INT100014

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 7.85
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
smooth muscle cells 6
forearm 4
Coronary sinus 4
plasma 2
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 13 100.00 Very High Very High Very High
corticosteroid 3 99.80 Very High Very High Very High
Migraine 152 97.68 Very High Very High Very High
cytokine 41 97.24 Very High Very High Very High
Inflammation 57 97.04 Very High Very High Very High
Kinase C 12 96.20 Very High Very High Very High
Serotonin 7 94.80 High High
Catecholamine 1 91.20 High High
Osteoarthritis 140 86.52 High High
substance P 35 82.68 Quite High
Disease Link Frequency Relevance Heat
Depression 13 100.00 Very High Very High Very High
Stress 50 99.40 Very High Very High Very High
Disease 72 99.00 Very High Very High Very High
Natriuresis 2 98.52 Very High Very High Very High
Headache 153 97.68 Very High Very High Very High
INFLAMMATION 63 97.04 Very High Very High Very High
Hypoxia 5 94.68 High High
Endometriosis (extended) 12 94.60 High High
Pulmonary Hypertension 228 94.44 High High
Increased Venous Pressure Under Development 84 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The endothelin-1 (ET-1) levels in the coronary sinus were significantly reduced after estrogen infusion, which was negatively correlated with the degree of coronary artery constriction (r = ?
Negative_regulation (reduced) of Gene_expression (levels) of ET-1 in coronary sinus
1) Confidence 0.42 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2515431 Disease Relevance 0.14 Pain Relevance 0
RESULTS: The authors show that propofol inhibits strain-induced ET-1 expression, strain-increased reactive oxygen species formation, and extracellular signal-regulated protein kinase phosphorylation.
Negative_regulation (inhibits) of Gene_expression (expression) of ET-1
2) Confidence 0.42 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
Coronary sinus ET-1 levels were significantly decreased after estrogen infusion by 0.66 pmol/L (41%) in the treated group (1.60 ± 0.48 versus 0.94 ± 0.53 pmol/L, p < 0.0001), but remained unchanged in the control group after saline infusion (1.64 ± 0.29 versus 1.58 ± 0.33 pmol/L, p = NS).


Negative_regulation (decreased) of Gene_expression (levels) of ET-1 in Coronary sinus
3) Confidence 0.42 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.37 Pain Relevance 0.10
SB202190, a p38 inhibitor, completely suppressed the ET-1-stimulated production of both enzymes, whereas the phosphatidyl inositol 3 kinase inhibitor Wortmannin and the PKA inhibitor KT5720 partially but significantly (P < 0.01) decreased the level of MMP-13 only.
Negative_regulation (suppressed) of Gene_expression (production) of ET-1-stimulated
4) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.25 Pain Relevance 0.03
The ET-1-induced iNOS protein expression was completely suppressed by SB202190 and LY83583, and was partially suppressed by Wortmannin and KT5720.
Negative_regulation (suppressed) of Gene_expression (expression) of ET-1-induced
5) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
Moreover, the guanylate cyclase inhibitor LY83583 reduced the NO production as significant differences were found when compared with either the ET-1 stimulation (P < 0.05) or with the control (P < 0.05), and this inhibitor also decreased both the endogenous and ET-1-induced iNOS level (Fig. 2d).
Negative_regulation (decreased) of Gene_expression (level) of ET-1-induced
6) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
In the present study, subtle differences are shown in the pattern of inhibition of the ET-1-induced overproduction of MMP-1 and MMP-13.
Negative_regulation (inhibition) of Gene_expression (overproduction) of ET-1-induced
7) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.41 Pain Relevance 0.16
In pathological situations circulating pro-inflammatory cytokines induce the expression of iNOS and ET-1 in smooth muscle cells, also downregulating endothelial eNOS expression, resulting in an elevated ET-1 production and a decrease of NO [18,39].
Negative_regulation (decrease) of Gene_expression (production) of ET-1 in smooth muscle cells associated with inflammation and cytokine
8) Confidence 0.37 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.89 Pain Relevance 0.38
In addition, in postmenopausal women, long-term ERT decreased plasma ET-1 levels in the systematic circulation, associated with an increased NO-to-ET-1 ratio (Polderman et al 1993; Lieberman et al 1994).
Negative_regulation (decreased) of Gene_expression (levels) of ET-1 in plasma
9) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.09 Pain Relevance 0.07
Interestingly, in patients who went into remission following successful corticosteroid therapy, ET-1 levels decreased and other parameters of disease activity normalized.
Negative_regulation (decreased) of Gene_expression (levels) of ET-1 associated with corticosteroid and disease
10) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072890 Disease Relevance 1.57 Pain Relevance 0.31
The nicotinamide adenine dinucleotide phosphate oxidase inhibitor, apocynin, had the effect of extinguishing not only ROS but also the appearance of ET-1.
Negative_regulation (extinguishing) of Gene_expression (appearance) of ET-1
11) Confidence 0.33 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.65 Pain Relevance 0.20
In contrast, the synthesis of ET-1 is inhibited by high-shear stress, nitric oxide, natriuretic peptides, heparin, and prostaglandins (Boulanger and Luscher 1990; Hu et al 1992; Yokokawa et al 1993; Prins et al 1994; Gray and Webb 1996).
Negative_regulation (inhibited) of Gene_expression (synthesis) of ET-1 associated with natriuresis and stress
12) Confidence 0.31 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.53 Pain Relevance 0.13
CSD: cortical spreading depression; ET-1: endothelin-1; FBF: forearm blood flow; FMD: flow-mediated dilation; L-NMMA: NG-monomethyl-L-arginine; NO: nitric oxide; NOS: nitric oxide synthase; SBP: systolic blood pressure; SNP: sodium nitroprusside; t-PA: tissue plasminogen activator

Competing interests

Negative_regulation (oxide) of Gene_expression (depression) of endothelin-1 in forearm associated with depression
13) Confidence 0.21 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.74 Pain Relevance 0.45
CSD: cortical spreading depression; ET-1: endothelin-1; FBF: forearm blood flow; FMD: flow-mediated dilation; L-NMMA: NG-monomethyl-L-arginine; NO: nitric oxide; NOS: nitric oxide synthase; SBP: systolic blood pressure; SNP: sodium nitroprusside; t-PA: tissue plasminogen activator

Competing interests

Negative_regulation (oxide) of Gene_expression (depression) of ET-1 in forearm associated with depression
14) Confidence 0.21 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.74 Pain Relevance 0.45
The pathogenic consequences of PKC activation include dysregulation of the vascular permeability through the induction of vascular endothelial growth factor (VEGF) in smooth muscle cells [80], dysregulation of blood flow by decreasing endothelial NOS activity and/or increasing ET-1 synthesis [81], basement membrane thickening through Transforming Growth Factor-beta (TGF-?)
Negative_regulation (decreasing) of Gene_expression (synthesis) of ET-1 in smooth muscle cells associated with kinase c
15) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.50 Pain Relevance 0.29
Ibuprofen reduced the ET production which was induced by the endotoxin administration.
Negative_regulation (reduced) of Gene_expression (production) of ET
16) Confidence 0.06 Published 2002 Journal Clin. Chim. Acta Section Body Doc Link 11750279 Disease Relevance 0.06 Pain Relevance 0
This imbalance consisting of reduced production of prostacyclin and nitric oxide and upregulation of ET-1 resulting in the abnormal proliferation and contraction of pulmonary smooth muscle cells via three pathways, all of which are potential targets for therapy (Figure 1 and Table 2) (Humbert, Sitbon et al 2004).
Negative_regulation (reduced) of Gene_expression (production) of ET-1 in smooth muscle cells
17) Confidence 0.04 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350123 Disease Relevance 0.77 Pain Relevance 0.10
For example, oligomeric procyanidins of red wine have been shown to reduce vasoconstrictor endothelin-1 production in vitro [24].
Negative_regulation (reduce) of Gene_expression (production) of vasoconstrictor endothelin-1
18) Confidence 0.03 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2427009 Disease Relevance 0.14 Pain Relevance 0.04

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