INT100021

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Context Info
Confidence 0.80
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.40
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Tnfrsf1b) nucleus (Tnfrsf1b)
Anatomy Link Frequency
dorsal root ganglion 1
Tnfrsf1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 100 98.88 Very High Very High Very High
rheumatoid arthritis 22 98.56 Very High Very High Very High
Spinal cord 2 97.48 Very High Very High Very High
Inflammation 103 97.08 Very High Very High Very High
Dorsal horn 1 96.88 Very High Very High Very High
Thermal hyperalgesia 15 92.88 High High
allodynia 5 91.88 High High
Spinal nerve ligature 4 90.32 High High
Neuropathic pain 3 86.96 High High
Pain 30 80.56 Quite High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 1 99.44 Very High Very High Very High
Ganglion Cysts 100 98.88 Very High Very High Very High
Rheumatoid Arthritis 23 98.56 Very High Very High Very High
INFLAMMATION 102 97.08 Very High Very High Very High
Uveitis 2 95.04 Very High Very High Very High
Hyperalgesia 69 92.88 High High
Neuropathic Pain 22 91.88 High High
Arthritis 69 86.92 High High
Bordatella Infection 1 85.68 High High
Death 6 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chimeric TNF-alpha soluble receptor (hTNFR-Is) electrotransfer led to elevated protein secretion in aqueous humor and to drastic inhibition of clinical and histological inflammation scores in rats with endotoxin-induced uveitis.
Localization (secretion) of TNF-alpha soluble receptor associated with inflammation and uveitis
1) Confidence 0.80 Published 2006 Journal FASEB J. Section Abstract Doc Link 16352651 Disease Relevance 0.27 Pain Relevance 0.16
The link between TNF receptor activation and Ca2+ release from stores remains to be elucidated.
Localization (release) of TNF receptor
2) Confidence 0.70 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11750919 Disease Relevance 0.92 Pain Relevance 0.33
At all time points studied, TNFR2 colocalisation was observed exclusively with ED1-positive cells (Fig. 4e), and no colocalisation was observed with GFAP-positive cells (Fig. 4f).
Localization (colocalisation) of TNFR2
3) Confidence 0.70 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.62 Pain Relevance 0.24
Forward and reverse primers were designed for the TNFR1 and TNFR2 mRNA using Primer Express software (Applied Biosystems, Foster City, CA, USA).
Localization (using) of TNFR2 mRNA
4) Confidence 0.70 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.18 Pain Relevance 0.09
Results

Residues W89 and E92 of TNFR2 are critical for ligand binding

Localization (critical) of TNFR2
5) Confidence 0.66 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816690 Disease Relevance 0.10 Pain Relevance 0.08
Indeed photographs presented in cited publications [42,43] clearly show both cytoplasmic and membrane-bound localization of TNFR1 and TNFR2.
Localization (localization) of TNFR2
6) Confidence 0.65 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.29 Pain Relevance 0.03
Local release of the soluble p55 TNF receptor, achieved by herpes simplex virus vector-based gene transfer to dorsal root ganglion, resulted in a reduction of mTNFalpha and concomitant reductions in interleukin-1beta and phosphorylated p38 MAP kinase.
Localization (release) of p55 TNF receptor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and herpes simplex virus
7) Confidence 0.48 Published 2007 Journal Gene Ther. Section Abstract Doc Link 17443214 Disease Relevance 1.03 Pain Relevance 1.04

General Comments

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