INT10000

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2010
Negated 17
Speculated 5
Reported most in Abstract
Documents 56
Total Number 61
Disease Relevance 15.33
Pain Relevance 16.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
lymphocytes 19
T-cell 18
monocytes 3
plasma 2
Th1 cells 2
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 732 100.00 Very High Very High Very High
chemokine 78 100.00 Very High Very High Very High
Opioid 29 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
aspirin 24 100.00 Very High Very High Very High
tramadol 6 100.00 Very High Very High Very High
narcan 31 99.70 Very High Very High Very High
cINOD 17 99.68 Very High Very High Very High
Inflammatory response 33 99.36 Very High Very High Very High
opioid receptor 47 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Uremia 24 99.64 Very High Very High Very High
INFLAMMATION 592 99.56 Very High Very High Very High
Infection 170 99.48 Very High Very High Very High
Multiple Myeloma 176 99.42 Very High Very High Very High
Toxicity 18 98.80 Very High Very High Very High
Cancer 171 97.84 Very High Very High Very High
Pulmonary Disease 33 97.64 Very High Very High Very High
Immune System Diseases 5 97.64 Very High Very High Very High
Stress 34 97.60 Very High Very High Very High
Necrosis 33 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro IL-2 levels
Regulation (vitro) of Gene_expression (levels) of IL-2
1) Confidence 0.45 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Venipuncture controls were examined and touched by the clinician in a manner comparable to the SMT groups, making it unlikely that the observed effect on IL-2 synthesis is due to "laying on of the hands" or anticipation-related stress.
Spec (observed) Regulation (effect) of Gene_expression (synthesis) of IL-2 associated with stress
2) Confidence 0.45 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.24 Pain Relevance 0.04
The data show that Tenoxicam inhibits the neutrophil and monocyte functional chemotactic response in vitro, and to some extent in vivo for monocytes, but has no effect on the expression of IL-2 receptors or IL-1 release.
Neg (no) Regulation (effect) of Gene_expression (expression) of IL-2 in monocytes
3) Confidence 0.44 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 2133022 Disease Relevance 0.24 Pain Relevance 0.16
Surprisingly, the expression of several other cytokine receptor chains including the common gamma-chain, IL-2Rbeta, or the IL-2Ralpha, IL-4Ralpha, and IL-15Ralpha chains, was not altered.
Neg (not) Regulation (altered) of Gene_expression (expression) of IL-2 associated with cytokine
4) Confidence 0.44 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10799865 Disease Relevance 0 Pain Relevance 0.65
after ERCP, increased sIL-2r levels was observed in a study in the patients
Regulation (observed) of Gene_expression (levels) of IL-2
5) Confidence 0.44 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.93 Pain Relevance 0.36
Surprisingly, the expression of several other cytokine receptor chains including the common gamma-chain, IL-2Rbeta, or the IL-2Ralpha, IL-4Ralpha, and IL-15Ralpha chains, was not altered.
Neg (not) Regulation (altered) of Gene_expression (expression) of IL-2 associated with cytokine
6) Confidence 0.44 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10799865 Disease Relevance 0 Pain Relevance 0.65
In the present study we examined the immune pharmacological effects of this compound on lymphocyte function by determining its effect on the expression of IL-2 receptors, on monocyte function by looking at chemotaxis and IL-1 release and on neutrophil function by evaluating the chemotactic response to a standard stimulus. 3.
Spec (determining) Regulation (effect) of in lymphocyte Gene_expression (expression) of IL-2 in monocyte
7) Confidence 0.44 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 2133022 Disease Relevance 0.23 Pain Relevance 0.16
In addition, naloxone had an apparent additive effect on the morphine-associated enhancement of IFN gamma and IL-2 expression in the dual-infection model.
Regulation (effect) of Gene_expression (expression) of IL-2 associated with narcan, infection and morphine
8) Confidence 0.42 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.27 Pain Relevance 1.23
An inhibitor of the lipoxygenase pathway, 15-hydroxyeicosatetraenoic acid, did not significantly change IL-2 production by PBL or influence the enhancement by TF5.
Neg (not) Regulation (change) of Gene_expression (production) of IL-2 in PBL
9) Confidence 0.41 Published 1985 Journal Immunopharmacology Section Abstract Doc Link 3926716 Disease Relevance 0.06 Pain Relevance 0.34
We have studied the effects of natural opioids on interleukin-1 (IL-1) -induced interleukin 2 (IL-2) production by the lymphoid cell line EL-4. beta-Endorphin (beta-end) significantly enhanced IL-2 production by IL-1-stimulated EL-4 cells.
Regulation (effects) of Gene_expression (production) of IL-2 associated with opioid
10) Confidence 0.39 Published 1990 Journal Immunopharmacology Section Abstract Doc Link 1689707 Disease Relevance 0 Pain Relevance 0.10
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production.
Regulation (regulate) of Gene_expression (production) of IL-2 in lymphocytes associated with inflammation, cinod and cytokine
11) Confidence 0.36 Published 1995 Journal Cytokine Section Title Doc Link 8589268 Disease Relevance 0.33 Pain Relevance 0.65
Changes on receptor expression and production of interleukin-2 in circulating lymphocyte population after open heart surgery.
Regulation (Changes) of Gene_expression (production) of interleukin-2 in lymphocyte
12) Confidence 0.35 Published 1997 Journal Chin. Med. Sci. J. Section Title Doc Link 11360554 Disease Relevance 0 Pain Relevance 0.16
Effects of Zizyphus on T-cell blastogenesis and IL-2 expression
Regulation (Effects) of Gene_expression (expression) of IL-2 in T-cell
13) Confidence 0.33 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2955679 Disease Relevance 0.10 Pain Relevance 0
A variable effect of piroxicam was observed on IL-1 and IL-2 generation despite the efficacy of piroxicam in reducing the clinical activity of the disease.
Regulation (effect) of Gene_expression (generation) of IL-2 associated with disease
14) Confidence 0.29 Published 1986 Journal J. Rheumatol. Section Abstract Doc Link 3493347 Disease Relevance 0.36 Pain Relevance 0.25
Beta-endorphin modulation of IL-1-induced IL-2 production.
Regulation (modulation) of Gene_expression (production) of IL-2 associated with narcan
15) Confidence 0.28 Published 1990 Journal Immunopharmacology Section Title Doc Link 1689707 Disease Relevance 0 Pain Relevance 0.48
We have studied the effects of natural opioids on interleukin-1 (IL-1) -induced interleukin 2 (IL-2) production by the lymphoid cell line EL-4. beta-Endorphin (beta-end) significantly enhanced IL-2 production by IL-1-stimulated EL-4 cells.
Regulation (effects) of Gene_expression (production) of interleukin 2 associated with opioid
16) Confidence 0.28 Published 1990 Journal Immunopharmacology Section Abstract Doc Link 1689707 Disease Relevance 0 Pain Relevance 0.10
In the present study, these conditions were met in SPA- but not TPA-stimulated cultures of PBMCs, which overall, showed no alterations in IL-2 production (Figs 2A, 2B).
Neg (no) Regulation (alterations) of Gene_expression (production) of IL-2
17) Confidence 0.27 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.22 Pain Relevance 0
No significant alterations in serum-associated IL-2 levels were observed in any of the study groups.


Neg (No) Regulation (alterations) of Gene_expression (levels) of IL-2
18) Confidence 0.27 Published 2008 Journal Chiropr Osteopat Section Abstract Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Conversely, IL-2 synthesis induced by TPA and calcium ionophore was unaltered by either type of SMT and was comparable to that in VC group at all time points.
Regulation (unaltered) of Gene_expression (synthesis) of IL-2
19) Confidence 0.27 Published 2008 Journal Chiropr Osteopat Section Abstract Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Results from the ex vivo study showed that treatment with tiaprofenic acid had no significant effects on the immune parameters investigated, i.e. unstimulated and mitogen-induced proliferation and IL-2 production, spontaneous and stimulated Ig synthesis, lymphocyte subpopulations, serum Ig and complement levels.
Neg (no) Regulation (effects) of Gene_expression (production) of IL-2 in lymphocyte
20) Confidence 0.27 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1452412 Disease Relevance 0.08 Pain Relevance 0.12

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