INT100029

Context Info Confidence 0.01 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.78 Pain Relevance 0.31

signal transduction (TNF, Mapk1) nucleoplasm (Mapk1) mitochondrion (Mapk1) microtubule organizing center (Mapk1) extracellular space (TNF) plasma membrane (TNF)

TNF (Homo sapiens) Mapk1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat dorsal root ganglion 7 89.60 Pain 1 80.60 cytokine 1 75.40

Disease Link Frequency Relevance Heat Ganglion Cysts 7 89.60 Pain 1 80.60 Autoimmune Disease 1 78.52 Necrosis 1 76.04 Cancer 1 75.68 Stress 1 75.00 Bordatella Infection 1 36.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Biochemical and immunocytochemical analysis showed that TNF activated p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) but not p42/p44 MAPK.

TNF Positive_regulation (activated) of p38MAPK

1) Confidence 0.01 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11750919 Disease Relevance 0.78 Pain Relevance 0.31

General Comments

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