INT100009

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Context Info
Confidence 0.38
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.02
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1)
signal transducer activity (FPR1)
Anatomy Link Frequency
neutrophils 4
FPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 30 99.62 Very High Very High Very High
Nerve growth factor 4 98.26 Very High Very High Very High
Hsan 6 96.16 Very High Very High Very High
Deep tissue 1 86.80 High High
Inflammatory stimuli 3 76.08 Quite High
Analgesic 4 25.00 Low Low
chemokine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 3 99.52 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 6 96.16 Very High Very High Very High
Infection 3 90.64 High High
Lacerations 1 85.36 High High
INFLAMMATION 3 75.76 Quite High
Stress 3 75.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the cells were incubated with fMLP in the presence of LGME, LGEE and AG, fMLP-induced tyrosyl phosphorylation of 45-kDa proteins of the cells was dose-dependently suppressed in parallel to the suppression of fMLP-induced superoxide generation.
Phosphorylation (phosphorylation) of fMLP
1) Confidence 0.38 Published 2002 Journal Clin. Chim. Acta Section Body Doc Link 11750278 Disease Relevance 0 Pain Relevance 0
Here, we show that treatment with S(+)-ketamine or R(-)-ketamine at different concentrations (50, 100, 200, 400 microM) reduced fMLP-induced superoxide anion generation and p47(phox) phosphorylation in neutrophils in a concentration-dependent manner (y = -0.093x + 93.35 for S(+)-ketamine and y = -0.0982x + 95.603 for R(-)-ketamine, respectively).
Phosphorylation (phosphorylation) of fMLP in neutrophils associated with ketamine
2) Confidence 0.36 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.15 Pain Relevance 0.42
Interestingly, treatment with SB203580, the p38 MAPK inhibitor, also mitigated fMLP-induced superoxide anion generation and p38 MAPK and p47(phox) phosphorylation as well as apoptosis in a concentration-dependent fashion in neutrophils.
Phosphorylation (phosphorylation) of fMLP in neutrophils associated with apoptosis
3) Confidence 0.36 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.10 Pain Relevance 0.40
Therefore, ketamine racemes inhibited fMLP-induced superoxide anion generation and p47(phox) phosphorylation by modulating fMLP-mediated p38 MAPK activation in neutrophils.
Phosphorylation (phosphorylation) of fMLP in neutrophils associated with ketamine
4) Confidence 0.28 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.10 Pain Relevance 0.37
Although NGF alone did not exert a chemotactic effect, its presence enhanced both migration toward fMLP and phosphorylation of MAP kinases (ERK and JNK) in neutrophils from healthy controls, but not in neutrophils from CIPA patients.
Phosphorylation (phosphorylation) of fMLP in neutrophils associated with nerve growth factor and hsan
5) Confidence 0.06 Published 2009 Journal Clin. Immunol. Section Abstract Doc Link 18955016 Disease Relevance 0.68 Pain Relevance 0.71

General Comments

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