GOS:transcription factor binding

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This page displays the top molecular interactions and top single events that were mentioned in the literature for transcription factor binding. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transcription factor binding. They are ordered first by their pain relevance and then by number of times they were reported for transcription factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to transcription factor binding Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 1 0.09 0.22 12.65
3 INT206768 TP53 Positive_regulation of Ltp 1 2 0.01 5.83 10.21
4 INT11250 Cck Positive_regulation of Gene_expression of Fos 1 14 0.78 0.08 7.29
5 INT338167 Binding of CDKN2A and MC1R 1 1 0.42 6.14 5.76
6 INT186566 Hpcl1 Positive_regulation of Fos 1 1 0.17 0.38 4.49
7 INT259209 Binding of Glul and Flna 1 1 0.03 0 4.2
8 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 1 0.02 0 4.15
9 INT200322 Binding of Rest and Sp3 1 1 0.39 2.93 3.98
10 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 1 2 0.27 0.43 3.88
11 INT11252 Cck Positive_regulation of Fos 1 6 0.78 0 3.79
12 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 1 0.47 0.72 3.63
13 INT17317 Binding of Jun and Fos 3 7 0.42 1.03 3.5
14 INT108810 Esr1 Positive_regulation of Binding of Oprm1 and 1 1 0.51 1.79 3.22
15 INT161164 Prkcg Regulation of Phosphorylation of Creb1 1 3 0.41 0.62 3.11
16 INT309150 Edc4 Positive_regulation of Creb1 1 1 0.03 3.46 3.09
17 INT190167 Binding of JUN and MMP12 1 1 0.26 0.82 2.76
18 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 1 0.26 0 2.73
19 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 1 0.00 0 2.64
20 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 1 0.01 0 2.64
21 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 1 2 0.46 0.75 2.61
22 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 1 0.19 3.22 2.35
23 INT54489 Binding of Jun and Rabep2 2 4 0.16 1.48 2.3
24 INT156622 Umod Regulation of Phosphorylation of Creb1 1 1 0.05 0.33 2.27
25 INT32586 H2-Ab1 Regulation of Pomc 1 1 0.03 0.14 2.19
26 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 1 0.69 0.5 2.18
27 INT184262 Binding of AGER and HMGB1 1 1 0.34 4.49 2.17
28 INT221181 Binding of GOPC and Flna 1 1 0.03 0.06 2.08
29 INT158964 FosB Negative_regulation of Creb1 1 1 0.21 0 2.07
30 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 1 0.17 0.28 2.07
31 INT281084 Prkaca Positive_regulation of Mapk1 1 2 0.25 0 2.06
32 INT114923 Binding of Oprm1 and Creb1 1 1 0.16 0.28 2.06
33 INT32585 H2-Ab1 Negative_regulation of Pomc 1 1 0.03 0.13 2
34 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 1 0.46 0 2
35 INT117794 Hpcl1 Positive_regulation of Gene_expression of Fos 1 3 0.17 0.15 1.98
36 INT54488 Npepo Regulation of Gene_expression of Jun 2 1 0.30 0 1.98
37 INT97208 Binding of Gabrg1 and Gabbr1 1 2 0.07 0.31 1.94
38 INT227493 Binding of TCEA1 and SIRT2 1 1 0.01 1.55 1.93
39 INT125348 Decr1 Regulation of Gene_expression of Fos 1 1 0.00 0.1 1.92
40 INT186435 Prkcg Regulation of Creb1 1 1 0.44 0.45 1.9
41 INT186432 Prkaca Regulation of Creb1 1 1 0.14 0.45 1.9
42 INT50993 Il1b Positive_regulation of Fos 1 2 0.40 0.43 1.84
43 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 1 1 0.03 0.28 1.8
44 INT146512 Tmem132a Negative_regulation of Gene_expression of Fos 1 1 0.23 0 1.76
45 INT139640 Jun Regulation of Gene_expression of Npy 2 1 0.21 1.98 1.75
46 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 1 0.03 0.32 1.71
47 INT200335 Binding of Oprm1 and Rest 1 1 0.40 0.07 1.7
48 INT215100 Binding of Hmgb1 and Tlr4 1 5 0.29 3.21 1.68
49 INT160304 Npy Regulation of Gene_expression of Fos 1 3 0.67 1.43 1.68
50 INT149680 Binding of Parp1 and Oprm1 1 1 0.53 0 1.66
51 INT54484 Npepo Positive_regulation of Gene_expression of Fos 1 1 0.43 0 1.63
52 INT215096 Binding of Hmgb1 and Tlr2 1 9 0.38 11.61 1.61
53 INT335405 Binding of Arntl and Npas2 1 1 0.28 1.82 1.61
54 INT105112 Plat Positive_regulation of JUN 1 1 0.01 1.55 1.58
55 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 1 0.41 0.33 1.58
56 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 1 0.07 0 1.57
57 INT212660 Nr3c1 Regulation of KCNA1 1 1 0.00 1.25 1.57
58 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 1 0.37 0.78 1.56
59 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 1 0.13 0.23 1.56
60 INT158877 PRS Positive_regulation of Gene_expression of Fos 1 1 0.09 5.14 1.54
61 INT256360 Car2 Positive_regulation of Localization of Rela 1 1 0.14 0 1.51
62 INT79021 Regulation of Binding of Jun and Fos 3 2 0.50 0.66 1.5
63 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 1 0.16 0.2 1.5
64 INT29093 Binding of H2-Ab1 and Rbm39 1 1 0.06 0 1.5
65 INT93781 Racgap1 Positive_regulation of Positive_regulation of Gnptab 1 1 0.02 0.07 1.49
66 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 1 0.10 0.2 1.49
67 INT93783 Racgap1 Positive_regulation of Gnptab 1 1 0.02 0.07 1.49
68 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 1 0.50 1.4 1.48
69 INT156008 Bcl2 Regulation of Localization of Aifm1 1 1 0.17 1.92 1.47
70 INT73650 Binding of Pim3 and Creb1 1 1 0.03 2.48 1.47
71 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 1 0.39 1.04 1.45
72 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 1 3 0.10 0.1 1.44
73 INT131156 Binding of RUNX1 and TNF 1 2 0.03 3.44 1.42
74 INT157540 Binding of SP1 and YY1 1 1 0.41 2.55 1.42
75 INT261831 Mapk1 Negative_regulation of Hspg2 1 1 0.00 1.26 1.42
76 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 1 0.07 1.35 1.41
77 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 1 0.14 0.73 1.41
78 INT68723 Pomgnt1 Negative_regulation of Gene_expression of Fos 1 1 0.12 0 1.41
79 INT108583 Binding of Vip and Fos 1 1 0.36 0 1.39
80 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 1 0.03 0 1.39
81 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 1 0.46 1.09 1.38
82 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 1 0.53 1.07 1.37
83 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 1 2 0.49 0.73 1.36
84 INT168722 Creb1 Positive_regulation of Calca 1 1 0.73 1.05 1.35
85 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 1 0.13 0.16 1.35
86 INT158079 Binding of Esr1 and Gper 2 1 0.31 0.97 1.35
87 INT222182 Binding of ESR1 and HLA-DRB2 1 1 0.00 3.1 1.35
88 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 2 1 0.01 2.06 1.34
89 INT259211 Binding of Ppp1r9b and Flna 1 1 0.06 0 1.33
90 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 1 2 0.03 0.1 1.32
91 INT120929 Prkcg Regulation of Gene_expression of Fos 1 2 0.50 0.34 1.31
92 INT150890 Binding of Esr1 and Esr2 1 2 0.52 2.06 1.31
93 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 1 0.03 0 1.31
94 INT192080 Foxm1 Positive_regulation of Cnr1 1 2 0.14 0.72 1.3
95 INT94367 Binding of ARRB1 and TP53INP2 1 1 0.25 0 1.3
96 INT66428 Dcc Positive_regulation of Fos 1 2 0.05 0.39 1.29
97 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 1 0.35 0 1.29
98 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 1 0.02 0.44 1.29
99 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 1 0.23 0 1.29
100 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 1 0.06 0.14 1.28
101 INT89876 Pdyn Positive_regulation of Gata4 1 1 0.23 0 1.28
102 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 2 1 0.15 1.14 1.27
103 INT114925 Binding of Oprm1 and Crebbp 1 1 0.06 0.14 1.27
104 INT124767 Creb1 Regulation of Oprm1 1 1 0.45 0 1.26
105 INT114635 Hmox2 Positive_regulation of Gene_expression of Fos 1 1 0.47 0.88 1.26
106 INT162163 CDKN2A Positive_regulation of PLD2 1 1 0.24 0 1.24
107 INT167278 Binding of OPRM1 and REST 1 1 0.08 0.94 1.24
108 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 1 0.02 0.18 1.24
109 INT141244 Fos Regulation of Prkaca 1 1 0.18 0.07 1.24
110 INT71443 CSAD Positive_regulation of Gene_expression of Fos 1 1 0.58 0.81 1.23
111 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 1 0.02 0 1.23
112 INT136256 Creb1 Regulation of SGCG 1 1 0.26 0.18 1.23
113 INT136258 Creb1 Regulation of GRIA1 1 1 0.26 0.18 1.23
114 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 1 2 0.27 0.61 1.22
115 INT256298 Binding of Creb1 and Ephb1 1 1 0.16 1.27 1.22
116 INT159837 Trim2 Negative_regulation of Transcription of Fos 1 1 0.10 1.92 1.22
117 INT166388 Binding of Gnb2l1 and Mapk1 1 1 0.49 0.49 1.21
118 INT109380 Binding of Adarb1 and Fos 1 1 0.02 0.38 1.19
119 INT256297 Binding of Creb1 and Insrr 1 1 0.00 1.22 1.19
120 INT256295 Binding of Creb1 and Grin2b 1 1 0.11 1.21 1.19
121 INT55162 Binding of NFKB1 and RELA 1 10 0.30 2.82 1.18
122 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 1 0.06 0.61 1.18
123 INT73075 Adarb1 Regulation of Fos 1 1 0.01 0.07 1.18
124 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 1 0.01 0 1.17
125 INT169557 Cacna1h Positive_regulation of Mapk1 1 1 0.07 0.91 1.17
126 INT124435 Gene_expression of Chrna9 Positive_regulation of Phosphorylation of Creb1 1 1 0.11 0.6 1.17
127 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 1 0.19 1.61 1.17
128 INT200312 Rest Regulation of Oprm1 1 1 0.23 0.27 1.16
129 INT161510 Tlr4 Positive_regulation of Mapk1 1 1 0.14 0.3 1.16
130 INT290667 Il6 Positive_regulation of Stat3 1 3 0.69 2.42 1.15
131 INT147447 ADCYAP1 Regulation of Localization of RELA 1 1 0.50 1.12 1.15
132 INT139188 Binding of Daxx and Fas 1 1 0.03 0.55 1.14
133 INT123454 CNR1 Regulation of Fos 1 1 0.00 0.06 1.12
134 INT130471 Prkcg Regulation of Regulation of Fos 1 1 0.45 0.27 1.12
135 INT112608 DNAJC15 Regulation of Gene_expression of Fos 1 1 0.02 0.14 1.12
136 INT123455 CNR1 Regulation of Positive_regulation of Fos 1 1 0.00 0.06 1.12
137 INT202620 Binding of Ppara and Rxra 1 15 0.09 2.63 1.11
138 INT143941 Il1f5 Negative_regulation of Gene_expression of Fos 1 1 0.00 1.03 1.11
139 INT102421 POMC Regulation of Gene_expression of Fos 1 1 0.12 0.34 1.11
140 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 1 0.12 1.33 1.11
141 INT308173 Binding of DRG1 and Tnfrsf1b 1 1 0.01 1.64 1.1
142 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 1 0.52 0.88 1.09
143 INT105423 Jun Positive_regulation of Gene_expression of Penk 2 1 0.43 0 1.09
144 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 1 0.75 0.2 1.08
145 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 1 0.54 0.2 1.08
146 INT132701 Adarb1 Negative_regulation of Gene_expression of Fos 1 1 0.01 0.73 1.07
147 INT134971 Positive_regulation of OPRK1 Positive_regulation of Binding of OPRK1 and SP1 1 1 0.00 0 1.07
148 INT156462 Creb1 Regulation of Ephb1 1 1 0.29 0 1.07
149 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 1 2 0.05 1.85 1.06
150 INT100564 CRX Positive_regulation of Fos 1 1 0.04 0.89 1.06
151 INT145408 H2-Ab1 Negative_regulation of Gene_expression of Dbi 1 1 0.05 0 1.06
152 INT105109 Cxcl12 Positive_regulation of JUN 1 1 0.01 1.07 1.05
153 INT119888 Binding of Creb1 and Usf1 1 1 0.18 0.15 1.05
154 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 1 0.00 0 1.05
155 INT270680 Fos Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 1 0.03 0.39 1.05
156 INT214875 Ap3d1 Negative_regulation of Gene_expression of Fos 1 1 0.00 0.39 1.04
157 INT134969 Binding of OPRK1 and SP1 1 1 0.00 0 1.04
158 INT69011 Binding of Cebpb and Nfkb1 1 1 0.19 0.75 1.04
159 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 1 0.35 0 1.04
160 INT146518 Tmem132a Positive_regulation of Gene_expression of Fos 1 1 0.68 0.06 1.04
161 INT200307 Rest Negative_regulation of Rorb 1 1 0.00 0.1 1.03
162 INT307047 Foxm1 Positive_regulation of Casp3 1 1 0.11 0.06 1.03
163 INT255336 Csnk2b Regulation of Phosphorylation of Nav1 2 1 0.10 0 1.03
164 INT118859 GNA14 Positive_regulation of STAT3 1 1 0.01 0.38 1.03
165 INT101067 MAP3K15 Positive_regulation of MAPK1 1 1 0.21 0.47 1.03
166 INT95378 Binding of Jun and Jund 2 5 0.20 2.06 1.02
167 INT74027 Creb1 Regulation of Jun 3 4 0.27 1.04 1.02
168 INT101065 MAP3K15 Positive_regulation of JUN 1 1 0.43 0.46 1.02
169 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 1 0.46 1.03 1.02
170 INT139636 Jun Negative_regulation of Phosphorylation of Npy 2 1 0.33 1.07 1.01
171 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 1 0.02 0.51 1.01
172 INT143177 Apcs Negative_regulation of Gene_expression of Fos 1 1 0.02 0.36 1.01
173 INT113453 Ngf Positive_regulation of JUN 1 1 0.27 0.6 1.01
174 INT11251 Negative_regulation of Cck Positive_regulation of Fos 1 2 0.48 0 1
175 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 1 0.19 0.33 1
176 INT139639 Jun Negative_regulation of Positive_regulation of Vip 2 1 0.53 1.07 1
177 INT139643 Jun Negative_regulation of Positive_regulation of Npy 2 1 0.33 1.07 1
178 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 1 0.19 0.33 1
179 INT71319 Binding of Penk and Fos 1 3 0.40 0.15 0.99
180 INT142202 FL Positive_regulation of Bcl2 2 1 0.05 0.39 0.99
181 INT228498 Il10 Negative_regulation of Hand1 2 1 0.03 1.4 0.99
182 INT228496 Il4 Negative_regulation of Hand1 2 1 0.02 1.4 0.99
183 INT139641 Positive_regulation of Jun Positive_regulation of Positive_regulation of Vip 2 1 0.37 0.95 0.99
184 INT228495 Il13 Negative_regulation of Hand1 2 1 0.01 1.4 0.98
185 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 1 0.32 0.63 0.98
186 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 1 0.26 0.63 0.98
187 INT255330 Nav1 Regulation of Phosphorylation of Csnk2b 2 1 0.10 0 0.97
188 INT133614 Map2k1 Regulation of Daxx 3 1 0.02 0.29 0.97
189 INT139642 Positive_regulation of Jun Regulation of Gene_expression of Npy 2 1 0.21 1.07 0.97
190 INT145823 Ngf Positive_regulation of Fos 1 1 0.52 0.95 0.97
191 INT137919 Binding of Oprm1 and Stat3 1 1 0.30 0 0.97
192 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 1 0.47 0.61 0.97
193 INT145824 Negative_regulation of Ngf Positive_regulation of Fos 1 1 0.48 0.95 0.97
194 INT278292 Binding of CRP and ESR1 1 6 0.09 10.92 0.96
195 INT61860 Akr1d1 Regulation of Egr1 1 1 0.01 0 0.96
196 INT93234 Negative_regulation of Pde4b Negative_regulation of Gene_expression of Fos 1 1 0.41 0.1 0.96
197 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 1 0.00 0 0.96
198 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 1 0.06 0.99 0.96
199 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 1 0.01 0 0.96
200 INT281380 Fos Negative_regulation of Gene_expression of FSCN1 1 1 0.07 0.4 0.96

Single Events

The table below shows the top 100 pain related interactions that have been reported for transcription factor binding. They are ordered first by their pain relevance and then by number of times they were reported in transcription factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02
2 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684
3 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87
4 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84
5 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54
6 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78
7 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
8 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
9 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
10 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05
11 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
12 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
13 INT5587 Regulation of Fos 191 0.62 40.81 99.7
14 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31
15 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
16 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
17 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98
18 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16
19 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26
20 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54
21 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
22 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
23 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
24 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
25 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77
26 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39
27 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96
28 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82
29 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6
30 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
31 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
32 INT221172 Binding of Flna 32 0.42 1.37 51.59
33 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
34 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64
35 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
36 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
37 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
38 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
39 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
40 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
41 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
42 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
43 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
44 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
45 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
46 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
47 INT666 Gene_expression of Jun 124 0.78 54.61 33.67
48 INT16714 Regulation of Creb1 64 0.62 22.23 33.56
49 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
50 INT6053 Transcription of Fos 107 0.72 20.97 31.88
51 INT47764 Binding of Jun 106 0.48 22.62 31.39
52 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
53 INT6058 Localization of Fos 73 0.81 16.7 30.84
54 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
55 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25
56 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73
57 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04
58 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
59 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
60 INT37296 Binding of Esr1 117 0.43 62.51 27.33
61 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
62 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
63 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41
64 INT20462 Binding of ESR1 210 0.44 102.7 26.34
65 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
66 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
67 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
68 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
69 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
70 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95
71 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28
72 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
73 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17
74 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
75 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46
76 INT19949 Regulation of Positive_regulation of Fos 36 0.60 6.11 22.05
77 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
78 INT5586 Binding of Fos 47 0.48 12.7 21.33
79 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
80 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52
81 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
82 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19
83 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
84 INT133478 Phosphorylation of Csnk2b 29 0.37 1.19 18.73
85 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61
86 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
87 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42
88 INT11275 Regulation of Fos 37 0.60 5.79 18.18
89 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1
90 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06
91 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
92 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9
93 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
94 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
95 INT8526 Negative_regulation of Positive_regulation of Fos 26 0.59 5.99 17.52
96 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
97 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
98 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96
99 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
100 INT102023 Regulation of Creb1 51 0.62 16.29 16.71
101 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
102 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
103 INT104045 Regulation of Hand1 65 0.35 51.32 16.26
104 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
105 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
106 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
107 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
108 INT92354 Localization of ESR1 77 0.75 33.04 15.51
109 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
110 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
111 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
112 INT41558 Localization of Sp1 9 0.48 0.56 14.9
113 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
114 INT93482 Localization of Rela 56 0.78 24.52 14.82
115 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
116 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
117 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45
118 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
119 INT17593 Regulation of Jun 37 0.60 5.5 14.35
120 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
121 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
122 INT173505 Localization of Hand2 63 0.57 45.32 13.66
123 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
124 INT10499 Positive_regulation of Cenpf 11 0.46 1.27 13.42
125 INT107248 Negative_regulation of Gene_expression of Creb1 26 0.58 9.24 13.41
126 INT6794 Negative_regulation of Jun 37 0.53 8.04 13.37
127 INT20378 Localization of Hand1 53 0.71 41.96 13.31
128 INT2038 Localization of Esr1 104 0.79 40.12 13.27
129 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
130 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
131 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
132 INT16713 Binding of Creb1 53 0.48 20.24 13.06
133 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
134 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5
135 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39
136 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39
137 INT245517 Positive_regulation of Gene_expression of Runx1 49 0.69 17.7 12.38
138 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
139 INT11766 Negative_regulation of H2-Ab1 15 0.43 5.27 12.32
140 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
141 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23
142 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
143 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
144 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06
145 INT133212 Negative_regulation of Runx1 21 0.58 11.16 11.89
146 INT3699 Gene_expression of H2-Ab1 24 0.74 12.06 11.82
147 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
148 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
149 INT6051 Positive_regulation of Transcription of Fos 27 0.69 6.3 11.48
150 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
151 INT70816 Negative_regulation of Fos 32 0.58 13 11.18
152 INT2956 Binding of H2-Ab1 19 0.37 3.1 11.18
153 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
154 INT52233 Transcription of Jun 37 0.66 6.39 11.15
155 INT15597 Negative_regulation of Gene_expression of Jun 20 0.48 6.04 11.08
156 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88
157 INT221448 Gene_expression of CREG1 8 0.05 27.44 10.87
158 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7
159 INT52657 Phosphorylation of Fos 20 0.80 6.36 10.64
160 INT62576 Transcription of Creb1 34 0.69 16.97 10.6
161 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
162 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
163 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
164 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37
165 INT60198 Binding of JUN 54 0.48 11.56 10.27
166 INT5476 Regulation of Gabbr1 21 0.45 4.01 10.26
167 INT133210 Positive_regulation of Runx1 33 0.69 18.25 10.12
168 INT17592 Positive_regulation of Regulation of Fos 21 0.67 3.54 10.07
169 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04
170 INT245538 Negative_regulation of Gene_expression of Runx1 20 0.58 11.68 9.97
171 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
172 INT6356 Binding of Gabbr1 30 0.48 4.62 9.82
173 INT8527 Positive_regulation of Positive_regulation of Fos 20 0.70 6.87 9.62
174 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
175 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
176 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
177 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41
178 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
179 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
180 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
181 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
182 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05
183 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
184 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
185 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
186 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97
187 INT109279 Regulation of Phosphorylation of Creb1 14 0.62 4.06 8.96
188 INT35366 Binding of AR 87 0.47 30.52 8.9
189 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89
190 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84
191 INT66213 Localization of RELA 63 0.78 14.71 8.77
192 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77
193 INT61264 Regulation of Jun 36 0.61 18.42 8.71
194 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
195 INT47769 Phosphorylation of Fos 20 0.61 3.03 8.68
196 INT26751 Regulation of Nr3c1 13 0.61 6.58 8.65
197 INT64815 Binding of Jun 49 0.48 21.47 8.59
198 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56
199 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
200 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
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