INT100018

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Context Info
Confidence 0.24
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.56
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, MAPK1) nucleoplasm (MAPK1) mitochondrion (MAPK1)
DNA binding (MAPK1) microtubule organizing center (MAPK1) extracellular space (TNF)
TNF (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 97.96 Very High Very High Very High
cytokine 13 97.44 Very High Very High Very High
methotrexate 14 90.92 High High
agonist 13 87.36 High High
dorsal root ganglion 7 86.24 High High
Pain 3 80.60 Quite High
rheumatoid arthritis 77 72.92 Quite High
Arthritis 3 64.60 Quite High
antagonist 5 55.92 Quite High
Leflunomide 15 49.04 Quite Low
Disease Link Frequency Relevance Heat
Disease 31 98.44 Very High Very High Very High
INFLAMMATION 24 97.96 Very High Very High Very High
Ganglion Cysts 7 86.24 High High
Pain 3 80.60 Quite High
Autoimmune Disease 8 78.52 Quite High
Necrosis 2 76.04 Quite High
Cancer 3 75.68 Quite High
Stress 3 75.00 Quite High
Rheumatoid Arthritis 122 72.92 Quite High
Experimental Arthritis 1 64.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical and immunocytochemical analysis showed that TNF activated p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK.
TNF Positive_regulation (activated) of p38
1) Confidence 0.24 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11750919 Disease Relevance 0.77 Pain Relevance 0.31
signalling was pathway specific (Fig. 2), as no equivalent inhibition of p38 MAP kinase was observed following SLIGKV-OH pre-treatment (Panel A) whilst ERK activation in response to TNF?
TNF Positive_regulation (activation) of ERK
2) Confidence 0.04 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.07
TNF activates multiple kinases (p38, ERK, JNK) and will induce the expression of other pro-inflammatory cytokines that, in turn, invoke pro-inflammatory signaling events associated with kinase activation.
TNF Positive_regulation (activates) of ERK associated with inflammation and cytokine
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.79 Pain Relevance 0.56

General Comments

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