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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.78
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MIA PaCa-2 1
PC-3 1
BTG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 7 99.68 Very High Very High Very High
cINOD 17 92.56 High High
Potency 2 75.88 Quite High
Inflammation 5 75.00 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 1 100.00 Very High Very High Very High
Reprotox - General 1 4 98.16 Very High Very High Very High
Apoptosis 3 90.76 High High
INFLAMMATION 9 85.44 High High
Lung Cancer 2 85.40 High High
Death 1 84.48 Quite High
Cancer 5 75.00 Quite High
Frailty 2 75.00 Quite High
Prostate Cancer 1 75.00 Quite High
Prostatic Intraepithelial Neoplasia 1 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Nitrosulindac but not sulindac exerted a cytotoxic effect on all cell lines and an anti-proliferative effect on LNCaP and PC3 cells only.
Regulation (effect) of PC3
1) Confidence 0.23 Published 2004 Journal Prostate Section Body Doc Link 15305336 Disease Relevance 0.08 Pain Relevance 0
NO-aspirin showed similar effects on two pancreatic cancer cell lines, BxPC-3 (expresses COX) and MIA PaCa-2 (no COX expression), suggesting a COX-independent effect.
Regulation (effects) of BxPC-3 in MIA PaCa-2 associated with aspirin and pancreatic cancer
2) Confidence 0.12 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438552 Disease Relevance 0.91 Pain Relevance 1.05
In the cell lines, LNCaP, DU145, PC-3, and TSU, COX-2 protein expression was undetectable under basal conditions but could be induced transiently by phorbol ester treatment in PC-3 and TSU cells, but not in DU145 and LNCaP cells.
Regulation (undetectable) of PC-3 in PC-3
3) Confidence 0.08 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11751373 Disease Relevance 0.80 Pain Relevance 0.15

General Comments

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