INT100005

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.93
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MITF) protein complex assembly (MITF) DNA binding (MITF)
protein complex (MITF)
MITF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 98.04 Very High Very High Very High
rheumatoid arthritis 56 83.36 Quite High
melanocortin 1 receptor 2 75.00 Quite High
cytokine 12 71.92 Quite High
psoriasis 2 61.76 Quite High
Arthritis 1 52.08 Quite High
Spinal cord 4 41.64 Quite Low
Chronic pancreatitis 8 29.96 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 40 100.00 Very High Very High Very High
Microphthalmia 2 100.00 Very High Very High Very High
Cancer 679 99.98 Very High Very High Very High
INFLAMMATION 13 98.04 Very High Very High Very High
Death 6 94.16 High High
Repression 3 91.16 High High
Rheumatoid Arthritis 56 83.36 Quite High
Apoptosis 44 82.68 Quite High
Disease 33 76.84 Quite High
Primary Effusion Lymphoma 4 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immediate promoter region has an E-box site with homology to the M-box consensus known to bind the microphthalmia transcription factor (MITF); however, promoter deletion analysis and transactivation studies have failed to show activation through this element by MITF.
microphthalmia transcription factor Binding (bind) of associated with microphthalmia
1) Confidence 0.47 Published 2001 Journal Gene Section Abstract Doc Link 11750130 Disease Relevance 0.10 Pain Relevance 0.07
The immediate promoter region has an E-box site with homology to the M-box consensus known to bind the microphthalmia transcription factor (MITF); however, promoter deletion analysis and transactivation studies have failed to show activation through this element by MITF.
MITF Binding (bind) of associated with microphthalmia
2) Confidence 0.47 Published 2001 Journal Gene Section Abstract Doc Link 11750130 Disease Relevance 0.10 Pain Relevance 0.07
It was predicted by miRanda to have 34 binding sites for 12 KSHV miRNAs [64].
miRNAs Binding (binding) of associated with herpes simplex virus
3) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.12 Pain Relevance 0
The cancer-miRNA network throws up several useful information such as, showing several cancer types and its associated miRNAs, identifying the miRNAs that act as hubs or those that are cancer specific.
miRNAs Binding (associated) of associated with cancer
4) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.24 Pain Relevance 0
Analysis of cancer associated miRNAs based on the proposed network architecture revealed the fact that miRNAs dysregulation patterns are highly tissue dependent.
miRNAs Binding (associated) of associated with cancer
5) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.26 Pain Relevance 0
Here U is a set of cancer types and V is a set of cancer associated miRNAs.
miRNAs Binding (associated) of associated with cancer
6) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.03 Pain Relevance 0
Recently, miRNAs have been recognized as a novel player in normal immune function and inflammation [15].
miRNAs Binding (recognized) of associated with inflammation
7) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.08 Pain Relevance 0.29

General Comments

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