INT1000

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Context Info
Confidence 0.75
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 2.74
Pain Relevance 16.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ggh) extracellular space (Ggh) extracellular region (Ggh)
lysosome (Ggh)
Anatomy Link Frequency
anterior pituitary 3
hypothalamus 2
plasma 1
somatotrope 1
pituitary 1
Ggh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 78 99.96 Very High Very High Very High
Clonidine 72 99.76 Very High Very High Very High
Morphine 33 99.72 Very High Very High Very High
antagonist 40 99.64 Very High Very High Very High
Analgesic 11 99.52 Very High Very High Very High
tolerance 2 99.10 Very High Very High Very High
anesthesia 9 98.96 Very High Very High Very High
Opioid 2 98.90 Very High Very High Very High
Potency 2 98.72 Very High Very High Very High
dexamethasone 15 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 2 99.80 Very High Very High Very High
Hyperinsulinism 2 99.48 Very High Very High Very High
Obesity 28 99.30 Very High Very High Very High
Hyperlipidemia 2 98.76 Very High Very High Very High
Impaired Glucose Tolerance 2 98.00 Very High Very High Very High
Cv Unclassified Under Development 4 94.40 High High
Precocious Puberty 2 89.64 High High
Cancer 4 84.96 Quite High
Acromegaly 1 82.32 Quite High
Sprains And Strains 4 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine in intravenous doses ranging from 10 mug/kg to 8 mg/kg was shown to be effective in stimulating GH release in the unanesthetized rat.
Localization (release) of GH associated with morphine
1) Confidence 0.75 Published 1975 Journal Endocrinology Section Abstract Doc Link 123501 Disease Relevance 0 Pain Relevance 0.47
These results indicate that morphine is a remarkably potent agent for stimulation of GH release but the precise mechanism and site of action of the drug remain to be determined.
Localization (release) of GH associated with morphine
2) Confidence 0.75 Published 1975 Journal Endocrinology Section Abstract Doc Link 123501 Disease Relevance 0 Pain Relevance 0.49
Effects of somatostatin and hypothalamic ventromedial lesions on GH release induced by morphine.
Localization (release) of GH associated with somatostatin and morphine
3) Confidence 0.75 Published 1975 Journal Endocrinology Section Title Doc Link 123501 Disease Relevance 0 Pain Relevance 0.53
Somatostatin (GH-release inhibiting factor) administered SC in a dose of 200 mug/kg 5 min before morphine prevented the GH rise.
Localization (release) of GH associated with somatostatin and morphine
4) Confidence 0.70 Published 1975 Journal Endocrinology Section Abstract Doc Link 123501 Disease Relevance 0 Pain Relevance 0.50
GH secretion from monolayers of dispersed rat anterior pituitary cells was also examined.
Spec (examined) Localization (secretion) of GH in anterior pituitary
5) Confidence 0.65 Published 1990 Journal Endocrinology Section Abstract Doc Link 1967576 Disease Relevance 0 Pain Relevance 0.87
Propranolol (1-100 microM) had no significant effect on basal GH secretion or GH secretion stimulated by rat GRF.
Localization (secretion) of GH
6) Confidence 0.65 Published 1990 Journal Endocrinology Section Abstract Doc Link 1967576 Disease Relevance 0 Pain Relevance 0.87
In conclusion, 1) beta-adrenergic antagonists caused inhibition of stimulated SRIF release; 2) clonidine had no detectable effect on SRIF release; and 3) propranolol did not affect GH secretion in vitro.
Localization (secretion) of GH associated with antagonist, somatostatin and clonidine
7) Confidence 0.65 Published 1990 Journal Endocrinology Section Abstract Doc Link 1967576 Disease Relevance 0 Pain Relevance 0.86
Propranolol (1-100 microM) had no significant effect on basal GH secretion or GH secretion stimulated by rat GRF.
Localization (secretion) of GH
8) Confidence 0.65 Published 1990 Journal Endocrinology Section Abstract Doc Link 1967576 Disease Relevance 0 Pain Relevance 0.87
Genetically obese male Zucker rats have an impaired secretion of GH, coupled to hyperinsulinemia, hyperlipidemia and glucose intolerance.
Localization (secretion) of GH associated with obesity, hyperinsulinism, hyperlipidemia and impaired glucose tolerance
9) Confidence 0.62 Published 2000 Journal J. Endocrinol. Section Abstract Doc Link 10974647 Disease Relevance 0.84 Pain Relevance 0.09
Furthermore, as decreased GH secretion and insulin resistance are associated with increased cardiovascular risk, we also tested the capacity of hexarelin to prevent postischemic ventricular dysfunction in hearts of male obese Zucker rats.
Localization (secretion) of GH in hearts associated with obesity, cv unclassified under development and insulin resistance
10) Confidence 0.62 Published 2000 Journal J. Endocrinol. Section Abstract Doc Link 10974647 Disease Relevance 1.12 Pain Relevance 0.09
These results suggest that the opioids play a modulating role, stimulating the synthesis and secretion of GH, which affects the ultrastructural features of the hypophyseal GH cells.
Localization (secretion) of GH associated with opioid
11) Confidence 0.50 Published 1993 Journal J. Submicrosc. Cytol. Pathol. Section Abstract Doc Link 8462066 Disease Relevance 0 Pain Relevance 0.31
Orchidectomy on day 83 reduced this GHRH-induced GH secretion on day 90.
Localization (secretion) of GH
12) Confidence 0.46 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2109443 Disease Relevance 0 Pain Relevance 0.08
In the sham-operated animals, GHRH stimulated GH secretion on day 90, but not on day 30.
Localization (secretion) of GH
13) Confidence 0.46 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2109443 Disease Relevance 0 Pain Relevance 0.09
Results: 150 micrograms clonidine alone does not stimulate GH-secretion.
Localization (secretion) of GH associated with clonidine
14) Confidence 0.46 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2514051 Disease Relevance 0 Pain Relevance 1.25
In vitro, clonidine had no stimulatory effect on GHRH-stimulated GH secretion.
Localization (secretion) of GH associated with clonidine
15) Confidence 0.46 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2514051 Disease Relevance 0 Pain Relevance 1.16
Interaction of clonidine and GHRH on GH secretion in vivo and in vitro.
Localization (secretion) of GH associated with clonidine
16) Confidence 0.46 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 2514051 Disease Relevance 0 Pain Relevance 0.97
To investigate the mechanism by which clonidine stimulates GH-secretion in vivo and in vitro, we studied its interaction with GHRH.
Localization (secretion) of GH associated with clonidine
17) Confidence 0.43 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2514051 Disease Relevance 0 Pain Relevance 0.59
GABAergic, cholinergic, and serotoninergic systems may thus interact at the level of the hypothalamus to modulate SS secretion in vivo and thereby influence anterior pituitary release of GH and TSH.
Localization (release) of GH in hypothalamus associated with gabaergic and somatostatin
18) Confidence 0.35 Published 1983 Journal Endocrinology Section Abstract Doc Link 6129132 Disease Relevance 0 Pain Relevance 0.66
Growth Hormone-Releasing Hormone (GHRH) is the main factor, which regulates GH secretion and somatotrope proliferation.
Localization (secretion) of GH in somatotrope
19) Confidence 0.28 Published 2005 Journal Endokrynol Pol Section Abstract Doc Link 16821213 Disease Relevance 0.40 Pain Relevance 0
BIM-23454 and BIM-23627, given iv, were able to counteract the SS-induced inhibition of GH secretion occurring after urethane anesthesia in a dose-dependent manner.
Localization (secretion) of GH associated with anesthesia and somatostatin
20) Confidence 0.27 Published 2002 Journal Endocrinology Section Abstract Doc Link 11897676 Disease Relevance 0 Pain Relevance 0.72

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