GOS:transmembrane transporter activity

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This page displays the top molecular interactions and top single events that were mentioned in the literature for transmembrane transporter activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to transmembrane transporter activity Documents TM Confidence Disease Relevance Pain Relevance
1 INT105917 Binding of SLC22A6 and SLC22A8 2 2 0.31 0.34 1.67
2 INT134742 Binding of OPRM1 and SV2A 1 1 0.33 0.18 1.64
3 INT342165 Binding of Aqp1 and Nav1 1 1 0.25 0.57 1.25
4 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 1 0.65 0.73 0.73
5 INT115811 Binding of Slc22a6 and Mtx1 1 1 0.02 0.17 0.65
6 INT115812 Binding of Slc22a8 and Mtx1 1 1 0.08 0.17 0.65
7 INT346412 Binding of Tesc and Sv2a 1 1 0.02 0.6 0.59
8 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 1 0.42 0.48 0.55
9 INT144128 Binding of Gja1 and Prkce 1 1 0.40 0.5 0.52
10 INT144130 Binding of Gja1 and Prkcg 1 1 0.48 0.5 0.52
11 INT177981 Binding of RUNX1 and SLC22A4 1 1 0.08 1.04 0.5
12 INT309157 Aqp1 Positive_regulation of Bdnf 1 1 0.00 0.74 0.42
13 INT264209 Binding of Igh-Lev and Sv2a 1 1 0.17 1.78 0.38
14 INT139778 Binding of AQP1 and GBE1 1 1 0.00 0.22 0.3
15 INT58305 AQP1 Regulation of Localization of TNF 1 1 0.10 0.16 0.22
16 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 1 0.10 0.16 0.22
17 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 1 0.06 0.51 0.2
18 INT55300 Slc2a1 Regulation of Gene_expression of Slc2a4 2 1 0.41 0.41 0.19
19 INT55295 Slc2a1 Regulation of Ins1 1 1 0.17 0.41 0.19
20 INT55296 Slc2a4 Regulation of Ins1 1 1 0.17 0.41 0.19
21 INT55299 Slc2a4 Regulation of Gene_expression of Slc2a1 2 1 0.41 0.41 0.19
22 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 1 0.25 0.67 0.15
23 INT327829 Aqp1 Regulation of Binding of Csf2 and 1 1 0.11 1 0.14
24 INT252421 Gja1 Regulation of P2ry1 1 1 0.00 0.28 0.09
25 INT262335 Binding of Sv2a and Bri3 1 1 0.01 0.71 0.08
26 INT177255 Binding of SV2A and NR1H4 1 1 0.04 0 0.07
27 INT346415 Binding of Mns1 and Sv2a 1 1 0.03 0.14 0.07
28 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 1 0.10 0.88 0.06
29 INT55297 Gene_expression of Slc2a4 Positive_regulation of Ins1 1 1 0.19 0.36 0.06
30 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 1 0.09 0.88 0.06
31 INT267046 Binding of SLC2A1 and SV2A 1 1 0.12 0 0.05
32 INT329219 Ins1 Positive_regulation of Gene_expression of Slc2a4 1 1 0.04 0.93 0.05
33 INT177288 Binding of CXADR and SV2A 1 1 0.32 0 0.04
34 INT352062 Binding of SV2A and Chrna7 1 1 0.00 0.7 0.04
35 INT346418 Sv2a Positive_regulation of Binding of Tesc and 1 1 0.02 0.1 0.04
36 INT177275 Binding of CA2 and SV2A 1 1 0.30 0 0.04
37 INT352519 INS Positive_regulation of Localization of Slc2a4 1 1 0.07 0.97 0.03
38 INT346407 Negative_regulation of Binding of Tesc and Sv2a 1 1 0.02 0 0.03
39 INT323483 Slc2a2 Positive_regulation of Localization of Ins1 1 1 0.07 0.1 0.03
40 INT177258 SV2A Regulation of CXADR 1 1 0.63 0 0.03
41 INT255752 hs Positive_regulation of Phosphorylation of Slc2a4 1 1 0.08 1.32 0
42 INT177262 Binding of MED1 and SV2A 1 1 0.23 0 0
43 INT177299 SV2A Regulation of FAUP1 1 1 0.02 0 0
44 INT233304 Binding of SRY and SLC22A8 1 1 0.34 0.93 0
45 INT177252 SV2A Positive_regulation of CYP2B6 1 1 0.45 0 0
46 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 1 0.03 0 0
47 INT262498 Binding of Aqp1 and Cav1 1 1 0.03 0.56 0
48 INT177264 Positive_regulation of Binding of NCOA1 and SV2A 1 1 0.17 0 0
49 INT177271 Binding of NCOA1 and SV2A 1 1 0.17 0 0
50 INT98626 Aqp1 Positive_regulation of Aqp4 1 1 0.52 0 0
51 INT177256 SV2A Positive_regulation of ABCB1 1 1 0.38 0 0
52 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 1 0.15 1.32 0
53 INT219634 Binding of NLRP1 and Slc22a6 1 1 0.26 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
2 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
3 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
4 INT95099 Gene_expression of SLC22A8 14 0.67 1.59 5.14
5 INT95101 Binding of SLC22A8 6 0.48 0.75 5.07
6 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
7 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
8 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24
9 INT95102 Localization of SLC22A8 3 0.75 0.69 4.24
10 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
11 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
12 INT134747 Gene_expression of SV2A 10 0.72 0.44 3.48
13 INT96304 Gene_expression of Slc22a8 9 0.66 0.63 3.12
14 INT104134 Binding of SLC22A6 3 0.34 0.52 2.75
15 INT129695 Binding of Sv2a 6 0.47 4.96 2.51
16 INT156373 Binding of Sv2a 4 0.39 1.54 2.3
17 INT19157 Gene_expression of SLC22A6 5 0.71 1.39 2.18
18 INT55291 Gene_expression of Slc2a1 20 0.68 11.46 2.16
19 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15
20 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
21 INT87778 Positive_regulation of Gene_expression of Gja1 6 0.69 1.46 2.14
22 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
23 INT87779 Positive_regulation of Gja1 4 0.53 0.9 1.95
24 INT128030 Gene_expression of GJA1 23 0.75 7.81 1.88
25 INT87776 Positive_regulation of Phosphorylation of Gja1 3 0.62 0.71 1.86
26 INT208874 Gene_expression of Sv2b 6 0.54 0.98 1.65
27 INT346404 Gene_expression of Sv2a 1 0.72 3.2 1.62
28 INT230805 Localization of Slc2a4 23 0.46 11 1.48
29 INT62015 Gene_expression of Sv2a 3 0.30 0.99 1.45
30 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41
31 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
32 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
33 INT92405 Negative_regulation of Slc22a6 2 0.47 1.52 1.34
34 INT109469 Negative_regulation of SLC22A2 1 0.42 0.31 1.34
35 INT90829 Negative_regulation of SLC22A6 3 0.40 0.75 1.22
36 INT95168 Negative_regulation of ATP5E 1 0.57 0.76 1.2
37 INT115810 Negative_regulation of Slc22a8 3 0.41 0.27 1.18
38 INT55294 Gene_expression of Slc2a4 17 0.70 6.84 1.11
39 INT11934 Regulation of Sv2a 4 0.44 1.72 1.1
40 INT123213 Negative_regulation of SLC22A8 2 0.35 1.43 1.05
41 INT134822 Gene_expression of Gja1 18 0.72 4.2 1
42 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99
43 INT108805 Binding of Slc22a8 3 0.18 0.44 0.97
44 INT183362 Regulation of AQP1 3 0.23 1.49 0.92
45 INT90830 Localization of SLC22A6 3 0.69 0.86 0.89
46 INT177997 Regulation of SLC22A4 2 0.20 3.88 0.86
47 INT134748 Positive_regulation of SV2A 7 0.46 2.89 0.82
48 INT168284 Localization of Slc22a8 1 0.78 0.1 0.82
49 INT87777 Regulation of Gja1 1 0.62 0.76 0.81
50 INT134745 Localization of SVOPL 1 0.16 0.08 0.8
51 INT112780 Positive_regulation of Slc2a1 6 0.46 1.85 0.78
52 INT81604 Transcription of SLC22A6 2 0.63 0.67 0.78
53 INT178004 Binding of SLC22A4 2 0.26 2.45 0.77
54 INT76293 Gene_expression of SLC22A1 8 0.75 1.24 0.76
55 INT143306 Positive_regulation of Gja1 3 0.50 0.42 0.75
56 INT178116 Phosphorylation of GJA1 7 0.80 4.09 0.74
57 INT172412 Negative_regulation of SV2A 6 0.47 0.88 0.74
58 INT128402 Negative_regulation of Phosphorylation of Gja1 1 0.58 0.73 0.73
59 INT230808 Positive_regulation of Localization of Slc2a4 12 0.40 5.42 0.7
60 INT134744 Positive_regulation of Gene_expression of SV2A 1 0.50 0.08 0.69
61 INT152909 Regulation of Gene_expression of Gja1 1 0.61 0.46 0.69
62 INT87781 Regulation of Phosphorylation of Gja1 1 0.27 0 0.67
63 INT246207 Positive_regulation of GJA1 3 0.67 0.91 0.65
64 INT115809 Binding of Slc22a6 1 0.03 0.17 0.65
65 INT70515 Gene_expression of Slc22a6 7 0.78 1.26 0.63
66 INT86222 Binding of SLC22A11 2 0.48 0.1 0.63
67 INT177327 Localization of SV2A 6 0.69 0.08 0.62
68 INT214707 Gene_expression of Slc2a8 5 0.24 2.76 0.61
69 INT172411 Regulation of SV2A 3 0.22 0.93 0.61
70 INT346381 Localization of Sv2a 1 0.69 1.12 0.61
71 INT346389 Negative_regulation of Sv2a 1 0.47 0.41 0.61
72 INT90831 Negative_regulation of Gene_expression of SLC22A6 1 0.40 0.39 0.58
73 INT215899 Negative_regulation of Gene_expression of Slc2a1 6 0.43 3.96 0.55
74 INT139780 Binding of AQP1 7 0.32 4.62 0.54
75 INT154837 Regulation of Gja1 2 0.45 1.42 0.53
76 INT55293 Positive_regulation of Gene_expression of Slc2a4 7 0.63 4.18 0.51
77 INT134820 Positive_regulation of Gene_expression of Gja1 3 0.64 0.84 0.49
78 INT117370 Gene_expression of SLC22A2 2 0.22 0.22 0.48
79 INT87774 Binding of Gja1 2 0.48 0.19 0.48
80 INT329831 Positive_regulation of Positive_regulation of GJA1 1 0.49 0.58 0.48
81 INT346400 Localization of Sv2b 1 0.49 1.15 0.48
82 INT76294 Binding of SLC22A1 3 0.47 0.28 0.47
83 INT55292 Positive_regulation of Gene_expression of Slc2a1 5 0.61 2.98 0.46
84 INT192937 Positive_regulation of Gene_expression of GJA1 4 0.67 0.4 0.44
85 INT19592 Localization of AQP1 4 0.81 1.09 0.44
86 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44
87 INT168285 Negative_regulation of Localization of Slc22a8 1 0.36 0 0.44
88 INT177338 Binding of SV2A 21 0.44 1.14 0.42
89 INT76765 Gene_expression of ATP5A1 1 0.00 0 0.42
90 INT156776 Regulation of Slc22a12 3 0.25 1.74 0.4
91 INT95100 Transcription of SLC22A8 4 0.45 0.57 0.39
92 INT147225 Positive_regulation of Slc22a8 2 0.49 0 0.38
93 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
94 INT55449 Localization of Slc22a1 1 0.75 0 0.34
95 INT86223 Gene_expression of SLC22A11 4 0.77 0.09 0.33
96 INT253118 Negative_regulation of Localization of Slc2a4 3 0.25 2.47 0.33
97 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
98 INT262284 Negative_regulation of Positive_regulation of Slc22a6 1 0.06 0.79 0.31
99 INT262299 Negative_regulation of Positive_regulation of SLC22A8 1 0.06 0.79 0.31
100 INT262283 Positive_regulation of Slc22a6 1 0.07 0.73 0.3
101 INT262300 Positive_regulation of SLC22A8 1 0.07 0.73 0.3
102 INT184526 Phosphorylation of Slc2a1 2 0.18 1.53 0.29
103 INT246648 Binding of Slc22a1 2 0.31 0.76 0.28
104 INT346373 Negative_regulation of Binding of Sv2b 1 0.26 0.21 0.27
105 INT126820 Negative_regulation of Gene_expression of Slc22a6 2 0.26 0.85 0.26
106 INT262296 Negative_regulation of Transcription of SLC22A8 1 0.06 0.58 0.26
107 INT262292 Negative_regulation of Gene_expression of SLC22A8 1 0.06 0.58 0.26
108 INT346396 Positive_regulation of Gene_expression of Sv2a 1 0.43 1.09 0.26
109 INT262285 Negative_regulation of Transcription of Slc22a6 1 0.06 0.58 0.26
110 INT262286 Transcription of Slc22a6 1 0.09 0.58 0.26
111 INT346374 Binding of Sv2b 1 0.22 0.31 0.26
112 INT208838 Regulation of Gene_expression of Sv2b 1 0.26 0 0.25
113 INT308149 Gene_expression of Slc22a5 1 0.63 2.77 0.25
114 INT128384 Transcription of Slc22a2 1 0.41 0 0.25
115 INT128385 Transcription of Slc22a1 1 0.39 0 0.25
116 INT128386 Transcription of Slc22a8 1 0.38 0 0.25
117 INT132951 Regulation of GJA1 2 0.57 0.79 0.24
118 INT247021 Binding of GJA1 6 0.47 0.91 0.23
119 INT126761 Negative_regulation of Gja1 1 0.33 0.08 0.22
120 INT96305 Gene_expression of Slc22a1 3 0.73 0.34 0.21
121 INT96306 Gene_expression of Slc22a2 2 0.64 0 0.21
122 INT131264 Positive_regulation of Gene_expression of SLC22A1 2 0.26 0.53 0.2
123 INT104568 Negative_regulation of Localization of Aqp1 1 0.36 2.47 0.2
124 INT263884 Gene_expression of Slc2a3 2 0.18 0.86 0.19
125 INT308617 Positive_regulation of Gene_expression of Slc2a3 1 0.13 0.07 0.19
126 INT231256 Regulation of Slc2a4 3 0.21 0.76 0.18
127 INT186146 Negative_regulation of GJA1 2 0.41 1.29 0.18
128 INT178124 Positive_regulation of Phosphorylation of GJA1 2 0.65 1.21 0.18
129 INT156777 Localization of Slc22a12 1 0.70 0.78 0.18
130 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17
131 INT346382 Regulation of Sv2a 1 0.36 0 0.17
132 INT184525 Phosphorylation of Slc2a3 1 0.03 1.47 0.17
133 INT128390 Negative_regulation of Slc22a3 1 0.40 0 0.17
134 INT308147 Gene_expression of Slc22a4 1 0.33 1.55 0.17
135 INT98625 Regulation of Aqp1 1 0.27 0.1 0.17
136 INT346383 Gene_expression of Sv2c 1 0.23 0.21 0.17
137 INT290795 Gene_expression of Slc2a2 3 0.44 1.22 0.16
138 INT131266 Transcription of SLC22A2 1 0.01 0 0.16
139 INT131261 Positive_regulation of Gene_expression of SLC22A2 1 0.00 0 0.16
140 INT209954 Negative_regulation of Transcription of SLC22A1 1 0.41 0.28 0.16
141 INT209953 Transcription of SLC22A1 1 0.67 0.28 0.16
142 INT310884 Localization of Slc2a8 1 0.23 0 0.15
143 INT209185 Regulation of Phosphorylation of GJA1 2 0.44 0.09 0.14
144 INT308623 Localization of Slc2a2 1 0.23 0.1 0.14
145 INT309645 Regulation of Gene_expression of SLC22A1 1 0.60 0.37 0.14
146 INT267068 Binding of SVOP 1 0.34 0.17 0.13
147 INT346402 Negative_regulation of Gene_expression of Sv2b 1 0.29 0 0.12
148 INT160112 Localization of SLC22A2 1 0.02 0.32 0.11
149 INT85340 Positive_regulation of Slc22a13 1 0.04 0.95 0.11
150 INT308608 Gene_expression of Slc2a5 1 0.22 0 0.11
151 INT155667 Negative_regulation of Gene_expression of Gja1 3 0.42 1.16 0.1
152 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1
153 INT161127 Localization of SLC22A16 2 0.73 1.34 0.1
154 INT151665 Gene_expression of Slc22a25 1 0.54 0.07 0.1
155 INT159343 Positive_regulation of Localization of AQP1 1 0.11 0 0.1
156 INT236581 Regulation of Gene_expression of Slc2a4 3 0.36 0.5 0.09
157 INT125225 Regulation of Slc22a7 1 0.14 0.44 0.09
158 INT209182 Regulation of Gene_expression of GJA1 1 0.57 0.09 0.09
159 INT267065 Gene_expression of SVOP 1 0.63 0.27 0.09
160 INT308632 Localization of Slc2a5 1 0.21 0.09 0.08
161 INT327827 Negative_regulation of Gene_expression of Aqp1 1 0.45 0.8 0.08
162 INT308139 Negative_regulation of Slc22a4 1 0.21 0.79 0.08
163 INT346394 Regulation of Negative_regulation of Sv2a 1 0.36 0.16 0.08
164 INT352512 Regulation of Localization of Slc2a4 1 0.06 0.66 0.08
165 INT188177 Localization of GJA1 2 0.75 0.07 0.07
166 INT178132 Negative_regulation of Gene_expression of GJA1 2 0.35 0.84 0.07
167 INT11935 Positive_regulation of Sv2a 2 0.39 0.14 0.07
168 INT209187 Positive_regulation of Localization of GJA1 1 0.65 0.07 0.07
169 INT321483 Regulation of Localization of Slc22a12 1 0.26 0 0.07
170 INT262510 Regulation of Gene_expression of Aqp1 1 0.33 1.18 0.07
171 INT327254 Regulation of Protein_catabolism of Slc2a8 1 0.01 1.18 0.06
172 INT327261 Regulation of Slc2a8 1 0.01 1.17 0.06
173 INT327235 Protein_catabolism of Slc2a8 1 0.02 1.17 0.06
174 INT321484 Localization of Slc22a12 1 0.43 0 0.06
175 INT134437 Positive_regulation of Slc2a8 2 0.24 0.71 0.05
176 INT214703 Positive_regulation of Gene_expression of Slc2a8 2 0.09 1.4 0.05
177 INT157747 Gene_expression of SLC22A16 2 0.65 0.35 0.05
178 INT257689 Negative_regulation of Gja1 1 0.37 0.58 0.05
179 INT315852 Negative_regulation of Gene_expression of SLC22A1 1 0.01 0.59 0.05
180 INT228786 Regulation of Gene_expression of Gja1 2 0.29 0.49 0.04
181 INT248313 Positive_regulation of Slc22a12 1 0.02 1.55 0.04
182 INT253095 Regulation of Gene_expression of Slc2a1 1 0.30 0.14 0.04
183 INT315851 Negative_regulation of SLC22A1 1 0.01 0.85 0.04
184 INT248314 Negative_regulation of Slc22a12 1 0.01 1.47 0.04
185 INT177310 Negative_regulation of Binding of SV2A 1 0.54 0 0.04
186 INT241012 Gene_expression of Svop 1 0.04 0.71 0.04
187 INT228802 Negative_regulation of Gene_expression of Gja1 4 0.37 0.87 0.03
188 INT215896 Binding of Slc2a1 2 0.36 0.42 0.03
189 INT216569 Localization of Gja1 2 0.36 0.35 0.03
190 INT329877 Gene_expression of Slc22a5 1 0.34 0 0.03
191 INT185438 Gene_expression of SLC22A4 1 0.39 1.51 0.03
192 INT253101 Binding of Slc2a4 1 0.21 0 0.03
193 INT177311 Negative_regulation of Localization of SV2A 1 0.34 0 0.03
194 INT329874 Negative_regulation of Gene_expression of Slc22a5 1 0.21 0 0.03
195 INT109770 Gene_expression of ATP5J 6 0.48 1.73 0
196 INT298759 Regulation of ATP5A1 4 0.60 0.25 0
197 INT109769 Localization of ATP5J 3 0.49 0.42 0
198 INT247813 Localization of Gja1 2 0.45 0.47 0
199 INT247793 Regulation of Localization of Gja1 2 0.17 0.47 0
200 INT298758 Negative_regulation of ATP5A1 2 0.57 0.12 0
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