMC Positive_regulation of Localization of PENK 1 1 0.34 0.05 1.41
84 INT128913 Binding of COMT and PENK 1 1 0.30 0.07 1.41
85 INT154110 PENK Positive_regulation of Localization of POMC 1 1 0.34 0.05 1.41
86 INT154113 POMC Positive_regulation of YY1 1 1 0.70 0.06 1.41
87 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 1 0.02 2.66 1.4
88 INT140314 PCSK7 Positive_regulation of LDHA 1 1 0.07 1.6 1.4
89 INT128914 COMT Regulation of OPRM1 1 1 0.39 0.07 1.39
90 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 1 0.04 1.21 1.38
91 INT108727 Binding of ATP1A2 and CACNA1A 1 2 0.34 1.97 1.37
92 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 1 0.13 0.15 1.36
93 INT122659 Binding of CACNA1A and SAR1B 1 1 0.06 1.38 1.35
94 INT19633 GNRH1 Regulation of Localization of CGA 1 4 0.44 0.82 1.33
95 INT39950 Binding of ALB and PDYN 1 1 0.31 0 1.32
96 INT90221 Binding of CYP2D6 and Cyp1a2 1 1 0.03 0.09 1.31
97 INT86636 POMC Positive_regulation of Gene_expression of KRT16 1 2 0.39 0.83 1.28
98 INT136200 Binding of Penk and NUP37 1 1 0.04 0 1.28
99 INT48117 GH1 Positive_regulation of CGA 1 1 0.10 0 1.28
100 INT42579 SOD1 Negative_regulation of POMC 1 1 0.16 0.43 1.27
101 INT34052 POMC Regulation of Gene_expression of IFNG 1 1 0.11 0 1.27
102 INT105295 WAS Regulation of PTGS1 1 1 0.02 0.13 1.27
103 INT124099 Binding of GGT5 and RYBP 1 1 0.00 0.34 1.26
104 INT219686 Binding of CEL and COPD 1 1 0.12 11.35 1.26
105 INT42580 CAT Negative_regulation of POMC 2 1 0.20 0.42 1.26
106 INT46853 POMC Regulation of GAST 1 1 0.11 0.07 1.26
107 INT45269 POMC Negative_regulation of Penk 1 1 0.01 0 1.24
108 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 1 0.58 0.81 1.23
109 INT123453 Binding of POMC and Penk 1 1 0.01 0.31 1.23
110 INT190130 Binding of CPOX and MRXS5 1 1 0.00 1.4 1.23
111 INT40900 PDYN Regulation of Localization of POMC 1 2 0.07 0.56 1.22
112 INT301166 LRP2 Regulation of TRD@ 1 1 0.12 1.93 1.21
113 INT209926 IL1B Regulation of PPARA 1 1 0.21 2.45 1.2
114 INT17601 Binding of POMC and Oprl1 1 1 0.01 0 1.2
115 INT131462 NGF Regulation of Localization of INS 1 1 0.40 0.97 1.2
116 INT65203 OPRL1 Negative_regulation of ADCY1 1 1 0.19 0 1.19
117 INT35459 POMC Negative_regulation of Gene_expression of IL16 1 1 0.45 0 1.19
118 INT142075 IL4 Negative_regulation of Binding of IDO1 and 1 1 0.02 2.07 1.19
119 INT142077 TGFB1 Negative_regulation of Binding of IDO1 and 1 1 0.15 2.07 1.19
120 INT49955 OPRM1 Positive_regulation of ADCY1 1 1 0.21 0.31 1.19
121 INT98908 Binding of NTRK1 and PKLR 1 1 0.41 1.95 1.18
122 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 1 0.56 1.95 1.18
123 INT169082 Binding of GRIA1 and MOCOS 1 2 0.07 1.23 1.17
124 INT62382 Binding of IGHG3 and SMPD2 1 1 0.02 0.37 1.17
125 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 1 0.03 0.37 1.17
126 INT43509 Avp Positive_regulation of Localization of POMC 1 2 0.13 1.26 1.16
127 INT111221 MMEL1 Negative_regulation of HMOX1 1 1 0.01 1 1.16
128 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 1 0.07 1.18 1.16
129 INT19535 Binding of ADRA1D and ALB 1 3 0.42 0.8 1.15
130 INT164722 Avp Regulation of NT5C 1 1 0.06 0.88 1.15
131 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 1 0.26 4.75 1.15
132 INT348398 LPA Positive_regulation of Pik3cb 1 1 0.04 0.88 1.14
133 INT65204 PNOC Negative_regulation of ADCY1 1 1 0.07 0 1.14
134 INT348400 LPA Positive_regulation of Trib3 1 1 0.00 0.87 1.14
135 INT76199 CASP1 Positive_regulation of CEL 1 1 0.06 0.32 1.14
136 INT106069 TH Positive_regulation of Th 1 1 0.07 0.16 1.14
137 INT13098 POMC Regulation of Localization of CGA 2 1 0.58 0 1.14
138 INT59035 Binding of CPB1 and POMC 1 1 0.00 0 1.12
139 INT108409 AGT Positive_regulation of AGTR2 1 2 0.31 1.49 1.11
140 INT102421 POMC Regulation of Gene_expression of Fos 1 1 0.12 0.34 1.11
141 INT29874 OXTR Negative_regulation of POMC 1 1 0.22 0 1.1
142 INT323175 PRKCA Positive_regulation of Akt1 1 1 0.02 0 1.1
143 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 1 0.20 0.2 1.1
144 INT264988 Binding of CYP2C19 and CYP3A4 2 1 0.18 0.72 1.09
145 INT108547 AKT1 Regulation of MAPKAPK5 1 1 0.04 1.2 1.08
146 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 1 0.04 0.33 1.08
147 INT264987 Binding of CYP2C9 and CYP3A4 2 1 0.19 0.71 1.08
148 INT187176 Binding of BSG and MMP1 1 1 0.09 1.18 1.08
149 INT168185 Binding of PLXNA2 and MRI1 1 1 0.25 0.78 1.08
150 INT341897 Positive_regulation of NT5C3 Positive_regulation of Positive_regulation of Oxt 1 1 0.32 0.42 1.07
151 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 1 0.42 1.09 1.07
152 INT69874 POMC Negative_regulation of TYRP1 1 1 0.13 0 1.07
153 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 1 0.40 0 1.05
154 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 1 0.00 1.57 1.05
155 INT312097 ELANE Regulation of ALOX5 1 1 0.08 1.75 1.05
156 INT97011 Binding of CALM3 and OPRM1 1 1 0.35 0 1.05
157 INT30905 SST Negative_regulation of Localization of GCG 1 2 0.12 1.56 1.04
158 INT60794 Binding of TREH and Chrna9 1 1 0.00 0 1.04
159 INT65986 IL1B Positive_regulation of PTGS2 1 3 0.32 2.05 1.03
160 INT101381 POMC Regulation of Localization of IL8 1 1 0.28 1.49 1.02
161 INT160879 POMC Positive_regulation of DECR1 2 1 0.04 0.08 1.02
162 INT106706 POMC Negative_regulation of Binding of FN1 and 1 1 0.19 0.79 1.02
163 INT79602 Binding of PSMA5 and Oprd1 1 2 0.19 1.05 1.01
164 INT322808 Binding of RS1 and MOCOS 1 1 0.00 0.86 1.01
165 INT54737 PPBP Regulation of NCOR2 1 1 0.01 0.15 1.01
166 INT278962 LEP Positive_regulation of CPOX 1 1 0.05 1.33 1
167 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 1 0.00 0.27 1
168 INT154237 Binding of CYP2D6 and Ugt2b7 1 1 0.41 0.75 1
169 INT32327 POMC Positive_regulation of Localization of PRL 1 4 0.45 0 0.99
170 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 1 0.12 1.07 0.99
171 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 1 0.01 0.66 0.99
172 INT209151 OXT Positive_regulation of PNLIP 1 1 0.08 0.73 0.99
173 INT38579 Binding of POMC and Hps4 1 1 0.00 0.32 0.99
174 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 1 0.30 0.38 0.99
175 INT209923 IL17A Negative_regulation of PPARA 1 1 0.14 2.46 0.99
176 INT1415 Binding of OPRM1 and POMC 1 3 0.16 0.3 0.98
177 INT73680 KNG1 Positive_regulation of ALB 1 1 0.51 0.38 0.98
178 INT69506 CA2 Positive_regulation of PRKCA 1 1 0.50 0.42 0.98
179 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 1 0.43 0.61 0.98
180 INT40424 CCK Regulation of Localization of INS 1 1 0.02 0 0.97
181 INT75283 SST Negative_regulation of Localization of INS 1 2 0.47 1.45 0.96
182 INT303690 KNG1 Positive_regulation of CPOX 1 1 0.01 0.76 0.96
183 INT108729 Binding of CACNA1A and Cacna1a 1 3 0.13 1.21 0.95
184 INT52806 CYP2E1 Positive_regulation of RYBP 1 1 0.43 0.24 0.95
185 INT266659 Binding of MMP9 and MOCS1 1 1 0.01 1.71 0.94
186 INT62109 SLC25A4 Negative_regulation of Localization of Gh 1 1 0.06 0 0.94
187 INT106707 POMC Regulation of Binding of LAMB2 and 1 1 0.03 0.7 0.94
188 INT265649 TBK1 Negative_regulation of COMT 1 1 0.01 0.61 0.94
189 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 1 0.05 0.17 0.93
190 INT20888 POMC Positive_regulation of Localization of PDYN 1 1 0.40 0 0.92
191 INT156989 LPA Positive_regulation of Gene_expression of EFNB1 1 1 0.00 0.91 0.92
192 INT34457 AGT Positive_regulation of POMC 2 1 0.01 0 0.91
193 INT124742 ARSA Positive_regulation of Localization of CSF2 1 1 0.10 0.15 0.91
194 INT185417 Binding of ALOX5 and PLA2G2A 1 4 0.16 3.13 0.9
195 INT52114 Oprd1 Regulation of ADCY1 1 2 0.05 0.46 0.9
196 INT48113 GH1 Positive_regulation of Localization of CGA 1 1 0.07 0 0.9
197 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 1 0.41 0 0.9
198 INT211128 Binding of P4HB and TNF 1 1 0.09 0.97 0.9
199 INT211129 Negative_regulation of Binding of P4HB and TNF 1 1 0.10 0.97 0.9
200 INT69870 ASIP Negative_regulation of Binding of MC1R and POMC 1 1 0.37 0 0.9

Single Events

The table below shows the top 100 pain related interactions that have been reported for small molecule metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in small molecule metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
5 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19
6 INT738 Regulation of POMC 459 0.62 111.19 243.74
7 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
8 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02
9 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
10 INT812 Localization of INS 1026 0.81 515.6 145.31
11 INT695 Binding of POMC 304 0.48 56.66 126.85
12 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
13 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
14 INT1793 Localization of CGA 379 0.81 67.38 114.69
15 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
16 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14
17 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
18 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
19 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
20 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61
21 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
22 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
23 INT546 Binding of ALB 311 0.48 85.98 60.14
24 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06
25 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
26 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
27 INT251 Regulation of INS 398 0.62 232.47 55.04
28 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
29 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
30 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
31 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
32 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
33 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
34 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
35 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
36 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75
37 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
38 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
39 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
40 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03
41 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
42 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
43 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
44 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
45 INT103094 Binding of PPARA 308 0.47 177.26 34.75
46 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98
47 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
48 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
49 INT64171 Regulation of CPOX 109 0.36 55.36 32.96
50 INT16290 Gene_expression of BSG 60 0.68 38.73 32.86
51 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
52 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
53 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
54 INT9650 Gene_expression of LPA 141 0.75 104.57 29
55 INT6855 Binding of NCOR2 71 0.41 15.64 28.96
56 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
57 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63
58 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
59 INT7035 Regulation of CGA 87 0.45 29.04 28.45
60 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
61 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
62 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
63 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
64 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7
65 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
66 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
67 INT17625 Localization of GCG 210 0.80 55.69 24.97
68 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
69 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68
70 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23
71 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
72 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58
73 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54
74 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
75 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
76 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07
77 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
78 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
79 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36
80 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
81 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
82 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41
83 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
84 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
85 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
86 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
87 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
88 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
89 INT135629 Binding of COMT 33 0.48 16.68 19.37
90 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11
91 INT5372 Localization of LHB 55 0.68 9.47 19
92 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
93 INT81194 Binding of CPOX 40 0.29 23.7 18.95
94 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54
95 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
96 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35
97 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29
98 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
99 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
100 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
101 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
102 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
103 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
104 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
105 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
106 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65
107 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3
108 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
109 INT13716 Positive_regulation of TH 33 0.68 19.11 16
110 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
111 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
112 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
113 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
114 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
115 INT1416 Transcription of POMC 40 0.72 10.71 15.38
116 INT11918 Localization of CGB 35 0.51 8.21 15.01
117 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94
118 INT180497 Binding of MRI1 45 0.42 28.35 14.77
119 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
120 INT103096 Regulation of PPARA 113 0.60 62.47 14.57
121 INT40478 Negative_regulation of NCOR2 23 0.48 12.77 14.56
122 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53
123 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25
124 INT70265 Regulation of MRI1 42 0.39 30.95 14.18
125 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
126 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89
127 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83
128 INT18773 Localization of ALB 117 0.80 69.18 13.8
129 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
130 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
131 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4
132 INT14572 Binding of INS 205 0.48 175.43 13.38
133 INT3962 Regulation of AGT 50 0.62 20.96 13.01
134 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93
135 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87
136 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
137 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
138 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66
139 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
140 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
141 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
142 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
143 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23
144 INT17619 Regulation of COMT 12 0.45 8.46 12.22
145 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05
146 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
147 INT2415 Binding of MAOA 26 0.47 13.26 11.86
148 INT398 Localization of AGT 45 0.78 16.97 11.54
149 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5
150 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
151 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
152 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
153 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27
154 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19
155 INT9946 Regulation of Localization of LHB 27 0.52 2.47 11.08
156 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
157 INT8065 Binding of AGT 54 0.48 20.54 10.85
158 INT36453 Binding of ABCA1 48 0.45 19.9 10.84
159 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78
160 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
161 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68
162 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67
163 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
164 INT74272 Localization of CPOX 39 0.63 25.12 10.53
165 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52
166 INT9385 Localization of LDHA 74 0.81 31.67 10.5
167 INT173159 Localization of PPARA 96 0.74 64.55 10.26
168 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
169 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18
170 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17
171 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
172 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
173 INT31780 Binding of DIO2 17 0.36 10.07 10
174 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
175 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76
176 INT4494 Regulation of GCG 41 0.45 18.38 9.68
177 INT15722 Positive_regulation of PPAP2A 25 0.43 4.83 9.65
178 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62
179 INT1648 Regulation of LHB 21 0.61 3.32 9.6
180 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
181 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
182 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48
183 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37
184 INT52924 Negative_regulation of GSR 49 0.58 28.08 9.28
185 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
186 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27
187 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27
188 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21
189 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06
190 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96
191 INT860 Regulation of ALB 48 0.60 25.11 8.95
192 INT3755 Positive_regulation of GBE1 29 0.40 8.99 8.91
193 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9
194 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
195 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85
196 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83
197 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81
198 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
199 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
200 INT85651 Positive_regulation of ACACA 17 0.67 4.73 8.63
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