INT1

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Context Info
Confidence 0.36
First Reported 1967
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 2.66
Pain Relevance 9.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 3
nerve 2
Mononuclear cells 2
brain 1
muscle fiber 1
membrane (Staphylococcus aureus)
Pain Link Frequency Relevance Heat
tetrodotoxin 35 100.00 Very High Very High Very High
Clonidine 7 99.98 Very High Very High Very High
opiate 15 99.98 Very High Very High Very High
Pain 6 99.40 Very High Very High Very High
Opioid 2 98.24 Very High Very High Very High
cINOD 9 97.52 Very High Very High Very High
Sodium channel 8 97.44 Very High Very High Very High
Analgesic 5 96.60 Very High Very High Very High
Potency 6 96.40 Very High Very High Very High
Potassium channel 1 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 12 100.00 Very High Very High Very High
Pain 4 99.40 Very High Very High Very High
INFLAMMATION 6 97.12 Very High Very High Very High
Cold Sores 1 96.24 Very High Very High Very High
Arthritis 1 95.04 Very High Very High Very High
Anorectal Disorders 1 94.60 High High
Interstitial Cystitis 1 93.72 High High
Injury 1 92.80 High High
Burns 1 92.44 High High
Disease 2 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measuring membrane protein interactions using optical biosensors.
membrane Binding (interactions) of
1) Confidence 0.36 Published 2010 Journal Methods Mol. Biol. Section Title Doc Link 20336440 Disease Relevance 0.18 Pain Relevance 0.09
A model for the interaction of anesthetics with the phospholipid membrane headgroup-interface region.
membrane Binding (interaction) of
2) Confidence 0.27 Published 1984 Journal Biochim. Biophys. Acta Section Title Doc Link 6691974 Disease Relevance 0 Pain Relevance 0.08
Electrostatic attraction, hydrogen bonding, and intermolecular hemilactal formation are possible mechanisms of interaction with membrane receptors.
membrane Binding (interaction) of
3) Confidence 0.27 Published 1967 Journal Science Section Abstract Doc Link 6025123 Disease Relevance 0 Pain Relevance 0.43
As a consequence, the membranes are less able to facilitate the conformational changes in proteins that may be the basis for such membrane events as ion gating, synaptic transmitter release, and transmitter binding to receptors.
membrane Binding (binding) of
4) Confidence 0.26 Published 1977 Journal Anesthesiology Section Abstract Doc Link 12686 Disease Relevance 0.07 Pain Relevance 0.20
To study the interaction of voltage-sensitive Na+-channels with membrane lipids, the phospholipid and fatty acid composition of highly purified membrane fragments from the remarkably differentiated plasma membrane of Electrophorus electricus has been analyzed.
membrane Spec (analyzed) Binding (interaction) of in plasma
5) Confidence 0.26 Published 1983 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6871220 Disease Relevance 0 Pain Relevance 0.15
They dissociate from their membrane complex with half-lives of 10.8 and 20 min.
membrane Binding (complex) of
6) Confidence 0.26 Published 1981 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6789875 Disease Relevance 0 Pain Relevance 0.21
Colonic tissue membrane binding to peripheral blood mononuclear leukocytes was quantitated by 125I labeling of membrane fragments and by determining the acquisition of membrane-specific enzyme activity and radioactivity in mononuclear cells after contact with the tissue membrane fragments.
membrane Binding (binding) of in mononuclear cells
7) Confidence 0.05 Published 1977 Journal Cancer Res. Section Abstract Doc Link 302737 Disease Relevance 0.14 Pain Relevance 0
Binding of colonic tissue membrane to mononuclear peripheral blood leukocytes.
membrane Binding (Binding) of in leukocytes
8) Confidence 0.05 Published 1977 Journal Cancer Res. Section Title Doc Link 302737 Disease Relevance 0.36 Pain Relevance 0.07
Mononuclear cells bound equal amounts of normal and tumor tissue membrane fragments.
membrane Binding (bound) of in Mononuclear cells associated with cancer
9) Confidence 0.05 Published 1977 Journal Cancer Res. Section Abstract Doc Link 302737 Disease Relevance 0.33 Pain Relevance 0.07
Small unilamellar vesicles (SUVs) formed by the dimyristoylphosphatidylcholine (DMPC), a phospholipid; serve as a membrane mimetic system that can be used to study the effect of absence of net surface charges on drug-membrane interaction.
membrane Binding (interaction) of in SUVs
10) Confidence 0.04 Published 2005 Journal Chem. Phys. Lipids Section Abstract Doc Link 16183046 Disease Relevance 0.10 Pain Relevance 0.47
[structure: see text] A modular, flexible solid-phase synthetic route for the preparation of biotinylated cross-linking probes of membrane receptors is described.
membrane Binding (cross-linking) of
11) Confidence 0.04 Published 2005 Journal Org. Lett. Section Abstract Doc Link 15844884 Disease Relevance 0 Pain Relevance 0.04
The detailed mechanisms of action are not fully understood but seem to involve a reversible interaction with membrane proteins and lipids thus regulating cell metabolic activity, migration, exocytosis and phagocytosis.
membrane Binding (interaction) of
12) Confidence 0.04 Published 2006 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 16480459 Disease Relevance 1.05 Pain Relevance 0.87
A new working hypothesis is proposed in which tetrodotoxin and chiriquitoxin are postulated to bind to a membrane receptor located in the outside surface of the muscle fiber membrane.
membrane Binding (bind) of in muscle fiber associated with tetrodotoxin
13) Confidence 0.04 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6262484 Disease Relevance 0 Pain Relevance 0.55
These receptor studies have led, for example, to (a) the identification of 17-alpha estrogens that interact with the opiate receptor, (b) the delineation of a unique class of opiate receptor that mediates explosive motor behavior and is resistant to naloxone, (c) the discovery of progesterone derivatives and active tissue fractions that compete for specific binding sites for cardiac glycosides, (d) the observation that both the opiate and digitalis RRA's permit discrimination between classes of centrally active compounds that differ only trivially in their physicochemical properties but exert opposing actions on nerve excitability, and (e) the hypothesis that the correlation between lipid solubility and potency of general anesthetics applies to the accommodation of this class of drugs by hydrophobic crypts of membrane proteins and other proteins rather than to an ill-defined hydrophobic interaction with membrane lipid.
membrane Binding (interaction) of in nerve associated with narcan, opiate and potency
14) Confidence 0.01 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6188522 Disease Relevance 0 Pain Relevance 0.35
Drug interactions with nerve membrane components regulating ionic permeability: action of tetrodotoxin, procaine, pentobarbital, and ethanol.
membrane Binding (interactions) of in nerve associated with tetrodotoxin
15) Confidence 0.01 Published 1979 Journal Prog. Clin. Biol. Res. Section Title Doc Link 34166 Disease Relevance 0 Pain Relevance 0.16
The fraction was essentially free of mitochondria and secretory granules. [3H]clonidine binding to this membrane fraction revealed a single, high affinity binding site with a Kd of 2.3 nmol/l.
membrane Binding (binding) of associated with clonidine
16) Confidence 0.01 Published 1989 Journal Acta Endocrinol. Section Abstract Doc Link 2572128 Disease Relevance 0.07 Pain Relevance 0.61
The distribution was followed by determination of opiate binding, acetylcholinesterase, and total membrane (using protein and light-scattering measurements).
membrane Binding (binding) of associated with opiate
17) Confidence 0.01 Published 1994 Journal J. Chromatogr. Section Abstract Doc Link 7516343 Disease Relevance 0 Pain Relevance 0.10
Finally, we have tried to focus on the role of the steroid metabolites in the brain, both when they interact with genomic and with membrane receptors.
membrane Binding (interact) of in brain
18) Confidence 0.01 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9370201 Disease Relevance 0 Pain Relevance 0.13
This suggests not only that D-KTP meets the structural constraints needed for receptor-ligand interaction in a manner similar to that of KTP, but also that the stronger membrane interaction and ability to discriminate rigid membrane domains might contribute to its improved analgesic effect.
membrane Binding (interaction) of in KTP associated with analgesic
19) Confidence 0.01 Published 2006 Journal ChemMedChem Section Abstract Doc Link 16902926 Disease Relevance 0.07 Pain Relevance 0.32
Cross-linking of the membrane proteins with a dilute solution of glutaraldehyde produced miniature responses repeating at progressively falling frequencies.
membrane Binding (Cross-linking) of
20) Confidence 0.01 Published 1978 Journal Jpn. J. Physiol. Section Abstract Doc Link 661014 Disease Relevance 0 Pain Relevance 0.10

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